This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it ... See more...

Aliases for AWAT2 Gene

Aliases for AWAT2 Gene

  • Acyl-CoA Wax Alcohol Acyltransferase 2 2 3 4 5
  • Multifunctional O-Acyltransferase 2 3 4
  • MFAT 2 3 4
  • Diacylglycerol O-Acyltransferase 2-Like Protein 4 3 4
  • Diacylglycerol O-Acyltransferase Candidate 4 3 4
  • Long-Chain-Alcohol O-Fatty-Acyltransferase 2 3 4
  • Acyl-CoA Retinol O-Fatty-Acyltransferase 3 4
  • 11-Cis-Specific Retinyl-Ester Synthase 3 4
  • Retinol O-Fatty-Acyltransferase 3 4
  • 11-Cis-RE-Synthase 3 4
  • DGAT2L4 3 4
  • ARAT 3 4
  • DC4 3 4
  • WS 3 4
  • Diacylglycerol O-Acyltransferase 2-Like 4 2
  • Wax Synthase 4
  • EC 2.3.1.75 4
  • EC 2.3.1.76 4
  • AWAT2 5
  • HDC4 4
  • HWS 4

External Ids for AWAT2 Gene

Previous HGNC Symbols for AWAT2 Gene

  • DGAT2L4

Previous GeneCards Identifiers for AWAT2 Gene

  • GC0XM069178
  • GC0XM063081

Summaries for AWAT2 Gene

Entrez Gene Summary for AWAT2 Gene

  • This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters. [provided by RefSeq, May 2010]

GeneCards Summary for AWAT2 Gene

AWAT2 (Acyl-CoA Wax Alcohol Acyltransferase 2) is a Protein Coding gene. Diseases associated with AWAT2 include Arthrogryposis, Distal, Type 4 and Lymph Node Tuberculosis. Among its related pathways are Glycerophospholipid biosynthesis and Wax biosynthesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and long-chain-alcohol O-fatty-acyltransferase activity. An important paralog of this gene is DGAT2L6.

UniProtKB/Swiss-Prot Summary for AWAT2 Gene

  • Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15220349, PubMed:15671038, PubMed:16106050, PubMed:28420705). Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively (PubMed:15220349, PubMed:15671038). Also possesses acyl-CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis-specific retinyl ester synthesis (PubMed:16106050, PubMed:24799687). Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13-cis-retinol, and all-trans-retinol substrates (PubMed:24799687).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AWAT2 Gene

Genomics for AWAT2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AWAT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ070049 Enhancer 0.3 Ensembl 250.7 -0.2 -231 0.8 EGR2 AWAT2 OTUD6A
GH0XJ070022 Enhancer 0.7 Ensembl ENCODE 13 +24.6 24581 6 NFIC RXRA RARA JUND ATF4 HNF4A NR2F2 SP1 AWAT2 AB372767 MIR676 EDA
GH0XJ070087 Enhancer 0.4 Ensembl 12.9 -39.0 -39031 3.2 FEZF1 NFIB ZNF114 PRDM1 OTUD6A AWAT2 piR-57138-051 piR-59805-003 IGBP1
GH0XJ069524 Enhancer 0.3 Ensembl 11.8 +525.0 524969 0.4 EGR2 ZFHX2 FAM155B AWAT2 IGBP1-AS1 ENSG00000228160 EDA
GH0XJ069523 Enhancer 0.2 Ensembl 11.8 +526.5 526469 0.6 FAM155B AWAT2 ENSG00000228160 EDA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AWAT2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AWAT2

Top Transcription factor binding sites by QIAGEN in the AWAT2 gene promoter:
  • Brachyury
  • FOXC1
  • HNF-4alpha1
  • HNF-4alpha2
  • NF-AT
  • NF-AT1
  • NF-AT2
  • SEF-1 (1)
  • SRF
  • SRF (504 AA)

Genomic Locations for AWAT2 Gene

Latest Assembly
chrX:70,040,542-70,049,970
(GRCh38/hg38)
Size:
9,429 bases
Orientation:
Minus strand

Previous Assembly
chrX:69,260,392-69,269,788
(GRCh37/hg19 by Entrez Gene)
Size:
9,397 bases
Orientation:
Minus strand

chrX:69,260,392-69,269,788
(GRCh37/hg19 by Ensembl)
Size:
9,397 bases
Orientation:
Minus strand

Genomic View for AWAT2 Gene

Genes around AWAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AWAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AWAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AWAT2 Gene

Proteins for AWAT2 Gene

  • Protein details for AWAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6E213-AWAT2_HUMAN
    Recommended name:
    Acyl-CoA wax alcohol acyltransferase 2
    Protein Accession:
    Q6E213
    Secondary Accessions:
    • Q6IEE3
    • Q6P437

    Protein attributes for AWAT2 Gene

    Size:
    333 amino acids
    Molecular mass:
    38094 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for AWAT2 Gene

Post-translational modifications for AWAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AWAT2 Gene

No data available for DME Specific Peptides for AWAT2 Gene

Domains & Families for AWAT2 Gene

Gene Families for AWAT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for AWAT2 Gene

InterPro:

Suggested Antigen Peptide Sequences for AWAT2 Gene

GenScript: Design optimal peptide antigens:
  • Wax synthase (AWAT2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6E213

UniProtKB/Swiss-Prot:

AWAT2_HUMAN :
  • Belongs to the diacylglycerol acyltransferase family.
Family:
  • Belongs to the diacylglycerol acyltransferase family.
genes like me logo Genes that share domains with AWAT2: view

Function for AWAT2 Gene

Molecular function for AWAT2 Gene

UniProtKB/Swiss-Prot Function:
Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15220349, PubMed:15671038, PubMed:16106050, PubMed:28420705). Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively (PubMed:15220349, PubMed:15671038). Also possesses acyl-CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis-specific retinyl ester synthesis (PubMed:16106050, PubMed:24799687). Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13-cis-retinol, and all-trans-retinol substrates (PubMed:24799687).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a long chain fatty alcohol + an acyl-CoA = a wax ester + CoA; Xref=Rhea:RHEA:38443, ChEBI:CHEBI:10036, ChEBI:CHEBI:17135, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; EC=2.3.1.75; Evidence={ECO:0000269|PubMed:15220349, ECO:0000269|PubMed:15671038, ECO:0000269|PubMed:16106050, ECO:0000269|PubMed:28420705};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA; Xref=Rhea:RHEA:11488, ChEBI:CHEBI:17336, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:63410; EC=2.3.1.76; Evidence={ECO:0000269|PubMed:16106050, ECO:0000269|PubMed:24799687};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA; Xref=Rhea:RHEA:38071, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:73990, ChEBI:CHEBI:75466; Evidence={ECO:0000269|PubMed:16106050};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA; Xref=Rhea:RHEA:38163, ChEBI:CHEBI:52333, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75583; Evidence={ECO:0000269|PubMed:16106050};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl hexadecanoate; Xref=Rhea:RHEA:38167, ChEBI:CHEBI:16125, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75584; Evidence={ECO:0000269|PubMed:15671038, ECO:0000269|PubMed:16106050};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA; Xref=Rhea:RHEA:38171, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75586, ChEBI:CHEBI:75587; Evidence={ECO:0000269|PubMed:16106050};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA; Xref=Rhea:RHEA:38175, ChEBI:CHEBI:17336, ChEBI:CHEBI:17616, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; Evidence={ECO:0000269|PubMed:16106050};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38219, ChEBI:CHEBI:52333, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence={ECO:0000269|PubMed:15671038};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl (9Z)-octadecenoate; Xref=Rhea:RHEA:38227, ChEBI:CHEBI:16125, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75622; Evidence={ECO:0000269|PubMed:15671038};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA; Xref=Rhea:RHEA:38231, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75623, ChEBI:CHEBI:75624; Evidence={ECO:0000269|PubMed:15671038};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + octadecan-1-ol = 1-O-octadecyl (9Z)-octadecenoate + CoA; Xref=Rhea:RHEA:38235, ChEBI:CHEBI:32154, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75625; Evidence={ECO:0000269|PubMed:15671038};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA; Xref=Rhea:RHEA:38239, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:73504, ChEBI:CHEBI:75626; Evidence={ECO:0000269|PubMed:15671038};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-hexadecenoyl-CoA + hexadecan-1-ol = 1-O-hexadecyl (9Z)-hexadecenoate + CoA; Xref=Rhea:RHEA:38247, ChEBI:CHEBI:16125, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540, ChEBI:CHEBI:75629; Evidence={ECO:0000269|PubMed:15671038};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecan-1-ol + octadecanoyl-CoA = CoA + hexadecanyl octadecanoate; Xref=Rhea:RHEA:38251, ChEBI:CHEBI:16125, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:75631; Evidence={ECO:0000269|PubMed:15671038};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA; Xref=Rhea:RHEA:55324, ChEBI:CHEBI:16254, ChEBI:CHEBI:16302, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; Evidence={ECO:0000269|PubMed:24799687};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:55340, ChEBI:CHEBI:34116, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:138734; Evidence={ECO:0000269|PubMed:28420705};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:37915, ChEBI:CHEBI:52323, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75342; Evidence={ECO:0000269|PubMed:28420705};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA; Xref=Rhea:RHEA:55272, ChEBI:CHEBI:16302, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:138676; Evidence={ECO:0000250|UniProtKB:Q6E1M8};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA; Xref=Rhea:RHEA:55276, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:78272, ChEBI:CHEBI:138691; Evidence={ECO:0000250|UniProtKB:Q6E1M8};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA; Xref=Rhea:RHEA:55280, ChEBI:CHEBI:45479, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:138704; Evidence={ECO:0000250|UniProtKB:Q6E1M8};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA; Xref=Rhea:RHEA:55284, ChEBI:CHEBI:17336, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:138718; Evidence={ECO:0000250|UniProtKB:Q6E1M8};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=tetradecan-1-ol + tetradecanoyl-CoA = CoA + tetradecanyl tetradecanoate; Xref=Rhea:RHEA:55288, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:77417, ChEBI:CHEBI:138721; Evidence={ECO:0000250|UniProtKB:Q6E1M8};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=5.8 uM for 11-cis-retinol {ECO:0000269|PubMed:24799687}; KM=19.8 uM for 9-cis-retinol {ECO:0000269|PubMed:24799687}; KM=27.4 uM for 13-cis-retinol {ECO:0000269|PubMed:24799687}; KM=24.8 uM for all-trans-retinol {ECO:0000269|PubMed:24799687}; Vmax=980 pmol/min/mg enzyme for 11-cis-retinol {ECO:0000269|PubMed:24799687}; Vmax=1010 pmol/min/mg enzyme for 9-cis-retinol {ECO:0000269|PubMed:24799687}; Vmax=6.4 pmol/min/mg enzyme for 13-cis-retinol {ECO:0000269|PubMed:24799687}; Vmax=148 pmol/min/mg enzyme for all-trans-retinol {ECO:0000269|PubMed:24799687};
UniProtKB/Swiss-Prot EnzymeRegulation:
11-cis retinoids act as allosteric modulators of acyl-CoA retinol O-fatty-acyltransferase (ARAT) activity by suppressing esterification of 9-cis, 13-cis, or all-trans retinols concurrently increasing the enzyme specificity toward 11-cis isomer.

Enzyme Numbers (IUBMB) for AWAT2 Gene

Gene Ontology (GO) - Molecular Function for AWAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003846 2-acylglycerol O-acyltransferase activity TAS --
GO:0008374 O-acyltransferase activity IBA 21873635
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IEA --
genes like me logo Genes that share ontologies with AWAT2: view
genes like me logo Genes that share phenotypes with AWAT2: view

miRNA for AWAT2 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AWAT2

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AWAT2 Gene

Localization for AWAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AWAT2 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AWAT2 gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for AWAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AWAT2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AWAT2 Gene

Pathways & Interactions for AWAT2 Gene

genes like me logo Genes that share pathways with AWAT2: view

Interacting Proteins for AWAT2 Gene

Gene Ontology (GO) - Biological Process for AWAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006629 lipid metabolic process IBA 21873635
GO:0006640 monoacylglycerol biosynthetic process IDA 28420705
GO:0010025 wax biosynthetic process IEA,TAS --
GO:0036155 acylglycerol acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with AWAT2: view

No data available for SIGNOR curated interactions for AWAT2 Gene

Drugs & Compounds for AWAT2 Gene

(10) Drugs for AWAT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1-Hexadecanol Approved Pharma 0
Isopropyl alcohol Approved, Investigational Pharma 0
Propyl alcohol Approved Pharma 0
Vitamin A Approved, Vet_approved Nutra 747
1-Butanol Experimental Pharma 0

(46) Additional Compounds for AWAT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • Dodecenoyl-CoA
  • Dodecenoyl+2-dodecenoyl, (e)-isomer
  • Dodecenoyl-coenzyme A
  • Dodecenoyl+2-dodecenoyl
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1
(2E)-Octenoyl-CoA
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
38795-33-4
genes like me logo Genes that share compounds with AWAT2: view

Transcripts for AWAT2 Gene

mRNA/cDNA for AWAT2 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AWAT2

Alternative Splicing Database (ASD) splice patterns (SP) for AWAT2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - -
SP2: -
SP3: - - -
SP4:
SP5:

Relevant External Links for AWAT2 Gene

GeneLoc Exon Structure for
AWAT2

Expression for AWAT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AWAT2 Gene

mRNA differential expression in normal tissues according to GTEx for AWAT2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x32.0) and Skin - Sun Exposed (Lower leg) (x16.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AWAT2

SOURCE GeneReport for Unigene cluster for AWAT2 Gene:

Hs.661507

mRNA Expression by UniProt/SwissProt for AWAT2 Gene:

Q6E213-AWAT2_HUMAN
Tissue specificity: Highly expressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas.

Evidence on tissue expression from TISSUES for AWAT2 Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with AWAT2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AWAT2 Gene

Orthologs for AWAT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AWAT2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AWAT2 29 30
  • 99.9 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia AWAT2 29 30
  • 86.69 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Awat2 29 16 30
  • 85.99 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia AWAT2 29 30
  • 84.74 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Awat2 29
  • 84.38 (n)
Oppossum
(Monodelphis domestica)
Mammalia AWAT2 30
  • 65 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG1942 30
  • 29 (a)
ManyToMany
CG1941 30
  • 28 (a)
ManyToMany
CG1946 30
  • 28 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea Y53G8B.2 30
  • 34 (a)
ManyToMany
dgat-2 30
  • 33 (a)
ManyToMany
dgtr-1 30
  • 33 (a)
ManyToMany
K07B1.4 30
  • 32 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DGA1 30
  • 26 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 39 (a)
OneToMany
Species where no ortholog for AWAT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for AWAT2 Gene

ENSEMBL:
Gene Tree for AWAT2 (if available)
TreeFam:
Gene Tree for AWAT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AWAT2: view image
Alliance of Genome Resources:
Additional Orthologs for AWAT2

Paralogs for AWAT2 Gene

Paralogs for AWAT2 Gene

(6) SIMAP similar genes for AWAT2 Gene using alignment to 2 proteins:

  • AWAT2_HUMAN
  • H0YAL0_HUMAN
genes like me logo Genes that share paralogs with AWAT2: view

Variants for AWAT2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for AWAT2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for AWAT2 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv3574029 CNV loss 25503493
nsv6949 CNV insertion 18451855

Variation tolerance for AWAT2 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AWAT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AWAT2
Leiden Open Variation Database (LOVD)
AWAT2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AWAT2 Gene

Disorders for AWAT2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for AWAT2 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search AWAT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AWAT2

genes like me logo Genes that share disorders with AWAT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AWAT2 Gene

Publications for AWAT2 Gene

  1. Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily. (PMID: 15671038) Turkish AR … Sturley SL (The Journal of biological chemistry 2005) 2 3 4
  2. A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters. (PMID: 16106050) Yen CL … Farese RV (Journal of lipid research 2005) 2 3 4
  3. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PMID: 14970677) Winter A … Fries R (Cytogenetic and genome research 2003) 2 3 4
  4. Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases. (PMID: 28420705) Ma Z … Cheng D (Journal of lipid research 2017) 3 4
  5. Identification of the 11-cis-specific retinyl-ester synthase in retinal Müller cells as multifunctional O-acyltransferase (MFAT). (PMID: 24799687) Kaylor JJ … Travis GH (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 4

Products for AWAT2 Gene

Sources for AWAT2 Gene