The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. [provided by RefSeq, Jul 20... See more...

Aliases for ATP5PO Gene

Aliases for ATP5PO Gene

  • ATP Synthase Peripheral Stalk Subunit OSCP 2 3 4 5
  • ATPO 2 3 4
  • OSCP 2 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, O Subunit 2 3
  • Oligomycin Sensitivity Conferring Protein 2 3
  • ATP Synthase Subunit O, Mitochondrial 3 4
  • ATP5O 3 4
  • Oligomycin Sensitivity Conferral Protein Oscp-Like Protein 3
  • Oligomycin Sensitivity Conferral Protein 4
  • Human ATP Synthase OSCP Subunit 3
  • HMC08D05 3
  • ATP5PO 5

External Ids for ATP5PO Gene

Previous HGNC Symbols for ATP5PO Gene

  • ATP5O

Summaries for ATP5PO Gene

Entrez Gene Summary for ATP5PO Gene

  • The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP5PO Gene

ATP5PO (ATP Synthase Peripheral Stalk Subunit OSCP) is a Protein Coding gene. Diseases associated with ATP5PO include Hashimoto Thyroiditis and Acute Thyroiditis. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Parkinson disease. An important paralog of this gene is ENSG00000249209.

UniProtKB/Swiss-Prot Summary for ATP5PO Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Gene Wiki entry for ATP5PO Gene

Additional gene information for ATP5PO Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATP5PO Gene

Genomics for ATP5PO Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ATP5PO Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATP5PO on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ATP5PO

Genomic Locations for ATP5PO Gene

Genomic Locations for ATP5PO Gene
chr21:33,903,453-33,915,814
(GRCh38/hg38)
Size:
12,362 bases
Orientation:
Minus strand
chr21:35,275,757-35,288,284
(GRCh37/hg19)
Size:
12,528 bases
Orientation:
Minus strand

Genomic View for ATP5PO Gene

Genes around ATP5PO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5PO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5PO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5PO Gene

Proteins for ATP5PO Gene

  • Protein details for ATP5PO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48047-ATPO_HUMAN
    Recommended name:
    ATP synthase subunit O, mitochondrial
    Protein Accession:
    P48047
    Secondary Accessions:
    • B2R4E2
    • Q5U042
    • Q6IBI2

    Protein attributes for ATP5PO Gene

    Size:
    213 amino acids
    Molecular mass:
    23277 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MD and ATP5MPL (By similarity).

neXtProt entry for ATP5PO Gene

Post-translational modifications for ATP5PO Gene

  • Acetylation at Lys-162 decreases ATP production. Deacetylated by SIRT3.
  • Ubiquitination at Lys51, Lys54, Lys60, Lys73, Lys84, Lys88, Lys90, Lys98, Lys158, Lys162, Lys172, Lys176, Lys192, and Lys199
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP5PO Gene

No data available for DME Specific Peptides for ATP5PO Gene

Domains & Families for ATP5PO Gene

Gene Families for ATP5PO Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ATP5PO Gene

InterPro:
Blocks:
  • H+-transporting two-sector ATPase, delta (OSCP) subunit
ProtoNet:

Suggested Antigen Peptide Sequences for ATP5PO Gene

GenScript: Design optimal peptide antigens:
  • Oligomycin sensitivity conferral protein (ATPO_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P48047

UniProtKB/Swiss-Prot:

ATPO_HUMAN :
  • Belongs to the ATPase delta chain family.
Family:
  • Belongs to the ATPase delta chain family.
genes like me logo Genes that share domains with ATP5PO: view

Function for ATP5PO Gene

Molecular function for ATP5PO Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Phenotypes From GWAS Catalog for ATP5PO Gene

Gene Ontology (GO) - Molecular Function for ATP5PO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0008144 drug binding IDA 15850986
GO:0046933 contributes_to proton-transporting ATP synthase activity, rotational mechanism IEA,IDA 12110673
genes like me logo Genes that share ontologies with ATP5PO: view
genes like me logo Genes that share phenotypes with ATP5PO: view

Animal Models for ATP5PO Gene

MGI Knock Outs for ATP5PO:
  • Atp5o Atp5o<tm1.1(KOMP)Vlcg>

miRNA for ATP5PO Gene

miRTarBase miRNAs that target ATP5PO

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP5PO Gene

Localization for ATP5PO Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5PO Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5PO gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
nucleus 4
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATP5PO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005739 mitochondrion IEA,IDA 12110673
GO:0005743 mitochondrial inner membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex NAS 7490082
GO:0005886 plasma membrane IDA 17851741
genes like me logo Genes that share ontologies with ATP5PO: view

Pathways & Interactions for ATP5PO Gene

genes like me logo Genes that share pathways with ATP5PO: view

Gene Ontology (GO) - Biological Process for ATP5PO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process TAS --
GO:0006811 ion transport IEA --
GO:0015986 ATP synthesis coupled proton transport IEA --
GO:0042407 cristae formation TAS --
GO:0042776 mitochondrial ATP synthesis coupled proton transport TAS --
genes like me logo Genes that share ontologies with ATP5PO: view

No data available for SIGNOR curated interactions for ATP5PO Gene

Drugs & Compounds for ATP5PO Gene

(6) Drugs for ATP5PO Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Dihydroartemisinin Experimental, Investigational Pharma Target, ligand 115
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(4) Additional Compounds for ATP5PO Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with ATP5PO: view

Transcripts for ATP5PO Gene

mRNA/cDNA for ATP5PO Gene

1 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5PO Gene

No ASD Table

Relevant External Links for ATP5PO Gene

GeneLoc Exon Structure for
ATP5PO

Expression for ATP5PO Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ATP5PO

Evidence on tissue expression from TISSUES for ATP5PO Gene

  • Heart(4.9)
  • Nervous system(4.9)
  • Muscle(4.7)
  • Liver(4.6)
  • Blood(4.5)
  • Thyroid gland(3.5)
  • Lung(3.4)
  • Pancreas(3)
  • Eye(3)
  • Kidney(2.9)
  • Skin(2.8)
  • Adrenal gland(2.6)
  • Stomach(2.6)
  • Intestine(2.6)
  • Lymph node(2.4)
  • Bone marrow(2.4)
  • Spleen(2.3)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP5PO Gene

Orthologs for ATP5PO Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP5PO Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ATP5O 30 31
  • 99.37 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 88 (a)
ManyToMany
ATP5O 30
  • 86.95 (n)
-- 31
  • 83 (a)
ManyToMany
-- 31
  • 81 (a)
ManyToMany
-- 31
  • 69 (a)
ManyToMany
-- 31
  • 69 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia ATP5O 30 31
  • 86.85 (n)
OneToMany
Mouse
(Mus musculus)
Mammalia Atp5o 30 17 31
  • 79.81 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Atp5o 30
  • 79.03 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 77 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 72 (a)
ManyToMany
-- 31
  • 72 (a)
ManyToMany
-- 31
  • 68 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves ATP5O 30
  • 66.99 (n)
-- 31
  • 60 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 56 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia atp5o 30
  • 64.91 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23878 30
Zebrafish
(Danio rerio)
Actinopterygii atp5o 30 31
  • 61.67 (n)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9319 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003599 30
  • 54.28 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Oscp 30 31
  • 53.03 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea atp-3 30 31
  • 47.62 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AAL065C 30
  • 46.77 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP5 30 31 33
  • 45.96 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C10384g 30
  • 45.52 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons ATP5 30
  • 45.33 (n)
Rice
(Oryza sativa)
Liliopsida Os06g0646500 30
  • 45.62 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atp5 30
  • 48.98 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU01606 30
  • 44.78 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5137 31
  • 33 (a)
OneToMany
Species where no ortholog for ATP5PO was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ATP5PO Gene

ENSEMBL:
Gene Tree for ATP5PO (if available)
TreeFam:
Gene Tree for ATP5PO (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATP5PO: view image

Paralogs for ATP5PO Gene

Paralogs for ATP5PO Gene

Pseudogenes.org Pseudogenes for ATP5PO Gene

genes like me logo Genes that share paralogs with ATP5PO: view

Variants for ATP5PO Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ATP5PO Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
rs4842 - p.Lys98Arg

Additional dbSNP identifiers (rs#s) for ATP5PO Gene

Structural Variations from Database of Genomic Variants (DGV) for ATP5PO Gene

Variant ID Type Subtype PubMed ID
nsv587399 CNV gain 21841781

Variation tolerance for ATP5PO Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATP5PO Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5PO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5PO Gene

Disorders for ATP5PO Gene

MalaCards: The human disease database

(10) MalaCards diseases for ATP5PO Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hashimoto thyroiditis
  • ht
acute thyroiditis
graves' disease
  • toxic diffuse goiter
goiter
  • goitre
nontoxic goiter
  • goiter, non-toxic
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ATP5PO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATP5PO Gene

Publications for ATP5PO Gene

  1. Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2. (PMID: 7490082) Chen H … Antonarakis SE (Genomics 1995) 2 3 4 23
  2. Genetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins. (PMID: 19274082) Rönn T … Ling C (PloS one 2009) 3 23
  3. IF(1) distribution in HepG2 cells in relation to ecto-F(0)F (1)ATPsynthase and calmodulin. (PMID: 17851741) Contessi S … Mavelli I (Journal of bioenergetics and biomembranes 2007) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ATP5PO Gene

Sources for ATP5PO Gene