Aliases for ATXN10 Gene
External Ids for ATXN10 Gene
Previous HGNC Symbols for ATXN10 Gene
Previous GeneCards Identifiers for ATXN10 Gene
This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016]
GeneCards Summary for ATXN10 Gene
ATXN10 (Ataxin 10) is a Protein Coding gene. Diseases associated with ATXN10 include Spinocerebellar Ataxia 10 and Autosomal Dominant Cerebellar Ataxia. Among its related pathways are Akt Signaling and Chks in Checkpoint Regulation. Gene Ontology (GO) annotations related to this gene include identical protein binding and binding.
UniProtKB/Swiss-Prot Summary for ATXN10 Gene
Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.