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AXL Gene(Protein Coding)

AXL Receptor Tyrosine Kinase

GCID:
GC19P041219
GIFtS:
58
Genes Participants
UDN Logo

Aliases for AXL Gene

Aliases for AXL Gene

  • AXL Receptor Tyrosine Kinase 2 3 5
  • AXL Oncogene 3 4
  • UFO 3 4
  • Tyrosine-Protein Kinase Receptor UFO 3
  • AXL Transforming Sequence/Gene 3
  • EC 2.7.10.1 4
  • JTK11 3
  • Tyro7 3
  • ARK 3

External Ids for AXL Gene

Previous GeneCards Identifiers for AXL Gene

  • GC19P042364
  • GC19P042116
  • GC19P046400
  • GC19P046416
  • GC19P041725
  • GC19P038157

Summaries for AXL Gene

Entrez Gene Summary for AXL Gene

  • The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

CIViC summary for AXL Gene

GeneCards Summary for AXL Gene

AXL (AXL Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with AXL include Hypogonadotropic Hypogonadism 7 With Or Without Anosmia and Lymphocytic Choriomeningitis. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MERTK.

UniProtKB/Swiss-Prot for AXL Gene

  • Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.

  • (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.

  • (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.

Gene Wiki entry for AXL Gene

Additional gene information for AXL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AXL Gene

Genomics for AXL Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for AXL Gene

Promoters and enhancers for AXL Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J041217 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 661.1 +3.9 3874 10.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF416 ZNF143 AXL ENSG00000269652 ZNF574 ZNF526 SNRPA ENSG00000269843 HNRNPUL1 CCDC97 ENSG00000271299 CYP2G2P
GH19J041294 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29 +84.1 84098 16.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 CCDC97 ZNF526 HNRNPUL1 SNRPA ZNF574 ENSG00000269843 COQ8B TGFB1 AXL ITPKC
GH19J040596 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13 -617.5 -617503 10 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 LTBP4 HNRNPUL1 SNRPA ENSG00000269843 ZNF780B CCDC97 ZNF780A AKT2 FBL COQ8B
GH19J040747 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13 -466.4 -466438 9.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF213 E2F8 ZNF416 SNRPA C19orf54 HNRNPUL1 ENSG00000269843 CCDC97 COQ8B ZNF780A AKT2 FBL ZNF780B
GH19J041348 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.1 +132.4 132414 6.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A YBX1 DMAP1 IRF4 YY1 ZNF213 TMEM91 ENSG00000255730 TGFB1 ZNF526 SNRPA ZNF574 HNRNPUL1 CCDC97 ENSG00000269843 COQ8B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AXL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AXL gene promoter:

Genomic Locations for AXL Gene

Genomic Locations for AXL Gene
chr19:41,219,199-41,261,767
(GRCh38/hg38)
Size:
42,569 bases
Orientation:
Plus strand
chr19:41,725,108-41,767,671
(GRCh37/hg19)

Genomic View for AXL Gene

Genes around AXL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AXL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AXL Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for AXL Gene

Proteins for AXL Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for AXL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30530-UFO_HUMAN
    Recommended name:
    Tyrosine-protein kinase receptor UFO
    Protein Accession:
    P30530
    Secondary Accessions:
    • Q8N5L2
    • Q9UD27

    Protein attributes for AXL Gene

    Size:
    894 amino acids
    Molecular mass:
    98337 Da
    Quaternary structure:
    • Heterodimer and heterotetramer with ligand GAS6. Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2, PIK3R3, PLCG1, SOCS1 and TNS2. Part of a complex including AXL, TNK2 and GRB2, in which GRB2 promotes AXL recruitment by TNK2.

    Three dimensional structures from OCA and Proteopedia for AXL Gene

    Alternative splice isoforms for AXL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AXL Gene

Protein Expression for AXL Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for AXL Gene

  • Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion.
  • Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity.
  • Glycosylation at Asn401, posLast=345345, Asn339, posLast=198198, posLast=157157, and posLast=4343
  • Ubiquitination at Lys540
  • Modification sites at PhosphoSitePlus

Other Protein References for AXL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AXL Gene

Domains & Families for AXL Gene

Gene Families for AXL Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted membrane proteins

Protein Domains for AXL Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for AXL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30530

UniProtKB/Swiss-Prot:

UFO_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
genes like me logo Genes that share domains with AXL: view

Function for AXL Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for AXL Gene

UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by GAS6-binding and subsequent autophosphorylation.
GENATLAS Biochemistry:
AXL transforming sequence,activated by GAS6,involved in the protection of neurons from apoptosis across neuronal migration,expressed in neural lymphoid,vascular and reproductive tissue,involved in the regulation of spermatogenesis and in primary and tumor cell lines derived from these sources

Enzyme Numbers (IUBMB) for AXL Gene

Phenotypes From GWAS Catalog for AXL Gene

Gene Ontology (GO) - Molecular Function for AXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0001786 phosphatidylserine binding IDA 21501828
GO:0004672 protein kinase activity IEA --
GO:0004709 MAP kinase kinase kinase activity IBA --
GO:0004713 protein tyrosine kinase activity IBA,IEA --
genes like me logo Genes that share ontologies with AXL: view
genes like me logo Genes that share phenotypes with AXL: view

Human Phenotype Ontology for AXL Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for AXL Gene

MGI Knock Outs for AXL:
  • Axl Axl<tm1Grl>
  • Axl Axl<tm1Dgen>

Animal Model Products

  • Taconic Biosciences Mouse Models for AXL

Clone Products

  • Addgene plasmids for AXL

No data available for Transcription Factor Targets and HOMER Transcription for AXL Gene

Localization for AXL Gene

Subcellular locations from UniProtKB/Swiss-Prot for AXL Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AXL gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 3
nucleus 2
mitochondrion 1
cytosol 1
lysosome 1
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for AXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20088931
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1656220
genes like me logo Genes that share ontologies with AXL: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AXL Gene

Pathways & Interactions for AXL Gene

genes like me logo Genes that share pathways with AXL: view

SIGNOR curated interactions for AXL Gene

Is activated by:

Gene Ontology (GO) - Biological Process for AXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0001779 natural killer cell differentiation IEA --
GO:0001818 negative regulation of cytokine production IEA --
GO:0001961 positive regulation of cytokine-mediated signaling pathway IDA 18840707
GO:0001974 blood vessel remodeling IEA --
genes like me logo Genes that share ontologies with AXL: view

Drugs & Compounds for AXL Gene

Products:

  1. Drug

(17) Drugs for AXL Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
cabozantinib Approved, Investigational Pharma Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
BMS-777607 Investigational Pharma C-Met inhibitor, potent and selective, Kinase Inhibitors 0
XL999 Investigational Pharma inhibitor Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(3) Additional Compounds for AXL Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(6) ApexBio Compounds for AXL Gene

Compound Action Cas Number
BMS-777607 C-Met inhibitor, potent and selective 1025720-94-8
Cabozantinib (XL184, BMS-907351) VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor 849217-68-1
LDC1267 TAM kinase inhibitor,highly selective 1361030-48-9
R428 Selective Axl inhibitor 1037624-75-1
TP-0903 AXL receptor tyrosine kinase inhibitor, anti-cancer agent 1341200-45-0
UNC2881 1493764-08-1
genes like me logo Genes that share compounds with AXL: view

Drug Products

Transcripts for AXL Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for AXL Gene

(304) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AXL Gene

AXL receptor tyrosine kinase:
Representative Sequences:

Clone Products

  • Addgene plasmids for AXL

Alternative Splicing Database (ASD) splice patterns (SP) for AXL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: -
SP2: - -
SP3:

Relevant External Links for AXL Gene

GeneLoc Exon Structure for
AXL
ECgene alternative splicing isoforms for
AXL

Expression for AXL Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AXL Gene

mRNA expression in normal human tissues for AXL Gene
mRNA expression by GTEx for AXL GenemRNA expression by BioGPS for AXL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AXL Gene

This gene is overexpressed in Urine (41.6) and Breast (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AXL Gene



NURSA nuclear receptor signaling pathways regulating expression of AXL Gene:

AXL

SOURCE GeneReport for Unigene cluster for AXL Gene:

Hs.590970

mRNA Expression by UniProt/SwissProt for AXL Gene:

P30530-UFO_HUMAN
Tissue specificity: Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.

Evidence on tissue expression from TISSUES for AXL Gene

  • Nervous system(3.8)
  • Lung(2.3)
  • Eye(2.2)
  • Heart(2.2)
  • Spleen(2.2)
  • Skin(2.1)
  • Kidney(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with AXL: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AXL Gene

Orthologs for AXL Gene

This gene was present in the common ancestor of animals.

Orthologs for AXL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia AXL 34 33
  • 99.32 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia AXL 34 33
  • 89.12 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Axl 16 34 33
  • 85.61 (n)
rat
(Rattus norvegicus)
 Mammalia Axl 33
  • 85.34 (n)
cow
(Bos Taurus)
 Mammalia AXL 34 33
  • 84.39 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia AXL 34
  • 79 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 52 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia AXL 34
  • 61 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia axl 33
  • 63.02 (n)
zebrafish
(Danio rerio)
 Actinopterygii CABZ01088927.1 34
  • 57 (a)
 OneToMany
CABZ01088930.1 34
  • 57 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea F11E6.8 34
  • 34 (a)
 ManyToMany
T14E8.1b 35
  • 34 (a)
T14E8.1a 35
  • 34 (a)
old-2 35
  • 33 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 30 (a)
 OneToMany
Species where no ortholog for AXL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AXL Gene

ENSEMBL:
Gene Tree for AXL (if available)
TreeFam:
Gene Tree for AXL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AXL: view image

Paralogs for AXL Gene

Paralogs for AXL Gene

(31) SIMAP similar genes for AXL Gene using alignment to 2 proteins:

  • UFO_HUMAN
  • M0R0W6_HUMAN
genes like me logo Genes that share paralogs with AXL: view

Variants for AXL Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for AXL Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
VAR_041877 A gastric adenocarcinoma sample p.Arg499Cys
VAR_045597 A lung neuroendocrine carcinoma sample p.Arg295Trp
rs1000072986 -- 41,261,862(+) C/A downstream_transcript_variant
rs1000076660 -- 41,219,472(+) C/T coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs1000124895 -- 41,262,078(+) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for AXL Gene

Variant ID Type Subtype PubMed ID
dgv2014e59 CNV duplication 20981092
esv995062 CNV loss 20482838
nsv819422 CNV loss 19587683

Variation tolerance for AXL Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AXL Gene

Human Gene Mutation Database (HGMD)
AXL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AXL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AXL Gene

Disorders for AXL Gene

MalaCards: The human disease database

(9) MalaCards diseases for AXL Gene - From: HGMD, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypogonadotropic hypogonadism 7 with or without anosmia
  • hh7
lymphocytic choriomeningitis
  • lcm
zika virus infection
  • zika fever
femoral neuropathy
  • femoral nerve dysfunction
mesangial proliferative glomerulonephritis
  • glomerulonephritis - mesangial proliferative
- elite association - COSMIC cancer census association via MalaCards
Search AXL in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

UFO_HUMAN
  • Note=AXL and its ligand GAS6 are highly expressed in thyroid carcinoma tissues, and might thus be involved in thyroid tumorigenesis. Overexpression of AXL and its ligand was also detected in many other cancers such as myeloproliferative disorders, prostatic carcinoma cells, or breast cancer.

Additional Disease Information for AXL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with AXL: view

No data available for Genatlas for AXL Gene

Publications for AXL Gene

  1. axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. (PMID: 1656220) O'Bryan JP … Liu ET (Molecular and cellular biology 1991) 2 3 4 22 58
  2. The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development. (PMID: 18840707) Park IK … Caligiuri MA (Blood 2009) 3 4 22 58
  3. Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling. (PMID: 19815557) Pao-Chun L … Manser E (The Journal of biological chemistry 2009) 3 4 22 58
  4. Structural basis for Gas6-Axl signalling. (PMID: 16362042) Sasaki T … Hohenester E (The EMBO journal 2006) 3 4 22 58
  5. Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation. (PMID: 15958209) Valverde P (Biochemical and biophysical research communications 2005) 3 4 22 58

Products for AXL Gene