Aliases for ATP6V0B Gene
- ATPase, H+ Transporting, Lysosomal, 21-KD, V0 Subunit C-Prime, Prime 3
- ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) 21kD 2
- ATPase, H+ Transporting, Lysosomal 21kDa, V0 Subunit C'' 2
- Vacuolar ATP Synthase 21 KDa Proteolipid Subunit 3
- H(+)-Transporting Two-Sector ATPase, Subunit F 3
- ATPase, H+ Transporting, Lysosomal, Subunit F 3
- V-ATPase Subunit C'' 3
- ATP6V0B 5
External Ids for ATP6V0B Gene
Previous HGNC Symbols for ATP6V0B Gene
Previous GeneCards Identifiers for ATP6V0B Gene
This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
GeneCards Summary for ATP6V0B Gene
ATP6V0B (ATPase H+ Transporting V0 Subunit B) is a Protein Coding gene. Among its related pathways are Lysosome and Synaptic vesicle cycle. Gene Ontology (GO) annotations related to this gene include transporter activity and proton transmembrane transporter activity. An important paralog of this gene is ATP6V0C.
UniProtKB/Swiss-Prot Summary for ATP6V0B Gene
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes and endosomes.