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The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dep... See more...
Aliases for AXL Gene
Aliases for AXL Gene
External Ids for AXL Gene
- HGNC: 905
- NCBI Entrez Gene: 558
- Ensembl: ENSG00000167601
- OMIM®: 109135
- UniProtKB/Swiss-Prot: P30530
Previous GeneCards Identifiers for AXL Gene
- GC19P042364
- GC19P042116
- GC19P046400
- GC19P046416
- GC19P041725
- GC19P038157
Summaries for AXL Gene
-
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
GeneCards Summary for AXL Gene
AXL (AXL Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with AXL include Hypogonadotropic Hypogonadism 7 With Or Without Anosmia and Nk-Cell Enteropathy. Among its related pathways are RET signaling and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MERTK.
UniProtKB/Swiss-Prot Summary for AXL Gene
-
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
-
(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.
-
(Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.
Additional gene information for AXL Gene
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AXL Gene
Genomics for AXL Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for AXL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around AXL on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AXL
- Top Transcription factor binding sites by QIAGEN in the AXL gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- c-Myc
Genomic Locations for AXL Gene
Latest Assembly
- chr19:41,219,223-41,261,766
- (GRCh38/hg38)
- Size:
- 42,544 bases
- Orientation:
- Plus strand
Previous Assembly
- chr19:41,725,128-41,767,671
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 42,544 bases
- Orientation:
- Plus strand
Genomic View for AXL Gene
Genes around AXL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by HGNC
- 19q13.2 by Entrez Gene
- 19q13.2 by Ensembl
AXL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AXL Gene
Proteins for AXL Gene
-
Protein details for AXL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P30530-UFO_HUMAN
- Recommended name:
- Tyrosine-protein kinase receptor UFO
- Protein Accession:
- P30530
- Q8N5L2
- Q9UD27
Protein attributes for AXL Gene
- Size:
- 894 amino acids
- Molecular mass:
- 98337 Da
- Quaternary structure:
-
- Heterodimer and heterotetramer with ligand GAS6. Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2, PIK3R3, PLCG1, SOCS1 and TNS2. Part of a complex including AXL, TNK2 and GRB2, in which GRB2 promotes AXL recruitment by TNK2.
Three dimensional structures from OCA and Proteopedia for AXL Gene
Protein Expression for AXL Gene
Selected DME Specific Peptides for AXL Gene
- P30530:
-
- GNRLKQP
- RDLAARN
- TSKSDVW
- FGVTMWEIATRG
- GDYYRQG
- KSDVWSFG
- KVAVKTMK
- FSCEAHN
- TRGQTPY
Post-translational modifications for AXL Gene
- Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion.
- Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity.
-
Glycosylation at Asn43, Asn157, Asn198, Asn339, Asn345, and Asn401
- NX_P30530 (NX_P30530-1)
-
Ubiquitination at Lys540
- NX_P30530 (NX_P30530-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- UFO_HUMAN (1983)
Other Protein References for AXL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences AXL Monoclonal Antibody and AXL Antibody
- NSJ Bioreagents AXL Antibody
-
Custom Antibody ServicesOriGene Antibodies for AXL
- Novus Biologicals Antibodies for AXL
-
Abcam antibodies for AXL
- Invitrogen Antibodies for AXL (AFLGC-AXL)
- antibodies-online: Show 112 available AXL Antibodies ranked by validation data
- Compare Top AXL Antibodies
-
Recommended
- 173 WB Antibodies (anti-human)
- 49 FACS Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 62 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 12 FACS Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 45 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
-
Boster Bio Antibodies for AXL
-
Custom Antibody ServicesProSci Antibodies for AXL
- Sino Biological Antibodies for AXL
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for AXL
- Origene Custom Protein Services for AXL
- Sino Biological Recombinant Proteins for AXL
- Sino Biological Cell Lysates for AXL
- antibodies-online: Show 20 available AXL Proteins ranked by validation data
- Compare Top AXL Proteins
-
ProSci Proteins for AXL
-
Abcam proteins for AXL
Assay products for research
- RayBiotech Human Axl ELISA
- antibodies-online: Show 44 available AXL Elisa Kits ranked by validation data
- Compare Top AXL Elisa Kits
-
Quality Products:
-
Abcam assays for AXL
- Sino Biological Assays for AXL
Domains & Families for AXL Gene
Gene Families for AXL Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted membrane proteins
Protein Domains for AXL Gene
- InterPro:
- Blocks:
-
- Immunoglobulin subtype
- Tyrosine protein kinase, active site
Suggested Antigen Peptide Sequences for AXL Gene
- GenScript: Design optimal peptide antigens:
-
- Ufo protein (Q15839_HUMAN)
- AXL oncogene (UFO_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P30530UniProtKB/Swiss-Prot:
UFO_HUMAN :- Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Function for AXL Gene
Molecular function for AXL Gene
- UniProtKB/Swiss-Prot Function:
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by GAS6-binding and subsequent autophosphorylation.
- GENATLAS Biochemistry:
- AXL transforming sequence,activated by GAS6,involved in the protection of neurons from apoptosis across neuronal migration,expressed in neural lymphoid,vascular and reproductive tissue,involved in the regulation of spermatogenesis and in primary and tumor cell lines derived from these sources
Enzyme Numbers (IUBMB) for AXL Gene
Phenotypes From GWAS Catalog for AXL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0001618 | virus receptor activity | IDA | 22156524 |
| GO:0001786 | phosphatidylserine binding | IDA | 21501828 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004713 | protein tyrosine kinase activity | IEA,EXP | 22327215 |
Phenotypes for AXL Gene
- MGI mutant phenotypes for AXL:
-
inferred from 2 alleles
- normal phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- immune system phenotype
- mortality/aging
- liver/biliary system phenotype
- hematopoietic system phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- skeleton phenotype
- integument phenotype
- GenomeRNAi human phenotypes for AXL:
-
- Strongly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability ratio
- Increased transferrin (TF) endocytosis
- Decreased vaccinia virus (VACV) infection
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Decreased ionizing radiation sensitivity
- Decreased substrate adherent cell growth
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between BLM-/- and BLM+/+
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Increased Nanog expression
- Decreased shRNA abundance (Z-score < -2)
- Increased viability after borna disease (rVSVΔG*/BDVG) virus infection
- Decreased viability
- Increased mitotic index
- Condensed cis-Golgi, condensed medial Golgi, condensed trans-Golgi
Animal Models for research
-
Taconic Biosciences Mouse Models for AXL
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for AXL - Starting at $85 >
- * AXL CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for AXL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AXL
-
Santa Cruz Biotechnology (SCBT) CRISPR for AXL
miRNA for AXL Gene
- miRTarBase miRNAs that target AXL
-
- hsa-miR-1-3p (MIRT002758)
- hsa-miR-34a-5p (MIRT006664)
- mmu-miR-34b-5p (MIRT012893)
- hsa-miR-375 (MIRT019798)
- hsa-miR-155-5p (MIRT020726)
- hsa-miR-122-5p (MIRT438639)
- mmu-miR-3064-5p (MIRT593005)
- mmu-miR-3085-3p (MIRT593006)
- mmu-miR-149-5p (MIRT593007)
- mmu-miR-760-3p (MIRT593008)
- mmu-miR-1896 (MIRT593009)
- mmu-miR-3473c (MIRT606532)
- mmu-miR-343 (MIRT606533)
- mmu-miR-1930-5p (MIRT606534)
- hsa-miR-6818-3p (MIRT707494)
- hsa-miR-4684-5p (MIRT707495)
- hsa-miR-593-3p (MIRT707496)
- hsa-miR-5699-3p (MIRT707497)
- hsa-miR-6895-3p (MIRT707498)
- hsa-miR-4421 (MIRT707499)
- hsa-miR-339-5p (MIRT707500)
- hsa-miR-3163 (MIRT707501)
- hsa-miR-10b-5p (MIRT707502)
- hsa-miR-10a-5p (MIRT707503)
- hsa-miR-6732-3p (MIRT707504)
- hsa-miR-548c-3p (MIRT707505)
- hsa-miR-34c-5p (MIRT734120)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AXL
- Browse OriGene Inhibitory RNA Products For AXL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AXL
Clone products for research
- Applied Biological Materials (abm): Clones for AXL - Starting at $45 >
- * AXL as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG211073
- MG222556
- MG222558
- MR211073
- MR211073L1
- MR211073L2
- MR211073L3
- MR211073L4
- MR222556
- MR222556L3
- MR222556L4
- MR222558
- MR222558L3
- MR222558L4
- RC206431
- RC206431L1
- RC206431L2
- RC206431L3
- RC206431L4
- RC220728
- RC220728L3
- RC220728L4
- RC239138
- RC600072
- RC600073
- RG206431
- RG220728
- RR200095
- RR200095L3
- RR200095L4
- RR200096
- RR200096L3
- RR200096L4
- MR211073L1V
- MR211073L2V
- MR211073L3V
- MR211073L4V
- MR222556L3V
- MR222556L4V
- MR222558L3V
- MR222558L4V
- RC206431L1V
- RC206431L2V
- RC206431L3V
- RC206431L4V
- RC220728L3V
- RC220728L4V
- RR200095L3V
- RR200095L4V
- RR200096L3V
- RR200096L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for AXL
- Addgene plasmids for AXL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AXL
Cell Lines for research
-
Horizon Cell Lines for AXL
No data available for Transcription Factor Targets and HOMER Transcription for AXL Gene
Localization for AXL Gene
Subcellular locations from UniProtKB/Swiss-Prot for AXL Gene
- Cell membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| nucleus | 3 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Plasma membrane (3)
- Actin filaments (1)
- Vesicles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 20088931 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS,IBA | 21873635 |
| GO:0009986 | cell surface | IDA | 19657094 |
| GO:0015629 | actin cytoskeleton | IDA | -- |
Pathways & Interactions for AXL Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
| 2 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 3 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.61
Nanog in Mammalian ESC Pluripotency
.61
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
| 4 | Actin Nucleation by ARP-WASP Complex |
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
|
CDC42 Pathway
.41
|
| 5 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
|
Activation of PKA through GPCR
.71
|
Pathways by source for AXL Gene
3 Reactome pathways for AXL Gene
1 KEGG pathway for AXL Gene
29 Qiagen pathways for AXL Gene
- 14-3-3 Induced Intracellular Signaling
- Actin Nucleation and Branching
- Actin Nucleation by ARP-WASP Complex
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
1 Cell Signaling Technology pathway for AXL Gene
Interacting Proteins for AXL Gene
Selected Interacting proteins:
P30530-UFO_HUMAN
ENSP00000301178
for AXL Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for AXL
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001764 | neuron migration | IEA | -- |
| GO:0001779 | natural killer cell differentiation | IBA | 21873635 |
| GO:0001818 | negative regulation of cytokine production | IEA | -- |
| GO:0001961 | positive regulation of cytokine-mediated signaling pathway | IDA | 18840707 |
| GO:0001974 | blood vessel remodeling | IEA | -- |
Drugs & Compounds for AXL Gene
(20) Drugs for AXL Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Fludarabine | Approved | Pharma | DNA synthsis inhibitor | 1633,1633 | ||
| Tyrosine | Approved, Investigational | Nutra | 1149 | |||
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| gilteritinib | Approved, Investigational | Pharma | Target, inhibitor | 0 | ||
| Cyclophosphamide | Approved, Investigational | Pharma | Nitrogen mustard alkylating agent and prodrug. | 3864 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
58-64-0 |
|
(6) ApexBio Compounds for AXL Gene
| Compound | Action | Cas Number |
|---|---|---|
| BMS-777607 | C-Met inhibitor, potent and selective | 1025720-94-8 |
| Cabozantinib (XL184, BMS-907351) | VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor | 849217-68-1 |
| LDC1267 | TAM kinase inhibitor,highly selective | 1361030-48-9 |
| R428 | Selective Axl inhibitor | 1037624-75-1 |
| TP-0903 | AXL receptor tyrosine kinase inhibitor, anti-cancer agent | 1341200-45-0 |
| UNC2881 | 1493764-08-1 |
Transcripts for AXL Gene
mRNA/cDNA for AXL Gene
- 3 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000301178 4717 nts (view in UCSC)
- ENST00000359092 3206 nts (view in UCSC)
- ENST00000593513 2557 nts (view in UCSC)
- ENST00000594880 543 nts (view in UCSC)
- ENST00000599659 1708 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for AXL - Starting at $85 >
- * AXL CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for AXL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AXL
-
Santa Cruz Biotechnology (SCBT) CRISPR for AXL
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AXL
- Browse OriGene Inhibitory RNA Products For AXL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AXL
Clone products for research
- Applied Biological Materials (abm): Clones for AXL - Starting at $45 >
- * AXL as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG211073
- MG222556
- MG222558
- MR211073
- MR211073L1
- MR211073L2
- MR211073L3
- MR211073L4
- MR222556
- MR222556L3
- MR222556L4
- MR222558
- MR222558L3
- MR222558L4
- RC206431
- RC206431L1
- RC206431L2
- RC206431L3
- RC206431L4
- RC220728
- RC220728L3
- RC220728L4
- RC239138
- RC600072
- RC600073
- RG206431
- RG220728
- RR200095
- RR200095L3
- RR200095L4
- RR200096
- RR200096L3
- RR200096L4
- MR211073L1V
- MR211073L2V
- MR211073L3V
- MR211073L4V
- MR222556L3V
- MR222556L4V
- MR222558L3V
- MR222558L4V
- RC206431L1V
- RC206431L2V
- RC206431L3V
- RC206431L4V
- RC220728L3V
- RC220728L4V
- RR200095L3V
- RR200095L4V
- RR200096L3V
- RR200096L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for AXL
- Addgene plasmids for AXL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AXL
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: |
Relevant External Links for AXL Gene
- GeneLoc Exon Structure for
- AXL
Expression for AXL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Epithelial Cells
- Basal Cells Trachea
-
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
- Smooth Muscle (Muscoskeletal System)
-
Bone (Muscoskeletal System)
This gene is overexpressed in Urine (41.6) and Breast (10.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AXL Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AXL
SOURCE GeneReport for Unigene cluster for AXL Gene:
Hs.590970mRNA Expression by UniProt/SwissProt for AXL Gene:
P30530-UFO_HUMAN
Tissue specificity:
Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.
Evidence on tissue expression from TISSUES for AXL Gene
- Nervous system(4)
- Skin(3)
- Spleen(2.9)
- Heart(2.8)
- Intestine(2.7)
- Lung(2.6)
- Kidney(2.6)
- Bone(2.5)
- Muscle(2.5)
- Lymph node(2.5)
- Liver(2.5)
- Blood(2.4)
- Eye(2.3)
- Adrenal gland(2)
Primer products for research
-
OriGene qPCR primer pairs for AXL
-
OriGene qPCR primer pairs and template standards for AXL
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AXL Gene
Orthologs for AXL Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | AXL 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | AXL 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Axl 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Axl 29 |
|
||
| Cow (Bos Taurus) |
Mammalia | AXL 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | AXL 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | AXL 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | axl 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | CABZ01088927.1 30 |
|
OneToMany | |
| CABZ01088930.1 30 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | F11E6.8 30 |
|
ManyToMany | |
| T14E8.1a 31 |
|
|
|||
| T14E8.1b 31 |
|
|
|||
| old-2 31 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany |
- Species where no ortholog for AXL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for AXL Gene
- ENSEMBL:
- Gene Tree for AXL (if available)
- TreeFam:
- Gene Tree for AXL (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for AXL: view image
- Alliance of Genome Resources:
- Additional Orthologs for AXL
Paralogs for AXL Gene
Paralogs for AXL Gene
- MERTK 5
- TYRO3 5
- EPHB1 5
- EPHB3 5
- EPHA2 5
- EPHB2 5
- EPHA7 5
- EPHB4 5
- EPHA3 5
- EPHA1 5
- EPHA4 5
- EPHA5 5
- EPHA8 5
- EPHA6 5
- ROR1 5
- DDR1 5
- ROR2 5
- DDR2 5
- EPHA10 5
- FLT4 5
- FLT1 5
- RET 5
- INSR 5
- ALK 5
- PDGFRA 5
- KDR 5
- MST1R 5
- ERBB2 5
- ROS1 5
- MET 5
- PDGFRB 5
- IGF1R 5
- EGFR 5
- TIE1 5
- CSF1R 5
- FGFR4 5
- ERBB4 5
- TEK 5
- FGFR3 5
- FGFR1 5
- MUSK 5
- KIT 5
- FGFR2 5
- INSRR 5
- FLT3 5
- NTRK2 5
- LTK 5
- LMTK2 5
- ERBB3 5
- NTRK3 5
- NTRK1 5
- RYK 5
- ENSG00000282278 5
- EPHB6 5
(31) SIMAP similar genes for AXL Gene using alignment to 2 proteins:
- UFO_HUMAN
- M0R0W6_HUMAN