Aliases for ATP6V1D Gene
- ATPase H+ Transporting V1 Subunit D 2 3 5
- ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) 2 3
- ATPase, H+ Transporting, Lysosomal 34kDa, V1 Subunit D 2 3
- V-ATPase 28 KDa Accessory Protein 3 4
- Vacuolar Proton Pump Subunit D 3 4
- V-ATPase Subunit D 3 4
- ATP6M 3 4
- VATD 3 4
- H(+)-Transporting Two-Sector ATPase, Subunit M 3
- ATPase, H+ Transporting Lysosomal, Member M 3
External Ids for ATP6V1D Gene
Previous HGNC Symbols for ATP6V1D Gene
Previous GeneCards Identifiers for ATP6V1D Gene
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for ATP6V1D Gene
ATP6V1D (ATPase H+ Transporting V1 Subunit D) is a Protein Coding gene. Among its related pathways are Rheumatoid arthritis and Insulin receptor recycling. Gene Ontology (GO) annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances.
UniProtKB/Swiss-Prot for ATP6V1D Gene
Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.
H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes and endosomes.