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The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]
AVPR1B (Arginine Vasopressin Receptor 1B) is a Protein Coding gene. Diseases associated with AVPR1B include Bronchial Neuroendocrine Tumor and Acth-Independent Macronodular Adrenal Hyperplasia. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and protein kinase C binding. An important paralog of this gene is AVPR1A.
Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to oxytocin receptors (OT).
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IBA | 21873635 |
GO:0005000 | vasopressin receptor activity | TAS,IDA | 9322919 |
GO:0005080 | protein kinase C binding | TAS | 10858434 |
GO:0042277 | peptide binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005768 | endosome | TAS | 10858434 |
GO:0005794 | Golgi apparatus | IDA | 15528211 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS,IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors |
.34
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2 | Signaling by GPCR | ||
3 | Regulation of activated PAK-2p34 by proteasome mediated degradation | ||
4 | RET signaling | ||
5 | Calcium signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001992 | regulation of systemic arterial blood pressure by vasopressin | IEA,IBA | 21873635 |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IDA,TAS | -- |
GO:0007202 | activation of phospholipase C activity | IDA | 9322919 |
GO:0007204 | positive regulation of cytosolic calcium ion concentration | TAS | 7929452 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Desmopressin | Approved | Pharma | Agonist, Full agonist, Target, stimulator | Hemostatic and anti-diuretic, Synthetic vasopressin analog; V1B and V2 agonist | 0 | |
Vasopressin | Approved | Pharma | Agonist, Full agonist, Partial agonist, Target, agonist | 0 | ||
Terlipressin | Approved, Investigational | Pharma | Target, stimulator | 80 | ||
Atosiban | Approved, Investigational | Pharma | Antagonist, Target, antagonist | mixed antagonist of oxytocin and vasopressin receptors | 16 | |
Oxytocin | Approved, Vet_approved | Pharma | Agonist, Full agonist, agonist | Involved in uterine contraction and lactation | 620 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
[<sup>3</sup>H]AVP |
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Agonist, Full agonist, Partial agonist |
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[<sup>3</sup>H]SSR149415 |
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Antagonist |
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AVT |
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Agonist, Full agonist |
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OPC-31260 |
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Antagonist, Inverse agonist, Inverse antagonist |
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SR 121463A |
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Antagonist |
|
Compound | Action | Cas Number |
---|---|---|
[Arg8]-Vasopressin | Antidiuretic hormone | 113-79-1 |
[Lys8]-Vasopressin | Antidiuretic hormone | 50-57-7 |
d[Cha4]-AVP | Potent and selective human V1B agonist | 500170-27-4 |
d[Leu4,Lys8]-VP | Selective V1B agonist | 42061-33-6 |
Desmopressin | Synthetic vasopressin analog; V1B and V2 agonist | 16679-58-6 |
Compound | Action | Cas Number |
---|---|---|
Conivaptan HCl | 168626-94-6 | |
d[Cha4]-AVP | ||
d[Leu4,Lys8]-VP | 42061-33-6 | |
Desmopressin | Hemostatic and anti-diuretic | 16679-58-6 |
Desmopressin Acetate | Synthetic analogue of arginine vasopressin | 62288-83-9 |
Mozavaptan | 137975-06-5 | |
Tolvaptan | AVP V2-receptor antagonist | 150683-30-0 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | AVPR1B 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | AVPR1B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | AVPR1B 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC100909648 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Avpr1b 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | AVPR1B 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | AVPR1B 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | AVPR1B 30 |
|
||
AVT2R 31 |
|
OneToOne | |||
Zebrafish (Danio rerio) |
Actinopterygii | avpr2l 31 |
|
ManyToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG6111 32 |
|
|
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
711259 | Likely Benign: not provided | 206,116,332(-) | A/G | MISSENSE_VARIANT | |
721385 | Likely Benign: not provided | 206,110,330(-) | C/A | SYNONYMOUS_VARIANT | |
757827 | Likely Benign: not provided | 206,116,621(-) | T/C | SYNONYMOUS_VARIANT | |
781800 | Likely Benign: not provided | 206,116,504(-) | C/A | SYNONYMOUS_VARIANT | |
rs28632197 | - | p.Arg364His |
Disorder | Aliases | PubMed IDs |
---|---|---|
bronchial neuroendocrine tumor |
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acth-independent macronodular adrenal hyperplasia |
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acth-dependent cushing syndrome |
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diabetes insipidus |
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asperger syndrome |
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