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Aliases for AURKAIP1 Gene

Aliases for AURKAIP1 Gene

  • Aurora Kinase A Interacting Protein 1 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein MS38 3 4
  • 28S Ribosomal Protein S38, Mitochondrial 3 4
  • AURKA-Interacting Protein 3 4
  • MRP-S38 3 4
  • AKIP 3 4
  • AIP 3 4
  • Aurora Kinase A-Interacting Protein 3
  • Aurora-A Kinase Interacting Protein 3
  • MRPS38 4

External Ids for AURKAIP1 Gene

Previous GeneCards Identifiers for AURKAIP1 Gene

  • GC01M001350
  • GC01M001298
  • GC01M000581

Summaries for AURKAIP1 Gene

GeneCards Summary for AURKAIP1 Gene

AURKAIP1 (Aurora Kinase A Interacting Protein 1) is a Protein Coding gene. Diseases associated with AURKAIP1 include Cancer-Associated Retinopathy. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.

UniProtKB/Swiss-Prot for AURKAIP1 Gene

  • May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.

Additional gene information for AURKAIP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AURKAIP1 Gene

Genomics for AURKAIP1 Gene

GeneHancer (GH) Regulatory Elements for AURKAIP1 Gene

Promoters and enhancers for AURKAIP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I001373 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.7 +0.4 372 3.9 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 AURKAIP1 GC01M001374 CDK11A ENSG00000230092 ATAD3B LOC100288379 ENSG00000237094 LINC01786 LOC100288069 CCNL2
GH01I001356 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.1 +16.1 16124 6.5 HDGF ARNT ARID4B YBX1 DMAP1 ZNF2 FOS SP5 NFYC ZHX2 MXRA8 SLC35E2 LOC100129381 ANKRD65 CCNL2 LOC100288379 SDF4 ENSG00000272455 INTS11 ENSG00000240731
GH01I001204 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.9 +168.2 168229 4.8 HDGF ARNT ZNF133 GLIS2 FOS RUNX3 YY2 REST TSHZ1 ZNF623 TNFRSF18 CCNL2 ENSG00000240731 LOC100288379 MXRA8 SLC35E2 ANKRD65 ENSG00000230092 VWA1 LOC100129381
GH01I001397 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 4.9 -24.6 -24619 5.5 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 CCNL2 LOC148413 INTS11 ATAD3B ENSG00000240731 LOC100288379 ENSG00000230092 CDK11A SLC35E2 LOC100129381
GH01I001370 Enhancer 1.2 Ensembl ENCODE dbSUPER 8.3 +3.6 3595 1.9 HDGF RB1 ARID4B SIN3A RAD21 GLIS2 ZNF143 ATF7 RUNX3 THAP11 INTS11 CDK11A CCNL2 LOC100288379 LINC00115 SDF4 ATAD3B ENSG00000230092 LINC01786 UBE2J2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AURKAIP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AURKAIP1 gene promoter:

Genomic Locations for AURKAIP1 Gene

Genomic Locations for AURKAIP1 Gene
1,766 bases
Minus strand

Genomic View for AURKAIP1 Gene

Genes around AURKAIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AURKAIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AURKAIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AURKAIP1 Gene

Proteins for AURKAIP1 Gene

  • Protein details for AURKAIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Aurora kinase A-interacting protein
    Protein Accession:
    Secondary Accessions:
    • Q5TA36
    • Q8TBD3

    Protein attributes for AURKAIP1 Gene

    199 amino acids
    Molecular mass:
    22354 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:23908630, PubMed:25838379). Interacts with Aurora-A (PubMed:12244051).
    • Sequence=AAH22808.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AURKAIP1 Gene

neXtProt entry for AURKAIP1 Gene

Post-translational modifications for AURKAIP1 Gene

Other Protein References for AURKAIP1 Gene

No data available for DME Specific Peptides for AURKAIP1 Gene

Domains & Families for AURKAIP1 Gene

Gene Families for AURKAIP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for AURKAIP1 Gene


Suggested Antigen Peptide Sequences for AURKAIP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrion-specific ribosomal protein mS38 family.
  • Belongs to the mitochondrion-specific ribosomal protein mS38 family.
genes like me logo Genes that share domains with AURKAIP1: view

Function for AURKAIP1 Gene

Molecular function for AURKAIP1 Gene

UniProtKB/Swiss-Prot Function:
May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.

Gene Ontology (GO) - Molecular Function for AURKAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12244051
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with AURKAIP1: view
genes like me logo Genes that share phenotypes with AURKAIP1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AURKAIP1 Gene

Localization for AURKAIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AURKAIP1 Gene

Mitochondrion. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AURKAIP1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AURKAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12244051
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with AURKAIP1: view

Pathways & Interactions for AURKAIP1 Gene

genes like me logo Genes that share pathways with AURKAIP1: view

Gene Ontology (GO) - Biological Process for AURKAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IBA --
GO:0016310 phosphorylation IEA --
GO:0045839 negative regulation of mitotic nuclear division NAS 12244051
GO:0045862 positive regulation of proteolysis IDA 12244051
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with AURKAIP1: view

No data available for SIGNOR curated interactions for AURKAIP1 Gene

Drugs & Compounds for AURKAIP1 Gene

No Compound Related Data Available

Transcripts for AURKAIP1 Gene

Unigene Clusters for AURKAIP1 Gene

Aurora kinase A interacting protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AURKAIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP7: -

Relevant External Links for AURKAIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AURKAIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AURKAIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AURKAIP1 Gene

This gene is overexpressed in Lung (35.9), Breast (16.9), and Pancreas (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AURKAIP1 Gene

Protein tissue co-expression partners for AURKAIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AURKAIP1 Gene:


SOURCE GeneReport for Unigene cluster for AURKAIP1 Gene:


mRNA Expression by UniProt/SwissProt for AURKAIP1 Gene:

Tissue specificity: Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis.

Evidence on tissue expression from TISSUES for AURKAIP1 Gene

  • Pancreas(4.3)
  • Nervous system(3.2)
  • Lung(3)
  • Intestine(2.7)
  • Muscle(2.6)
  • Skin(2.5)
genes like me logo Genes that share expression patterns with AURKAIP1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AURKAIP1 Gene

Orthologs for AURKAIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AURKAIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AURKAIP1 33 34
  • 99.5 (n)
(Canis familiaris)
Mammalia AURKAIP1 33 34
  • 81.14 (n)
(Bos Taurus)
Mammalia AURKAIP1 33 34
  • 80.23 (n)
(Rattus norvegicus)
Mammalia Aurkaip1 33
  • 75.54 (n)
(Mus musculus)
Mammalia Aurkaip1 33 16 34
  • 74.04 (n)
(Monodelphis domestica)
Mammalia AURKAIP1 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia AURKAIP1 34
  • 50 (a)
(Gallus gallus)
Aves AURKAIP1 33 34
  • 58.25 (n)
(Anolis carolinensis)
Reptilia AURKAIP1 34
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC549720 33
  • 53.3 (n)
(Danio rerio)
Actinopterygii aurkaip1 33 34
  • 56.33 (n)
Species where no ortholog for AURKAIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AURKAIP1 Gene

Gene Tree for AURKAIP1 (if available)
Gene Tree for AURKAIP1 (if available)

Paralogs for AURKAIP1 Gene Pseudogenes for AURKAIP1 Gene

genes like me logo Genes that share paralogs with AURKAIP1: view

No data available for Paralogs for AURKAIP1 Gene

Variants for AURKAIP1 Gene

Sequence variations from dbSNP and Humsavar for AURKAIP1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000297776 -- 1,376,957(-) G/A upstream_transcript_variant
rs1000639625 -- 1,375,720(-) G/C upstream_transcript_variant
rs1001558956 -- 1,375,854(-) G/C upstream_transcript_variant
rs1001885257 -- 1,376,068(-) C/T upstream_transcript_variant
rs1002260828 -- 1,375,124(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for AURKAIP1 Gene

Variant ID Type Subtype PubMed ID
nsv997291 CNV gain 25217958
nsv950452 CNV deletion 24416366
nsv544969 CNV loss 21841781
nsv482937 CNV loss 15286789
nsv470680 CNV loss 18288195
nsv1160788 CNV deletion 26073780
nsv10161 CNV gain+loss 18304495
nsv1009541 CNV gain 25217958
esv3584994 CNV gain 21293372
esv2758912 CNV loss 17122850
dgv7n100 CNV loss 25217958
dgv2n67 CNV gain 20364138

Variation tolerance for AURKAIP1 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AURKAIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AURKAIP1 Gene

Disorders for AURKAIP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AURKAIP1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cancer-associated retinopathy
  • car syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AURKAIP1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with AURKAIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AURKAIP1 Gene

Publications for AURKAIP1 Gene

  1. Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase. (PMID: 12244051) Kiat LS … Gopalan G (The Journal of biological chemistry 2002) 2 3 4 22 58
  2. Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome. (PMID: 23908630) Koc EC … Koc H (Frontiers in physiology 2013) 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex. (PMID: 17957726) Katayama H … Sen S (Journal of cellular biochemistry 2007) 3 22 58
  5. Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A. (PMID: 17452972) Lim SK … Gopalan G (Oncogene 2007) 3 22 58

Products for AURKAIP1 Gene

Sources for AURKAIP1 Gene

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