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Aliases for ATP6V1G3 Gene

Aliases for ATP6V1G3 Gene

  • ATPase H+ Transporting V1 Subunit G3 2 3 5
  • ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G3 2 3
  • Vacuolar Proton Pump Subunit G 3 3 4
  • V-ATPase 13 KDa Subunit 3 3 4
  • V-ATPase Subunit G 3 3 4
  • ATP6G3 3 4
  • ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) Subunit G3 3
  • ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G Isoform 3 2
  • ATPase, H+ Transporting, Lysosomal 13kD, V1 Subunit G Isoform 3 2
  • Vacuolar ATP Synthase Subunit G 3 3
  • V-Type Proton ATPase Subunit G 3 3
  • Vacuolar Proton Pump G Subunit 3 3
  • Vacuolar Proton Pump, Subunit G3 3
  • V-ATPase G Subunit 3 3
  • V-ATPase G3 Subunit 3
  • Vma10 3

External Ids for ATP6V1G3 Gene

Previous GeneCards Identifiers for ATP6V1G3 Gene

  • GC01M196219
  • GC01M193950
  • GC01M194958
  • GC01M195780
  • GC01M195224
  • GC01M196758
  • GC01M169660

Summaries for ATP6V1G3 Gene

Entrez Gene Summary for ATP6V1G3 Gene

  • This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP6V1G3 Gene

ATP6V1G3 (ATPase H+ Transporting V1 Subunit G3) is a Protein Coding gene. Among its related pathways are Rheumatoid arthritis and Insulin receptor recycling. Gene Ontology (GO) annotations related to this gene include ATPase binding and proton-exporting ATPase activity, phosphorylative mechanism. An important paralog of this gene is ATP6V1G2.

UniProtKB/Swiss-Prot for ATP6V1G3 Gene

  • Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Tocris Summary for ATP6V1G3 Gene

  • H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes and endosomes.

Gene Wiki entry for ATP6V1G3 Gene

Additional gene information for ATP6V1G3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP6V1G3 Gene

Genomics for ATP6V1G3 Gene

GeneHancer (GH) Regulatory Elements for ATP6V1G3 Gene

Promoters and enhancers for ATP6V1G3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J198597 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 662 -57.6 -57619 3 SMAD1 ARNT IRF4 TCF12 GATA2 ATF7 RUNX3 NCOA1 ZNF592 MBD2 ATP6V1G3 ENSG00000223881
GH01J198540 Promoter 0.5 EPDnew 650.7 +0.2 245 0.1 ATP6V1G3 LOC105371677
GH01J198538 Enhancer 0.2 ENCODE 650.7 +1.9 1919 0.9 ATP6V1G3 LOC105371677
GH01J198636 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.8 -99.3 -99298 7.7 ATF1 PKNOX1 SMAD1 IRF4 ATF7 RUNX3 JUNB MYNN NBN HMBOX1 PTPRC ATP6V1G3 ENSG00000261573
GH01J198660 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -135.4 -135397 32.1 PKNOX1 SMAD1 FOXA2 NEUROD1 FEZF1 IRF4 YY1 POLR2B ZNF766 ZNF213 PTPRC ATP6V1G3 LOC105371679 GC01P198684 PEBP1P3 PIR61364 ENSG00000261573
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATP6V1G3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ATP6V1G3 gene promoter:
  • POU2F1a
  • POU2F1
  • RSRFC4
  • AML1a
  • FOXC1
  • FOXO4
  • Ik-2
  • Lmo2
  • c-Ets-1
  • HNF-1A

Genomic Locations for ATP6V1G3 Gene

Genomic Locations for ATP6V1G3 Gene
17,724 bases
Minus strand
17,724 bases
Minus strand

Genomic View for ATP6V1G3 Gene

Genes around ATP6V1G3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP6V1G3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP6V1G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP6V1G3 Gene

Proteins for ATP6V1G3 Gene

  • Protein details for ATP6V1G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-type proton ATPase subunit G 3
    Protein Accession:
    Secondary Accessions:
    • Q495K2
    • Q495K4
    • Q5T9L6

    Protein attributes for ATP6V1G3 Gene

    118 amino acids
    Molecular mass:
    13917 Da
    Quaternary structure:
    • V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c, c and d).

    Alternative splice isoforms for ATP6V1G3 Gene


neXtProt entry for ATP6V1G3 Gene

Post-translational modifications for ATP6V1G3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATP6V1G3 Gene

Domains & Families for ATP6V1G3 Gene

Gene Families for ATP6V1G3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for ATP6V1G3 Gene


Suggested Antigen Peptide Sequences for ATP6V1G3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the V-ATPase G subunit family.
  • Belongs to the V-ATPase G subunit family.
genes like me logo Genes that share domains with ATP6V1G3: view

Function for ATP6V1G3 Gene

Molecular function for ATP6V1G3 Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Phenotypes From GWAS Catalog for ATP6V1G3 Gene

Gene Ontology (GO) - Molecular Function for ATP6V1G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008553 proton-exporting ATPase activity, phosphorylative mechanism IEA --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA --
GO:0051117 ATPase binding IPI 17360703
genes like me logo Genes that share ontologies with ATP6V1G3: view
genes like me logo Genes that share phenotypes with ATP6V1G3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATP6V1G3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP6V1G3 Gene

Localization for ATP6V1G3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP6V1G3 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for ATP6V1G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA 17360703
GO:0016471 vacuolar proton-transporting V-type ATPase complex IEA --
genes like me logo Genes that share ontologies with ATP6V1G3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ATP6V1G3 Gene

Pathways & Interactions for ATP6V1G3 Gene

genes like me logo Genes that share pathways with ATP6V1G3: view

Gene Ontology (GO) - Biological Process for ATP6V1G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0033572 transferrin transport TAS --
GO:0034220 ion transmembrane transport TAS --
GO:0090383 phagosome acidification TAS --
genes like me logo Genes that share ontologies with ATP6V1G3: view

No data available for SIGNOR curated interactions for ATP6V1G3 Gene

Drugs & Compounds for ATP6V1G3 Gene

(5) Drugs for ATP6V1G3 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Bafilomycin A1 Experimental Pharma V-ATPase inhibitor,selective and reversible, H+-ATPase (vacuolar) inhibitor 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
Thonzonium Bromide Pharma surface active agent and inhibitor of V-ATPase proton transport 0
Concanamycin A Pharma V-type (vacuolar) H+-ATPase inhibitor, H+-ATPase (vacuolar) inhibitor 0

(2) Additional Compounds for ATP6V1G3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid

(2) Tocris Compounds for ATP6V1G3 Gene

Compound Action Cas Number
Bafilomycin A1 H+-ATPase (vacuolar) inhibitor 88899-55-2
Concanamycin A H+-ATPase (vacuolar) inhibitor 80890-47-7
genes like me logo Genes that share compounds with ATP6V1G3: view

Transcripts for ATP6V1G3 Gene

Unigene Clusters for ATP6V1G3 Gene

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATP6V1G3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP6V1G3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for ATP6V1G3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP6V1G3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP6V1G3 Gene

mRNA differential expression in normal tissues according to GTEx for ATP6V1G3 Gene

This gene is overexpressed in Kidney - Cortex (x51.8).

Protein differential expression in normal tissues from HIPED for ATP6V1G3 Gene

This gene is overexpressed in Kidney (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ATP6V1G3 Gene

Protein tissue co-expression partners for ATP6V1G3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ATP6V1G3 Gene:


SOURCE GeneReport for Unigene cluster for ATP6V1G3 Gene:


mRNA Expression by UniProt/SwissProt for ATP6V1G3 Gene:

Tissue specificity: Kidney.

Evidence on tissue expression from TISSUES for ATP6V1G3 Gene

  • Kidney(3.1)
genes like me logo Genes that share expression patterns with ATP6V1G3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP6V1G3 Gene

Orthologs for ATP6V1G3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP6V1G3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATP6V1G3 34 33
  • 99.72 (n)
(Canis familiaris)
Mammalia ATP6V1G3 34 33
  • 88.14 (n)
(Mus musculus)
Mammalia Atp6v1g3 16 34 33
  • 84.18 (n)
(Bos Taurus)
Mammalia ATP6V1G3 34 33
  • 83.76 (n)
(Rattus norvegicus)
Mammalia Atp6v1g3 33
  • 82.2 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 71 (a)
-- 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia ATP6V1G3 34
  • 51 (a)
(Gallus gallus)
Aves ATP6V1G3 34 33
  • 71.3 (n)
(Anolis carolinensis)
Reptilia ATP6V1G3 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp6v1g3 33
  • 68.42 (n)
Str.15644 33
fruit fly
(Drosophila melanogaster)
Insecta Vha13 34
  • 37 (a)
(Caenorhabditis elegans)
Secernentea vha-10 34
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VMA10 36 34
  • 34 (a)
Species where no ortholog for ATP6V1G3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ATP6V1G3 Gene

Gene Tree for ATP6V1G3 (if available)
Gene Tree for ATP6V1G3 (if available)
Evolutionary constrained regions (ECRs) for ATP6V1G3: view image

Paralogs for ATP6V1G3 Gene

Paralogs for ATP6V1G3 Gene

(3) SIMAP similar genes for ATP6V1G3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ATP6V1G3: view

Variants for ATP6V1G3 Gene

Sequence variations from dbSNP and Humsavar for ATP6V1G3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000084319 -- 198,538,633(-) A/G intron_variant
rs1000435028 -- 198,538,844(-) C/G intron_variant
rs1001202095 -- 198,532,992(-) A/G intron_variant
rs1001230033 -- 198,531,702(-) A/T intron_variant
rs1001255623 -- 198,538,218(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ATP6V1G3 Gene

Variant ID Type Subtype PubMed ID
esv3588521 CNV loss 21293372
nsv1004900 CNV loss 25217958
nsv4043 CNV insertion 18451855
nsv474653 CNV novel sequence insertion 20440878
nsv548903 CNV loss 21841781
nsv832259 CNV gain 17160897

Variation tolerance for ATP6V1G3 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATP6V1G3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP6V1G3 Gene

Disorders for ATP6V1G3 Gene

Additional Disease Information for ATP6V1G3

No disorders were found for ATP6V1G3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP6V1G3 Gene

Publications for ATP6V1G3 Gene

  1. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y … Kamatani N (Nature genetics 2010) 3 44 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis. (PMID: 12384298) Smith AN … Karet FE (Gene 2002) 3 4 58
  5. Structure, function and regulation of the vacuolar (H+)-ATPase. (PMID: 9442887) Stevens TH … Forgac M (Annual review of cell and developmental biology 1997) 2 3 58

Products for ATP6V1G3 Gene

Sources for ATP6V1G3 Gene

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