Aliases for ADORA1 Gene
External Ids for ADORA1 Gene
Previous GeneCards Identifiers for ADORA1 Gene
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADORA1 Gene
ADORA1 (Adenosine A1 Receptor) is a Protein Coding gene. Diseases associated with ADORA1 include Sleep Disorder and Ischemia. Among its related pathways are Signaling by GPCR and Microglia Activation During Neuroinflammation: Overview. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled receptor binding. An important paralog of this gene is ADORA2A.
UniProtKB/Swiss-Prot Summary for ADORA1 Gene
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
The A1 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A2A, A2B and A3. A1 receptors display high expression levels in the brain (cortex, cerebellum, hippocampus), dorsal horn of the spinal cord, eye and atria.