Aliases for ATP6V1G3 Gene
- ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) Subunit G3 3
- ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G Isoform 3 2
- ATPase, H+ Transporting, Lysosomal 13kD, V1 Subunit G Isoform 3 2
- Vacuolar ATP Synthase Subunit G 3 3
- Vacuolar Proton Pump G Subunit 3 3
- Vacuolar Proton Pump, Subunit G3 3
- V-ATPase G Subunit 3 3
- V-ATPase G3 Subunit 3
- ATP6V1G3 5
External Ids for ATP6V1G3 Gene
Previous GeneCards Identifiers for ATP6V1G3 Gene
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ATP6V1G3 Gene
ATP6V1G3 (ATPase H+ Transporting V1 Subunit G3) is a Protein Coding gene. Diseases associated with ATP6V1G3 include Renal Tubular Acidosis and Cutis Laxa, Autosomal Recessive, Type Iid. Among its related pathways are Synaptic vesicle cycle and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include ATPase binding and proton-exporting ATPase activity, phosphorylative mechanism. An important paralog of this gene is ATP6V1G1.
UniProtKB/Swiss-Prot Summary for ATP6V1G3 Gene
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes and endosomes.