Aliases for AURKB Gene
Aliases for AURKB Gene
- Aurora Kinase B 2 3 3 5
- Protein Phosphatase 1, Regulatory Subunit 48 2 3
- Serine/Threonine-Protein Kinase Aurora-B 3 4
- Serine/Threonine-Protein Kinase 12 3 4
- Serine/Threonine-Protein Kinase 5 3 4
- Aurora/IPL1-Related Kinase 2 3 4
- Serine/Threonine Kinase 12 2 3
- Aurora-Related Kinase 2 3 4
- Aurora-1 2 3
- Aurora-B 2 3
- STK12 3 4
- AIM-1 3 4
- ARK-2 3 4
- STK-1 3 4
- AIK2 3 4
- AIM1 3 4
External Ids for AURKB Gene
- HGNC: 11390
- Entrez Gene: 9212
- Ensembl: ENSG00000178999
- OMIM: 604970
- UniProtKB: Q96GD4
Previous HGNC Symbols for AURKB Gene
- STK12
Previous GeneCards Identifiers for AURKB Gene
- GC17M008050
- GC17M008308
- GC17M008048
- GC17M008108
- GC17M008006
- GC17M008218
- GC17M008264
- GC17M008309
- GC17M008344
- GC17M008378
- GC17M008418
- GC17M008452
- GC17M008492
Summaries for AURKB Gene
-
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
GeneCards Summary for AURKB Gene
AURKB (Aurora Kinase B) is a Protein Coding gene. Diseases associated with AURKB include Giant Cell Glioblastoma and Spinocerebellar Ataxia 10. Among its related pathways are Gene Expression and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKC.
UniProtKB/Swiss-Prot for AURKB Gene
-
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, HASPIN, and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at Ser-10 and Ser-28 during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between HASPIN and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.
-
Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in regulating many of the processes that are pivotal to mitosis. Each of the isoforms, Aurora A, Aurora B and Aurora C, has a different function in the control of mitosis.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AURKB Gene
Genomics for AURKB Gene
GeneHancer (GH) Regulatory Elements for AURKB Gene
Promoters and enhancers for AURKB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around AURKB on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the AURKB gene promoter:
-
- SREBP-1c
- SREBP-1b
- SREBP-1a
- Tal-1beta
- ITF-2
- LCR-F1
- PPAR-gamma2
- PPAR-gamma1
- Olf-1
- AREB6
Regulatory Element Products
Genomic Locations for AURKB Gene
Genomic Locations for AURKB Gene
- chr17:8,204,731-8,210,776
- (GRCh38/hg38)
- Size:
- 6,046 bases
- Orientation:
- Minus strand
- chr17:8,108,049-8,113,918
- (GRCh37/hg19)
- Size:
- 5,870 bases
- Orientation:
- Minus strand
Genomic View for AURKB Gene
Genes around AURKB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.1 by Entrez Gene
- 17p13.1 by HGNC
- 17p13.1 by Ensembl
AURKB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AURKB Gene
Proteins for AURKB Gene
-
Protein details for AURKB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96GD4-AURKB_HUMAN
- Recommended name:
- Aurora kinase B
- Protein Accession:
- Q96GD4
- B4DNM4
- C7G533
- C7G534
- C7G535
- D3DTR4
- J9JID1
- O14630
- O60446
- O95083
- Q96DV5
- Q9UQ46
Protein attributes for AURKB Gene
- Size:
- 344 amino acids
- Molecular mass:
- 39311 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist. Associates with RACGAP1 during M phase. Interacts with CDCA1, EVI5, JTB, NDC80, PSMA3, SEPT1, SIRT2 and TACC1. Interacts with SPDYC; this interaction may be required for proper localization of active, Thr-232-phosphorylated AURKB form during prometaphase and metaphase. Interacts with p53/TP53. Interacts (via the middle kinase domain) with NOC2L (via the N- and C-terminus domains). Interacts with TTC28. Interacts with RNF2/RING1B.
- SequenceCaution:
-
- Sequence=AAH13300.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for AURKB Gene
Post-translational modifications for AURKB Gene
- The phosphorylation of Thr-232 requires the binding to INCENP and occurs by means of an autophosphorylation mechanism. Thr-232 phosphorylation is indispensable for the AURKB kinase activity.
- Ubiquitinated by different BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes. Ubiquitinated by the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, ubiquitination leads to removal from mitotic chromosomes and is required for cytokinesis. During anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex from chromosomes to the spindle midzone and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
- Ubiquitination at Lys215, posLast=211211, Lys202, posLast=168168, posLast=5656, Lys31, and Lys4
- Modification sites at PhosphoSitePlus
Other Protein References for AURKB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for AURKB (Aurora B)
- Novus Biologicals Antibodies for AURKB
-
Abcam antibodies for AURKB
- Invitrogen Antibodies for AURKB (AFLGC-AURKB)
- antibodies-online: Search results for 307 available Aurora Kinase B Antibodies ranked by validation data
- Compare Top Aurora Kinase B Antibodies
-
Recommended
- 231 WB Antibodies (anti-human)
- 21 IF Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 FACS Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 117 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 90 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IF Antibody (anti-rat)
- GeneTex Aurkb Antibody for AURKB
-
Santa Cruz Biotechnology (SCBT) Antibodies for AURKB
Protein Products
-
OriGene Purified Proteins for AURKB
- Search Origene for MassSpec and Protein Over-expression Lysates for AURKB
- Origene Custom Protein Services for AURKB
- ProSpec Recombinant Proteins for AURKB
- Search GeneTex for Proteins for AURKB
-
Abcam proteins for AURKB
Assay Products
No data available for DME Specific Peptides for AURKB Gene
Domains & Families for AURKB Gene
Gene Families for AURKB Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for AURKB Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for AURKB Gene
Graphical View of Domain Structure for InterPro Entry
Q96GD4UniProtKB/Swiss-Prot:
AURKB_HUMAN :- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Function for AURKB Gene
Molecular function for AURKB Gene
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, HASPIN, and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at Ser-10 and Ser-28 during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between HASPIN and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activity is greatly increased when AURKB is within the CPC complex. In particular, AURKB-phosphorylated INCENP acts as an activator of AURKB. Positive feedback between HASPIN and AURKB contributes to CPC localization.
- UniProtKB/Swiss-Prot Induction:
- Expression is cell cycle-regulated, with a low in G1/S, an increase during G2 and M. Expression decreases again after M phase.
Enzyme Numbers (IUBMB) for AURKB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA,TAS | -- |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | TAS | 19774610 |
| GO:0005515 | protein binding | IPI | 12689593 |
Phenotypes for AURKB Gene
- MGI mutant phenotypes for AURKB:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for AURKB:
-
- Condensed cis-Golgi
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Decreased substrate adherent cell growth
- Decreased HPV16-GFP infection
- Inhibition of centrosomal clustering
- Multipolar spindles
- Wnt reporter downregulated
- Decreased telomerase activity
- G0/1 arrest
- Increased G1 DNA content
- Effect on mitosis
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Increased ID2::GFP protein expression
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased ionizing radiation sensitivity
- Decreased viability in esophageal squamous lineage
- Increased Nanog expression
- Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection
- Decreased cella89culturea89derived Hepatitis C virus (HCVcc; Luca89Jc1) infection
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
- no effect
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased vaccinia virus (VACV) infection
- Paclitaxel antagonistic effect
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Decreased viability after Maraba virus infection
- Increased cell number in S
- shRNA abundance <= 50%
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased vesicular stomatitis virus (VSV) infection
Animal Models for AURKB Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for AURKB
- Cyagen custom Knockout/knockin (KOKI) mouse models for AURKB
-
CRISPR Products
-
OriGene CRISPR knockouts for AURKB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AURKB
- Applied Biological Materials CRISPR for AURKB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AURKB
- GenScript: Design CRISPR guide RNA sequences for AURKB
miRNA for AURKB Gene
- miRTarBase miRNAs that target AURKB
-
- hsa-mir-24-3p (MIRT000120)
- hsa-let-7b-5p (MIRT001649)
- hsa-mir-16-5p (MIRT004742)
- hsa-mir-155-5p (MIRT020616)
- hsa-mir-124-3p (MIRT022319)
- hsa-mir-125b-5p (MIRT046053)
- hsa-mir-148a-3p (MIRT048044)
- hsa-mir-92a-3p (MIRT049133)
- hsa-let-7a-5p (MIRT053129)
- hsa-let-7e-5p (MIRT437396)
- hsa-let-7i-5p (MIRT734398)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AURKB
- Browse OriGene Inhibitory RNA Products For AURKB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AURKB
Clone Products
- Sino Biological Human cDNA Clone for AURKB
- Addgene plasmids for AURKB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AURKB
- genomics-online: cdna clones - Search results for 136 available Aurora Kinase B gene related products
- Overview of 136 available Aurora Kinase B gene related products
- orf clones - Search results for 136 available Aurora Kinase B gene related products
- Overview of 136 available Aurora Kinase B gene related products
- Applied Biological Materials Clones for AURKB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AURKB Gene
Localization for AURKB Gene
Subcellular locations from UniProtKB/Swiss-Prot for AURKB Gene
- Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the midbody. Proper localization of the active, Thr-232-phosphorylated form during metaphase may be dependent upon interaction with SPDYC. Colocalized with SIRT2 during cytokinesis with the midbody. Localization (and probably targeting of the CPC) to the inner centromere occurs predominantly in regions with overlapping mitosis-specific histone phosphorylations H3pT3 and H2ApT12. {ECO:0000269 PubMed:20929775}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 1 |
- Midbody (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000776 | colocalizes_with kinetochore | IDA | 22024163 |
| GO:0000779 | condensed chromosome, centromeric region | IDA | 19465021 |
| GO:0000780 | condensed nuclear chromosome, centromeric region | IDA | 18195732 |
| GO:0005634 | nucleus | IDA,IEA | 20959462 |
Pathways & Interactions for AURKB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 2 | Cell Cycle, Mitotic |
.83
|
.60
|
| 3 | Mitotic Metaphase and Anaphase |
.94
|
|
| 4 | Mitotic Prometaphase | ||
| 5 | Regulation of TP53 Activity | ||
Pathways by source for AURKB Gene
2 GeneTex pathways for AURKB Gene
6 BioSystems pathways for AURKB Gene
3 GeneGo (Thomson Reuters) pathways for AURKB Gene
2 Qiagen pathways for AURKB Gene
1 Cell Signaling Technology pathway for AURKB Gene
Interacting Proteins for AURKB Gene
Selected Interacting proteins:
ENSP00000463999
Q96GD4-AURKB_HUMAN
for AURKB Gene via
STRING
UniProtKB
MINT
IID
GPS-Prot Interaction Network for AURKB
SIGNOR curated interactions for AURKB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 20959462 |
| GO:0000278 | mitotic cell cycle | IEA | -- |
| GO:0002903 | negative regulation of B cell apoptotic process | IDA | 20959462 |
| GO:0006468 | protein phosphorylation | IDA,IEA | 21820309 |
| GO:0007049 | cell cycle | IEA | -- |
Drugs & Compounds for AURKB Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Magnesium | Approved | Nutra | 0 | |||
| Hesperidin | Experimental, Investigational | Nutra | Target | 15 | ||
| N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine | Experimental | Pharma | Target | 0 | ||
| AT9283 | Investigational | Pharma | inhibitor, Target | Aurora kinase/JAK inhibitor, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
||
| Hesperadin hydrochloride |
|
422513-13-1 |
|
|
(3) Tocris Compounds for AURKB Gene
| Compound | Action | Cas Number |
|---|---|---|
| Hesperadin hydrochloride | Potent Aurora kinase B inhibitor | 422513-13-1 |
| TC-A 2317 hydrochloride | Potent, selective Aurora kinase A inhibitor | 1245907-03-2 |
| ZM 447439 | Inhibits Aurora kinase B | 331771-20-1 |
Drug Products
Transcripts for AURKB Gene
mRNA/cDNA for AURKB Gene
- (15) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (274) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000316199 1254 bps (uc002gkn.5)
- ENST00000534871 1167 bps (uc010vuu.4)
- ENST00000585124 1227 bps (uc002gkm.5)
- ENST00000584972 739 bps (uc060azc.1)
- ENST00000578549 939 bps (uc021tpy.2)
CRISPR Products
-
OriGene CRISPR knockouts for AURKB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AURKB
- Applied Biological Materials CRISPR for AURKB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AURKB
- GenScript: Design CRISPR guide RNA sequences for AURKB
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AURKB
- Browse OriGene Inhibitory RNA Products For AURKB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AURKB
Clone Products
- Sino Biological Human cDNA Clone for AURKB
- Addgene plasmids for AURKB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AURKB
- genomics-online: cdna clones - Search results for 136 available Aurora Kinase B gene related products
- Overview of 136 available Aurora Kinase B gene related products
- orf clones - Search results for 136 available Aurora Kinase B gene related products
- Overview of 136 available Aurora Kinase B gene related products
- Applied Biological Materials Clones for AURKB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: |
| ExUns: | 10a | · | 10b | · | 10c | · | 10d |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: | |||||||
| SP9: | |||||||
| SP10: | |||||||
| SP11: | |||||||
| SP12: | |||||||
| SP13: | |||||||
| SP14: | |||||||
| SP15: | |||||||
| SP16: | |||||||
| SP17: | |||||||
| SP18: | |||||||
| SP19: | |||||||
| SP20: |
Expression for AURKB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Endothelial Cells Blood Brain Barrier
- Striatum
- Cerebral Cortex
- Blood (Hematopoietic System)
- Umbilical Cord (Extraembryonic Tissues)
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
-
Testis (Reproductive System)
- XY Germ Cells Testis Cord
-
Gonad
- XY Germ Cells Testis Cord
- Neural Tube (Nervous System)
- Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for AURKB Gene
This gene is overexpressed in Nerve - Tibial (x4.6) and Esophagus - Mucosa (x4.0).
This gene is overexpressed in Breast (56.8) and Lung (12.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AURKB Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of AURKB Gene:
AURKBSOURCE GeneReport for Unigene cluster for AURKB Gene:
Hs.442658mRNA Expression by UniProt/SwissProt for AURKB Gene:
Q96GD4-AURKB_HUMAN
Tissue specificity:
High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.
Evidence on tissue expression from TISSUES for AURKB Gene
- Liver(4.5)
- Lung(4.4)
- Muscle(4.2)
- Spleen(4.2)
- Intestine(2.3)
- Bone marrow(2)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for AURKB
-
OriGene qPCR primer pairs and template standards for AURKB
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AURKB Gene
Orthologs for AURKB Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AURKB 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | AURKB 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | AURKB 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Aurkb 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Aurkb 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | aurkb 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398457 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | aurkb 34 33 |
|
OneToMany | |
| stka 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | aur 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | air-2 34 |
|
OneToMany | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFL101C 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B02332g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IPL1 34 33 |
|
OneToMany | |
| barley (Hordeum vulgare) |
Liliopsida | Hv.9199 33 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.5439 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4656 34 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU00108 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ark1 33 |
|
- Species where no ortholog for AURKB was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for AURKB Gene
- ENSEMBL:
- Gene Tree for AURKB (if available)
- TreeFam:
- Gene Tree for AURKB (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for AURKB: view image
Paralogs for AURKB Gene
(109) SIMAP similar genes for AURKB Gene using alignment to 8 proteins:
- AURKB_HUMAN
- J3KRF8_HUMAN
- J3KRJ2_HUMAN
- J3KT86_HUMAN
- J3KTD6_HUMAN
- J3QLN8_HUMAN
- J3QR41_HUMAN
- J9JID1_HUMAN
- AURKA
- AURKC
- BRSK2
- STK36
- MARK2
- PHKG2
- NUAK1
- PLK1
- PLK4
- CDK7
- MARK4
- MARK3
- SIK3
- ULK3
- RPS6KA3
- KIAA0999
- STK32A
- RPS6KA6
- Par1b
- DAPK3
- BRSK1
- RPS6KA2
- PRKACB
- PRKACG
- KIN27
- DAPK1
- PRKACA
- PRKAA1
- MKNK1
- CDK3
- PRKY
- CDK1
- RPS6KA1
- STK11
- MAPK3
- DKFZp564L2416
- SNRK
- MARK1
- CAMK1D
- AKT1
- PKN2
- PHKG1
- TSSK3
- PAK2
- TSSK4
- CHEK1
- CAMK1
- SIK1
- RPS6KB2
- PRKCQ
- PRKCH
- ULK1
- PNCK
- PRKCB
- STK38L
- SGK2
- CDC2
- TSSK6
- MYO3A
- FGFR1
- RPS6KB1
- PRKCA
- MELK
- CAMK2D
- NEK10
- STK25
- TBK1
- PAK1
- TRIB1
- NEK3
- STK33
- PRKX
- PRKCE
- CAMK2G
- CAMK2A
- PDPK1
- MAP3K11
- CCRK
- SGKL
- SGK3
- PkB-like 1
- PRKG1
- PRKCG
- PRKAA2
- PDPK2
- DKFZp781N0293
- CDK12
- CAMK1G
- PRKG2
- RPS6KA5
- HUNK
- PIM2
- PAK4
- CDK5
- RPS6KA4
- PRKCI
- MYLK
- MAP4K5
- CHEK2
- CDK4
- STK32C
- PKN3
- PKN1
- DCLK3
- DCLK1
- MAP4K1
- AKT2
- MAPKAPK3
- AKT3
Pseudogenes.org Pseudogenes for AURKB Gene
Variants for AURKB Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000064659 | -- | 8,205,159(-) | C/T | intron_variant | |
| rs1000237490 | -- | 8,212,291(-) | T/G | upstream_transcript_variant | |
| rs1000422409 | -- | 8,205,643(-) | T/C | intron_variant | |
| rs1000574839 | -- | 8,210,696(-) | G/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1000627099 | -- | 8,210,437(-) | C/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3639878 | CNV | loss | 21293372 |
| nsv833353 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
53.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.23;
40.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AURKB Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AURKB Gene
Disorders for AURKB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| giant cell glioblastoma |
|
|
| spinocerebellar ataxia 10 |
|
|
Search AURKB in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
AURKB_HUMAN- Note=Disruptive regulation of expression is a possible mechanism of the perturbation of chromosomal integrity in cancer cells through its dominant-negative effect on cytokinesis.
Additional Disease Information for AURKB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for AURKB Gene
Publications for AURKB Gene
- Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1. (PMID: 9858806) Kimura M … Okano Y (Cytogenetics and cell genetics 1998) 2 3 4 22 58
- Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. (PMID: 17617734) Pouwels J … Kallio MJ (Cell cycle (Georgetown, Tex.) 2007) 3 4 22 58
- Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. (PMID: 14610074) Wheatley SP … Earnshaw WC (The Journal of biological chemistry 2004) 3 4 22 58
- Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. (PMID: 12925766) Honda R … Nigg EA (Molecular biology of the cell 2003) 3 4 22 58
- CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. (PMID: 11756469) Zeitlin SG … Sullivan KF (The Journal of cell biology 2001) 3 4 22 58
Products for AURKB Gene
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- antibodies-online: Search results for 307 available Aurora Kinase B Antibodies ranked by validation data
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- genomics-online: cdna clones - Search results for 136 available Aurora Kinase B gene related products
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