AURKB Gene (Protein Coding)

Aurora Kinase B

GC17M009073
GIFtS:
50
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on ch... See more...

Aliases for AURKB Gene

Aliases for AURKB Gene

  • Aurora Kinase B 2 3 4 5
  • AIM-1 2 3 4
  • ARK2 2 3 4
  • STK5 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 48 2 3
  • Serine/Threonine-Protein Kinase Aurora-B 3 4
  • Serine/Threonine-Protein Kinase 12 3 4
  • Serine/Threonine-Protein Kinase 5 3 4
  • Aurora/IPL1-Related Kinase 2 3 4
  • Serine/Threonine Kinase 12 2 3
  • Aurora-Related Kinase 2 3 4
  • EC 2.7.11.1 4 50
  • Aurora-B 2 3
  • Aurora-1 2 3
  • PPP1R48 2 3
  • ARK-2 3 4
  • STK-1 3 4
  • STK12 3 4
  • AIK2 3 4
  • AIM1 3 4
  • AurB 2 3
  • IPL1 2 3
  • Aurora- And Ipl1-Like Midbody-Associated Protein 1 3
  • Aurora- And IPL1-Like Midbody-Associated Protein 1 4
  • Aurora Kinase B-Sv1 3
  • Aurora Kinase B-Sv2 3
  • Aurkb-Sv1 3
  • Aurkb-Sv2 3
  • EC 2.7.11 50
  • Aurora 1 4
  • AURKB 5
  • AIRK2 4
  • Aik2 2
  • STK1 4

External Ids for AURKB Gene

Previous HGNC Symbols for AURKB Gene

  • STK12

Previous GeneCards Identifiers for AURKB Gene

  • GC17M008050
  • GC17M008308
  • GC17M008048
  • GC17M008108
  • GC17M008006
  • GC17M008218
  • GC17M008264
  • GC17M008600
  • GC17M008636
  • GC17M008676
  • GC17M008770
  • GC17M008309
  • GC17M008344
  • GC17M008378
  • GC17M008418
  • GC17M008452
  • GC17M008492
  • GC17M008525
  • GC17M008557
  • GC17M008864
  • GC17M008959

Summaries for AURKB Gene

Entrez Gene Summary for AURKB Gene

  • This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

GeneCards Summary for AURKB Gene

AURKB (Aurora Kinase B) is a Protein Coding gene. Diseases associated with AURKB include Nk-Cell Enteropathy and Polyploidy. Among its related pathways are Cell Cycle, Mitotic and Aurora B signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKC.

UniProtKB/Swiss-Prot Summary for AURKB Gene

  • Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between HASPIN and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.

Tocris Summary for AURKB Gene

  • Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in regulating many of the processes that are pivotal to mitosis. Each of the isoforms, Aurora A, Aurora B and Aurora C, has a different function in the control of mitosis.

Gene Wiki entry for AURKB Gene

Additional gene information for AURKB Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AURKB Gene

Genomics for AURKB Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for AURKB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AURKB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AURKB

Top Transcription factor binding sites by QIAGEN in the AURKB gene promoter:
  • AREB6
  • ITF-2
  • LCR-F1
  • Olf-1
  • PPAR-gamma1
  • PPAR-gamma2
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • Tal-1beta

Genomic Locations for AURKB Gene

Latest Assembly
chr17:8,204,731-8,210,767
(GRCh38/hg38)
Size:
6,037 bases
Orientation:
Minus strand

Previous Assembly
chr17:8,108,049-8,113,893
(GRCh37/hg19 by Entrez Gene)
Size:
5,845 bases
Orientation:
Minus strand

chr17:8,108,056-8,113,918
(GRCh37/hg19 by Ensembl)
Size:
5,863 bases
Orientation:
Minus strand

Genomic View for AURKB Gene

Genes around AURKB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AURKB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AURKB Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for AURKB Gene

Proteins for AURKB Gene

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  • Protein details for AURKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GD4-AURKB_HUMAN
    Recommended name:
    Aurora kinase B
    Protein Accession:
    Q96GD4
    Secondary Accessions:
    • B4DNM4
    • C7G533
    • C7G534
    • C7G535
    • D3DTR4
    • J9JID1
    • O14630
    • O60446
    • O95083
    • Q96DV5
    • Q9UQ46

    Protein attributes for AURKB Gene

    Size:
    344 amino acids
    Molecular mass:
    39311 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist. Associates with RACGAP1 during M phase. Interacts with CDCA1, EVI5, JTB, NDC80, PSMA3, SEPTIN1, SIRT2 and TACC1. Interacts with SPDYC; this interaction may be required for proper localization of active, Thr-232-phosphorylated AURKB form during prometaphase and metaphase. Interacts with p53/TP53. Interacts (via the middle kinase domain) with NOC2L (via the N- and C-terminus domains). Interacts with TTC28. Interacts with RNF2/RING1B.
    SequenceCaution:
    • Sequence=AAH13300.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 3]: Not expressed in normal liver, high expression in metastatic liver.

    Three dimensional structures from OCA and Proteopedia for AURKB Gene

    Alternative splice isoforms for AURKB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AURKB Gene

Protein Expression for AURKB Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for AURKB Gene

Q96GD4:
  • VIHRDIKPEN
  • VDLWCIGVLCYEL
  • TFDEQRTATIMEEL
  • IVALKVLFK
  • IGRPLGKGKFGNVYLARE
  • LYNYFYD
  • CGTLDYL
  • HRDIKPEN
  • GELKIADFGWSVHAPS
  • EHQLRRE
  • ALKVLFKS
  • PPFESASH
  • TAAPGQK
  • LCYELLVG
  • GELYKELQ
  • HPNILRLY
  • VYLAREK
  • SRRVLPP

Post-translational modifications for AURKB Gene

  • The phosphorylation of Thr-232 requires the binding to INCENP and occurs by means of an autophosphorylation mechanism. Thr-232 phosphorylation is indispensable for the AURKB kinase activity.
  • Ubiquitinated by different BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes. Ubiquitinated by the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, ubiquitination leads to removal from mitotic chromosomes and is required for cytokinesis. During anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex from chromosomes to the spindle midzone and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
  • Ubiquitination at Lys4, Lys56, Lys31, Lys168, Lys202, Lys211, and Lys215
  • Modification sites at PhosphoSitePlus

Other Protein References for AURKB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

Domains & Families for AURKB Gene

Gene Families for AURKB Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for AURKB Gene

InterPro:

Suggested Antigen Peptide Sequences for AURKB Gene

GenScript: Design optimal peptide antigens:
  • Serine/threonine-protein kinase aurora-B (AURKB_HUMAN)
  • cDNA FLJ57406, highly similar to Serine/threonine-protein kinase 12 (EC 2.7.11.1) (B4DNM4_HUMAN)
  • Aurora kinase B (C7G533_HUMAN)
  • Aurora kinase B-Sv1 (C7G534_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96GD4

UniProtKB/Swiss-Prot:

AURKB_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
genes like me logo Genes that share domains with AURKB: view

Function for AURKB Gene

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Molecular function for AURKB Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between HASPIN and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot Induction:
Expression is cell cycle-regulated, with a low in G1/S, an increase during G2 and M. Expression decreases again after M phase.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is greatly increased when AURKB is within the CPC complex. In particular, AURKB-phosphorylated INCENP acts as an activator of AURKB. Positive feedback between HASPIN and AURKB contributes to CPC localization.

Enzyme Numbers (IUBMB) for AURKB Gene

Phenotypes From GWAS Catalog for AURKB Gene

Gene Ontology (GO) - Molecular Function for AURKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,TAS --
GO:0004712 protein serine/threonine/tyrosine kinase activity TAS 19774610
GO:0005515 protein binding IPI 12689593
genes like me logo Genes that share ontologies with AURKB: view

Phenotypes for AURKB Gene

MGI mutant phenotypes for AURKB:
inferred from 6 alleles
GenomeRNAi human phenotypes for AURKB:
genes like me logo Genes that share phenotypes with AURKB: view

Animal Models for AURKB Gene

MGI Knock Outs for AURKB:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AURKB

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AURKB Gene

Localization for AURKB Gene

Subcellular locations from UniProtKB/Swiss-Prot for AURKB Gene

Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the midbody. Proper localization of the active, Thr-232-phosphorylated form during metaphase may be dependent upon interaction with SPDYC. Colocalized with SIRT2 during cytokinesis with the midbody. Localization (and probably targeting of the CPC) to the inner centromere occurs predominantly in regions with overlapping mitosis-specific histone phosphorylations H3pT3 and H2ApT12. {ECO:0000269 PubMed:20929775}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AURKB gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
mitochondrion 2
endosome 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Midbody (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AURKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IDA 22024163
GO:0000779 condensed chromosome, centromeric region IBA,IDA 18195732
GO:0005634 nucleus IEA,IDA 20959462
GO:0005654 nucleoplasm IDA,TAS --
genes like me logo Genes that share ontologies with AURKB: view

Pathways & Interactions for AURKB Gene

genes like me logo Genes that share pathways with AURKB: view

Pathways by source for AURKB Gene

3 GeneGo (Thomson Reuters) pathways for AURKB Gene
  • Cell cycle_Chromosome condensation in prometaphase
  • Cell cycle_Role of APC in cell cycle regulation
  • Cell cycle_Spindle assembly and chromosome separation
2 Qiagen pathways for AURKB Gene
  • Molecular Mechanisms of Cancer
  • Sperm Motility
1 Cell Signaling Technology pathway for AURKB Gene
2 GeneTex pathways for AURKB Gene

SIGNOR curated interactions for AURKB Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for AURKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 20959462
GO:0002903 negative regulation of B cell apoptotic process IDA 20959462
GO:0006468 protein phosphorylation IEA,IDA 21820309
GO:0006511 ubiquitin-dependent protein catabolic process TAS --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with AURKB: view

Drugs & Compounds for AURKB Gene

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(50) Drugs for AURKB Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hesperidin Approved, Investigational Pharma Target 33
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
Reversine Experimental Pharma Target A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor 0
AT9283 Investigational Pharma Target, inhibitor Aurora kinase/JAK inhibitor, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors 0

(2) Additional Compounds for AURKB Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 58-64-0
Hesperadin hydrochloride
422513-13-1

(3) Tocris Compounds for AURKB Gene

Compound Action Cas Number
Hesperadin hydrochloride Potent Aurora kinase B inhibitor 422513-13-1
TC-A 2317 hydrochloride Potent, selective Aurora kinase A inhibitor 1245907-03-2
ZM 447439 Inhibits Aurora kinase B 331771-20-1

(26) ApexBio Compounds for AURKB Gene

Compound Action Cas Number
AMG-900 Aurora kinase inhibitor 945595-80-2
Anacardic acid HAT inhibitor 16611-84-0
AT9283 Aurora kinase/JAK inhibitor 896466-04-9
Aurora A Inhibitor I Aurora A inhibitor 1158838-45-9
AZD1152 Aurora B kinase inhibitor,highly potent and selective 722543-31-9
Barasertib (AZD1152-HQPA) Aurora Kinase B inhibitor, Potent and selective 722544-51-6
CCT129202 Aurora kinase inhibitor,ATP-competitive and potent 942947-93-5
CCT137690 Aurora A/B/C inhibitor 1095382-05-0
CYC116 Potent Aurora A/B inhibitor 693228-63-6
Danusertib (PHA-739358) Pan-aurora kinase inhibitor 827318-97-8
ENMD-2076 Selective Aurora A/Flt3 inhibitor 934353-76-1
ENMD-2076 L-(+)-Tartaric acid Aurora kinases inhibitor 1291074-87-7
GSK1070916 Aurora B/C inhibitor 942918-07-2
Hesperadin Aurora B kinase inhibitor 422513-13-1
JNJ-7706621 Potent CDK/Aurora kinase inhibitor 443797-96-4
MK-5108 (VX-689) Aurora-A kinase inhibitor,highly selective 1010085-13-8
MK-8745 Aurora A inhibitor,potent and selective 885325-71-3
MLN8054 Aurora A inhibitor 869363-13-3
PF-03814735 Aurora A/B inhibitor 942487-16-3
PHA-680632 Aurora kinase inhibitor,novel and potent 398493-79-3
Reversine A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor 656820-32-5
SCH-1473759 Aurora A/B inhibitor 1094069-99-4
SNS-314 Mesylate Aurora A/B/C kinases inhibitor, potent and selective 1146618-41-8
TAK-901 Novel Aurora A/B inhibitor 934541-31-8
VX-680 (MK-0457,Tozasertib) Aurora kinase inhibitor 639089-54-6
ZM 447439 Aurora Kinase inhibitor,potent and selective 331771-20-1
genes like me logo Genes that share compounds with AURKB: view

Drug products for research

Transcripts for AURKB Gene

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mRNA/cDNA for AURKB Gene

9 REFSEQ mRNAs :
25 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AURKB

Alternative Splicing Database (ASD) splice patterns (SP) for AURKB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - - -
SP14: - - -
SP15: - - -
SP16: - - - - - -
SP17: - - - - -
SP18: - - -
SP19:
SP20:

ExUns: 10a · 10b · 10c · 10d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for AURKB Gene

GeneLoc Exon Structure for
AURKB

Expression for AURKB Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AURKB Gene

mRNA expression in normal human tissues for AURKB Gene
mRNA expression by GTEx for AURKB GenemRNA expression by BioGPS for AURKB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AURKB Gene

This gene is overexpressed in Nerve - Tibial (x4.6) and Esophagus - Mucosa (x4.0).

Protein differential expression in normal tissues from HIPED for AURKB Gene

This gene is overexpressed in Breast (56.8) and Lung (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AURKB Gene



Protein tissue co-expression partners for AURKB Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AURKB

SOURCE GeneReport for Unigene cluster for AURKB Gene:

Hs.442658

mRNA Expression by UniProt/SwissProt for AURKB Gene:

Q96GD4-AURKB_HUMAN
Tissue specificity: High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.

Evidence on tissue expression from TISSUES for AURKB Gene

  • Liver(4.6)
  • Lung(4.5)
  • Muscle(4.4)
  • Spleen(4.4)
  • Intestine(2.8)
  • Skin(2.7)
  • Bone marrow(2.5)
  • Lymph node(2.5)
  • Blood(2.4)
  • Nervous system(2.3)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with AURKB: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AURKB Gene

Orthologs for AURKB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AURKB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia AURKB 29 30
  • 98.84 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia AURKB 29 30
  • 90.86 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia AURKB 29 30
  • 89.99 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Aurkb 29
  • 84.07 (n)
Mouse
(Mus musculus)
 Mammalia Aurkb 29 16 30
  • 83.19 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 76 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 30
  • 66 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia aurkb 29
  • 66.27 (n)
African clawed frog
(Xenopus laevis)
 Amphibia LOC398457 29
Zebrafish
(Danio rerio)
 Actinopterygii aurkb 29 30
  • 69.37 (n)
 OneToMany
stka 29
Fruit Fly
(Drosophila melanogaster)
 Insecta aur 30
  • 42 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea air-2 30
  • 55 (a)
 OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_AFL101C 29
  • 55.08 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0B02332g 29
  • 52.62 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes IPL1 29 30
  • 50.72 (n)
 OneToMany
Barley
(Hordeum vulgare)
 Liliopsida Hv.9199 29
Corn
(Zea mays)
 Liliopsida Zm.5439 29
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.4656 30
  • 59 (a)
 OneToMany
Bread mold
(Neurospora crassa)
 Ascomycetes NCU00108 29
  • 58.66 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes ark1 29
  • 55.94 (n)
Species where no ortholog for AURKB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for AURKB Gene

ENSEMBL:
Gene Tree for AURKB (if available)
TreeFam:
Gene Tree for AURKB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AURKB: view image
Alliance of Genome Resources:
Additional Orthologs for AURKB

Paralogs for AURKB Gene

Paralogs for AURKB Gene

(109) SIMAP similar genes for AURKB Gene using alignment to 8 proteins:

  • AURKB_HUMAN
  • J3KRF8_HUMAN
  • J3KRJ2_HUMAN
  • J3KT86_HUMAN
  • J3KTD6_HUMAN
  • J3QLN8_HUMAN
  • J3QR41_HUMAN
  • J9JID1_HUMAN

Pseudogenes.org Pseudogenes for AURKB Gene

genes like me logo Genes that share paralogs with AURKB: view

Variants for AURKB Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AURKB Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
931197 Benign: not provided 8,206,543(-) C/G
NM_004217.4(AURKB):c.634G>C (p.Gly212Arg) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
931198 Uncertain Significance: not provided 8,207,815(-) G/A
NM_004217.4(AURKB):c.74C>T (p.Pro25Leu) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR
rs1597343914 Likely Pathogenic: NK-cell enteropathy 8,205,230(-) G/A
NM_004217.4(AURKB):c.847C>T (p.Arg283Cys) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs565442198 Likely Benign: not provided 8,205,240(-) G/A
NM_004217.4(AURKB):c.837C>T (p.Asn279=) 		NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs1059476 -- p.Met298Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for AURKB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for AURKB Gene

Variant ID Type Subtype PubMed ID
esv3639878 CNV loss 21293372
nsv833353 CNV loss 17160897

Variation tolerance for AURKB Gene

Residual Variation Intolerance Score: 53.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AURKB Gene

Human Gene Mutation Database (HGMD)
AURKB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AURKB
Leiden Open Variation Database (LOVD)
AURKB

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AURKB Gene

Disorders for AURKB Gene

MalaCards: The human disease database

(14) MalaCards diseases for AURKB Gene - From: CVR, COP, and GCD

Disorder Aliases PubMed IDs
nk-cell enteropathy
polyploidy
tetraploidy
  • tetraploidy syndrome
hyperinsulinemic hypoglycemia, familial, 3
  • hhf3
giant cell glioblastoma
  • monstrocellular sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search AURKB in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

AURKB_HUMAN
  • Note=Disruptive regulation of expression is a possible mechanism of the perturbation of chromosomal integrity in cancer cells through its dominant-negative effect on cytokinesis.

Additional Disease Information for AURKB

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with AURKB: view

No data available for Genatlas for AURKB Gene

Publications for AURKB Gene

  1. Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1. (PMID: 9858806) Kimura M … Okano Y (Cytogenetics and cell genetics 1998) 2 3 4 22
  2. Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. (PMID: 17617734) Pouwels J … Kallio MJ (Cell cycle (Georgetown, Tex.) 2007) 3 4 22
  3. EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis. (PMID: 16764853) Faitar SL … Cowell JK (Experimental cell research 2006) 3 4 22
  4. Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. (PMID: 14610074) Wheatley SP … Earnshaw WC (The Journal of biological chemistry 2004) 3 4 22
  5. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. (PMID: 15249581) Gassmann R … Earnshaw WC (The Journal of cell biology 2004) 3 4 22

ExternalLinks

View latest publications for AURKB gene in Mastermind

Products for AURKB Gene

  • Addgene plasmids for AURKB