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The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
AXL (AXL Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with AXL include Hypogonadotropic Hypogonadism 7 With Or Without Anosmia and Lymphocytic Choriomeningitis. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MERTK.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0001618 | virus receptor activity | IEA | -- |
GO:0001786 | phosphatidylserine binding | IDA | 21501828 |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004713 | protein tyrosine kinase activity | IEA,EXP | 22327215 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 20088931 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS,IBA | 21873635 |
GO:0009986 | cell surface | IDA | 19657094 |
GO:0015629 | actin cytoskeleton | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
2 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
3 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.62
Nanog in Mammalian ESC Pluripotency
.62
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
4 | Actin Nucleation by ARP-WASP Complex |
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
|
CDC42 Pathway
.41
|
5 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
|
Activation of PKA through GPCR
.71
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001764 | neuron migration | IEA | -- |
GO:0001779 | natural killer cell differentiation | IBA | 21873635 |
GO:0001818 | negative regulation of cytokine production | IEA | -- |
GO:0001961 | positive regulation of cytokine-mediated signaling pathway | IDA | 18840707 |
GO:0001974 | blood vessel remodeling | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Fludarabine | Approved | Pharma | DNA synthsis inhibitor | 1533,1533 | ||
Tyrosine | Approved, Investigational | Nutra | 1044 | |||
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
gilteritinib | Approved, Investigational | Pharma | Target, inhibitor | 0 | ||
Cyclophosphamide | Approved, Investigational | Pharma | Nitrogen mustard alkylating agent and prodrug. | 3670 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Compound | Action | Cas Number |
---|---|---|
BMS-777607 | C-Met inhibitor, potent and selective | 1025720-94-8 |
Cabozantinib (XL184, BMS-907351) | VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor | 849217-68-1 |
LDC1267 | TAM kinase inhibitor,highly selective | 1361030-48-9 |
R428 | Selective Axl inhibitor | 1037624-75-1 |
TP-0903 | AXL receptor tyrosine kinase inhibitor, anti-cancer agent | 1341200-45-0 |
UNC2881 | 1493764-08-1 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | AXL 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | AXL 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Axl 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Axl 30 |
|
||
Cow (Bos Taurus) |
Mammalia | AXL 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | AXL 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | AXL 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | axl 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | CABZ01088927.1 31 |
|
OneToMany | |
CABZ01088930.1 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | F11E6.8 31 |
|
ManyToMany | |
T14E8.1a 32 |
|
|
|||
T14E8.1b 32 |
|
|
|||
old-2 32 |
|
|
|||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |