Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AUNIP Gene

Aliases for AUNIP Gene

  • Aurora Kinase A And Ninein Interacting Protein 2 3 5
  • C1orf135 3 4
  • AIBP 3 4
  • Aurora Kinase A And Ninein-Interacting Protein 3
  • Chromosome 1 Open Reading Frame 135 2
  • Aurora A-Binding Protein 3

External Ids for AUNIP Gene

Previous HGNC Symbols for AUNIP Gene

  • C1orf135

Previous GeneCards Identifiers for AUNIP Gene

  • GC01M026159

Summaries for AUNIP Gene

GeneCards Summary for AUNIP Gene

AUNIP (Aurora Kinase A And Ninein Interacting Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AUNIP Gene

  • DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination (PubMed:29042561). Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair (PubMed:29042561). Inhibits non-homologous end joining (NHEJ) (PubMed:29042561). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle (PubMed:20596670).

Additional gene information for AUNIP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AUNIP Gene

Genomics for AUNIP Gene

GeneHancer (GH) Regulatory Elements for AUNIP Gene

Promoters and enhancers for AUNIP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I025858 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 -1.1 -1111 4.6 CLOCK YBX1 YY1 ZNF213 ZNF416 ZNF143 SP3 MEF2D SSRP1 ZNF610 AUNIP ENSG00000236528 ARID1A HMGN2 MTFR1L ENSG00000261349 SELENON LOC101928324 RPL17P9 ZNF593
GH01I025903 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.9 -46.2 -46158 4.9 HDGF CLOCK SMAD1 FOXA2 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 LOC105376885 PIR46219 MIR3917 STMN1 MTFR1L GPN2 ENSG00000261349 ARID1A HMGN2 PIGV
GH01I025835 Enhancer 0.4 dbSUPER 11.9 +24.0 23975 0.8 NFIC NFIA PRDM10 PAQR7 AUNIP ENSG00000236528 ENSG00000207302 ENSG00000252190 ENSG00000252691 EXTL1 RNU6-110P PIR62460
GH01I025831 Enhancer 0.9 ENCODE dbSUPER 0.3 +27.1 27097 2 BCOR PKNOX1 ZMYM3 ZNF121 CTBP1 NCOR1 POLR2A ZSCAN29 FOS ETV6 ENSG00000272478 PIR56916 PIR62460 SELENON PAQR7 ENSG00000207302 EXTL1 SLC30A2 MTFR1L AUNIP
GH01I025834 Enhancer 0.3 dbSUPER 0.3 +24.7 24708 0.3 PRDM10 SELENON ENSG00000207302 PAQR7 EXTL1 PIR62460 AUNIP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AUNIP on UCSC Golden Path with GeneCards custom track

Genomic Locations for AUNIP Gene

Genomic Locations for AUNIP Gene
chr1:25,831,913-25,859,458
(GRCh38/hg38)
Size:
27,546 bases
Orientation:
Minus strand
chr1:26,158,414-26,185,903
(GRCh37/hg19)

Genomic View for AUNIP Gene

Genes around AUNIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AUNIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AUNIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AUNIP Gene

Proteins for AUNIP Gene

  • Protein details for AUNIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7T9-AUNIP_HUMAN
    Recommended name:
    Aurora kinase A and ninein-interacting protein
    Protein Accession:
    Q9H7T9
    Secondary Accessions:
    • C9EI59
    • Q53F70

    Protein attributes for AUNIP Gene

    Size:
    357 amino acids
    Molecular mass:
    40253 Da
    Quaternary structure:
    • Interacts (via C-terminus) with AURKA (via C-terminus) (PubMed:20596670). Interacts (via N-terminus) with NIN; this interaction blocks NIN phosphorylation by both AURKA and GSK3B (PubMed:20596670). Identified in a complex with NIN and AURKA (PubMed:20596670). Interacts with RBBP8/CtIP (PubMed:29042561).

    Alternative splice isoforms for AUNIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AUNIP Gene

Post-translational modifications for AUNIP Gene

No Post-translational modifications

Other Protein References for AUNIP Gene

No data available for DME Specific Peptides for AUNIP Gene

Domains & Families for AUNIP Gene

Gene Families for AUNIP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AUNIP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H7T9

UniProtKB/Swiss-Prot:

AUNIP_HUMAN :
  • Belongs to the AUNIP family.
Family:
  • Belongs to the AUNIP family.
genes like me logo Genes that share domains with AUNIP: view

No data available for Suggested Antigen Peptide Sequences for AUNIP Gene

Function for AUNIP Gene

Molecular function for AUNIP Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination (PubMed:29042561). Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair (PubMed:29042561). Inhibits non-homologous end joining (NHEJ) (PubMed:29042561). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle (PubMed:20596670).
UniProtKB/Swiss-Prot Induction:
Overexpressed in brain tumors.

Gene Ontology (GO) - Molecular Function for AUNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003684 damaged DNA binding IDA 29042561
GO:0005515 protein binding IPI 20596670
genes like me logo Genes that share ontologies with AUNIP: view

Phenotypes for AUNIP Gene

genes like me logo Genes that share phenotypes with AUNIP: view

Animal Model Products

CRISPR Products

miRNA for AUNIP Gene

miRTarBase miRNAs that target AUNIP

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AUNIP Gene

Localization for AUNIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for AUNIP Gene

Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Accumulates at sites of DNA damage by binding to DNA substrates that mimick structures generated at stalled replication forks (PubMed:29042561). Localizes to the centrosome in interphase and to the spindle pole in metaphase (PubMed:20596670). {ECO:0000269 PubMed:20596670, ECO:0000269 PubMed:29042561}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AUNIP gene
Compartment Confidence
cytoskeleton 5
nucleus 4
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AUNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 20596670
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 20596670
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with AUNIP: view

Pathways & Interactions for AUNIP Gene

SuperPathways for AUNIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for AUNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IDA 29042561
GO:0007051 spindle organization IMP 20596670
GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining IDA 29042561
genes like me logo Genes that share ontologies with AUNIP: view

No data available for Pathways by source and SIGNOR curated interactions for AUNIP Gene

Drugs & Compounds for AUNIP Gene

No Compound Related Data Available

Transcripts for AUNIP Gene

Unigene Clusters for AUNIP Gene

Aurora kinase A and ninein interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for AUNIP Gene

No ASD Table

Relevant External Links for AUNIP Gene

GeneLoc Exon Structure for
AUNIP
ECgene alternative splicing isoforms for
AUNIP

Expression for AUNIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AUNIP Gene

mRNA differential expression in normal tissues according to GTEx for AUNIP Gene

This gene is overexpressed in Testis (x13.5).

NURSA nuclear receptor signaling pathways regulating expression of AUNIP Gene:

AUNIP

SOURCE GeneReport for Unigene cluster for AUNIP Gene:

Hs.725400

mRNA Expression by UniProt/SwissProt for AUNIP Gene:

Q9H7T9-AUNIP_HUMAN
Tissue specificity: Expressed in heart, skeletal muscles, placenta and testis.

Evidence on tissue expression from TISSUES for AUNIP Gene

  • Kidney(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with AUNIP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AUNIP Gene

Orthologs for AUNIP Gene

This gene was present in the common ancestor of mammals.

Orthologs for AUNIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AUNIP 33 34
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia AUNIP 33 34
  • 83.43 (n)
cow
(Bos Taurus)
Mammalia AUNIP 33 34
  • 81.87 (n)
rat
(Rattus norvegicus)
Mammalia Aunip 33
  • 76.14 (n)
mouse
(Mus musculus)
Mammalia Clhc1 33
  • 74.95 (n)
Aunip 16 34
  • 59 (a)
oppossum
(Monodelphis domestica)
Mammalia AUNIP 34
  • 42 (a)
OneToOne
Species where no ortholog for AUNIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AUNIP Gene

ENSEMBL:
Gene Tree for AUNIP (if available)
TreeFam:
Gene Tree for AUNIP (if available)

Paralogs for AUNIP Gene

No data available for Paralogs for AUNIP Gene

Variants for AUNIP Gene

Sequence variations from dbSNP and Humsavar for AUNIP Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000034638 -- 25,838,657(-) C/T intron_variant
rs1000106488 -- 25,854,076(-) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000317190 -- 25,859,621(-) C/T upstream_transcript_variant
rs1000335090 -- 25,851,848(-) C/T intron_variant
rs1000474336 -- 25,833,703(-) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AUNIP Gene

Variant ID Type Subtype PubMed ID
nsv834502 CNV gain 17160897
nsv834491 CNV loss 17160897
nsv822165 CNV loss 20364138
nsv7490 CNV deletion 18451855
nsv545883 CNV loss 21841781
nsv460884 CNV loss 19166990

Variation tolerance for AUNIP Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AUNIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AUNIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AUNIP Gene

Disorders for AUNIP Gene

Additional Disease Information for AUNIP

No disorders were found for AUNIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AUNIP Gene

Publications for AUNIP Gene

  1. Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation. (PMID: 20596670) Lieu AS … Hong YR (International journal of oncology 2010) 2 3 4 58
  2. AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway. (PMID: 29042561) Lou J … Huang J (Nature communications 2017) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58

Products for AUNIP Gene

Sources for AUNIP Gene

Content
Loading form....