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Aliases for ATP6V0C Gene

Aliases for ATP6V0C Gene

  • ATPase H+ Transporting V0 Subunit C 2 3 5
  • ATPase, H+ Transporting, Lysosomal 16kDa, V0 Subunit C 2 3
  • Vacuolar Proton Pump 16 KDa Proteolipid Subunit 3 4
  • V-ATPase 16 KDa Proteolipid Subunit 3 4
  • ATP6C 3 4
  • ATP6L 3 4
  • ATPL 3 4
  • ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) 16kD 2
  • H(+)-Transporting Two-Sector ATPase, 16 KDa Subunit 3
  • Vacuolar ATP Synthase 16 KDa Proteolipid Subunit 3
  • V-Type Proton ATPase 16 KDa Proteolipid Subunit 3
  • Vacuolar H+ ATPase Proton Channel Subunit 3
  • VATL 3
  • VPPC 3
  • Vma3 3

External Ids for ATP6V0C Gene

Previous HGNC Symbols for ATP6V0C Gene

  • ATPL
  • ATP6C
  • ATP6L

Previous GeneCards Identifiers for ATP6V0C Gene

  • GC16P002565
  • GC16P002503
  • GC16P002563

Summaries for ATP6V0C Gene

Entrez Gene Summary for ATP6V0C Gene

  • This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]

GeneCards Summary for ATP6V0C Gene

ATP6V0C (ATPase H+ Transporting V0 Subunit C) is a Protein Coding gene. Among its related pathways are Rheumatoid arthritis and Insulin receptor recycling. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and proton-transporting ATPase activity, rotational mechanism.

UniProtKB/Swiss-Prot for ATP6V0C Gene

  • Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Tocris Summary for ATP6V0C Gene

  • H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes and endosomes.

Gene Wiki entry for ATP6V0C Gene

Additional gene information for ATP6V0C Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP6V0C Gene

Genomics for ATP6V0C Gene

GeneHancer (GH) Regulatory Elements for ATP6V0C Gene

Promoters and enhancers for ATP6V0C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J002511 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 +2.7 2727 10.7 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ATP6V0C ENSG00000279520 AMDHD2 ZNF75A TBC1D24 IFT140 ZNF213-AS1 CRAMP1 ERVK13-1 SNHG19
GH16J002534 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 7.7 +23.3 23272 4 HDGF PKNOX1 ARID4B SIN3A ZNF48 YY1 GTF3C2 GLIS2 ZFP91 FOS PDPK1 CRAMP1 TBL3 ZNF598 ZNF597 ZNF200 AMDHD2 TSC2 ZNF213-AS1 E4F1
GH16J002529 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 8.9 +18.1 18120 3.8 HDGF ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF207 ZNF143 CEMP1 GC16P003526 MIR3178 CRAMP1 ZNF174 TBC1D24 ZNF263 ZNF75A TSC2 E4F1
GH16J002523 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 8.6 +10.5 10533 2.3 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 RXRA SP5 MXD4 PPARG AMDHD2 PRSS27 ATP6V0C CEMP1 ENSG00000259784
GH16J003003 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 5.2 +494.1 494090 8.4 CLOCK MLX DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D GLIS1 ENSG00000272079 LOC105371056 CREBBP ZNF597 MMP25 AMDHD2 SRRM2 ZNF598 ZNF263 ZNF200
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATP6V0C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ATP6V0C gene promoter:
  • CUTL1
  • POU2F1a
  • POU2F1
  • CREB
  • SREBP-1b
  • SREBP-1a
  • SREBP-1c
  • p53
  • ATF

Genomic Locations for ATP6V0C Gene

Genomic Locations for ATP6V0C Gene
6,498 bases
Plus strand
6,498 bases
Plus strand

Genomic View for ATP6V0C Gene

Genes around ATP6V0C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP6V0C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP6V0C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP6V0C Gene

Proteins for ATP6V0C Gene

  • Protein details for ATP6V0C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-type proton ATPase 16 kDa proteolipid subunit
    Protein Accession:
    Secondary Accessions:
    • Q6FH26

    Protein attributes for ATP6V0C Gene

    155 amino acids
    Molecular mass:
    15736 Da
    Quaternary structure:
    • V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein; which is present as a hexamer that forms the proton-conducting pore). Interacts with LASS2. Interacts with HTLV-1 accessory protein p12I. Interacts with RNF182; this interaction leads to ubiquitination and degradation via the proteasome pathway.

neXtProt entry for ATP6V0C Gene

Post-translational modifications for ATP6V0C Gene

  • Ubiquitinated by RNF182, leading to its degradation via the ubiquitin-proteasome pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP6V0C Gene

No data available for DME Specific Peptides for ATP6V0C Gene

Domains & Families for ATP6V0C Gene

Gene Families for ATP6V0C Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ATP6V0C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the V-ATPase proteolipid subunit family.
  • Belongs to the V-ATPase proteolipid subunit family.
genes like me logo Genes that share domains with ATP6V0C: view

Function for ATP6V0C Gene

Molecular function for ATP6V0C Gene

UniProtKB/Swiss-Prot Function:
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Gene Ontology (GO) - Molecular Function for ATP6V0C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 1334459
GO:0015078 proton transmembrane transporter activity IEA --
GO:0031625 ubiquitin protein ligase binding IPI 18298843
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism TAS 1709739
GO:0046961 proton-transporting ATPase activity, rotational mechanism TAS 1709739
genes like me logo Genes that share ontologies with ATP6V0C: view
genes like me logo Genes that share phenotypes with ATP6V0C: view

Animal Models for ATP6V0C Gene

MGI Knock Outs for ATP6V0C:

Animal Model Products

CRISPR Products

miRNA for ATP6V0C Gene

miRTarBase miRNAs that target ATP6V0C

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATP6V0C

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP6V0C Gene

Localization for ATP6V0C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP6V0C Gene

Vacuole membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP6V0C gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 5
endosome 4
cytosol 1

Gene Ontology (GO) - Cellular Components for ATP6V0C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain IBA --
GO:0005765 lysosomal membrane HDA 17897319
GO:0005773 vacuole IEA --
GO:0005774 vacuolar membrane IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with ATP6V0C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ATP6V0C Gene

Pathways & Interactions for ATP6V0C Gene

genes like me logo Genes that share pathways with ATP6V0C: view

Gene Ontology (GO) - Biological Process for ATP6V0C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0007042 lysosomal lumen acidification IBA --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0015991 ATP hydrolysis coupled proton transport IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with ATP6V0C: view

No data available for SIGNOR curated interactions for ATP6V0C Gene

Drugs & Compounds for ATP6V0C Gene

(4) Drugs for ATP6V0C Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Bafilomycin A1 Experimental Pharma V-ATPase inhibitor,selective and reversible, H+-ATPase (vacuolar) inhibitor 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
Concanamycin A Pharma V-type (vacuolar) H+-ATPase inhibitor, H+-ATPase (vacuolar) inhibitor 0

(2) Additional Compounds for ATP6V0C Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid

(2) Tocris Compounds for ATP6V0C Gene

Compound Action Cas Number
Bafilomycin A1 H+-ATPase (vacuolar) inhibitor 88899-55-2
Concanamycin A H+-ATPase (vacuolar) inhibitor 80890-47-7
genes like me logo Genes that share compounds with ATP6V0C: view

Transcripts for ATP6V0C Gene

mRNA/cDNA for ATP6V0C Gene

Unigene Clusters for ATP6V0C Gene

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATP6V0C

Alternative Splicing Database (ASD) splice patterns (SP) for ATP6V0C Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for ATP6V0C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP6V0C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP6V0C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATP6V0C Gene

This gene is overexpressed in Retina (11.1) and Brain (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATP6V0C Gene

NURSA nuclear receptor signaling pathways regulating expression of ATP6V0C Gene:


SOURCE GeneReport for Unigene cluster for ATP6V0C Gene:


Evidence on tissue expression from TISSUES for ATP6V0C Gene

  • Nervous system(4.9)
  • Skin(4.7)
  • Muscle(4.5)
  • Pancreas(3.6)
  • Eye(3.5)
  • Lung(3.4)
  • Stomach(3)
  • Kidney(2.7)
  • Intestine(2.4)
  • Liver(2.3)
  • Heart(2.2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with ATP6V0C: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP6V0C Gene

Orthologs for ATP6V0C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP6V0C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATP6V0C 34 33
  • 99.35 (n)
(Bos Taurus)
Mammalia ATP6V0C 34 33
  • 90.32 (n)
(Canis familiaris)
Mammalia ATP6V0C 34 33
  • 90.11 (n)
(Mus musculus)
Mammalia Atp6v0c 16 34 33
  • 86.88 (n)
(Rattus norvegicus)
Mammalia Atp6v0c 33
  • 86.67 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 84 (a)
-- 34
  • 77 (a)
-- 34
  • 69 (a)
(Gallus gallus)
Aves ATP6V0C 34 33
  • 78.65 (n)
(Anolis carolinensis)
Reptilia ATP6V0C 34
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp6v0c 33
  • 77.06 (n)
MGC75730 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64475 33
(Danio rerio)
Actinopterygii atp6v0ca 34
  • 90 (a)
atp6v0cb 34 33
  • 80.7 (n)
atp6v0c 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13983 33
fruit fly
(Drosophila melanogaster)
Insecta Vha16 35
  • 81 (a)
Vha16-3 34
  • 75 (a)
Vha16-1 34 33
  • 74.78 (n)
Vha16-2 34
  • 66 (a)
Vha16-4 34
  • 65 (a)
CG9013 35
  • 65 (a)
Vha16-5 34
  • 50 (a)
(Caenorhabditis elegans)
Secernentea vha-2 34 35 33
  • 64.27 (n)
vha-3 34
  • 63 (a)
vha-1 34
  • 55 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL074W 33
  • 61.84 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VMA3 34 33
  • 59.23 (n)
VMA11 36
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22441g 33
  • 59.21 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1223 33
(Glycine max)
eudicotyledons Gma.12504 33
(Oryza sativa)
Liliopsida Os01g0962300 33
  • 68.6 (n)
Os.5911 33
(Triticum aestivum)
Liliopsida Ta.28372 33
(Hordeum vulgare)
Liliopsida Hv.861 33
(Zea mays)
Liliopsida Zm.6210 33
bread mold
(Neurospora crassa)
Ascomycetes NCU01332 33
  • 66.67 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes vma3 33
  • 62.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.10414 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10414 33
Species where no ortholog for ATP6V0C was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ATP6V0C Gene

Gene Tree for ATP6V0C (if available)
Gene Tree for ATP6V0C (if available)
Evolutionary constrained regions (ECRs) for ATP6V0C: view image

Paralogs for ATP6V0C Gene

(1) SIMAP similar genes for ATP6V0C Gene using alignment to 3 proteins:

  • H3BNI4_HUMAN Pseudogenes for ATP6V0C Gene

genes like me logo Genes that share paralogs with ATP6V0C: view

No data available for Paralogs for ATP6V0C Gene

Variants for ATP6V0C Gene

Sequence variations from dbSNP and Humsavar for ATP6V0C Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000014505 -- 2,514,828(+) G/C intron_variant
rs1000079139 -- 2,515,896(+) G/A intron_variant
rs1000131528 -- 2,516,208(+) G/C intron_variant
rs1000247388 -- 2,512,964(+) GGGGG/GGGGGG upstream_transcript_variant
rs1000338119 -- 2,517,303(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ATP6V0C Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV duplication 17116639
esv2760067 CNV gain+loss 17122850
nsv1052260 CNV gain 25217958
nsv1121904 CNV deletion 24896259
nsv833121 CNV loss 17160897
nsv833122 CNV loss 17160897

Variation tolerance for ATP6V0C Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATP6V0C Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP6V0C Gene

Disorders for ATP6V0C Gene

Additional Disease Information for ATP6V0C

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ATP6V0C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP6V0C Gene

Publications for ATP6V0C Gene

  1. CpG island in the region of an autosomal dominant polycystic kidney disease locus defines the 5' end of a gene encoding a putative proton channel. (PMID: 1709739) Gillespie GA … Reeders ST (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 58
  2. Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells. (PMID: 19299075) You H … Qin W (Cancer letters 2009) 3 22 58
  3. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M … van Ree JM (Biological psychiatry 2009) 3 44 58
  4. A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation. (PMID: 18298843) Liu QY … Liu R (Molecular neurodegeneration 2008) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ATP6V0C Gene

Sources for ATP6V0C Gene

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