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The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
AURKA (Aurora Kinase A) is a Protein Coding gene. Diseases associated with AURKA include Colorectal Cancer and Colorectal Adenocarcinoma. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKB.
Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in regulating many of the processes that are pivotal to mitosis. Each of the isoforms, Aurora A, Aurora B and Aurora C, has a different function in the control of mitosis.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IDA | 14580337 |
GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | TAS | 19774610 |
GO:0005515 | protein binding | IPI | 12244051 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000780 | condensed nuclear chromosome, centromeric region | IBA | 21873635 |
GO:0000922 | spindle pole | IEA | -- |
GO:0005634 | nucleus | TAS,IDA | 20531406 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of PLK1 Activity at G2/M Transition |
.50
|
|
2 | Regulation of activated PAK-2p34 by proteasome mediated degradation | ||
3 | Regulation of TP53 Activity | ||
4 | Oocyte meiosis |
.44
|
|
5 | Cell Cycle, Mitotic |
.83
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
GO:0000212 | meiotic spindle organization | IEA | -- |
GO:0000226 | microtubule cytoskeleton organization | IEA | -- |
GO:0000278 | mitotic cell cycle | TAS | 9153231 |
GO:0006468 | protein phosphorylation | IDA | 21600873 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Cyclophosphamide | Approved, Investigational | Pharma | Nitrogen mustard alkylating agent and prodrug. | 3670 | ||
Midazolam | Approved, Illicit | Pharma | 1043 | |||
Topotecan | Approved, Investigational | Pharma | Topoisomerase 1 inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors | 384 | ||
1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
||
Hesperadin hydrochloride |
|
422513-13-1 |
|
|
Compound | Action | Cas Number |
---|---|---|
Hesperadin hydrochloride | Potent Aurora kinase B inhibitor | 422513-13-1 |
TC-A 2317 hydrochloride | Potent, selective Aurora kinase A inhibitor | 1245907-03-2 |
ZM 447439 | Inhibits Aurora kinase B | 331771-20-1 |
Compound | Action | Cas Number |
---|---|---|
AMG-900 | Aurora kinase inhibitor | 945595-80-2 |
Anacardic acid | HAT inhibitor | 16611-84-0 |
AT9283 | Aurora kinase/JAK inhibitor | 896466-04-9 |
Aurora A Inhibitor I | Aurora A inhibitor | 1158838-45-9 |
Bendamustine HCl | Cytostatic agent for non-Hodgkin lymphomas | 3543-75-7 |
BI-847325 | dual inhibitor of MEK and Aurora kinases | 1207293-36-4 |
CCT129202 | Aurora kinase inhibitor,ATP-competitive and potent | 942947-93-5 |
CCT137690 | Aurora A/B/C inhibitor | 1095382-05-0 |
CYC116 | Potent Aurora A/B inhibitor | 693228-63-6 |
Danusertib (PHA-739358) | Pan-aurora kinase inhibitor | 827318-97-8 |
ENMD-2076 | Selective Aurora A/Flt3 inhibitor | 934353-76-1 |
ENMD-2076 L-(+)-Tartaric acid | Aurora kinases inhibitor | 1291074-87-7 |
GSK1070916 | Aurora B/C inhibitor | 942918-07-2 |
Hesperadin | Aurora B kinase inhibitor | 422513-13-1 |
JNJ-7706621 | Potent CDK/Aurora kinase inhibitor | 443797-96-4 |
KW 2449 | Multikinase inhibitor | 1000669-72-6 |
MK-5108 (VX-689) | Aurora-A kinase inhibitor,highly selective | 1010085-13-8 |
MK-8745 | Aurora A inhibitor,potent and selective | 885325-71-3 |
MLN8054 | Aurora A inhibitor | 869363-13-3 |
MLN8237 (Alisertib) | Aurora A Kinase inhibitor, Potent and selective | 1028486-01-2 |
PF-03814735 | Aurora A/B inhibitor | 942487-16-3 |
PHA-680632 | Aurora kinase inhibitor,novel and potent | 398493-79-3 |
Reversine | A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor | 656820-32-5 |
SCH-1473759 | Aurora A/B inhibitor | 1094069-99-4 |
SNS-314 Mesylate | Aurora A/B/C kinases inhibitor, potent and selective | 1146618-41-8 |
TAK-901 | Novel Aurora A/B inhibitor | 934541-31-8 |
TC-A 2317 hydrochloride | Aurora kinase A inhibitor,potent and selective | 1245907-03-2 |
VX-680 (MK-0457,Tozasertib) | Aurora kinase inhibitor | 639089-54-6 |
XL228 | IGF1R/AURORA /FGFR1-3/ABL/SRC family kinases inhibitor | 898280-07-4 |
ZM 447439 | Aurora Kinase inhibitor,potent and selective | 331771-20-1 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP16: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP17: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP18: | - | - | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | AURKA 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | AURKA 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | AURKA 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | AURKA 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Aurka 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Aurka 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | AURKA 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | AURKA 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | AURKA 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | aurka 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | LOC397925 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | aurka 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | aur 30 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001793 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | air-2 30 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IPL1 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AUR2 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0191800 30 |
|
||
Os.613 30 |
|
||||
Wheat (Triticum aestivum) |
Liliopsida | Ta.7757 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4656 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
732689 | Benign: not provided | 56,388,177(-) | G/A | SYNONYMOUS_VARIANT | |
800338 | Likely Pathogenic: Multiple myeloma | 56,370,332(-) | G/T | MISSENSE_VARIANT | |
rs2273535 | Risk Factor: Colon cancer, susceptibility to. - | 56,386,485(-) | A/Tp.Phe31Ile | MISSENSE_VARIANT | |
VAR_041128 | A colorectal adenocarcinoma sample | p.Ser155Arg | |||
VAR_041129 | A metastatic melanoma sample | p.Val174Met |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1000250 | CNV | insertion | 20482838 |
esv1411689 | CNV | insertion | 17803354 |
esv3302688 | CNV | tandem duplication | 20981092 |
esv3351171 | CNV | insertion | 20981092 |
esv3402144 | CNV | insertion | 20981092 |
esv990423 | CNV | insertion | 20482838 |
nsv1117286 | CNV | tandem duplication | 24896259 |
nsv179276 | CNV | insertion | 16902084 |
nsv179472 | CNV | insertion | 16902084 |
nsv834013 | CNV | gain | 17160897 |
nsv964411 | CNV | duplication | 23825009 |
nsv979444 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
colorectal cancer |
|
|
colorectal adenocarcinoma |
|
|
laryngeal squamous cell carcinoma |
|
|
atypical teratoid rhabdoid tumor |
|
|
tetraploidy |
|
|