The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two ... See more...

Aliases for ANG Gene

Aliases for ANG Gene

  • Angiogenin 2 3 4 5
  • RNASE5 2 3 4
  • Angiogenin, Ribonuclease, RNase A Family, 5 2 3
  • Ribonuclease A Family Member 5 2 3
  • Ribonuclease 5 3 4
  • RNase 5 3 4
  • RAA1 2 3
  • Epididymis Luminal Protein 168 3
  • Ribonuclease A A1 3
  • EC 3.1.27.- 4
  • EC 3.1.27 51
  • HEL168 3
  • RNASE4 3
  • ALS9 3
  • ANG 5

External Ids for ANG Gene

Previous GeneCards Identifiers for ANG Gene

  • GC14P018528
  • GC14P014944
  • GC14P019147
  • GC14P019143
  • GC14P019144
  • GC14P020223
  • GC14P021152
  • GC14P001273
  • GC14P020687
  • GC14P020695
  • GC14P020785
  • GC14P020789
  • GC14P020798
  • GC14P020810
  • GC14P020703
  • GC14P020712
  • GC14P020722
  • GC14P020735
  • GC14P020744
  • GC14P020753
  • GC14P020763
  • GC14P020772

Summaries for ANG Gene

Entrez Gene Summary for ANG Gene

  • The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014]

GeneCards Summary for ANG Gene

ANG (Angiogenin) is a Protein Coding gene. Diseases associated with ANG include Amyotrophic Lateral Sclerosis 9 and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Cell junction organization. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and actin binding. An important paralog of this gene is RNASE4.

UniProtKB/Swiss-Prot Summary for ANG Gene

  • Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.

Gene Wiki entry for ANG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ANG Gene

Genomics for ANG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ANG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ANG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ANG

Top Transcription factor binding sites by QIAGEN in the ANG gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • Nkx2-5

Genomic Locations for ANG Gene

Genomic Locations for ANG Gene
chr14:20,684,177-20,698,971
(GRCh38/hg38)
Size:
14,795 bases
Orientation:
Plus strand
chr14:21,152,336-21,167,130
(GRCh37/hg19)
Size:
14,795 bases
Orientation:
Plus strand

Genomic View for ANG Gene

Genes around ANG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANG Gene

Proteins for ANG Gene

  • Protein details for ANG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P03950-ANGI_HUMAN
    Recommended name:
    Angiogenin
    Protein Accession:
    P03950
    Secondary Accessions:
    • Q05CV1
    • Q53X86
    • Q6P5T2
    • Q8WXE7

    Protein attributes for ANG Gene

    Size:
    147 amino acids
    Molecular mass:
    16550 Da
    Quaternary structure:
    • Homodimer (PubMed:25372031). Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur.
    SequenceCaution:
    • Sequence=AAH20704.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANG Gene

neXtProt entry for ANG Gene

Selected DME Specific Peptides for ANG Gene

P03950:
  • LGLGLTP
  • LPVHLDQSIFR
  • FLTQHYDAKP
  • YRATAGFR
  • ENLRISKS
  • PPTLAQD
  • FQVTTCK
  • PTLAQDN
  • CENGLPVH
  • MRRRGLTSPCK
  • GGSPWPPC

Post-translational modifications for ANG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANG Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ANG Gene

Gene Families for ANG Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for ANG Gene

InterPro:
Blocks:
  • Pancreatic ribonuclease
ProtoNet:

Suggested Antigen Peptide Sequences for ANG Gene

GenScript: Design optimal peptide antigens:
  • Ribonuclease 5 (ANGI_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P03950

UniProtKB/Swiss-Prot:

ANGI_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with ANG: view

Function for ANG Gene

Molecular function for ANG Gene

UniProtKB/Swiss-Prot Function:
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
GENATLAS Biochemistry:
angiogenin,ribonuclease RNAse A family

Enzyme Numbers (IUBMB) for ANG Gene

Phenotypes From GWAS Catalog for ANG Gene

Gene Ontology (GO) - Molecular Function for ANG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA,IC 10649442
GO:0003779 actin binding IDA 7679494
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity TAS 10103013
genes like me logo Genes that share ontologies with ANG: view
genes like me logo Genes that share phenotypes with ANG: view

Human Phenotype Ontology for ANG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ANG Gene

MGI Knock Outs for ANG:
  • Ang Ang<tm1Dats>

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANG

No data available for Transcription Factor Targets and HOMER Transcription for ANG Gene

Localization for ANG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANG Gene

Cytoplasmic vesicle, secretory vesicle lumen. Secreted. Nucleus. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (PubMed:12051708). {ECO:0000269 PubMed:12051708}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANG gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 4
plasma membrane 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Actin filaments (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005604 basement membrane IDA 15166501
GO:0005615 extracellular space IDA 3663649
GO:0005634 nucleus IEA,IDA 10649442
GO:0005730 nucleolus ISS --
genes like me logo Genes that share ontologies with ANG: view

Pathways & Interactions for ANG Gene

genes like me logo Genes that share pathways with ANG: view

Gene Ontology (GO) - Biological Process for ANG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA,TAS 16567967
GO:0001541 ovarian follicle development NAS 12770725
GO:0001556 oocyte maturation NAS 11438326
GO:0001666 response to hypoxia NAS 15776477
GO:0001890 placenta development NAS 11984825
genes like me logo Genes that share ontologies with ANG: view

No data available for SIGNOR curated interactions for ANG Gene

Drugs & Compounds for ANG Gene

(10) Drugs for ANG Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Enzyme, cofactor 249
Pidolic acid Approved, Investigational Pharma 0
Citric acid Approved, Vet_approved Nutra Activator, Agonist 1509

(4) Additional Compounds for ANG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANG: view

Transcripts for ANG Gene

mRNA/cDNA for ANG Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ANG

Alternative Splicing Database (ASD) splice patterns (SP) for ANG Gene

No ASD Table

Relevant External Links for ANG Gene

GeneLoc Exon Structure for
ANG

Expression for ANG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANG Gene

This gene is overexpressed in Liver (x14.5).

Protein differential expression in normal tissues from HIPED for ANG Gene

This gene is overexpressed in Serum (36.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANG Gene



Protein tissue co-expression partners for ANG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ANG

SOURCE GeneReport for Unigene cluster for ANG Gene:

Hs.283749

mRNA Expression by UniProt/SwissProt for ANG Gene:

P03950-ANGI_HUMAN
Tissue specificity: Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.

Evidence on tissue expression from TISSUES for ANG Gene

  • Liver(4.9)
  • Intestine(4.6)
  • Lung(3.1)
  • Heart(3.1)
  • Nervous system(3.1)
  • Skin(2.8)
  • Kidney(2.7)
  • Muscle(2.7)
  • Blood(2.6)
  • Stomach(2.5)
  • Pancreas(2.2)
  • Eye(2.1)
  • Bone marrow(2)
  • Lymph node(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ANG Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • epiglottis
  • face
  • head
  • jaw
  • larynx
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • pharynx
  • skull
  • tongue
  • vocal cord
Thorax:
  • bronchus
  • clavicle
  • esophagus
  • heart
  • lung
  • scapula
  • trachea
Abdomen:
  • biliary tract
  • liver
  • stomach
Limb:
  • arm
  • digit
  • finger
  • foot
  • forearm
  • hand
  • humerus
  • lower limb
  • shin
  • shoulder
  • thigh
  • toe
  • upper limb
General:
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • spinal cord
genes like me logo Genes that share expression patterns with ANG: view

Orthologs for ANG Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ANG 30 31
  • 99.55 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ang 30 17 31
  • 83.87 (n)
OneToMany
Ang2 31
  • 66 (a)
OneToMany
Ang4 31
  • 64 (a)
OneToMany
Ang5 31
  • 64 (a)
OneToMany
Ang6 31
  • 57 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Ang 30
  • 82.67 (n)
Cow
(Bos Taurus)
Mammalia ANG 31
  • 64 (a)
OneToMany
-- 31
  • 62 (a)
OneToMany
ANG2 31
  • 55 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia ANG 31
  • 58 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 44 (a)
OneToMany
-- 31
  • 43 (a)
OneToMany
-- 31
  • 41 (a)
OneToMany
-- 31
  • 40 (a)
OneToMany
-- 31
  • 39 (a)
OneToMany
-- 31
  • 39 (a)
OneToMany
Species where no ortholog for ANG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ANG Gene

ENSEMBL:
Gene Tree for ANG (if available)
TreeFam:
Gene Tree for ANG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ANG: view image

Paralogs for ANG Gene

(3) SIMAP similar genes for ANG Gene using alignment to 1 proteins:

  • ANGI_HUMAN
genes like me logo Genes that share paralogs with ANG: view

Variants for ANG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ANG Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
804533 Conflicting Interpretations: not provided 20,693,625(+) C/T MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
807060 Uncertain Significance: Amyotrophic lateral sclerosis type 9; not provided 20,693,567(+) G/A INITIATIOR_CODON_VARIANT,MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
807061 Uncertain Significance: not provided 20,693,617(+) T/A MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
807062 Uncertain Significance: not provided 20,693,658(+) C/T MISSENSE_VARIANT,INTRON_VARIANT
873274 Uncertain Significance: Amyotrophic lateral sclerosis 20,693,887(+) A/AT FRAMESHIFT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ANG Gene

Structural Variations from Database of Genomic Variants (DGV) for ANG Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV gain+loss 19812545
esv3633687 CNV loss 21293372
esv3633688 CNV loss 21293372
nsv1203 CNV deletion 18451855

Variation tolerance for ANG Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANG Gene

Human Gene Mutation Database (HGMD)
ANG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANG Gene

Disorders for ANG Gene

MalaCards: The human disease database

(13) MalaCards diseases for ANG Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 9
  • als9
amyotrophic lateral sclerosis 1
  • als1
lateral sclerosis
  • adult-onset primary lateral sclerosis
lipodermatosclerosis
  • acute lipodermatosclerosis
amyotrophic lateral sclerosis 4, juvenile
  • als4
- elite association - COSMIC cancer census association via MalaCards
Search ANG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ANGI_HUMAN
  • Amyotrophic lateral sclerosis 9 (ALS9) [MIM:611895]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269 PubMed:15557516, ECO:0000269 PubMed:16501576, ECO:0000269 PubMed:17703939, ECO:0000269 PubMed:17886298, ECO:0000269 PubMed:17900154, ECO:0000269 PubMed:18087731, ECO:0000269 PubMed:22292843, ECO:0000269 PubMed:25372031}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for ANG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ANG: view

No data available for Genatlas for ANG Gene

Publications for ANG Gene

  1. Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis. (PMID: 18087731) Gellera C … Silani V (Neurogenetics 2008) 3 4 23 41
  2. [Genetic determinants of cardiovascular remodeling in Uzbek patients with essential hypertension]. (PMID: 19253715) Eliseeva MR … Abdullaeva GZh (Terapevticheskii arkhiv 2009) 3 23 41
  3. Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis. (PMID: 19363631) Fernández-Santiago R … Ludolph A (Journal of neurology 2009) 3 23 41
  4. A novel Angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern Italy. (PMID: 17703939) Conforti FL … Quattrone A (Neuromuscular disorders : NMD 2008) 3 4 23
  5. Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosis. (PMID: 18852347) Paubel A … French Amyotrophic Lateral Sclerosis (ALS) Study Group (Archives of neurology 2008) 3 23 41

Products for ANG Gene

Sources for ANG Gene