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Aliases for AZIN2 Gene

Aliases for AZIN2 Gene

  • Antizyme Inhibitor 2 2 3 3 5
  • Arginine Decarboxylase 2 3 4
  • Ornithine Decarboxylase-Like Protein 3 4
  • Ornithine Decarboxylase Like 2 3
  • ODC-Like Protein 3 4
  • ODC-P 3 4
  • ADC 3 4
  • Ornithine Decarboxylase-Paralog 3
  • Ornithine Decarboxylase Paralog 4
  • ODC Antizyme Inhibitor-2 3
  • ODC-Paralogue 3
  • KIAA1945 4
  • AZIB1 3
  • ODC1L 3
  • ARGDC 4
  • AZI2 3
  • ODCp 3
  • AzI2 4
  • ODCP 4

External Ids for AZIN2 Gene

Previous HGNC Symbols for AZIN2 Gene

  • ADC

Summaries for AZIN2 Gene

Entrez Gene Summary for AZIN2 Gene

  • The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. Accumulation of antizyme inhibitor 2 has also been observed in brains of patients with Alzheimer's disease. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for AZIN2 Gene

AZIN2 (Antizyme Inhibitor 2) is a Protein Coding gene. Diseases associated with AZIN2 include Chorioretinitis. Among its related pathways are Metabolism and Arginine and proline metabolism. Gene Ontology (GO) annotations related to this gene include ornithine decarboxylase activity and putrescine transmembrane transporter activity. An important paralog of this gene is ODC1.

UniProtKB/Swiss-Prot for AZIN2 Gene

  • Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728).

Gene Wiki entry for AZIN2 Gene

Additional gene information for AZIN2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AZIN2 Gene

Genomics for AZIN2 Gene

GeneHancer (GH) Regulatory Elements for AZIN2 Gene

Promoters and enhancers for AZIN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J033080 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.2 171 1.4 PKNOX1 ARID4B SIN3A ZNF48 FOS SP3 NFYC KAT8 MBD2 SREBF1 AZIN2 AK2 LOC105378635 KPNA6 ENSG00000239670 GC01P033098
GH01J032753 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -326.2 -326181 3 HDGF PKNOX1 CLOCK ARNT SIN3A ZNF2 ZNF766 SP3 REST ZNF592 ZBTB8B ENSG00000224409 SYNC AZIN2 FNDC5 S100PBP KIAA1522
GH01J032988 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -89.8 -89825 6.6 HDGF PKNOX1 SMAD1 ARNT ZFP64 SIN3A YBX1 IRF4 ZNF766 FOS RNF19B ENSG00000239670 AK2 AZIN2 ENSG00000236065 LOC100419257 ENSG00000276645
GH01J033126 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +46.7 46711 3.2 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF548 SP3 GC01M033124 GC01P033128 GC01P033127 TSSK3 TXLNA RBBP4 FAM229A ZBTB8B S100PBP AZIN2
GH01J033046 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -32.0 -32023 4.2 ELF3 ATF1 NFRKB DNMT3B RAD21 RFX5 EGR1 RCOR1 FOS ATF7 RNF19B RBBP4 ENSG00000239670 TMEM39B TXLNA TSSK3 S100PBP AK2 AZIN2 FAM229A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AZIN2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for AZIN2 Gene

Genomic Locations for AZIN2 Gene
chr1:33,081,104-33,178,892
(GRCh38/hg38)
Size:
97,789 bases
Orientation:
Plus strand
chr1:33,546,705-33,586,131
(GRCh37/hg19)

Genomic View for AZIN2 Gene

Genes around AZIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AZIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AZIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AZIN2 Gene

Proteins for AZIN2 Gene

  • Protein details for AZIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A70-AZIN2_HUMAN
    Recommended name:
    Antizyme inhibitor 2
    Protein Accession:
    Q96A70
    Secondary Accessions:
    • B2RDU5
    • D3DPQ9
    • Q5TIF4
    • Q5TIF5
    • Q5TIF6
    • Q8TF56
    • Q96L54
    • Q96L55
    • Q96L56
    • Q96L57
    • Q96MD9

    Protein attributes for AZIN2 Gene

    Size:
    460 amino acids
    Molecular mass:
    49980 Da
    Quaternary structure:
    • Monomer. Interacts with OAZ1, OAZ2 and OAZ3; this interaction disrupts the interaction between the antizyme and ODC1. Does not form a heterodimer with ODC1.

    Alternative splice isoforms for AZIN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AZIN2 Gene

Post-translational modifications for AZIN2 Gene

  • Ubiquitinated, leading to its proteosomal degradation; a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteosomal-independent manner.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AZIN2 Gene

Domains & Families for AZIN2 Gene

Gene Families for AZIN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q96A70

UniProtKB/Swiss-Prot:

AZIN2_HUMAN :
  • The N-terminus domain is necessary for its localization to the ER-Golgi intermediate compartment (ERGIC).
  • Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily.
Domain:
  • The N-terminus domain is necessary for its localization to the ER-Golgi intermediate compartment (ERGIC).
Family:
  • Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily.
genes like me logo Genes that share domains with AZIN2: view

Function for AZIN2 Gene

Molecular function for AZIN2 Gene

UniProtKB/Swiss-Prot Function:
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728).

Phenotypes From GWAS Catalog for AZIN2 Gene

Gene Ontology (GO) - Molecular Function for AZIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004586 NOT ornithine decarboxylase activity IBA --
GO:0005515 protein binding IPI 17900240
GO:0008792 arginine decarboxylase activity TAS --
GO:0015489 putrescine transmembrane transporter activity IEA,ISS --
GO:0042978 ornithine decarboxylase activator activity ISS --
genes like me logo Genes that share ontologies with AZIN2: view
genes like me logo Genes that share phenotypes with AZIN2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AZIN2

CRISPR Products

miRNA for AZIN2 Gene

miRTarBase miRNAs that target AZIN2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AZIN2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AZIN2 Gene

Localization for AZIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AZIN2 Gene

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Membrane. Cytoplasmic vesicle. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Golgi apparatus, trans-Golgi network. Cytoplasmic granule. Cell projection, axon. Cell projection, dendrite. Perikaryon. Note=Colocalizes with KDEL receptors in ER-Golgi intermediate compartment (ERGIC). Translocates from the ERGIC structure to the cytoplasm in an antizyme-dependent manner. Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules (By similarity). Detected as vesicle-like pattern in neurite outgrowths. Localizes to the vesicular compartments of the secretory pathway, predominantly in the trans-Golgi network (TGN). Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AZIN2 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
plasma membrane 2
mitochondrion 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for AZIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 19718454
GO:0005737 cytoplasm IBA,IEA --
GO:0005739 mitochondrion IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with AZIN2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AZIN2 Gene

Pathways & Interactions for AZIN2 Gene

genes like me logo Genes that share pathways with AZIN2: view

Pathways by source for AZIN2 Gene

Gene Ontology (GO) - Biological Process for AZIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006591 ornithine metabolic process IEA --
GO:0006596 polyamine biosynthetic process IEA --
GO:0007283 spermatogenesis NAS 11587527
GO:0015847 putrescine transport IEA,ISS --
GO:0033387 putrescine biosynthetic process from ornithine IBA --
genes like me logo Genes that share ontologies with AZIN2: view

No data available for SIGNOR curated interactions for AZIN2 Gene

Drugs & Compounds for AZIN2 Gene

(24) Drugs for AZIN2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Arginine Approved Nutra Full agonist, Agonist, Target 0
Pyridoxal Phosphate Approved, Investigational Nutra Target, cofactor 17
Carbon dioxide Approved, Investigational, Vet_approved Pharma 0
Famotidine Approved Pharma Histamine H2-receptor antagonist 64
gamma-Aminobutyric acid Approved, Investigational Pharma 263

(3) Additional Compounds for AZIN2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with AZIN2: view

Transcripts for AZIN2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AZIN2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AZIN2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: - -
SP9: - - -
SP10: - - -
SP11: - - -
SP12: - - - - - - - - - -
SP13: - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - -

Relevant External Links for AZIN2 Gene

GeneLoc Exon Structure for
AZIN2
ECgene alternative splicing isoforms for
AZIN2

Expression for AZIN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AZIN2 Gene

This gene is overexpressed in Pancreatic juice (32.1) and Adipocyte (25.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AZIN2 Gene



NURSA nuclear receptor signaling pathways regulating expression of AZIN2 Gene:

AZIN2

mRNA Expression by UniProt/SwissProt for AZIN2 Gene:

Q96A70-AZIN2_HUMAN
Tissue specificity: Expressed in the neocortex, thalamus, hippocampus, cerebellum, medulla oblongata, gray and white matter. Expressed in neurons, oligodendrocytes, basket, Purkinje and pyramidal cells. Expressed in spermatocytes and Leydig cells of the testis. Expressed in luteal theca cells lining corpus luteum cysts and in hilus cells of the ovary. Expressed in primary and neoplastic mast cells (MC) (at protein level). Highly expressed in brain. Also expressed in testis.

Evidence on tissue expression from TISSUES for AZIN2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with AZIN2: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AZIN2 Gene

Orthologs for AZIN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AZIN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADC 34 33
  • 94.1 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADC 34 33
  • 90.58 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADC 34 33
  • 89.42 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Adc 34 33
  • 87.51 (n)
OneToOne
Azin2 16
rat
(Rattus norvegicus)
Mammalia Adc 33
  • 87.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADC 34
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADC 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADC 34 33
  • 66.96 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADC 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adc 33
  • 64.63 (n)
Str.8128 33
fruit fly
(Drosophila melanogaster)
Insecta Odc1 34
  • 37 (a)
ManyToMany
Odc2 34
  • 35 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F53F10.2 34
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPE1 34
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10349 34
  • 35 (a)
OneToMany
Species where no ortholog for AZIN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for AZIN2 Gene

ENSEMBL:
Gene Tree for AZIN2 (if available)
TreeFam:
Gene Tree for AZIN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AZIN2: view image

Paralogs for AZIN2 Gene

Paralogs for AZIN2 Gene

genes like me logo Genes that share paralogs with AZIN2: view

Variants for AZIN2 Gene

Sequence variations from dbSNP and Humsavar for AZIN2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000016877 -- 33,092,249(+) G/C intron_variant
rs1000048917 -- 33,148,566(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000050725 -- 33,119,619(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000077036 -- 33,098,806(+) C/G intron_variant
rs1000082373 -- 33,162,597(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for AZIN2 Gene

Variant ID Type Subtype PubMed ID
esv3576805 CNV gain 25503493
nsv545962 CNV loss 21841781
nsv834602 CNV loss 17160897

Variation tolerance for AZIN2 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.73; 86.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AZIN2 Gene

Human Gene Mutation Database (HGMD)
AZIN2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AZIN2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AZIN2 Gene

Disorders for AZIN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AZIN2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
chorioretinitis
  • retinochoroiditis
- elite association - COSMIC cancer census association via MalaCards
Search AZIN2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AZIN2

genes like me logo Genes that share disorders with AZIN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AZIN2 Gene

Publications for AZIN2 Gene

  1. Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. (PMID: 17900240) Kanerva K … Andersson LC (The Biochemical journal 2008) 2 3 4 22 58
  2. Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine. (PMID: 14738999) Zhu MY … Regunathan S (Biochimica et biophysica acta 2004) 2 3 4 22 58
  3. Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes. (PMID: 11587527) Pitkänen LT … Andersson LC (Biochemical and biophysical research communications 2001) 2 3 4 22 58
  4. Ornithine decarboxylase antizyme inhibitor 2 regulates intracellular vesicle trafficking. (PMID: 20188728) Kanerva K … Andersson LC (Experimental cell research 2010) 3 4 58
  5. Antizyme inhibitor 2: molecular, cellular and physiological aspects. (PMID: 19956990) López-Contreras AJ … Peñafiel R (Amino acids 2010) 3 4 58

Products for AZIN2 Gene

Sources for AZIN2 Gene

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