Aliases for ATP6V0C Gene
External Ids for ATP6V0C Gene
Previous HGNC Symbols for ATP6V0C Gene
Previous GeneCards Identifiers for ATP6V0C Gene
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]
GeneCards Summary for ATP6V0C Gene
ATP6V0C (ATPase H+ Transporting V0 Subunit C) is a Protein Coding gene. Among its related pathways are Phagosome and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and proton-transporting ATPase activity, rotational mechanism. An important paralog of this gene is ATP6V0B.
UniProtKB/Swiss-Prot Summary for ATP6V0C Gene
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes and endosomes.