Aliases for ATR Gene
Aliases for ATR Gene
- ATR Serine/Threonine Kinase 2 3 5
- Ataxia Telangiectasia And Rad3-Related Protein 3 4
- FRP1 3 4
- MEC1, Mitosis Entry Checkpoint 1, Homolog (S. Cerevisiae) 2
- MEC1, Mitosis Entry Checkpoint 1, Homolog 3
- Ataxia Telangiectasia And Rad3 Related 2
- Serine/Threonine-Protein Kinase ATR 3
- FRAP-Related Protein-1 3
External Ids for ATR Gene
- HGNC: 882
- Entrez Gene: 545
- Ensembl: ENSG00000175054
- OMIM: 601215
- UniProtKB: Q13535
Previous GeneCards Identifiers for ATR Gene
- GC03M139200
- GC03M142996
- GC03M143449
- GC03M143488
- GC03M143650
- GC03M142168
- GC03M139541
Summaries for ATR Gene
-
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]
GeneCards Summary for ATR Gene
ATR (ATR Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with ATR include Cutaneous Telangiectasia And Cancer Syndrome, Familial and Seckel Syndrome 1. Among its related pathways are Gene Expression and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and binding. An important paralog of this gene is PRKDC.
UniProtKB/Swiss-Prot for ATR Gene
-
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates Ser-139 of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
-
ATM (Ataxia telangiectasia mutated) and ATR (Ataxia telangiectasia and Rad3 related) are closely related kinases that are activated by DNA damage. They are serine-threonine protein kinases which are part of the phosphatidylinositol 3' kinase-like kinase (PIKK) enzyme family.
Additional gene information for ATR Gene
- Monarch Initiative
- Search for ATR at DataMed
- Search for ATR at HumanCyc
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATR Gene
Genomics for ATR Gene
GeneHancer (GH) Regulatory Elements for ATR Gene
Promoters and enhancers for ATR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ATR on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ATR gene promoter:
-
- AP-1
- c-Jun
- ATF-2
- Tal-1beta
- E47
- AP-4
- Lhx3a
- LHX3b
Regulatory Element Products
Genomic Locations for ATR Gene
Genomic Locations for ATR Gene
- chr3:142,449,235-142,578,826
- (GRCh38/hg38)
- Size:
- 129,592 bases
- Orientation:
- Minus strand
- chr3:142,168,077-142,297,668
- (GRCh37/hg19)
- Size:
- 129,592 bases
- Orientation:
- Minus strand
Genomic View for ATR Gene
Genes around ATR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q23 by Entrez Gene
- 3q23 by HGNC
- 3q23 by Ensembl
ATR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ATR Gene
Proteins for ATR Gene
-
Protein details for ATR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13535-ATR_HUMAN
- Recommended name:
- Serine/threonine-protein kinase ATR
- Protein Accession:
- Q13535
- Q59HB2
- Q7KYL3
- Q93051
- Q9BXK4
Protein attributes for ATR Gene
- Size:
- 2644 amino acids
- Molecular mass:
- 301367 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Interacts with ATRIP; forming a heterodimer with ATRIP (PubMed:11721054). Binds to DNA, and to UV-damaged DNA with higher affinity. Interacts with RAD17, MSH2 and HDAC2. Present in a complex containing ATRIP and RPA-coated single-stranded DNA. Present in a complex containing CHD4 and HDAC2. Interacts with BCR-ABL after genotoxic stress. Interacts with EEF1E1. This interaction is enhanced by UV irradiation. Interacts with CLSPN and CEP164. Interacts with TELO2 and TTI1.
Protein Expression for ATR Gene
Post-translational modifications for ATR Gene
- Phosphorylated; autophosphorylates in vitro.
- Ubiquitination at posLast=26042604, Lys1005, Lys746, and Lys32
- Modification sites at PhosphoSitePlus
Other Protein References for ATR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ATR (ATR)
-
Custom Antibody ServicesOriGene Antibodies for ATR
- Novus Biologicals Antibodies for ATR
-
Abcam antibodies for ATR
- Invitrogen Antibodies for ATR
- GeneTex ATR Antibody for ATR
-
Boster Bio Antibodies for ATR
-
Santa Cruz Biotechnology (SCBT) Antibodies for ATR
- Sino Biological Antibodies for ATR
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ATR
- Origene Custom Protein Services for ATR
- Novus Biologicals proteins for ATR
- antibodies-online: Search results for available ATR related products ranked by validation data
- Search GeneTex for Proteins for ATR
-
Abcam proteins for ATR
No data available for DME Specific Peptides for ATR Gene
Domains & Families for ATR Gene
Gene Families for ATR Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ATR Gene
Suggested Antigen Peptide Sequences for ATR Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13535- Family:
-
- Belongs to the PI3/PI4-kinase family. ATM subfamily.
Function for ATR Gene
Molecular function for ATR Gene
- UniProtKB/Swiss-Prot Function:
- Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates Ser-139 of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Serine/threonine-protein kinase activity is directly stimulated by TOPBP1 (PubMed:16530042). ATR kinase activity is also directly activated by ETAA1, independently of TOPBP1 (PubMed:27723720, PubMed:27723717). Activated by DNA and inhibited by BCR-ABL oncogene (PubMed:10597277). Slightly activated by ATRIP (PubMed:14729973). Inhibited by caffeine, wortmannin and LY294002 (PubMed:9766667).
- GENATLAS Biochemistry:
- ataxia telangiectasia and RAD3 related,homologous to cell cycle G2 checkpoint genes Drosophila Mei-41,S cerevisiae Mec1p,S pombe RAD3,mainly expressed in testis and skeletal muscle,required for meiosisprophase I (associated with synaptomenal complex in RAD51 and RPA sites)
Enzyme Numbers (IUBMB) for ATR Gene
Phenotypes From GWAS Catalog for ATR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0004672 | protein kinase activity | IDA,TAS | 14657349 |
| GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
| GO:0005488 | binding | IEA | -- |
Phenotypes for ATR Gene
- MGI mutant phenotypes for ATR:
-
inferred from 8 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- pigmentation phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for ATR:
-
- Decreased substrate adherent cell growth
- Decreased telomerase activity
- Synthetic lethal with gemcitabine
- Synthetic lethal with cisplatin
- Decreased viability with cisplatin
- Dynamic nuclei (hole, folded or small irregular)
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after gemcitabine stimulation
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased homologous recombination repair frequency
- Increased cell death HMECs cells
- Reduced mammosphere formation
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance
- Apoptosis resistance
- Decreased viability with poly (ADPa89ribose)a89polymerasea891 (PARP) inhibitor
- Decreased hepcidin::fluc mRNA expression
- Increased viability with SS1P at EC90
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Transferrin accumulation in the perinuclear area
- Decreased vesicular stomatitis virus (VSV) infection
Animal Models for ATR Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ATR
-
CRISPR Products
-
OriGene CRISPR knockouts for ATR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATR
- genomics-online: gRNA clones - Search results for 10 available ATR gene related products
- Overview of 10 available ATR gene related products
- Applied Biological Materials CRISPR for ATR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ATR
- GenScript: Design CRISPR guide RNA sequences for ATR
miRNA for ATR Gene
- miRTarBase miRNAs that target ATR
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ATR
- Browse OriGene Inhibitory RNA Products For ATR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATR
- genomics-online: shRNA clones - Search results for 10 available ATR gene related products
- Overview of 10 available ATR gene related products
Clone Products
- Sino Biological Human cDNA Clone for ATR
- VectorBuilder custom plasmid, inducible vectors for ATR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ATR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ATR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATR
- Applied Biological Materials Clones for ATR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Transcription Factor Targets and HOMER Transcription for ATR Gene
Localization for ATR Gene
Subcellular locations from UniProtKB/Swiss-Prot for ATR Gene
- Nucleus. Nucleus, PML body. Chromosome. Note=Depending on the cell type, it can also be found in PML nuclear bodies. Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| golgi apparatus | 5 |
| plasma membrane | 3 |
| cytosol | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Golgi apparatus (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000784 | colocalizes_with nuclear chromosome, telomeric region | IC | 26586433 |
| GO:0005634 | nucleus | IEA,IBA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005694 | chromosome | ISS | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
Pathways & Interactions for ATR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DNA Double-Strand Break Repair |
.53
|
|
| 2 | Homologous DNA Pairing and Strand Exchange |
.01
|
|
| 3 | DNA Damage Response | ||
| 4 | Chks in Checkpoint Regulation | ||
| 5 | Regulation of TP53 Activity | ||
Pathways by source for ATR Gene
2 GeneTex pathways for ATR Gene
11 BioSystems pathways for ATR Gene
26 Reactome pathways for ATR Gene
1 PharmGKB pathway for ATR Gene
6 KEGG pathways for ATR Gene
5 GeneGo (Thomson Reuters) pathways for ATR Gene
1 Tocris pathway for ATR Gene
13 Qiagen pathways for ATR Gene
1 Cell Signaling Technology pathway for ATR Gene
Interacting Proteins for ATR Gene
Selected Interacting proteins:
Q13535-ATR_HUMAN
ENSP00000343741
for ATR Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for ATR
SIGNOR curated interactions for ATR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000077 | DNA damage checkpoint | IDA | 14657349 |
| GO:0006260 | DNA replication | TAS | -- |
| GO:0006281 | DNA repair | TAS | 8610130 |
| GO:0006974 | cellular response to DNA damage stimulus | TAS | 15538388 |
| GO:0007275 | multicellular organism development | TAS | 9590286 |
Drugs & Compounds for ATR Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Fluoxetine | Approved, Vet_approved | Pharma | Channel blocker, Antagonist, Inhibition, Inhibitor | 245 | ||
| Floxuridine | Approved | Pharma | Antineoplastic antimetabolite, RNA and DNA synthesis inhibitor, Inhibitor of thymidylate synthetase; anticancer agent | 50 | ||
| Niraparib | Approved, Investigational | Pharma | inhibitor, Biomarker | PARP inhibitor, PARP Inhibitors | 33 | |
| Olaparib | Approved | Pharma | inhibitor, Biomarker, other | PARP inhibitor, PARP Inhibitors, Other, Poly(ADPRIBOSE) polymerase (PARP) inhibitors | 162 | |
| Rucaparib | Approved, Investigational | Pharma | inhibitor, Biomarker, other | PARP inhibitor, PARP Inhibitors, Other | 23 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
||
| KU 60019 |
|
925701-46-8 |
|
|
(4) Tocris Compounds for ATR Gene
(10) ApexBio Compounds for ATR Gene
| Compound | Action | Cas Number |
|---|---|---|
| AZ20 | ATR inhibitor,potent and selective | 1233339-22-4 |
| AZD6738 | ATR inhibitor | 1352226-88-0 |
| CGK733 | ATM/ATR inhibitor,potent and selective | 905973-89-9 |
| ETP-46464 | ATR inhibitor,potent and selective | 1345675-02-6 |
| Floxuridine | Antineoplastic antimetabolite | 50-91-9 |
| KU 55933 | ATM inhibitor,potent and selective | 587871-26-9 |
| Mirin | 1198097-97-0 | |
| Torin 2 | MTOR inhibitor,highly potent and selective | 1223001-51-1 |
| VE-821 | ATR kinase inhibitor | 1232410-49-9 |
| VE-822 | ATR inhibitor | 1232416-25-9 |
Transcripts for ATR Gene
mRNA/cDNA for ATR Gene
- (4) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (59) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000504521 718 bps (uc062ooq.1)
- ENST00000515810 553 bps (uc062oor.1)
- ENST00000350721 8249 bps (uc003eux.5)
- ENST00000513291 5190 bps (uc062oos.1)
- ENST00000511016 681 bps (uc062oot.1)
Unigene Clusters for ATR Gene
CRISPR Products
-
OriGene CRISPR knockouts for ATR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATR
- genomics-online: gRNA clones - Search results for 10 available ATR gene related products
- Overview of 10 available ATR gene related products
- Applied Biological Materials CRISPR for ATR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ATR
- GenScript: Design CRISPR guide RNA sequences for ATR
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ATR
- Browse OriGene Inhibitory RNA Products For ATR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATR
- genomics-online: shRNA clones - Search results for 10 available ATR gene related products
- Overview of 10 available ATR gene related products
Clone Products
- Sino Biological Human cDNA Clone for ATR
- VectorBuilder custom plasmid, inducible vectors for ATR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ATR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ATR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATR
- Applied Biological Materials Clones for ATR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: |
| ExUns: | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37 | ^ | 38a | · | 38b | ^ | 39 | ^ | 40 | ^ | 41 | ^ | 42 | ^ | 43 | ^ | 44 | ^ | 45a | · | 45b | ^ | 46a | · | 46b | ^ | 47 | ^ | 48a | · | 48b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - |
Expression for ATR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
This gene is overexpressed in Serum (24.7), Liver, secretome (11.1), Testis (10.1), and Monocytes (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATR Gene
NURSA nuclear receptor signaling pathways regulating expression of ATR Gene:
ATRSOURCE GeneReport for Unigene cluster for ATR Gene:
Hs.271791mRNA Expression by UniProt/SwissProt for ATR Gene:
Q13535-ATR_HUMAN
Tissue specificity:
Ubiquitous, with highest expression in testis. Isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary.
Evidence on tissue expression from TISSUES for ATR Gene
- Blood(4.4)
- Nervous system(4.2)
- Heart(3.1)
- Skin(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ATR Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cerebellum
- cheek
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- larynx
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- skull
- tongue
- tooth
- vocal cord
Thorax:
- chest wall
- clavicle
- heart
- heart valve
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- kidney
Pelvis:
- pelvis
- penis
- testicle
- urethra
- vagina
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- hair
- peripheral nervous system
- red blood cell
- skin
- spinal column
- spinal cord
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for ATR
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ATR Gene
Orthologs for ATR Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ATR 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ATR 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ATR 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Atr 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Atr 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ATR 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ATR 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ATR 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | atr 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Atr 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | atr 34 33 |
|
ManyToMany | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5590 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | mei-41 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | atl-1 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MEC1 36 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| Cin.7365 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.7365 33 |
|
- Species where no ortholog for ATR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ATR Gene
- ENSEMBL:
- Gene Tree for ATR (if available)
- TreeFam:
- Gene Tree for ATR (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ATR: view image
Paralogs for ATR Gene
Variants for ATR Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1003651035 | uncertain-significance, Seckel syndrome | 142,566,188(-) | G/A | coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
| rs10935466 | likely-benign, uncertain-significance, not specified, Seckel syndrome | 142,562,979(-) | A/G | coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
| rs112018640 | benign, likely-benign, not specified, Seckel syndrome | 142,496,391(-) | G/A | coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
| rs112116713 | benign, uncertain-significance, not specified, Seckel syndrome | 142,522,851(-) | AAAAAAAAAAAA/AAAAAAAAAA/AAAAAAAAAAA/AAAAAAAAAAAAA/AAAAAAAAAAAAAA/AAAAAAAAAAAAAAA | intron_variant | |
| rs112726878 | uncertain-significance, not specified, Seckel syndrome | 142,512,435(-) | G/A/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant, synonymous_variant |
Residual Variation Intolerance Score:
2.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.66;
72.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ATR Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATR Gene
Disorders for ATR Gene
(14) MalaCards diseases for ATR Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cutaneous telangiectasia and cancer syndrome, familial |
|
|
| seckel syndrome 1 |
|
|
| seckel syndrome |
|
|
| ataxia-telangiectasia |
|
|
| bacillary angiomatosis |
|
|
Search ATR in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ATR_HUMAN- Seckel syndrome 1 (SCKL1) [MIM:210600]: A rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation. {ECO:0000269 PubMed:12640452}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Cutaneous telangiectasia and cancer syndrome, familial (FCTCS) [MIM:614564]: A disease characterized by cutaneous telangiectases in infancy with patchy alopecia over areas of affected skin, thinning of the lateral eyebrows, and mild dental and nail anomalies. Affected individuals are at increased risk of developing oropharyngeal cancer, and other malignancies have been reported as well. {ECO:0000269 PubMed:22341969}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for ATR
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ATR Gene
Publications for ATR Gene
- cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. (PMID: 8610130) Cimprich KA … Schreiber SL (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4 22 58
- ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes. (PMID: 19470935) Zighelboim I … Goodfellow PJ (Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009) 3 22 44 58
- Protein phosphatase 5 is required for ATR-mediated checkpoint activation. (PMID: 16260606) Zhang J … Wang XF (Molecular and cellular biology 2005) 3 4 22 58
- Mutation analysis of the ATR gene in breast and ovarian cancer families. (PMID: 15987455) Heikkinen K … Winqvist R (Breast cancer research : BCR 2005) 3 22 44 58
- Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities. (PMID: 14729973) Unsal-Kaçmaz K … Sancar A (Molecular and cellular biology 2004) 3 4 22 58
Products for ATR Gene
- R&D Systems Antibodies for ATR (ATR)
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Cyagen custom Knockout/knockin (KOKI) mouse models for ATR
- VectorBuilder custom plasmid, inducible vectors for ATR
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ATR
- antibodies-online: Search results for 11 available ATR Antibodies ranked by validation data
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- antibodies-online: Search results for available ATR related products ranked by validation data
- antibodies-online: Search results for available ATR related products ranked by validation data
- GeneTex ATR Antibody for ATR
- Search GeneTex for Proteins for ATR
- Santa Cruz Biotechnology (SCBT) Antibodies for ATR
- Search Santa Cruz Biotechnology (SCBT) for ATR siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ATR
- genomics-online: cdna clones - Search results for 10 available ATR gene related products
- Overview of 10 available ATR gene related products
- orf clones - Search results for 10 available ATR gene related products
- Overview of 10 available ATR gene related products
- genomics-online: gRNA clones - Search results for 10 available ATR gene related products
- Overview of 10 available ATR gene related products
- genomics-online: primer clones - Search results for 10 available ATR gene related products
- Overview of 10 available ATR gene related products
- genomics-online: shRNA clones - Search results for 10 available ATR gene related products
- Overview of 10 available ATR gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATR
- GeneCopoeia miRNA 3'UTR Target clone products for ATR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATR
- Boster Bio Antibodies for ATR
- Browse Boster Bio ELISA Kits
Sources for ATR Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100)