AVPR1B Gene (Protein Coding)

Arginine Vasopressin Receptor 1B

GC01M206109
GIFtS:
44
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimula... See more...

Aliases for AVPR1B Gene

Aliases for AVPR1B Gene

  • Arginine Vasopressin Receptor 1B 2 3 5
  • Vasopressin V1b Receptor 3 4
  • Vasopressin V3 Receptor 3 4
  • AVPR V1b 3 4
  • AVPR V3 3 4
  • AVPR3 3 4
  • V1bR 3 4
  • Antidiuretic Hormone Receptor 1B 3
  • Pituitary Vasopressin Receptor 3 3
  • Antidiuretic Hormone Receptor 1b 4
  • Arginine Vasopressin Receptor 3 3
  • AVPR1B 5
  • VPR3 4

External Ids for AVPR1B Gene

Previous HGNC Symbols for AVPR1B Gene

  • AVPR3

Previous GeneCards Identifiers for AVPR1B Gene

  • GC01U990014
  • GC01P202767
  • GC01P204390
  • GC01P206223
  • GC01P177157

Summaries for AVPR1B Gene

Entrez Gene Summary for AVPR1B Gene

  • The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for AVPR1B Gene

AVPR1B (Arginine Vasopressin Receptor 1B) is a Protein Coding gene. Diseases associated with AVPR1B include Bronchial Neuroendocrine Tumor and Acth-Independent Macronodular Adrenal Hyperplasia. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and protein kinase C binding. An important paralog of this gene is AVPR1A.

UniProtKB/Swiss-Prot Summary for AVPR1B Gene

  • Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

Tocris Summary for AVPR1B Gene

  • Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to oxytocin receptors (OT).

Gene Wiki entry for AVPR1B Gene

Additional gene information for AVPR1B Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AVPR1B Gene

Genomics for AVPR1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for AVPR1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AVPR1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AVPR1B

Top Transcription factor binding sites by QIAGEN in the AVPR1B gene promoter:
  • AML1a
  • FOXD3
  • FOXI1
  • GR
  • GR-alpha
  • GR-beta
  • HEN1
  • HFH-3
  • LCR-F1
  • MRF-2

Genomic Locations for AVPR1B Gene

Latest Assembly
chr1:206,106,936-206,117,699
(GRCh38/hg38)
Size:
10,764 bases
Orientation:
Minus strand

Previous Assembly
chr1:206,223,943-206,234,395
(GRCh37/hg19 by Entrez Gene)
Size:
10,453 bases
Orientation:
Plus strand

chr1:206,223,976-206,231,639
(GRCh37/hg19 by Ensembl)
Size:
7,664 bases
Orientation:
Plus strand

Genomic View for AVPR1B Gene

Genes around AVPR1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AVPR1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AVPR1B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for AVPR1B Gene

Proteins for AVPR1B Gene

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  • Protein details for AVPR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47901-V1BR_HUMAN
    Recommended name:
    Vasopressin V1b receptor
    Protein Accession:
    P47901
    Secondary Accessions:
    • B0M0J6
    • Q5TZ00

    Protein attributes for AVPR1B Gene

    Size:
    424 amino acids
    Molecular mass:
    46971 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AVPR1B Gene

Post-translational modifications for AVPR1B Gene

  • Glycosylation at Asn21
  • Modification sites at PhosphoSitePlus

Other Protein References for AVPR1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AVPR1B Gene

Domains & Families for AVPR1B Gene

Gene Families for AVPR1B Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for AVPR1B Gene

InterPro:
Blocks:
  • Vasopressin receptor signature
  • Vasopressin VIB receptor signature

Suggested Antigen Peptide Sequences for AVPR1B Gene

GenScript: Design optimal peptide antigens:
  • Vasopressin V3 receptor (V1BR_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P47901

UniProtKB/Swiss-Prot:

V1BR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
genes like me logo Genes that share domains with AVPR1B: view

Function for AVPR1B Gene

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  6. Cell Lines for research

Molecular function for AVPR1B Gene

UniProtKB/Swiss-Prot Function:
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.
GENATLAS Biochemistry:
vasopressin pituitary V3-type,receptor,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for AVPR1B Gene

Gene Ontology (GO) - Molecular Function for AVPR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0005000 vasopressin receptor activity TAS,IDA 9322919
GO:0005080 protein kinase C binding TAS 10858434
GO:0042277 peptide binding IBA 21873635
genes like me logo Genes that share ontologies with AVPR1B: view
genes like me logo Genes that share phenotypes with AVPR1B: view

Animal Models for AVPR1B Gene

MGI Knock Outs for AVPR1B:

Animal Models for research

  • Taconic Biosciences Mouse Models for AVPR1B

miRNA for AVPR1B Gene

miRTarBase miRNAs that target AVPR1B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AVPR1B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AVPR1B Gene

Localization for AVPR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for AVPR1B Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AVPR1B gene
Compartment Confidence
plasma membrane 5
endosome 4
golgi apparatus 4
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for AVPR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome TAS 10858434
GO:0005794 Golgi apparatus IDA 15528211
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with AVPR1B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AVPR1B Gene

Pathways & Interactions for AVPR1B Gene

genes like me logo Genes that share pathways with AVPR1B: view

SIGNOR curated interactions for AVPR1B Gene

Activates:

Gene Ontology (GO) - Biological Process for AVPR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001992 regulation of systemic arterial blood pressure by vasopressin IEA,IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IDA,TAS --
GO:0007202 activation of phospholipase C activity IDA 9322919
GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 7929452
genes like me logo Genes that share ontologies with AVPR1B: view

Drugs & Compounds for AVPR1B Gene

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(53) Drugs for AVPR1B Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Desmopressin Approved Pharma Agonist, Full agonist, Target, stimulator Hemostatic and anti-diuretic, Synthetic vasopressin analog; V1B and V2 agonist 0
Vasopressin Approved Pharma Agonist, Full agonist, Target 0
Terlipressin Approved, Investigational Pharma Target, stimulator 82
Atosiban Approved, Investigational Pharma Antagonist, Target mixed antagonist of oxytocin and vasopressin receptors 17
Oxytocin Approved, Vet_approved Pharma Agonist, Full agonist Involved in uterine contraction and lactation 662

(7) Additional Compounds for AVPR1B Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]AVP
Agonist, Full agonist
[<sup>3</sup>H]SSR149415
Antagonist
AVT
Agonist, Full agonist
OPC-31260
Antagonist
SR 121463A
Antagonist

(5) Tocris Compounds for AVPR1B Gene

Compound Action Cas Number
[Arg8]-Vasopressin Antidiuretic hormone 113-79-1
[Lys8]-Vasopressin Antidiuretic hormone 50-57-7
d[Cha4]-AVP Potent and selective human V1B agonist 500170-27-4
d[Leu4,Lys8]-VP Selective V1B agonist 42061-33-6
Desmopressin Synthetic vasopressin analog; V1B and V2 agonist 16679-58-6

(7) ApexBio Compounds for AVPR1B Gene

Compound Action Cas Number
Conivaptan HCl 168626-94-6
d[Cha4]-AVP
d[Leu4,Lys8]-VP 42061-33-6
Desmopressin Hemostatic and anti-diuretic 16679-58-6
Desmopressin Acetate Synthetic analogue of arginine vasopressin 62288-83-9
Mozavaptan 137975-06-5
Tolvaptan AVP V2-receptor antagonist 150683-30-0
genes like me logo Genes that share compounds with AVPR1B: view

Drug products for research

Transcripts for AVPR1B Gene

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mRNA/cDNA for AVPR1B Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AVPR1B

Alternative Splicing Database (ASD) splice patterns (SP) for AVPR1B Gene

No ASD Table

Relevant External Links for AVPR1B Gene

GeneLoc Exon Structure for
AVPR1B

Expression for AVPR1B Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AVPR1B Gene

mRNA expression in normal human tissues for AVPR1B Gene
mRNA expression by BioGPS for AVPR1B GenemRNA expression by GTEx for AVPR1B Gene

mRNA differential expression in normal tissues according to GTEx for AVPR1B Gene

This gene is overexpressed in Pituitary (x39.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AVPR1B

SOURCE GeneReport for Unigene cluster for AVPR1B Gene:

Hs.1372

Evidence on tissue expression from TISSUES for AVPR1B Gene

  • Nervous system(4.5)
  • Adrenal gland(2.7)
genes like me logo Genes that share expression patterns with AVPR1B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AVPR1B Gene

Orthologs for AVPR1B Gene

This gene was present in the common ancestor of animals.

Orthologs for AVPR1B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia AVPR1B 29 30
  • 99.21 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia AVPR1B 29 30
  • 85.87 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia AVPR1B 29 30
  • 85.39 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia LOC100909648 29
  • 83.21 (n)
Mouse
(Mus musculus)
 Mammalia Avpr1b 29 16 30
  • 83.17 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia AVPR1B 30
  • 75 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia AVPR1B 30
  • 73 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves AVPR1B 29
  • 71.42 (n)
AVT2R 30
  • 60 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii avpr2l 30
  • 48 (a)
 ManyToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta CG6111 31
  • 32 (a)
Species where no ortholog for AVPR1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for AVPR1B Gene

ENSEMBL:
Gene Tree for AVPR1B (if available)
TreeFam:
Gene Tree for AVPR1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AVPR1B: view image
Alliance of Genome Resources:
Additional Orthologs for AVPR1B

Paralogs for AVPR1B Gene

Paralogs for AVPR1B Gene

(4) SIMAP similar genes for AVPR1B Gene using alignment to 1 proteins:

  • V1BR_HUMAN
genes like me logo Genes that share paralogs with AVPR1B: view

Variants for AVPR1B Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AVPR1B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs113061513 Likely Benign: not provided 206,116,504(-) C/A
NM_000707.5(AVPR1B):c.387G>T (p.Thr129=) 		SYNONYMOUS
rs138202422 Likely Benign: not provided 206,116,332(-) A/G
NM_000707.5(AVPR1B):c.559T>C (p.Trp187Arg) 		MISSENSE
rs202134542 Likely Benign: not provided 206,116,621(-) T/C
NM_000707.5(AVPR1B):c.270A>G (p.Pro90=) 		SYNONYMOUS
rs782145142 Likely Benign: not provided 206,110,330(-) C/A
NM_000707.5(AVPR1B):c.1134G>T (p.Thr378=) 		SYNONYMOUS
rs28632197 -- p.Arg364His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for AVPR1B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for AVPR1B Gene

Variant ID Type Subtype PubMed ID
nsv549046 CNV gain 21841781
nsv832414 CNV gain 17160897

Variation tolerance for AVPR1B Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.00; 80.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AVPR1B Gene

Human Gene Mutation Database (HGMD)
AVPR1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AVPR1B
Leiden Open Variation Database (LOVD)
AVPR1B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AVPR1B Gene

Disorders for AVPR1B Gene

MalaCards: The human disease database

(15) MalaCards diseases for AVPR1B Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AVPR1B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with AVPR1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AVPR1B Gene

Publications for AVPR1B Gene

  1. Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders. (PMID: 17909131) Dempster EL … Barr CL (Archives of general psychiatry 2007) 3 4 22 40
  2. Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor. (PMID: 7929452) Sugimoto T … Kawashima H (The Journal of biological chemistry 1994) 2 3 4 22
  3. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. (PMID: 18384079) Keck ME … Binder EB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 22 40
  4. A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression. (PMID: 15094789) van West D … Claes S (Molecular psychiatry 2004) 3 22 40
  5. Associations between common arginine vasopressin 1b receptor and glucocorticoid receptor gene variants and HPA axis responses to psychosocial stress in a child psychiatric population. (PMID: 20472303) van West D … Claes S (Psychiatry research 2010) 3 40

ExternalLinks

View latest publications for AVPR1B gene in Mastermind

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