Aliases for ATP6V0B Gene
- ATPase H+ Transporting V0 Subunit B 2 3 5
- ATPase, H+ Transporting, Lysosomal 21kDa, V0 Subunit B 2 3
- Vacuolar Proton Pump 21 KDa Proteolipid Subunit 3 4
- V-ATPase 21 KDa Proteolipid Subunit 3 4
- HATPL 3 4
- ATP6F 3 4
- ATPase, H+ Transporting, Lysosomal, 21-KD, V0 Subunit C-Prime, Prime 3
- ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) 21kD 2
External Ids for ATP6V0B Gene
Previous HGNC Symbols for ATP6V0B Gene
Previous GeneCards Identifiers for ATP6V0B Gene
This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
GeneCards Summary for ATP6V0B Gene
ATP6V0B (ATPase H+ Transporting V0 Subunit B) is a Protein Coding gene. Diseases associated with ATP6V0B include Lymphocytic Choriomeningitis. Among its related pathways are Innate Immune System and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include transporter activity and hydrogen ion transmembrane transporter activity.
UniProtKB/Swiss-Prot for ATP6V0B Gene
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes and endosomes.