AURKA Gene (Protein Coding)

Aurora Kinase A

GC20M056370
GIFtS:
50
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogen... See more...

Aliases for AURKA Gene

Aliases for AURKA Gene

  • Aurora Kinase A 2 3 4 5
  • ARK1 2 3 4
  • BTAK 2 3 4
  • AIK 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 47 2 3
  • Serine/Threonine-Protein Kinase Aurora-A 3 4
  • Serine/Threonine-Protein Kinase 6 3 4
  • Breast Tumor-Amplified Kinase 3 4
  • Aurora/IPL1-Related Kinase 1 3 4
  • Aurora 2 3 4
  • PPP1R47 2 3
  • STK15 3 4
  • AURA 3 4
  • STK6 3 4
  • STK7 2 3
  • Serine/Threonine Protein Kinase 15 3
  • Serine/Threonine-Protein Kinase 15 4
  • Serine/Threonine Kinase 15 2
  • Serine/Threonine Kinase 6 2
  • Aurora/IPL1-Like Kinase 3
  • Aurora-Related Kinase 1 4
  • Aurora-A Kinase 2
  • EC 2.7.11.1 4
  • AURKA 5
  • AIRK1 4
  • ARK-1 4
  • HARK1 4
  • AurA 2
  • AYK1 4
  • IAK1 4

External Ids for AURKA Gene

Previous HGNC Symbols for AURKA Gene

  • STK15
  • STK6

Previous GeneCards Identifiers for AURKA Gene

  • GC20U900062
  • GC20M055629
  • GC20M054377
  • GC20M054944
  • GC20M051729

Summaries for AURKA Gene

Entrez Gene Summary for AURKA Gene

  • The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

CIViC Summary for AURKA Gene

GeneCards Summary for AURKA Gene

AURKA (Aurora Kinase A) is a Protein Coding gene. Diseases associated with AURKA include Colorectal Cancer and Colorectal Adenocarcinoma. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKB.

UniProtKB/Swiss-Prot Summary for AURKA Gene

  • Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735).

Tocris Summary for AURKA Gene

  • Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in regulating many of the processes that are pivotal to mitosis. Each of the isoforms, Aurora A, Aurora B and Aurora C, has a different function in the control of mitosis.

Gene Wiki entry for AURKA Gene

Additional gene information for AURKA Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AURKA Gene

Genomics for AURKA Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for AURKA Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH20J056390 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -0.2 -164 4.2 CEBPG SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 SIX5 CSTF1 AURKA ENSG00000280387 GCNT7 RAE1 CASS4
GH20J056358 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.7 +31.0 30965 6.1 SP1 HNRNPL GATAD2A LEF1 IKZF1 RCOR2 ZNF7 TARDBP JUND FOXA1 FAM210B AURKA CSTF1 lnc-CSTF1-1
GH20J056467 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -76.6 -76579 3 CREB1 GATAD2A ZNF629 TFE3 RFX1 SIX5 LEF1 SOX13 NFKBIZ POLR2A RTF2 lnc-GCNT7-1 CSTF1 GCNT7 AURKA RAE1 ENSG00000280387 SNODB1764 FAM209A
GH20J057349 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.6 -959.1 -959099 3 HNRNPL CREB1 GATAD2A ZNF629 TFE3 RFX1 SOX13 NFKBIZ ZNF692 POLR2A RAE1 RBM38 RBM38-AS1 AURKA BMP7 MTND1P9 MTRNR2L3 lnc-MTRNR2L3-2
GH20J057030 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 10.6 -638.8 -638764 2.6 CREB1 ZBTB33 ARID3A YBX1 TARDBP RFX1 ZIC2 ZSCAN4 GTF2F1 ATF7 AURKA lnc-BMP7-4 RF00017-3651 LOC112268270 TFAP2C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AURKA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AURKA

Top Transcription factor binding sites by QIAGEN in the AURKA gene promoter:
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for AURKA Gene

Genomic Locations for AURKA Gene
chr20:56,369,389-56,392,337
(GRCh38/hg38)
Size:
22,949 bases
Orientation:
Minus strand
chr20:54,944,445-54,967,393
(GRCh37/hg19)
Size:
22,949 bases
Orientation:
Minus strand

Genomic View for AURKA Gene

Genes around AURKA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AURKA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AURKA Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for AURKA Gene

Proteins for AURKA Gene

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  • Protein details for AURKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14965-AURKA_HUMAN
    Recommended name:
    Aurora kinase A
    Protein Accession:
    O14965
    Secondary Accessions:
    • E1P5F9
    • O60445
    • O75873
    • Q9BQD6
    • Q9UPG5

    Protein attributes for AURKA Gene

    Size:
    403 amino acids
    Molecular mass:
    45809 Da
    Quaternary structure:
    • Interacts with FBXL7 (By similarity). Interacts with CPEB1, JTB, TACC1, TPX2, PPP2CA, as well as with the protein phosphatase type 1 (PP1) isoforms PPP1CA, PPP1CB and PPP1CC. Interacts also with its substrates ARHGEF2, BORA, BRCA1, KIF2A, PARD3, and p53/TP53. Interaction with BORA promotes phosphorylation of PLK1. Interacts with PIFO. Interacts with GADD45A, competing with its oligomerization. Interacts (via C-terminus) with AUNIP (via C-terminus). Identified in a complex with AUNIP and NIN. Interacts with FRY; this interaction facilitates AURKA-mediated PLK1 phosphorylation. Interacts with SIRT2 (PubMed:17726514, PubMed:22014574). Interacts with MYCN; interaction is phospho-independent and triggers AURKA activation; AURKA competes with FBXW7 for binding to unphosphorylated MYCN but not for binding to phosphorylated MYCN (PubMed:27837025). Interacts with HNRNPU (PubMed:21242313, PubMed:25986610). Interacts with AAAS (PubMed:26246606). Interacts with KLHL18 and CUL3 (PubMed:23213400). Interacts with FOXP1 (PubMed:28218735).
    SequenceCaution:
    • Sequence=BAA23592.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • Centrosome amplification can occur when the cycles are uncoupled, and this amplification is associated with cancer and with an increase in the levels of chromosomal instability.

    Three dimensional structures from OCA and Proteopedia for AURKA Gene

neXtProt entry for AURKA Gene

Protein Expression for AURKA Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for AURKA Gene

  • Activated by phosphorylation at Thr-288; this brings about a change in the conformation of the activation segment. Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase. Autophosphorylated at Thr-288 upon TPX2 binding. Thr-288 can be phosphorylated by several kinases, including PAK and PKA. Protein phosphatase type 1 (PP1) binds AURKA and inhibits its activity by dephosphorylating Thr-288 during mitosis. Phosphorylation at Ser-342 decreases the kinase activity. PPP2CA controls degradation by dephosphorylating Ser-51 at the end of mitosis.
  • Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL7) during mitosis, leading to its degradation by the proteasome (By similarity). Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome (PubMed:10851084, PubMed:11039908). Ubiquitinated by the CUL3-KLHL18 ligase leading to its activation at the centrosome which is required for initiating mitotic entry (PubMed:23213400). Ubiquitination mediated by CUL3-KLHL18 ligase does not lead to its degradation by the proteasome (PubMed:23213400).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AURKA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AURKA Gene

Domains & Families for AURKA Gene

Gene Families for AURKA Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for AURKA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AURKA Gene

GenScript: Design optimal peptide antigens:
  • Serine/threonine-protein kinase aurora-A (STK6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14965

UniProtKB/Swiss-Prot:

AURKA_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
genes like me logo Genes that share domains with AURKA: view

Function for AURKA Gene

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Molecular function for AURKA Gene

UniProtKB/Swiss-Prot Function:
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:12237287, ECO:0000269|PubMed:16337122, ECO:0000269|PubMed:19140666, ECO:0000269|PubMed:19402633, ECO:0000269|PubMed:27837025, ECO:0000269|PubMed:28218735};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:12237287, ECO:0000269|PubMed:16337122, ECO:0000269|PubMed:19140666, ECO:0000269|PubMed:19402633, ECO:0000269|PubMed:27837025, ECO:0000269|PubMed:28218735};.
UniProtKB/Swiss-Prot Induction:
Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly after.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activation of CDK1, appears to be an upstream event of AURKA activation. Phosphatase inhibitor-2 (PPP1R2) and TPX2 act also as activators. Inactivated by the G2 checkpoint. Inhibited by GADD45A and p53/TP53, and through dephosphorylation by protein phosphatase type 1 (PP1). MLN8054 is also a potent and selective inhibitor. Activated during the early phase of cilia disassembly in the presence of PIFO. Inhibited by the small molecule inhibitor VX-680 (PubMed:28218735).

Enzyme Numbers (IUBMB) for AURKA Gene

Phenotypes From GWAS Catalog for AURKA Gene

Gene Ontology (GO) - Molecular Function for AURKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IDA 14580337
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004712 protein serine/threonine/tyrosine kinase activity TAS 19774610
GO:0005515 protein binding IPI 12244051
genes like me logo Genes that share ontologies with AURKA: view

Phenotypes for AURKA Gene

MGI mutant phenotypes for AURKA:
inferred from 6 alleles
GenomeRNAi human phenotypes for AURKA:
genes like me logo Genes that share phenotypes with AURKA: view

Animal Models for AURKA Gene

MGI Knock Outs for AURKA:
  • Aurka Aurka<tm1.2Sbsn>
  • Aurka Aurka<tm1.2Tvd>
  • Aurka Aurka<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for AURKA Gene

miRTarBase miRNAs that target AURKA

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AURKA

Clone Products

  • Addgene plasmids for AURKA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AURKA Gene

Localization for AURKA Gene

Subcellular locations from UniProtKB/Swiss-Prot for AURKA Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, neuron projection. Note=Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Moves to the midbody during both telophase and cytokinesis (PubMed:17726514). Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574). The localization to the spindle poles is regulated by AAAS (PubMed:26246606). {ECO:0000250 UniProtKB:P97477, ECO:0000269 PubMed:17229885, ECO:0000269 PubMed:17726514, ECO:0000269 PubMed:21225229, ECO:0000269 PubMed:22014574, ECO:0000269 PubMed:26246606, ECO:0000269 PubMed:9606188}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AURKA gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
golgi apparatus 2
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AURKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000780 condensed nuclear chromosome, centromeric region IBA 21873635
GO:0000922 spindle pole IEA --
GO:0005634 nucleus TAS,IDA 20531406
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with AURKA: view

Pathways & Interactions for AURKA Gene

genes like me logo Genes that share pathways with AURKA: view

Pathways by source for AURKA Gene

4 GeneGo (Thomson Reuters) pathways for AURKA Gene
  • Cell cycle_Chromosome condensation in prometaphase
  • Cell cycle_Role of APC in cell cycle regulation
  • Cell cycle_Spindle assembly and chromosome separation
  • Cytoskeleton remodeling_RalA regulation pathway
2 Qiagen pathways for AURKA Gene
  • Molecular Mechanisms of Cancer
  • Sperm Motility
1 Cell Signaling Technology pathway for AURKA Gene
1 GeneTex pathway for AURKA Gene

SIGNOR curated interactions for AURKA Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for AURKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000212 meiotic spindle organization IEA --
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0000278 mitotic cell cycle TAS 9153231
GO:0006468 protein phosphorylation IDA 21600873
genes like me logo Genes that share ontologies with AURKA: view

Drugs & Compounds for AURKA Gene

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(85) Drugs for AURKA Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 3670
Midazolam Approved, Illicit Pharma 1043
Topotecan Approved, Investigational Pharma Topoisomerase 1 inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 384
1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea Experimental Pharma Target 0

(3) Additional Compounds for AURKA Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
Hesperadin hydrochloride
422513-13-1

(3) Tocris Compounds for AURKA Gene

Compound Action Cas Number
Hesperadin hydrochloride Potent Aurora kinase B inhibitor 422513-13-1
TC-A 2317 hydrochloride Potent, selective Aurora kinase A inhibitor 1245907-03-2
ZM 447439 Inhibits Aurora kinase B 331771-20-1

(30) ApexBio Compounds for AURKA Gene

Compound Action Cas Number
AMG-900 Aurora kinase inhibitor 945595-80-2
Anacardic acid HAT inhibitor 16611-84-0
AT9283 Aurora kinase/JAK inhibitor 896466-04-9
Aurora A Inhibitor I Aurora A inhibitor 1158838-45-9
Bendamustine HCl Cytostatic agent for non-Hodgkin lymphomas 3543-75-7
BI-847325 dual inhibitor of MEK and Aurora kinases 1207293-36-4
CCT129202 Aurora kinase inhibitor,ATP-competitive and potent 942947-93-5
CCT137690 Aurora A/B/C inhibitor 1095382-05-0
CYC116 Potent Aurora A/B inhibitor 693228-63-6
Danusertib (PHA-739358) Pan-aurora kinase inhibitor 827318-97-8
ENMD-2076 Selective Aurora A/Flt3 inhibitor 934353-76-1
ENMD-2076 L-(+)-Tartaric acid Aurora kinases inhibitor 1291074-87-7
GSK1070916 Aurora B/C inhibitor 942918-07-2
Hesperadin Aurora B kinase inhibitor 422513-13-1
JNJ-7706621 Potent CDK/Aurora kinase inhibitor 443797-96-4
KW 2449 Multikinase inhibitor 1000669-72-6
MK-5108 (VX-689) Aurora-A kinase inhibitor,highly selective 1010085-13-8
MK-8745 Aurora A inhibitor,potent and selective 885325-71-3
MLN8054 Aurora A inhibitor 869363-13-3
MLN8237 (Alisertib) Aurora A Kinase inhibitor, Potent and selective 1028486-01-2
PF-03814735 Aurora A/B inhibitor 942487-16-3
PHA-680632 Aurora kinase inhibitor,novel and potent 398493-79-3
Reversine A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor 656820-32-5
SCH-1473759 Aurora A/B inhibitor 1094069-99-4
SNS-314 Mesylate Aurora A/B/C kinases inhibitor, potent and selective 1146618-41-8
TAK-901 Novel Aurora A/B inhibitor 934541-31-8
TC-A 2317 hydrochloride Aurora kinase A inhibitor,potent and selective 1245907-03-2
VX-680 (MK-0457,Tozasertib) Aurora kinase inhibitor 639089-54-6
XL228 IGF1R/AURORA /FGFR1-3/ABL/SRC family kinases inhibitor 898280-07-4
ZM 447439 Aurora Kinase inhibitor,potent and selective 331771-20-1
genes like me logo Genes that share compounds with AURKA: view

Transcripts for AURKA Gene

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mRNA/cDNA for AURKA Gene

9 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AURKA

Clone Products

  • Addgene plasmids for AURKA

Alternative Splicing Database (ASD) splice patterns (SP) for AURKA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: -
SP8: - - -
SP9: - - - - - - - - -
SP10: - - - - -
SP11: - -
SP12: - - -
SP13:
SP14: - - -
SP15: -
SP16: - -
SP17: - - - -
SP18: - - -

Relevant External Links for AURKA Gene

GeneLoc Exon Structure for
AURKA

Expression for AURKA Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AURKA Gene

mRNA expression in normal human tissues for AURKA Gene
mRNA expression by BioGPS for AURKA GenemRNA expression by GTEx for AURKA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AURKA Gene

This gene is overexpressed in Testis (x5.8).

Protein differential expression in normal tissues from HIPED for AURKA Gene

This gene is overexpressed in Lung (49.6) and Breast (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AURKA Gene



Protein tissue co-expression partners for AURKA Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AURKA

SOURCE GeneReport for Unigene cluster for AURKA Gene:

Hs.250822

mRNA Expression by UniProt/SwissProt for AURKA Gene:

O14965-AURKA_HUMAN
Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.

Evidence on tissue expression from TISSUES for AURKA Gene

  • Intestine(4.6)
  • Blood(4.6)
  • Kidney(4.5)
  • Muscle(4.4)
  • Nervous system(3.1)
  • Liver(3.1)
  • Skin(2.7)
  • Lymph node(2.7)
  • Bone marrow(2.5)
  • Pancreas(2.3)
  • Lung(2.3)
  • Heart(2.2)
  • Bone(2.2)
  • Spleen(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with AURKA: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AURKA Gene

Orthologs for AURKA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AURKA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia AURKA 30 31
  • 99.34 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia AURKA 30 31
  • 89.83 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia AURKA 30 31
  • 86.4 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia AURKA 31
  • 81 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Aurka 30
  • 80.05 (n)
Mouse
(Mus musculus)
 Mammalia Aurka 30 17 31
  • 78.76 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia AURKA 31
  • 77 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves AURKA 30 31
  • 70.94 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia AURKA 31
  • 57 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia aurka 30
  • 63.41 (n)
African clawed frog
(Xenopus laevis)
 Amphibia LOC397925 30
Zebrafish
(Danio rerio)
 Actinopterygii aurka 30 31
  • 60.95 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta aur 30 31
  • 54.29 (n)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP001793 30
  • 53.39 (n)
Worm
(Caenorhabditis elegans)
 Secernentea air-2 30 31
  • 57.11 (n)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes IPL1 31
  • 38 (a)
 OneToMany
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AUR2 30
  • 62.41 (n)
Rice
(Oryza sativa)
 Liliopsida Os01g0191800 30
  • 59.36 (n)
Os.613 30
Wheat
(Triticum aestivum)
 Liliopsida Ta.7757 30
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.4656 31
  • 65 (a)
 OneToMany
Species where no ortholog for AURKA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for AURKA Gene

ENSEMBL:
Gene Tree for AURKA (if available)
TreeFam:
Gene Tree for AURKA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AURKA: view image

Paralogs for AURKA Gene

Paralogs for AURKA Gene

(49) SIMAP similar genes for AURKA Gene using alignment to 7 proteins:

  • AURKA_HUMAN
  • A3KFJ0_HUMAN
  • A3KFJ1_HUMAN
  • A3KFJ2_HUMAN
  • Q5QPD1_HUMAN
  • Q5QPD2_HUMAN
  • Q5QPD4_HUMAN

Pseudogenes.org Pseudogenes for AURKA Gene

genes like me logo Genes that share paralogs with AURKA: view

Variants for AURKA Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AURKA Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
732689 Benign: not provided 56,388,177(-) G/A SYNONYMOUS_VARIANT
800338 Likely Pathogenic: Multiple myeloma 56,370,332(-) G/T MISSENSE_VARIANT
rs2273535 Risk Factor: Colon cancer, susceptibility to. - 56,386,485(-) A/Tp.Phe31Ile MISSENSE_VARIANT
VAR_041128 A colorectal adenocarcinoma sample p.Ser155Arg
VAR_041129 A metastatic melanoma sample p.Val174Met

Additional dbSNP identifiers (rs#s) for AURKA Gene

Structural Variations from Database of Genomic Variants (DGV) for AURKA Gene

Variant ID Type Subtype PubMed ID
esv1000250 CNV insertion 20482838
esv1411689 CNV insertion 17803354
esv3302688 CNV tandem duplication 20981092
esv3351171 CNV insertion 20981092
esv3402144 CNV insertion 20981092
esv990423 CNV insertion 20482838
nsv1117286 CNV tandem duplication 24896259
nsv179276 CNV insertion 16902084
nsv179472 CNV insertion 16902084
nsv834013 CNV gain 17160897
nsv964411 CNV duplication 23825009
nsv979444 CNV duplication 23825009

Variation tolerance for AURKA Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AURKA Gene

Human Gene Mutation Database (HGMD)
AURKA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AURKA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AURKA Gene

Disorders for AURKA Gene

MalaCards: The human disease database

(32) MalaCards diseases for AURKA Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • crc
colorectal adenocarcinoma
  • adenocarcinoma of large intestine
laryngeal squamous cell carcinoma
  • epidermoid carcinoma of the larynx
atypical teratoid rhabdoid tumor
  • at/rt
tetraploidy
  • tetraploidy syndrome
- elite association - COSMIC cancer census association via MalaCards
Search AURKA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AURKA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with AURKA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AURKA Gene

Publications for AURKA Gene

  1. Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk. (PMID: 15867347) Kimura MT … Nagase H (Cancer research 2005) 3 4 23 41
  2. Linkage disequilibrium and haplotype analysis of two single nucleotide polymorphisms in STK15 in Chinese. (PMID: 16011022) Chen L … Zhang X (Yi chuan xue bao = Acta genetica Sinica 2005) 3 4 23 41
  3. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. (PMID: 9771714) Zhou H … Sen S (Nature genetics 1998) 2 3 4 23
  4. Aurora A, centrosome structure, and the centrosome cycle. (PMID: 19774610) Lukasiewicz KB … Lingle WL (Environmental and molecular mutagenesis 2009) 3 4 23
  5. Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma. (PMID: 19551141) Ricketts C … Maher ER (PloS one 2009) 3 23 41

ExternalLinks

View latest publications for AURKA gene in Mastermind

Products for AURKA Gene