External Ids for AVIL Gene
Previous GeneCards Identifiers for AVIL Gene
The protein encoded by this gene is a member of the gelsolin/villin family of actin regulatory proteins. This protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form ganglia. [provided by RefSeq, Jul 2008]
GeneCards Summary for AVIL Gene
AVIL (Advillin) is a Protein Coding gene. Diseases associated with AVIL include Nephrotic Syndrome, Type 21 and Nephrotic Syndrome. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is VIL1.
UniProtKB/Swiss-Prot Summary for AVIL Gene
Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling (PubMed:29058690). May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (PubMed:29058690).