Aliases for ATP8B2 Gene
External Ids for ATP8B2 Gene
Previous GeneCards Identifiers for ATP8B2 Gene
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for ATP8B2 Gene
ATP8B2 (ATPase Phospholipid Transporting 8B2) is a Protein Coding gene. Diseases associated with ATP8B2 include Cholestasis, Benign Recurrent Intrahepatic, 1 and Cholestasis, Progressive Familial Intrahepatic, 1. Among its related pathways are Mesodermal Commitment Pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include nucleotide binding and cation-transporting ATPase activity. An important paralog of this gene is ATP8B4.
UniProtKB/Swiss-Prot Summary for ATP8B2 Gene
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).