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Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15. [provided by RefSeq, Jun 2010]
ATP5PD (ATP Synthase Peripheral Stalk Subunit D) is a Protein Coding gene. Diseases associated with ATP5PD include Dystonia 11, Myoclonic and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Pathways of neurodegeneration - multiple diseases and Prion disease.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 19688755 |
GO:0015078 | proton transmembrane transporter activity | IEA | -- |
GO:0044877 | protein-containing complex binding | IEA | -- |
GO:0046933 | contributes_to proton-transporting ATP synthase activity, rotational mechanism | IDA | 12110673 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000274 | mitochondrial proton-transporting ATP synthase, stator stalk | IBA | 21873635 |
GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) | IEA | -- |
GO:0005739 | mitochondrion | IEA,IDA | -- |
GO:0005743 | mitochondrial inner membrane | IEA,TAS | -- |
GO:0005753 | mitochondrial proton-transporting ATP synthase complex | IDA | 12110673 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
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2 | Pathways of neurodegeneration - multiple diseases | ||
3 | purine nucleotides de novo biosynthesis | ||
4 | Metabolism |
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5 | Prion disease |
.55
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006754 | ATP biosynthetic process | TAS | -- |
GO:0006811 | ion transport | IEA | -- |
GO:0015986 | ATP synthesis coupled proton transport | IEA,IBA | 21873635 |
GO:0042407 | cristae formation | TAS | -- |
GO:0042776 | mitochondrial ATP synthesis coupled proton transport | TAS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
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58-64-0 |
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This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ATP5H 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
LOC102154055 30 |
|
||||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | ATP5H 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Gm10250 31 |
|
OneToMany | |
Atp5h 30 17 31 |
|
OneToMany | |||
Gm4953 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Atp5h 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | ATP5H 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ATP5H 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ATP5H 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | atp5h 30 |
|
||
Str.1257 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.23901 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | atp5h 30 31 |
|
OneToOne | |
zgc73071 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8409 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011131 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | ATPsyn-d 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ATP7 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7968 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1720628 | CNV | deletion | 17803354 |
esv2566082 | CNV | deletion | 19546169 |
esv2716235 | CNV | deletion | 23290073 |
esv3554781 | CNV | deletion | 23714750 |
esv3893044 | CNV | loss | 25118596 |
nsv112456 | CNV | deletion | 16902084 |
Disorder | Aliases | PubMed IDs |
---|---|---|
dystonia 11, myoclonic |
|
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amyotrophic lateral sclerosis 1 |
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