This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggestin... See more...

Aliases for AURKC Gene

Aliases for AURKC Gene

  • Aurora Kinase C 2 3 4 5
  • ARK3 2 3 4
  • Serine/Threonine Kinase 13 (Aurora/IPL1-Like) 2 3
  • Serine/Threonine-Protein Kinase Aurora-C 3 4
  • Serine/Threonine-Protein Kinase 13 3 4
  • Aurora/IPL1-Related Kinase 3 3 4
  • Aurora-Related Kinase 3 3 4
  • EC 2.7.11.1 4 51
  • Aurora 3 3 4
  • STK13 3 4
  • ARK-3 3 4
  • AIE2 3 4
  • AIK3 3 4
  • AurC 2 3
  • Epididymis Secretory Protein Li 90 3
  • Aurora/IPL1/EG2 Protein 2 3
  • Aurora/IPL1/Eg2 Protein 2 4
  • EC 2.7.11 51
  • HEL-S-90 3
  • Aurora-C 3
  • SPGF5 3
  • AURKC 5
  • AIRK3 4

External Ids for AURKC Gene

Previous HGNC Symbols for AURKC Gene

  • STK13

Previous GeneCards Identifiers for AURKC Gene

  • GC19P062418
  • GC19P062433
  • GC19P057743
  • GC19P054054

Summaries for AURKC Gene

Entrez Gene Summary for AURKC Gene

  • This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for AURKC Gene

AURKC (Aurora Kinase C) is a Protein Coding gene. Diseases associated with AURKC include Spermatogenic Failure 5 and Infertility. Among its related pathways are Sweet Taste Signaling and Aurora B signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKB.

UniProtKB/Swiss-Prot Summary for AURKC Gene

  • Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

Gene Wiki entry for AURKC Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AURKC Gene

Genomics for AURKC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AURKC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J057231 Promoter 1.2 EPDnew Ensembl 627.5 +0.8 784 1.4 MTA1 MGA CBX3 POLR2A EGR1 ZBTB11 GABPA MEF2D MNT EHMT2 AURKC ZNF264 ZNF805
GH19J057190 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 18.5 -38.4 -38416 3.4 GATAD2A IKZF1 ZNF692 POLR2A BACH1 LARP7 GABPA ZNF143 ZSCAN4 RBFOX2 ZNF264 ZNF548 ZNF417 ZNF134 ZNF274 AURKC ENSG00000268379 ZNF773 ZNF550 ZIM3
GH19J057239 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 15.3 +10.9 10884 2.8 SP1 CREB1 PRDM10 ZNF629 SIX5 NFKBIZ POLR2A ZHX2 JUND LARP7 ZNF805 ZNF264 AURKC ZNF471 ZFP28 ENSG00000268713 ZNF460
GH19J057171 Promoter/Enhancer 1.4 EPDnew ENCODE CraniofacialAtlas 17.2 -58.1 -58099 1.6 PRDM10 ZNF692 ZNF501 ZNF600 ZNF341 ZNF561 KLF9 ZBTB20 SP2 ZNF580 ZNF264 ENSG00000268379 AURKC ZNF805 DUXA LOC100132009
GH19J057278 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 +51.2 51159 6.7 ZNF221 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 TFE3 ZNF460 ZNF460-AS1 ZNF549 ZNF805 ZNF17 ZNF329 ENSG00000176593 ZNF264 ZNF543 ZNF471
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AURKC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AURKC

Top Transcription factor binding sites by QIAGEN in the AURKC gene promoter:
  • AML1a
  • FOXF2
  • GCNF
  • GCNF-1
  • GCNF-2

Genomic Locations for AURKC Gene

Genomic Locations for AURKC Gene
chr19:57,230,317-57,235,550
(GRCh38/hg38)
Size:
5,234 bases
Orientation:
Plus strand
chr19:57,742,377-57,746,916
(GRCh37/hg19)
Size:
4,540 bases
Orientation:
Plus strand

Genomic View for AURKC Gene

Genes around AURKC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AURKC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AURKC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AURKC Gene

Proteins for AURKC Gene

  • Protein details for AURKC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQB9-AURKC_HUMAN
    Recommended name:
    Aurora kinase C
    Protein Accession:
    Q9UQB9
    Secondary Accessions:
    • O60681
    • O75442
    • Q6AZY8
    • Q6DLZ0
    • Q9UPK5

    Protein attributes for AURKC Gene

    Size:
    309 amino acids
    Molecular mass:
    35591 Da
    Quaternary structure:
    • Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist; in the complex interacts directly with BIRC5/survivin and INCENP. Interacts with TACC1.

    Three dimensional structures from OCA and Proteopedia for AURKC Gene

    Alternative splice isoforms for AURKC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AURKC Gene

Selected DME Specific Peptides for AURKC Gene

Q9UQB9:
  • VIHRDIKPEN
  • VDLWCIGVLCYEL
  • IVALKVLFK
  • CGTLDYL
  • HRDIKPEN
  • EHQLRRE
  • ALKVLFKS
  • PPFESASH
  • GELYKELQ
  • LCYELLVG
  • HPNILRLY
  • SRRVLPP

Post-translational modifications for AURKC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for AURKC Gene

Gene Families for AURKC Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for AURKC Gene

Suggested Antigen Peptide Sequences for AURKC Gene

GenScript: Design optimal peptide antigens:
  • Serine/threonine-protein kinase aurora-C (AURKC_HUMAN)
  • Aurora-C (Q5Y191_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UQB9

UniProtKB/Swiss-Prot:

AURKC_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
genes like me logo Genes that share domains with AURKC: view

Function for AURKC Gene

Molecular function for AURKC Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot Induction:
Expression is cell cycle-regulated, with an increase during G2 and M phases.
UniProtKB/Swiss-Prot EnzymeRegulation:
Okadaic acid, an inhibitor of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein phosphatase 5 (PP5), increases AURKC activity. AURKC is also stabilized through its interaction with INCENP, which acts also as an activator.

Enzyme Numbers (IUBMB) for AURKC Gene

Gene Ontology (GO) - Molecular Function for AURKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,IDA 15670791
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004712 protein serine/threonine/tyrosine kinase activity TAS 19774610
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with AURKC: view
genes like me logo Genes that share phenotypes with AURKC: view

Human Phenotype Ontology for AURKC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for AURKC Gene

MGI Knock Outs for AURKC:

Animal Model Products

  • Taconic Biosciences Mouse Models for AURKC

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AURKC

Clone Products

  • Addgene plasmids for AURKC

No data available for Phenotypes From GWAS Catalog , miRNA , Transcription Factor Targets and HOMER Transcription for AURKC Gene

Localization for AURKC Gene

Subcellular locations from UniProtKB/Swiss-Prot for AURKC Gene

Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis. {ECO:0000269 PubMed:21531210}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AURKC gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for AURKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000780 condensed nuclear chromosome, centromeric region IBA 21873635
GO:0000793 condensed chromosome IDA 15670791
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with AURKC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AURKC Gene

Pathways & Interactions for AURKC Gene

PathCards logo

SuperPathways for AURKC Gene

SuperPathway Contained pathways
1 Aurora B signaling
2 DNA Damage
3 ERK Signaling
.51
4 Sweet Taste Signaling
.37
genes like me logo Genes that share pathways with AURKC: view

Pathways by source for AURKC Gene

2 Qiagen pathways for AURKC Gene
  • Molecular Mechanisms of Cancer
  • Sperm Motility
1 Cell Signaling Technology pathway for AURKC Gene
1 GeneTex pathway for AURKC Gene

SIGNOR curated interactions for AURKC Gene

Activates:

Gene Ontology (GO) - Biological Process for AURKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 15670791
GO:0007049 cell cycle IEA --
GO:0007052 mitotic spindle organization IBA 21873635
GO:0007283 spermatogenesis IEA --
GO:0008608 attachment of spindle microtubules to kinetochore TAS 19774610
genes like me logo Genes that share ontologies with AURKC: view

Drugs & Compounds for AURKC Gene

(33) Drugs for AURKC Gene - From: DrugBank, ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Reversine Experimental Pharma A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor 0
SNS-314 Investigational Pharma Target, inhibitor Kinase Inhibitors 0
CYC116 Investigational Pharma inhibitor Potent Aurora A/B inhibitor, Inhibitors of mitosis Aurora kinase inhibitors 0
AT9283 Investigational Pharma Aurora kinase/JAK inhibitor, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors 0

(1) Additional Compounds for AURKC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0

(21) ApexBio Compounds for AURKC Gene

Compound Action Cas Number
AMG-900 Aurora kinase inhibitor 945595-80-2
Anacardic acid HAT inhibitor 16611-84-0
AT9283 Aurora kinase/JAK inhibitor 896466-04-9
Aurora A Inhibitor I Aurora A inhibitor 1158838-45-9
CCT129202 Aurora kinase inhibitor,ATP-competitive and potent 942947-93-5
CCT137690 Aurora A/B/C inhibitor 1095382-05-0
CYC116 Potent Aurora A/B inhibitor 693228-63-6
Danusertib (PHA-739358) Pan-aurora kinase inhibitor 827318-97-8
ENMD-2076 L-(+)-Tartaric acid Aurora kinases inhibitor 1291074-87-7
GSK1070916 Aurora B/C inhibitor 942918-07-2
Hesperadin Aurora B kinase inhibitor 422513-13-1
JNJ-7706621 Potent CDK/Aurora kinase inhibitor 443797-96-4
MK-5108 (VX-689) Aurora-A kinase inhibitor,highly selective 1010085-13-8
MK-8745 Aurora A inhibitor,potent and selective 885325-71-3
PF-03814735 Aurora A/B inhibitor 942487-16-3
PHA-680632 Aurora kinase inhibitor,novel and potent 398493-79-3
Reversine A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor 656820-32-5
SNS-314 Mesylate Aurora A/B/C kinases inhibitor, potent and selective 1146618-41-8
TAK-901 Novel Aurora A/B inhibitor 934541-31-8
VX-680 (MK-0457,Tozasertib) Aurora kinase inhibitor 639089-54-6
ZM 447439 Aurora Kinase inhibitor,potent and selective 331771-20-1
genes like me logo Genes that share compounds with AURKC: view

Drug Products

Transcripts for AURKC Gene

mRNA/cDNA for AURKC Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AURKC

Clone Products

  • Addgene plasmids for AURKC

Alternative Splicing Database (ASD) splice patterns (SP) for AURKC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for AURKC Gene

GeneLoc Exon Structure for
AURKC

Expression for AURKC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AURKC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for AURKC Gene

This gene is overexpressed in Testis (x17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AURKC Gene



Protein tissue co-expression partners for AURKC Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AURKC

SOURCE GeneReport for Unigene cluster for AURKC Gene:

Hs.98338

mRNA Expression by UniProt/SwissProt for AURKC Gene:

Q9UQB9-AURKC_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.

Evidence on tissue expression from TISSUES for AURKC Gene

  • Nervous system(4.4)
  • Thyroid gland(2.2)
  • Intestine(2.1)
  • Liver(2.1)
  • Kidney(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for AURKC Gene

Germ Layers:
  • mesoderm
Systems:
  • reproductive
Regions:
Pelvis:
  • penis
  • prostate
  • testicle
  • vas deferens
genes like me logo Genes that share expression patterns with AURKC: view

No data available for Protein differential expression in normal tissues for AURKC Gene

Orthologs for AURKC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AURKC Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AURKC 30 31
  • 99.24 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia STK13 31
  • 87 (a)
OneToOne
AURKC 30
  • 85.51 (n)
Cow
(Bos Taurus)
Mammalia LOC618599 30
  • 84.46 (n)
-- 31
  • 82 (a)
OneToMany
-- 31
  • 71 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Aurkc 30 17 31
  • 81.87 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 68 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 59 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii aurkb 31
  • 63 (a)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8843 30
Fruit Fly
(Drosophila melanogaster)
Insecta ial 30
  • 58.79 (n)
aur 31
  • 38 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007855 30
  • 56.54 (n)
Worm
(Caenorhabditis elegans)
Secernentea air-2 31
  • 53 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IPL1 31 33
  • 35 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AUR3 30
  • 57.28 (n)
Soybean
(Glycine max)
eudicotyledons Gma.9652 30
Rice
(Oryza sativa)
Liliopsida Os03g0765000 30
  • 57.48 (n)
Corn
(Zea mays)
Liliopsida Zm.17459 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4656 31
  • 59 (a)
OneToMany
Species where no ortholog for AURKC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rat (Rattus norvegicus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for AURKC Gene

ENSEMBL:
Gene Tree for AURKC (if available)
TreeFam:
Gene Tree for AURKC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AURKC: view image

Paralogs for AURKC Gene

Paralogs for AURKC Gene

Pseudogenes.org Pseudogenes for AURKC Gene

genes like me logo Genes that share paralogs with AURKC: view

Variants for AURKC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AURKC Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
781475 Benign: not provided 57,233,451(+) C/T INTRON_VARIANT
893059 Uncertain Significance: Infertility associated with multi-tailed spermatozoa and excessive DNA 57,231,196(+) A/C FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
893060 Uncertain Significance: Infertility associated with multi-tailed spermatozoa and excessive DNA 57,231,211(+) G/T FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
893061 Uncertain Significance: Infertility associated with multi-tailed spermatozoa and excessive DNA 57,231,260(+) C/G SYNONYMOUS_VARIANT,INTRON_VARIANT
893062 Uncertain Significance: Infertility associated with multi-tailed spermatozoa and excessive DNA 57,232,137(+) C/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for AURKC Gene

Structural Variations from Database of Genomic Variants (DGV) for AURKC Gene

Variant ID Type Subtype PubMed ID
esv3893256 CNV loss 25118596
nsv580400 CNV gain 21841781

Variation tolerance for AURKC Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AURKC Gene

Human Gene Mutation Database (HGMD)
AURKC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AURKC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AURKC Gene

Disorders for AURKC Gene

MalaCards: The human disease database

(5) MalaCards diseases for AURKC Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure 5
  • spgf5
infertility
polyploidy
spermatogenic failure 9
  • globozoospermia
male infertility
  • infertility male
- elite association - COSMIC cancer census association via MalaCards
Search AURKC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

AURKC_HUMAN
  • Spermatogenic failure 5 (SPGF5) [MIM:243060]: An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome. {ECO:0000269 PubMed:17435757, ECO:0000269 PubMed:21733974}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for AURKC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with AURKC: view

No data available for Genatlas for AURKC Gene

Publications for AURKC Gene

  1. The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population. (PMID: 19147683) Dieterich K … Ray PF (Human molecular genetics 2009) 3 23 41
  2. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. (PMID: 15499654) Sasai K … Sen S (Cell motility and the cytoskeleton 2004) 3 4 23
  3. Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. (PMID: 10066797) Kimura M … Okano Y (The Journal of biological chemistry 1999) 3 4 23
  4. Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter. (PMID: 9799611) Bernard M … Prigent C (Genomics 1998) 2 3 4
  5. Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex. (PMID: 27332895) Sasai K … Sen S (PloS one 2016) 3 4

Products for AURKC Gene

Sources for AURKC Gene