Aliases for AXL Gene
Aliases for AXL Gene
External Ids for AXL Gene
- HGNC: 905
- Entrez Gene: 558
- Ensembl: ENSG00000167601
- OMIM: 109135
- UniProtKB: P30530
Previous GeneCards Identifiers for AXL Gene
- GC19P042364
- GC19P042116
- GC19P046400
- GC19P046416
- GC19P041725
- GC19P038157
Summaries for AXL Gene
-
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
GeneCards Summary for AXL Gene
AXL (AXL Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with AXL include Hypogonadotropic Hypogonadism 7 With Or Without Anosmia and Zika Virus Infection. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MERTK.
UniProtKB/Swiss-Prot for AXL Gene
-
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
-
(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:22156524, PubMed:22673088, PubMed:25277499, PubMed:21501828). Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:17005688).
Additional gene information for AXL Gene
- Monarch Initiative
- Search for AXL at DataMed
- Search for AXL at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AXL Gene
Genomics for AXL Gene
GeneHancer (GH) Regulatory Elements for AXL Gene
Promoters and enhancers for AXL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around AXL on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the AXL gene promoter:
Regulatory Element Products
Genomic Locations for AXL Gene
Genomic Locations for AXL Gene
- chr19:41,219,199-41,261,767
- (GRCh38/hg38)
- Size:
- 42,569 bases
- Orientation:
- Plus strand
- chr19:41,725,108-41,767,671
- (GRCh37/hg19)
Genomic View for AXL Gene
Genes around AXL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
AXL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AXL Gene
Proteins for AXL Gene
-
Protein details for AXL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P30530-UFO_HUMAN
- Recommended name:
- Tyrosine-protein kinase receptor UFO
- Protein Accession:
- P30530
- Q8N5L2
- Q9UD27
Protein attributes for AXL Gene
- Size:
- 894 amino acids
- Molecular mass:
- 98336 Da
- Quaternary structure:
-
- Heterodimer and heterotetramer with ligand GAS6. Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2, PIK3R3, PLCG1, SOCS1 and TNS2. Part of a complex including AXL, TNK2 and GRB2, in which GRB2 promotes AXL recruitment by TNK2.
Three dimensional structures from OCA and Proteopedia for AXL Gene
Protein Expression for AXL Gene
Selected DME Specific Peptides for AXL Gene
- P30530:
-
- GNRLKQP
- RDLAARN
- TSKSDVW
- FGVTMWEIATRG
- GDYYRQG
- KSDVWSFG
- KVAVKTMK
- FSCEAHN
- TRGQTPY
Post-translational modifications for AXL Gene
- Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion.
- Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity.
- Ubiquitination at Lys540
- Glycosylation at posLast=4343, Asn157, Asn198, Asn339, Asn345, and posLast=401401
- Modification sites at PhosphoSitePlus
Other Protein References for AXL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for AXL (Axl)
-
Custom Antibody ServicesOriGene Antibodies for AXL
- Novus Biologicals Antibodies for AXL
-
Abcam antibodies for AXL
- Invitrogen Antibodies for AXL
- antibodies-online: Search results for 295 available AXL Antibodies ranked by validation data
- Compare Top AXL Antibodies
-
Recommended
- 161 WB Antibodies (anti-human)
- 41 FACS Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 52 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 19 FACS Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 1 CC Antibody (anti-mouse)
- 32 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- GeneTex AXL antibody for AXL
- Sino Biological Antibodies for AXL
Protein Products
- R&D Systems Proteins and Enzymes for AXL (Axl)
- Search Origene for MassSpec and Protein Over-expression Lysates for AXL
- Origene Custom Protein Services for AXL
- Sino Biological Cell Lysates for AXL
- Sino Biological Recombinant Proteins for AXL
- Search GeneTex for Proteins for AXL
-
ProSci Proteins for AXL
-
Abcam proteins for AXL
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for AXL
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for AXL (Axl)
- Novus Biologicals ELISA Kits for AXL
-
Cloud-Clone Corp. Assay Kits for AXL
-
Abcam assays for AXL
- Sino Biological Assays for AXL
Domains & Families for AXL Gene
Gene Families for AXL Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted membrane proteins
Protein Domains for AXL Gene
Suggested Antigen Peptide Sequences for AXL Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P30530UniProtKB/Swiss-Prot:
UFO_HUMAN :- Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Function for AXL Gene
Molecular function for AXL Gene
- GENATLAS Biochemistry:
- AXL transforming sequence,activated by GAS6,involved in the protection of neurons from apoptosis across neuronal migration,expressed in neural lymphoid,vascular and reproductive tissue,involved in the regulation of spermatogenesis and in primary and tumor cell lines derived from these sources
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by GAS6-binding and subsequent autophosphorylation.
- UniProtKB/Swiss-Prot Function:
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:22156524, PubMed:22673088, PubMed:25277499, PubMed:21501828). Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:17005688).
Enzyme Numbers (IUBMB) for AXL Gene
Phenotypes From GWAS Catalog for AXL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001618 | virus receptor activity | IEA | -- |
| GO:0001786 | phosphatidylserine binding | IDA | 21501828 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004713 | protein tyrosine kinase activity | EXP,IEA | 22327215 |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IEA,TAS | -- |
Phenotypes for AXL Gene
- MGI mutant phenotypes for AXL:
-
inferred from 2 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- integument phenotype
- hematopoietic system phenotype
- skeleton phenotype
- liver/biliary system phenotype
- GenomeRNAi human phenotypes for AXL:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased ionizing radiation sensitivity
- Decreased viability ratio
- Increased viability after borna disease (rVSVI9G*/BDVG) virus infection
- Increased transferrin (TF) endocytosis
- Strongly decreased CFP-tsO45G cell surface transport
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Decreased substrate adherent cell growth
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Negative genetic interaction between BLM-/- and BLM+/+
- Increased mitotic index
- Increased Nanog expression
- Condensed cis-Golgi
Animal Model Products
-
Taconic Biosciences Mouse Models for AXL
- Cyagen custom Knockout/knockin (KOKI) mouse models for AXL
-
-
ViGene Biosciences lentiviral particle packaged cDNA for AXL gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AXL gene
- Search ViGene Biosciences for AXL
CRISPR Products
-
OriGene CRISPR knockouts for AXL
- genomics-online: gRNA clones - Search results for 150 available AXL gene related products
- Overview of 150 available AXL gene related products
- Applied Biological Materials CRISPR for AXL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AXL
- GenScript: Design CRISPR guide RNA sequences for AXL
miRNA for AXL Gene
- miRTarBase miRNAs that target AXL
-
- hsa-mir-1-3p (MIRT002758)
- hsa-mir-34a-5p (MIRT006664)
- hsa-mir-375 (MIRT019798)
- hsa-mir-155-5p (MIRT020726)
- hsa-mir-122-5p (MIRT438639)
- hsa-mir-6818-3p (MIRT707494)
- hsa-mir-4684-5p (MIRT707495)
- hsa-mir-593-3p (MIRT707496)
- hsa-mir-5699-3p (MIRT707497)
- hsa-mir-6895-3p (MIRT707498)
- hsa-mir-4421 (MIRT707499)
- hsa-mir-339-5p (MIRT707500)
- hsa-mir-3163 (MIRT707501)
- hsa-mir-10b-5p (MIRT707502)
- hsa-mir-10a-5p (MIRT707503)
- hsa-mir-6732-3p (MIRT707504)
- hsa-mir-548c-3p (MIRT707505)
- hsa-mir-34c-5p (MIRT734120)
miRNA Products
- Search ViGene Biosciences for AXL
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for AXL
- Browse OriGene Inhibitory RNA Products For AXL
- genomics-online: shRNA clones - Search results for 150 available AXL gene related products
- Overview of 150 available AXL gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for AXL gene
Clone Products
- Sino Biological Human cDNA Clone for AXL
- VectorBuilder custom plasmid, inducible vectors for AXL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AXL
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for AXL
- Applied Biological Materials Clones for AXL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for AXL (Axl)
Cell Line Products
-
Horizon Cell Lines for AXL
-
ViGene Biosciences adenoviral particle packaged cDNA for AXL gene
-
ViGene Biosciences lentiviral particle packaged cDNA for AXL gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AXL gene
No data available for Transcription Factor Targets and HOMER Transcription for AXL Gene
Localization for AXL Gene
Subcellular locations from UniProtKB/Swiss-Prot for AXL Gene
- Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 3 |
| nucleus | 2 |
| mitochondrion | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 20088931 |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 1656220 |
| GO:0009986 | cell surface | IDA | 19657094 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for AXL Gene
Pathways & Interactions for AXL Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | GPCR Pathway |
.73
.62
|
.55
|
| 2 | ERK Signaling |
.61
.58
|
.49
|
| 3 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
| 4 | Actin Nucleation by ARP-WASP Complex |
.41
|
|
| 5 | Activation of cAMP-Dependent PKA | ||
Pathways by source for AXL Gene
3 Reactome pathways for AXL Gene
1 KEGG pathway for AXL Gene
29 Qiagen pathways for AXL Gene
1 Cell Signaling Technology pathway for AXL Gene
Interacting Proteins for AXL Gene
Selected Interacting proteins:
ENSP00000301178
P30530-UFO_HUMAN
for AXL Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001764 | neuron migration | IEA | -- |
| GO:0001779 | natural killer cell differentiation | IEA | -- |
| GO:0001818 | negative regulation of cytokine production | IEA | -- |
| GO:0001961 | positive regulation of cytokine-mediated signaling pathway | IDA | 18840707 |
| GO:0001974 | blood vessel remodeling | IEA | -- |
Drugs & Compounds for AXL Gene
(16) Drugs for AXL Gene - From: PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| cabozantinib | Approved, Investigational | Pharma | Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | ||
| BMS-777607 | Investigational | Pharma | C-Met inhibitor, potent and selective, Kinase Inhibitors | 0 | ||
| XL999 | Investigational | Pharma | inhibitor | Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
| ATP | Investigational | Nutra | Agonist | 0 | ||
| growth arrest specific protein 6 | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(6) ApexBio Compounds for AXL Gene
| Compound | Action | Cas Number |
|---|---|---|
| BMS-777607 | C-Met inhibitor, potent and selective | 1025720-94-8 |
| Cabozantinib (XL184, BMS-907351) | VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor | 849217-68-1 |
| LDC1267 | TAM kinase inhibitor,highly selective | 1361030-48-9 |
| R428 | Selective Axl inhibitor | 1037624-75-1 |
| TP-0903 | AXL receptor tyrosine kinase inhibitor, anti-cancer agent | 1341200-45-0 |
| UNC2881 | 1493764-08-1 |
Transcripts for AXL Gene
mRNA/cDNA for AXL Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (304) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for AXL Gene
CRISPR Products
-
OriGene CRISPR knockouts for AXL
- genomics-online: gRNA clones - Search results for 150 available AXL gene related products
- Overview of 150 available AXL gene related products
- Applied Biological Materials CRISPR for AXL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AXL
- GenScript: Design CRISPR guide RNA sequences for AXL
miRNA Products
- Search ViGene Biosciences for AXL
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for AXL
- Browse OriGene Inhibitory RNA Products For AXL
- genomics-online: shRNA clones - Search results for 150 available AXL gene related products
- Overview of 150 available AXL gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for AXL gene
Clone Products
- Sino Biological Human cDNA Clone for AXL
- VectorBuilder custom plasmid, inducible vectors for AXL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AXL
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for AXL
- Applied Biological Materials Clones for AXL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for AXL (Axl)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: |
Expression for AXL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Smooth Muscle (Muscoskeletal System)
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
-
Epithelial Cells
- Basal Cells Trachea
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Bone (Muscoskeletal System)
This gene is overexpressed in Urine (41.6) and Breast (10.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AXL Gene
NURSA nuclear receptor signaling pathways regulating expression of AXL Gene:
AXLSOURCE GeneReport for Unigene cluster for AXL Gene:
Hs.590970mRNA Expression by UniProt/SwissProt for AXL Gene:
P30530-UFO_HUMAN
Tissue specificity:
Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.
Evidence on tissue expression from TISSUES for AXL Gene
- Nervous system(3.7)
- Lung(2.3)
- Eye(2.2)
- Heart(2.2)
- Spleen(2.2)
- Skin(2.1)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for AXL
-
OriGene qPCR primer pairs and template standards for AXL
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AXL Gene
Orthologs for AXL Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AXL 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | AXL 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Axl 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Axl 33 |
|
||
| cow (Bos Taurus) |
Mammalia | AXL 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | AXL 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | AXL 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | axl 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | CABZ01088927.1 34 |
|
OneToMany | |
| CABZ01088930.1 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | T14E8.1a 35 |
|
|
|
| T14E8.1b 35 |
|
|
|||
| F11E6.8 34 |
|
ManyToMany | |||
| old-2 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for AXL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for AXL Gene
(31) SIMAP similar genes for AXL Gene using alignment to 2 proteins:
Variants for AXL Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_041877 | A gastric adenocarcinoma sample | p.Arg499Cys | |||
| VAR_045597 | A lung neuroendocrine carcinoma sample | p.Arg295Trp | |||
| rs1000072986 | -- | 41,261,862(+) | C/A | downstream_transcript_variant | |
| rs1000076660 | -- | 41,219,472(+) | C/T | coding_sequence_variant, genic_upstream_transcript_variant, missense_variant | |
| rs1000124895 | -- | 41,262,078(+) | T/C | downstream_transcript_variant |
Residual Variation Intolerance Score:
26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.47;
43.36% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AXL Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AXL Gene
Disorders for AXL Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypogonadotropic hypogonadism 7 with or without anosmia |
|
|
| zika virus infection |
|
|
| lymphocytic choriomeningitis |
|
|
| femoral neuropathy |
|
|
| mesangial proliferative glomerulonephritis |
|
Search AXL in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
UFO_HUMAN- Note=AXL and its ligand GAS6 are highly expressed in thyroid carcinoma tissues, and might thus be involved in thyroid tumorigenesis. Overexpression of AXL and its ligand was also detected in many other cancers such as myeloproliferative disorders, prostatic carcinoma cells, or breast cancer.
Additional Disease Information for AXL
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for AXL Gene
Publications for AXL Gene
- axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. (PMID: 1656220) O'Bryan JP … Liu ET (Molecular and cellular biology 1991) 2 3 4 22 58
- The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development. (PMID: 18840707) Park IK … Caligiuri MA (Blood 2009) 3 4 22 58
- Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling. (PMID: 19815557) Pao-Chun L … Manser E (The Journal of biological chemistry 2009) 3 4 22 58
- Structural basis for Gas6-Axl signalling. (PMID: 16362042) Sasaki T … Hohenester E (The EMBO journal 2006) 3 4 22 58
- Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor. (PMID: 15507525) Gallicchio M … Bussolino F (Blood 2005) 3 4 22 58
Products for AXL Gene
- R&D Systems Antibodies for AXL (Axl)
- R&D Systems Proteins and Enzymes for AXL (Axl)
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for AXL (Axl)
- R&D Systems cDNA Clones for AXL (Axl)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for AXL
- Custom Assay ServicesOriGene ELISA Kits for AXL
- Search Origene for MassSpec and Protein Over-expression Lysates for AXL
- Origene Custom Protein Services for AXL
- Origene shrna and RNAi products in human, mouse, rat for AXL
- Browse OriGene Inhibitory RNA Products For AXL
- OriGene qPCR primer pairs and template standards for AXL
- OriGene qPCR primer pairs for AXL
- OriGene CRISPR knockouts for AXL
- OriGene ORF clones in human for AXL
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For AXL
- GenScript: Next-day shipping of latest version cDNA ORF clones for AXL in any vector
- GenScript Custom Purified and Recombinant Proteins Services for AXL
- GenScript Custom Assay Services for AXL
- GenScript Custom overexpressing Cell Line Services for AXL
- GenScript: Design CRISPR guide RNA sequences for AXL
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for AXL
- Sino Biological Human cDNA Clone for AXL
- Sino Biological Recombinant Proteins for AXL
- Sino Biological Cell Lysates for AXL
- Sino Biological Antibodies for AXL
- Sino Biological Assays for AXL
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for AXL
- Novus Biologicals lysates and proteins for AXL
- Novus Biologicals ELISA Kits for AXL
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for AXL
- Abcam proteins for AXL
- Abcam assays for AXL
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Cloud-Clone Corp. Assay Kits for AXL
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.