Aliases for AURKA Gene
Aliases for AURKA Gene
- Aurora Kinase A 2 3 3 5
- Protein Phosphatase 1, Regulatory Subunit 47 2 3
- Serine/Threonine-Protein Kinase Aurora-A 3 4
- Serine/Threonine-Protein Kinase 6 3 4
- Breast Tumor-Amplified Kinase 3 4
- Aurora/IPL1-Related Kinase 1 3 4
- Aurora 2 3 4
- STK15 3 4
- STK6 3 4
- ARK1 3 4
- AURA 3 4
- BTAK 3 4
- AIK 3 4
- Serine/Threonine Protein Kinase 15 3
- Serine/Threonine-Protein Kinase 15 4
External Ids for AURKA Gene
- HGNC: 11393
- Entrez Gene: 6790
- Ensembl: ENSG00000087586
- OMIM: 603072
- UniProtKB: O14965
Previous HGNC Symbols for AURKA Gene
- STK15
- STK6
Previous GeneCards Identifiers for AURKA Gene
- GC20U900062
- GC20M055629
- GC20M054377
- GC20M054944
- GC20M051729
Summaries for AURKA Gene
-
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for AURKA Gene
AURKA (Aurora Kinase A) is a Protein Coding gene. Diseases associated with AURKA include Colorectal Cancer and Colorectal Adenocarcinoma. Among its related pathways are Gene Expression and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKB.
UniProtKB/Swiss-Prot for AURKA Gene
-
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
-
Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in regulating many of the processes that are pivotal to mitosis. Each of the isoforms, Aurora A, Aurora B and Aurora C, has a different function in the control of mitosis.
Additional gene information for AURKA Gene
- Monarch Initiative
- Search for AURKA at DataMed
- Search for AURKA at HumanCyc
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AURKA Gene
Genomics for AURKA Gene
GeneHancer (GH) Regulatory Elements for AURKA Gene
Promoters and enhancers for AURKA Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH20J056390 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 650.7 | -0.1 | -97 | 3.8 | CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 | CSTF1 AURKA ENSG00000280387 LINC01716 ENSG00000231078 ENSG00000203266 LINC01441 LINC01440 BMP7-AS1 SPO11 | |
| GH20J056358 | Promoter/Enhancer | 2.5 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 13.7 | +31.0 | 30965 | 6 | HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 SP3 | FAM210B CSTF1 AURKA GC20P056367 | |
| GH20J056483 | Enhancer | 0.8 | Ensembl ENCODE dbSUPER | 10.7 | -91.6 | -91596 | 1.3 | MITF CTCF GABPA | FAM209A RPL39P AURKA CSTF1 FAM210B LOC105372681 RTF2 | |
| GH20J056447 | Enhancer | 0.7 | dbSUPER | 11.2 | -55.7 | -55679 | 1.9 | HDGF PKNOX1 TAL1 JUN EBF1 ZIC2 FOSL1 TCF12 POLR2A NCOR1 | RTF2 AURKA CSTF1 RPL39P CASS4 | |
| GH20J056368 | Enhancer | 0.4 | dbSUPER | 12.3 | +23.3 | 23326 | 0.6 | MITF POLR2A SUPT5H | FAM210B AURKA CSTF1 GC20P056367 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around AURKA on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the AURKA gene promoter:
-
- NF-kappaB
- NF-kappaB1
Regulatory Element Products
Genomic Locations for AURKA Gene
Genomic Locations for AURKA Gene
- chr20:56,369,389-56,392,337
- (GRCh38/hg38)
- Size:
- 22,949 bases
- Orientation:
- Minus strand
- chr20:54,944,445-54,967,393
- (GRCh37/hg19)
- Size:
- 22,949 bases
- Orientation:
- Minus strand
Genomic View for AURKA Gene
Genes around AURKA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.2 by Entrez Gene
- 20q13.2 by HGNC
- 20q13.2 by Ensembl
AURKA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AURKA Gene
Proteins for AURKA Gene
-
Protein details for AURKA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14965-AURKA_HUMAN
- Recommended name:
- Aurora kinase A
- Protein Accession:
- O14965
- E1P5F9
- O60445
- O75873
- Q9BQD6
- Q9UPG5
Protein attributes for AURKA Gene
- Size:
- 403 amino acids
- Molecular mass:
- 45809 Da
- Quaternary structure:
-
- Interacts with FBXL7 (By similarity). Interacts with CPEB1, JTB, TACC1, TPX2, PPP2CA, as well as with the protein phosphatase type 1 (PP1) isoforms PPP1CA, PPP1CB and PPP1CC. Interacts also with its substrates ARHGEF2, BORA, BRCA1, KIF2A, PARD3, and p53/TP53. Interaction with BORA promotes phosphorylation of PLK1. Interacts with PIFO. Interacts with GADD45A, competing with its oligomerization. Interacts (via C-terminus) with AUNIP (via C-terminus). Identified in a complex with AUNIP and NIN. Interacts with FRY; this interaction facilitates AURKA-mediated PLK1 phosphorylation. Interacts with SIRT2. Interacts with MYCN; interaction is phospho-independent and triggers AURKA activation; AURKA competes with FBXW7 for binding to unphosphorylated MYCN but not for binding to phosphorylated MYCN (PubMed:27837025). Interacts with HNRNPU (PubMed:21242313, PubMed:25986610).
- Miscellaneous:
-
- Centrosome amplification can occur when the cycles are uncoupled, and this amplification is associated with cancer and with an increase in the levels of chromosomal instability.
- SequenceCaution:
-
- Sequence=BAA23592.1; Type=Frameshift; Positions=105, 125, 129, 235, 241; Evidence={ECO:0000305};
Protein Expression for AURKA Gene
Post-translational modifications for AURKA Gene
- Activated by phosphorylation at Thr-288; this brings about a change in the conformation of the activation segment. Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase. Autophosphorylated at Thr-288 upon TPX2 binding. Thr-288 can be phosphorylated by several kinases, including PAK and PKA. Protein phosphatase type 1 (PP1) binds AURKA and inhibits its activity by dephosphorylating Thr-288 during mitosis. Phosphorylation at Ser-342 decreases the kinase activity. PPP2CA controls degradation by dephosphorylating Ser-51 at the end of mitosis.
- Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL7) during mitosis, leading to its degradation by the proteasome. Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for AURKA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for AURKA (Aurora A)
-
Custom Antibody ServicesOriGene Antibodies for AURKA
- Novus Biologicals Antibodies for AURKA
-
Abcam antibodies for AURKA
- Invitrogen Antibodies for AURKA
- antibodies-online: Search results for 292 available AURKA Antibodies ranked by validation data
- Compare Top AURKA Antibodies
-
Recommended
- 206 WB Antibodies (anti-human)
- 16 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IP Antibodies (anti-human)
- 6 FACS Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 4 IF Antibodies (anti-human)
- 67 WB Antibodies (anti-mouse)
- 9 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 69 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 1 IF Antibody (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
- 206 WB Antibodies (anti-human)
- 16 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IP Antibodies (anti-human)
- 6 FACS Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 4 IF Antibodies (anti-human)
- 67 WB Antibodies (anti-mouse)
- 9 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 69 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 1 IF Antibody (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
- GeneTex AURKA Antibody for AURKA
-
Santa Cruz Biotechnology (SCBT) Antibodies for AURKA
- Sino Biological Antibodies for AURKA
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for AURKA
- Origene Custom Protein Services for AURKA
- ProSpec Recombinant Proteins for AURKA
- Search GeneTex for Proteins for AURKA
-
Abcam proteins for AURKA
Assay Products
No data available for DME Specific Peptides for AURKA Gene
Domains & Families for AURKA Gene
Gene Families for AURKA Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for AURKA Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for AURKA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O14965UniProtKB/Swiss-Prot:
AURKA_HUMAN :- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Function for AURKA Gene
Molecular function for AURKA Gene
- UniProtKB/Swiss-Prot Function:
- Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activation of CDK1, appears to be an upstream event of AURKA activation. Phosphatase inhibitor-2 (PPP1R2) and TPX2 act also as activators. Inactivated by the G2 checkpoint. Inhibited by GADD45A and p53/TP53, and through dephosphorylation by protein phosphatase type 1 (PP1). MLN8054 is also a potent and selective inhibitor. Activated during the early phase of cilia disassembly in the presence of PIFO.
- UniProtKB/Swiss-Prot Induction:
- Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly after.
Enzyme Numbers (IUBMB) for AURKA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IDA | 14580337 |
| GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | TAS | 19774610 |
| GO:0005515 | protein binding | IPI | 12244051 |
Phenotypes for AURKA Gene
- MGI mutant phenotypes for AURKA:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for AURKA:
-
- Decreased substrate adherent cell growth
- Decreased cell proliferation
- Increased number of mitotic cells
- G0/1 arrest
- Increased G1 DNA content
- Synthetic lethal with gemcitabine
- Synthetic lethal with paclitaxel
- Effect on mitosis
- Dynamic nuclei (hole, folded or small irregular)
- Decreased viability
- Increased cell death HMECs cells
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
- Decreased viability in esophageal squamous lineage
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Increased Nanog expression
- Decreased Salmonella enterica Typhimurium invasion
- Increased cell migration
- Decreased cell migration
- Increased cell viability after pRB stimulation
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
- no effect
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Decreased viability with SS1P at EC30
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- FOXO1 nuclear localization
- Transferrin accumulation in the perinuclear area
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for AURKA Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for AURKA
- Cyagen custom Knockout/knockin (KOKI) mouse models for AURKA
-
CRISPR Products
-
OriGene CRISPR knockouts for AURKA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AURKA
- genomics-online: gRNA clones - Search results for 145 available AURKA gene related products
- Overview of 145 available AURKA gene related products
- Applied Biological Materials CRISPR for AURKA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AURKA
- GenScript: Design CRISPR guide RNA sequences for AURKA
miRNA for AURKA Gene
- miRTarBase miRNAs that target AURKA
-
- hsa-let-7b-5p (MIRT005051)
- hsa-mir-155-5p (MIRT020589)
- hsa-mir-124-3p (MIRT022391)
- hsa-mir-193a-3p (MIRT044891)
- hsa-mir-3918 (MIRT296432)
- hsa-mir-3127-5p (MIRT541456)
- hsa-mir-137 (MIRT541457)
- hsa-mir-4448 (MIRT541458)
- hsa-mir-6736-3p (MIRT541459)
- hsa-mir-154-5p (MIRT541460)
- hsa-mir-7843-5p (MIRT541461)
- hsa-mir-6735-5p (MIRT541462)
- hsa-mir-6879-5p (MIRT541463)
- hsa-mir-4632-5p (MIRT541464)
- hsa-mir-4436b-3p (MIRT541465)
- hsa-mir-6876-5p (MIRT541466)
- hsa-mir-4476 (MIRT541467)
- hsa-mir-367-3p (MIRT541468)
- hsa-mir-363-3p (MIRT541469)
- hsa-mir-92b-3p (MIRT541470)
- hsa-mir-25-3p (MIRT541471)
- hsa-mir-32-5p (MIRT541472)
- hsa-mir-92a-3p (MIRT541473)
- hsa-mir-7152-5p (MIRT559278)
- hsa-mir-4326 (MIRT559279)
- hsa-mir-24-3p (MIRT559280)
- hsa-mir-4284 (MIRT559281)
- hsa-mir-885-3p (MIRT559282)
- hsa-mir-149-5p (MIRT559283)
- hsa-mir-5699-3p (MIRT559284)
- hsa-mir-4421 (MIRT559285)
- hsa-mir-6748-3p (MIRT559286)
- hsa-mir-183-5p (MIRT559287)
- hsa-mir-8076 (MIRT559288)
- hsa-mir-6779-3p (MIRT559289)
- hsa-mir-578 (MIRT568349)
- hsa-mir-6734-5p (MIRT568350)
- hsa-mir-1226-5p (MIRT568351)
- hsa-mir-6834-5p (MIRT568352)
- hsa-mir-4777-5p (MIRT568353)
- hsa-mir-526a (MIRT568354)
- hsa-mir-523-5p (MIRT568355)
- hsa-mir-522-5p (MIRT568356)
- hsa-mir-520c-5p (MIRT568357)
- hsa-mir-519c-5p (MIRT568358)
- hsa-mir-519b-5p (MIRT568359)
- hsa-mir-519a-5p (MIRT568360)
- hsa-mir-518f-5p (MIRT568361)
- hsa-mir-518e-5p (MIRT568362)
- hsa-mir-518d-5p (MIRT568363)
- hsa-mir-4721 (MIRT568364)
- hsa-mir-3616-3p (MIRT568365)
- hsa-mir-581 (MIRT568366)
- hsa-mir-129-1-3p (MIRT734891)
- hsa-mir-1290 (MIRT737103)
- hsa-mir-1914-5p (MIRT738533)
- hsa-mir-3152-5p (MIRT740372)
- hsa-mir-3167 (MIRT740586)
- hsa-mir-3611 (MIRT741535)
- hsa-mir-378j (MIRT742775)
- hsa-mir-4755-3p (MIRT748357)
- hsa-mir-4774-3p (MIRT748703)
- hsa-mir-4782-5p (MIRT748805)
- hsa-mir-518c-5p (MIRT749899)
- hsa-mir-5706 (MIRT751386)
- hsa-mir-660-3p (MIRT753534)
- hsa-mir-6778-3p (MIRT755404)
- hsa-mir-6791-3p (MIRT756031)
- hsa-mir-6829-3p (MIRT757085)
- hsa-mir-6836-3p (MIRT757195)
- hsa-mir-6839-5p (MIRT757300)
- hsa-mir-760 (MIRT759448)
- hsa-mir-876-5p (MIRT760365)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AURKA
- Browse OriGene Inhibitory RNA Products For AURKA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AURKA
- genomics-online: shRNA clones - Search results for 145 available AURKA gene related products
- Overview of 145 available AURKA gene related products
Clone Products
-
OriGene ORF clones in human for AURKA
- RC216460L1V
- RC216460L2V
- RC212018L1V
- RC212018L2V
- RC216513L1V
- RC216513L2V
- RC201583L1V
- RC201583L2V
- RC206572L1V
- RC206572L2V
- RC202904L1V
- RC202904L2V
- RC216460
- RC216460L1
- RC216460L2
- RG216460
- RC212018
- RC212018L1
- RC212018L2
- RC403785
- RC403786
- RC403787
- RG212018
- RC216513
- RC216513L1
- RC216513L2
- RG216513
- RC201583
- RC201583L1
- RC201583L2
- RG201583
- RC206572
- RC206572L1
- RC206572L2
- RG206572
- RC202904
- RC202904L1
- RC202904L2
- RG202904
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for AURKA
- VectorBuilder custom plasmid, inducible vectors for AURKA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AURKA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for AURKA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AURKA
- Applied Biological Materials Clones for AURKA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AURKA Gene
Localization for AURKA Gene
Subcellular locations from UniProtKB/Swiss-Prot for AURKA Gene
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Moves to the midbody during both telophase and cytokinesis (PubMed:17726514). Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574). {ECO:0000250 UniProtKB:P97477, ECO:0000269 PubMed:17229885, ECO:0000269 PubMed:17726514, ECO:0000269 PubMed:21225229, ECO:0000269 PubMed:22014574, ECO:0000269 PubMed:9606188}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
- Centrosome (2)
- Cytosol (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000780 | condensed nuclear chromosome, centromeric region | IBA | -- |
| GO:0000922 | spindle pole | IEA | -- |
| GO:0005634 | nucleus | TAS,IDA | 20531406 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for AURKA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of PLK1 Activity at G2/M Transition |
.49
|
|
| 2 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 3 | Regulation of TP53 Activity | ||
| 4 | Oocyte meiosis |
.41
|
|
| 5 | Cell Cycle, Mitotic |
.83
|
|
Pathways by source for AURKA Gene
1 GeneTex pathway for AURKA Gene
7 BioSystems pathways for AURKA Gene
23 Reactome pathways for AURKA Gene
2 KEGG pathways for AURKA Gene
4 GeneGo (Thomson Reuters) pathways for AURKA Gene
2 Qiagen pathways for AURKA Gene
1 Cell Signaling Technology pathway for AURKA Gene
Interacting Proteins for AURKA Gene
Selected Interacting proteins:
O14965-AURKA_HUMAN
ENSP00000216911
for AURKA Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for AURKA
SIGNOR curated interactions for AURKA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
| GO:0000212 | meiotic spindle organization | IEA | -- |
| GO:0000226 | microtubule cytoskeleton organization | IEA | -- |
| GO:0000278 | mitotic cell cycle | TAS | 9153231 |
| GO:0006468 | protein phosphorylation | IDA | 21600873 |
Drugs & Compounds for AURKA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea | Experimental | Pharma | Target | 0 | ||
| 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea | Experimental | Pharma | Target | 0 | ||
| 2-(1H-pyrazol-3-yl)-1H-benzimidazole | Experimental | Pharma | Target | 0 | ||
| 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
||
| Hesperadin hydrochloride |
|
422513-13-1 |
|
|
(3) Tocris Compounds for AURKA Gene
| Compound | Action | Cas Number |
|---|---|---|
| Hesperadin hydrochloride | Potent Aurora kinase B inhibitor | 422513-13-1 |
| TC-A 2317 hydrochloride | Potent, selective Aurora kinase A inhibitor | 1245907-03-2 |
| ZM 447439 | Inhibits Aurora kinase B | 331771-20-1 |
Drug Products
Transcripts for AURKA Gene
mRNA/cDNA for AURKA Gene
- (12) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (258) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000371356 2112 bps (uc002xxj.2)
- ENST00000347343 2248 bps (uc002xxi.2)
- ENST00000395911 2145 bps (uc061xwc.1)
- ENST00000312783 2223 bps (uc002xxf.2)
- ENST00000395915 2114 bps (uc002xxh.2)
CRISPR Products
-
OriGene CRISPR knockouts for AURKA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AURKA
- genomics-online: gRNA clones - Search results for 145 available AURKA gene related products
- Overview of 145 available AURKA gene related products
- Applied Biological Materials CRISPR for AURKA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AURKA
- GenScript: Design CRISPR guide RNA sequences for AURKA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AURKA
- Browse OriGene Inhibitory RNA Products For AURKA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AURKA
- genomics-online: shRNA clones - Search results for 145 available AURKA gene related products
- Overview of 145 available AURKA gene related products
Clone Products
-
OriGene ORF clones in human for AURKA
- RC216460L1V
- RC216460L2V
- RC212018L1V
- RC212018L2V
- RC216513L1V
- RC216513L2V
- RC201583L1V
- RC201583L2V
- RC206572L1V
- RC206572L2V
- RC202904L1V
- RC202904L2V
- RC216460
- RC216460L1
- RC216460L2
- RG216460
- RC212018
- RC212018L1
- RC212018L2
- RC403785
- RC403786
- RC403787
- RG212018
- RC216513
- RC216513L1
- RC216513L2
- RG216513
- RC201583
- RC201583L1
- RC201583L2
- RG201583
- RC206572
- RC206572L1
- RC206572L2
- RG206572
- RC202904
- RC202904L1
- RC202904L2
- RG202904
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for AURKA
- VectorBuilder custom plasmid, inducible vectors for AURKA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AURKA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for AURKA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AURKA
- Applied Biological Materials Clones for AURKA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - |
Expression for AURKA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
mRNA differential expression in normal tissues according to GTEx for AURKA Gene
This gene is overexpressed in Testis (x5.8).
This gene is overexpressed in Lung (49.6) and Breast (18.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AURKA Gene
NURSA nuclear receptor signaling pathways regulating expression of AURKA Gene:
AURKASOURCE GeneReport for Unigene cluster for AURKA Gene:
Hs.250822mRNA Expression by UniProt/SwissProt for AURKA Gene:
O14965-AURKA_HUMAN
Tissue specificity:
Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
Evidence on tissue expression from TISSUES for AURKA Gene
- Intestine(4.5)
- Blood(4.4)
- Kidney(4.3)
- Muscle(4.3)
- Nervous system(2.6)
- Liver(2.5)
Primer Products
-
OriGene qPCR primer pairs and template standards for AURKA
-
OriGene qPCR primer pairs for AURKA
- genomics-online: primer clones - Search results for 145 available AURKA gene related products
- Overview of 145 available AURKA gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AURKA Gene
Orthologs for AURKA Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AURKA 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | AURKA 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | AURKA 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | AURKA 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Aurka 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Aurka 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | AURKA 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | AURKA 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | AURKA 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | aurka 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397925 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | aurka 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | aur 34 33 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001793 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | air-2 34 33 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IPL1 34 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AUR2 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0191800 33 |
|
||
| Os.613 33 |
|
||||
| wheat (Triticum aestivum) |
Liliopsida | Ta.7757 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4656 34 |
|
OneToMany |
- Species where no ortholog for AURKA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for AURKA Gene
- ENSEMBL:
- Gene Tree for AURKA (if available)
- TreeFam:
- Gene Tree for AURKA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for AURKA: view image
Paralogs for AURKA Gene
(49) SIMAP similar genes for AURKA Gene using alignment to 7 proteins:
- AURKA_HUMAN
- A3KFJ0_HUMAN
- A3KFJ1_HUMAN
- A3KFJ2_HUMAN
- Q5QPD1_HUMAN
- Q5QPD2_HUMAN
- Q5QPD4_HUMAN
- AURKC
- AURKB
- MARK4
- RPS6KA2
- PLK4
- Par1b
- ULK3
- STK36
- SNRK
- RPS6KB2
- MARK2
- RPS6KA3
- NUAK1
- PRKACG
- PRKACA
- MARK1
- KIN27
- RPS6KB1
- SIK3
- PRKACB
- SGK2
- RPS6KA6
- STK11
- CAMK1
- MARK3
- KIAA0999
- PNCK
- DKFZp564L2416
- RPS6KA1
- TSSK6
- TSSK3
- PRKAA1
- CDK4
- CAMK1D
- PDPK1
- TSSK4
- PDPK2
- MGC45428
- DCLK2
- PRKX
- DCLK3
- PRKY
- PRKCQ
- CDK5
- PkB-like 1
- AKT2
- NEK7
- NEK6
- CDK1
Pseudogenes.org Pseudogenes for AURKA Gene
Variants for AURKA Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2273535 | risk-factor, Colon cancer, susceptibility to | 56,386,485(-) | A/T | coding_sequence_variant, missense_variant | |
| VAR_041128 | A colorectal adenocarcinoma sample | p.Ser155Arg | |||
| VAR_041129 | A metastatic melanoma sample | p.Val174Met | |||
| rs1000100584 | -- | 56,377,189(-) | A/C | intron_variant | |
| rs1000209810 | -- | 56,393,513(-) | A/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1000250 | CNV | insertion | 20482838 |
| esv1411689 | CNV | insertion | 17803354 |
| esv3302688 | CNV | tandem duplication | 20981092 |
| esv3351171 | CNV | insertion | 20981092 |
| esv3402144 | CNV | insertion | 20981092 |
| esv990423 | CNV | insertion | 20482838 |
| nsv1117286 | CNV | tandem duplication | 24896259 |
| nsv179276 | CNV | insertion | 16902084 |
| nsv179472 | CNV | insertion | 16902084 |
| nsv834013 | CNV | gain | 17160897 |
| nsv964411 | CNV | duplication | 23825009 |
| nsv979444 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.77;
33.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AURKA Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AURKA Gene
Disorders for AURKA Gene
(12) MalaCards diseases for AURKA Gene - From: HGMD, OMIM, ClinVar, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colorectal cancer |
|
|
| colorectal adenocarcinoma |
|
|
| postsurgical hypothyroidism |
|
|
| retinitis pigmentosa 62 |
|
|
| prostate small cell carcinoma |
|
|
Search AURKA in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for AURKA
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for AURKA Gene
Publications for AURKA Gene
- Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk. (PMID: 15867347) Kimura MT … Nagase H (Cancer research 2005) 3 4 22 44 58
- Linkage disequilibrium and haplotype analysis of two single nucleotide polymorphisms in STK15 in Chinese. (PMID: 16011022) Chen L … Zhang X (Yi chuan xue bao = Acta genetica Sinica 2005) 3 4 22 44 58
- Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. (PMID: 9771714) Zhou H … Sen S (Nature genetics 1998) 2 3 4 22 58
- Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma. (PMID: 19551141) Ricketts C … Maher ER (PloS one 2009) 3 22 44 58
- Aurora A, centrosome structure, and the centrosome cycle. (PMID: 19774610) Lukasiewicz KB … Lingle WL (Environmental and molecular mutagenesis 2009) 3 4 22 58
Products for AURKA Gene
- R&D Systems Antibodies for AURKA (Aurora A)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for AURKA
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for AURKA
- Origene Custom Protein Services for AURKA
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AURKA
- Browse OriGene Inhibitory RNA Products For AURKA
- OriGene qPCR primer pairs and template standards for AURKA
- OriGene qPCR primer pairs for AURKA
- OriGene CRISPR knockouts for AURKA
- OriGene ORF clones in human for AURKA
- RC216460L1V
- RC216460L2V
- RC212018L1V
- RC212018L2V
- RC216513L1V
- RC216513L2V
- RC201583L1V
- RC201583L2V
- RC206572L1V
- RC206572L2V
- RC202904L1V
- RC202904L2V
- RC216460
- RC216460L1
- RC216460L2
- RG216460
- RC212018
- RC212018L1
- RC212018L2
- RC403785
- RC403786
- RC403787
- RG212018
- RC216513
- RC216513L1
- RC216513L2
- RG216513
- RC201583
- RC201583L1
- RC201583L2
- RG201583
- RC206572
- RC206572L1
- RC206572L2
- RG206572
- RC202904
- RC202904L1
- RC202904L2
- RG202904
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For AURKA
- GenScript: Next-day shipping of latest version cDNA ORF clones for AURKA in any vector
- GenScript Custom Purified and Recombinant Proteins Services for AURKA
- GenScript Custom Assay Services for AURKA
- GenScript Custom overexpressing Cell Line Services for AURKA
- GenScript: Design CRISPR guide RNA sequences for AURKA
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for AURKA
- Sino Biological Human cDNA Clone for AURKA
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for AURKA
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for AURKA
- Novus Biologicals lysates and proteins for AURKA
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for AURKA
- Abcam proteins for AURKA
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for AURKA
- Taconic Biosciences Mouse Models for AURKA
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for AURKA
- Cyagen custom Knockout/knockin (KOKI) mouse models for AURKA
- VectorBuilder custom plasmid, inducible vectors for AURKA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AURKA
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for AURKA
- antibodies-online: Search results for 292 available AURKA Antibodies ranked by validation data
- Compare Top AURKA Antibodies
- Recommended
- 206 WB Antibodies (anti-human)
- 16 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IP Antibodies (anti-human)
- 6 FACS Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 4 IF Antibodies (anti-human)
- 67 WB Antibodies (anti-mouse)
- 9 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 69 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 1 IF Antibody (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
- 206 WB Antibodies (anti-human)
- 16 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IP Antibodies (anti-human)
- 6 FACS Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 4 IF Antibodies (anti-human)
- 67 WB Antibodies (anti-mouse)
- 9 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 69 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 1 IF Antibody (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
- antibodies-online: Search results for 3 available AURKA Elisa Kits ranked by validation data
- Compare Top AURKA Elisa Kits
- antibodies-online: Search results for 30 available AURKA Proteins ranked by validation data
- Compare Top AURKA Proteins
- GeneTex AURKA Antibody for AURKA
- Search GeneTex for Proteins for AURKA
- Santa Cruz Biotechnology (SCBT) Antibodies for AURKA
- Search Santa Cruz Biotechnology (SCBT) for AURKA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for AURKA
- genomics-online: cdna clones - Search results for 145 available AURKA gene related products
- Overview of 145 available AURKA gene related products
- orf clones - Search results for 145 available AURKA gene related products
- Overview of 145 available AURKA gene related products
- genomics-online: gRNA clones - Search results for 145 available AURKA gene related products
- Overview of 145 available AURKA gene related products
- genomics-online: primer clones - Search results for 145 available AURKA gene related products
- Overview of 145 available AURKA gene related products
- genomics-online: shRNA clones - Search results for 145 available AURKA gene related products
- Overview of 145 available AURKA gene related products
- Recommended