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This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
AURKB (Aurora Kinase B) is a Protein Coding gene. Diseases associated with AURKB include Nk-Cell Enteropathy and Polyploidy. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKC.
Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in regulating many of the processes that are pivotal to mitosis. Each of the isoforms, Aurora A, Aurora B and Aurora C, has a different function in the control of mitosis.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IEA,TAS | -- |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | TAS | 19774610 |
GO:0005515 | protein binding | IPI | 12689593 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000775 | chromosome, centromeric region | IEA | -- |
GO:0000776 | kinetochore | IDA | 22024163 |
GO:0000779 | condensed chromosome, centromeric region | IDA | 19465021 |
GO:0000780 | condensed nuclear chromosome, centromeric region | IDA | 18195732 |
GO:0005634 | nucleus | IEA,IDA | 20959462 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of activated PAK-2p34 by proteasome mediated degradation | ||
2 | Cell Cycle, Mitotic |
.83
|
.60
|
3 | Mitotic Metaphase and Anaphase |
.94
|
|
4 | Mitotic Prometaphase | ||
5 | Regulation of TP53 Activity |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 20959462 |
GO:0002903 | negative regulation of B cell apoptotic process | IDA | 20959462 |
GO:0006468 | protein phosphorylation | IEA,IDA | 21820309 |
GO:0006511 | ubiquitin-dependent protein catabolic process | TAS | -- |
GO:0007049 | cell cycle | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Hesperidin | Approved, Investigational | Pharma | Target | 29 | ||
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
Reversine | Experimental | Pharma | Target | A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor | 0 | |
AT9283 | Investigational | Pharma | Target, inhibitor | Aurora kinase/JAK inhibitor, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
||
Hesperadin hydrochloride |
|
422513-13-1 |
|
|
Compound | Action | Cas Number |
---|---|---|
Hesperadin hydrochloride | Potent Aurora kinase B inhibitor | 422513-13-1 |
TC-A 2317 hydrochloride | Potent, selective Aurora kinase A inhibitor | 1245907-03-2 |
ZM 447439 | Inhibits Aurora kinase B | 331771-20-1 |
Compound | Action | Cas Number |
---|---|---|
AMG-900 | Aurora kinase inhibitor | 945595-80-2 |
Anacardic acid | HAT inhibitor | 16611-84-0 |
AT9283 | Aurora kinase/JAK inhibitor | 896466-04-9 |
Aurora A Inhibitor I | Aurora A inhibitor | 1158838-45-9 |
AZD1152 | Aurora B kinase inhibitor,highly potent and selective | 722543-31-9 |
Barasertib (AZD1152-HQPA) | Aurora Kinase B inhibitor, Potent and selective | 722544-51-6 |
CCT129202 | Aurora kinase inhibitor,ATP-competitive and potent | 942947-93-5 |
CCT137690 | Aurora A/B/C inhibitor | 1095382-05-0 |
CYC116 | Potent Aurora A/B inhibitor | 693228-63-6 |
Danusertib (PHA-739358) | Pan-aurora kinase inhibitor | 827318-97-8 |
ENMD-2076 | Selective Aurora A/Flt3 inhibitor | 934353-76-1 |
ENMD-2076 L-(+)-Tartaric acid | Aurora kinases inhibitor | 1291074-87-7 |
GSK1070916 | Aurora B/C inhibitor | 942918-07-2 |
Hesperadin | Aurora B kinase inhibitor | 422513-13-1 |
JNJ-7706621 | Potent CDK/Aurora kinase inhibitor | 443797-96-4 |
MK-5108 (VX-689) | Aurora-A kinase inhibitor,highly selective | 1010085-13-8 |
MK-8745 | Aurora A inhibitor,potent and selective | 885325-71-3 |
MLN8054 | Aurora A inhibitor | 869363-13-3 |
PF-03814735 | Aurora A/B inhibitor | 942487-16-3 |
PHA-680632 | Aurora kinase inhibitor,novel and potent | 398493-79-3 |
Reversine | A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor | 656820-32-5 |
SCH-1473759 | Aurora A/B inhibitor | 1094069-99-4 |
SNS-314 Mesylate | Aurora A/B/C kinases inhibitor, potent and selective | 1146618-41-8 |
TAK-901 | Novel Aurora A/B inhibitor | 934541-31-8 |
VX-680 (MK-0457,Tozasertib) | Aurora kinase inhibitor | 639089-54-6 |
ZM 447439 | Aurora Kinase inhibitor,potent and selective | 331771-20-1 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP13: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP16: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP17: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP18: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP19: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP20: |
ExUns: | 10a | · | 10b | · | 10c | · | 10d |
---|---|---|---|---|---|---|---|
SP1: | |||||||
SP2: | |||||||
SP3: | |||||||
SP4: | |||||||
SP5: | |||||||
SP6: | |||||||
SP7: | |||||||
SP8: | |||||||
SP9: | |||||||
SP10: | |||||||
SP11: | |||||||
SP12: | |||||||
SP13: | |||||||
SP14: | |||||||
SP15: | |||||||
SP16: | |||||||
SP17: | |||||||
SP18: | |||||||
SP19: | |||||||
SP20: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | AURKB 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | AURKB 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | AURKB 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Aurkb 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Aurkb 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | aurkb 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | LOC398457 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | aurkb 30 31 |
|
OneToMany | |
stka 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | aur 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | air-2 31 |
|
OneToMany | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFL101C 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B02332g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IPL1 30 31 |
|
OneToMany | |
Barley (Hordeum vulgare) |
Liliopsida | Hv.9199 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.5439 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4656 31 |
|
OneToMany | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU00108 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ark1 30 |
|
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
638622 | Likely Pathogenic: NK-cell enteropathy | 8,205,230(-) | G/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
764909 | Likely Benign: not provided | 8,205,240(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
rs1059476 | - | p.Met298Thr | |||
rs3027254 | - | p.His100Gln | |||
rs55871613 | - | p.Thr179Met |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3639878 | CNV | loss | 21293372 |
nsv833353 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
nk-cell enteropathy |
|
|
polyploidy |
|
|
tetraploidy |
|
|
giant cell glioblastoma |
|
|
hyperinsulinemic hypoglycemia, familial, 4 |
|
|