Aliases for AWAT1 Gene
External Ids for AWAT1 Gene
Previous HGNC Symbols for AWAT1 Gene
Previous GeneCards Identifiers for AWAT1 Gene
The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009]
GeneCards Summary for AWAT1 Gene
AWAT1 (Acyl-CoA Wax Alcohol Acyltransferase 1) is a Protein Coding gene. Diseases associated with AWAT1 include Abnormal Pupillary Function and Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2. Among its related pathways are Wax biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and long-chain-alcohol O-fatty-acyltransferase activity. An important paralog of this gene is DGAT2L6.
UniProtKB/Swiss-Prot Summary for AWAT1 Gene
Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15671038). Shows a strong preference for decyl alcohol (C10), with less activity towards C16 and C18 alcohols (PubMed:15671038). Shows a strong preference for saturated acyl-CoAs (PubMed:15671038).