Aliases for ATXN7L3 Gene
External Ids for ATXN7L3 Gene
Previous GeneCards Identifiers for ATXN7L3 Gene
GeneCards Summary for ATXN7L3 Gene
ATXN7L3 (Ataxin 7 Like 3) is a Protein Coding gene. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is ATXN7L3B.
UniProtKB/Swiss-Prot for ATXN7L3 Gene
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583).