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Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15. [provided by RefSeq, Jun 2010]
ATP5PD (ATP Synthase Peripheral Stalk Subunit D) is a Protein Coding gene. Diseases associated with ATP5PD include Dystonia 11, Myoclonic and Alzheimer Disease. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Parkinson disease.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 19688755 |
GO:0015078 | proton transmembrane transporter activity | IEA | -- |
GO:0046933 | contributes_to proton-transporting ATP synthase activity, rotational mechanism | IDA | 12110673 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000274 | mitochondrial proton-transporting ATP synthase, stator stalk | IBA | 21873635 |
GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) | IEA | -- |
GO:0005739 | mitochondrion | IEA,IDA | -- |
GO:0005743 | mitochondrial inner membrane | TAS | -- |
GO:0005753 | mitochondrial proton-transporting ATP synthase complex | IDA | 12110673 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006754 | ATP biosynthetic process | TAS | -- |
GO:0006811 | ion transport | IEA | -- |
GO:0015986 | ATP synthesis coupled proton transport | IEA,IBA | 21873635 |
GO:0042407 | cristae formation | TAS | -- |
GO:0042776 | mitochondrial ATP synthesis coupled proton transport | TAS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
||
Phosphate |
|
14066-19-4, 14265-44-2 |
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This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ATP5H 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
LOC102154055 30 |
|
||||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | ATP5H 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Gm10250 31 |
|
OneToMany | |
Atp5h 30 17 31 |
|
OneToMany | |||
Gm4953 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Atp5h 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | ATP5H 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ATP5H 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ATP5H 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | atp5h 30 |
|
||
Str.1257 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.23901 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | atp5h 30 31 |
|
OneToOne | |
zgc73071 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8409 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011131 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | ATPsyn-d 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ATP7 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7968 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1720628 | CNV | deletion | 17803354 |
esv2566082 | CNV | deletion | 19546169 |
esv2716235 | CNV | deletion | 23290073 |
esv3554781 | CNV | deletion | 23714750 |
esv3893044 | CNV | loss | 25118596 |
nsv112456 | CNV | deletion | 16902084 |
Disorder | Aliases | PubMed IDs |
---|---|---|
dystonia 11, myoclonic |
|
|
alzheimer disease |
|
|
amyotrophic lateral sclerosis 1 |
|
|