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This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. [provided by RefSeq, Jul 2008]
ATP5PB (ATP Synthase Peripheral Stalk-Membrane Subunit B) is a Protein Coding gene. Diseases associated with ATP5PB include Huntington Disease and Alzheimer Disease. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Parkinson disease.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 19016746 |
GO:0015078 | proton transmembrane transporter activity | IEA | -- |
GO:0046933 | contributes_to proton-transporting ATP synthase activity, rotational mechanism | IDA | 12110673 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) | IEA,IBA | 21873635 |
GO:0005634 | nucleus | HDA | 21630459 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005739 | mitochondrion | IDA | -- |
GO:0005743 | mitochondrial inner membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
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2 | Parkinson disease | ||
3 | Metabolism |
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4 | Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006754 | ATP biosynthetic process | TAS | -- |
GO:0006811 | ion transport | IEA | -- |
GO:0015986 | ATP synthesis coupled proton transport | IEA,IBA | 21873635 |
GO:0021762 | substantia nigra development | HEP | 22926577 |
GO:0042407 | cristae formation | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Clotrimazole | Approved, Vet_approved | Pharma | Pore Blocker, Inhibition, Agonist, Antagonist, Channel blocker, Gating inhibitor | 3024 | ||
Water | Approved | Pharma | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
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Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
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Phosphate |
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14066-19-4, 14265-44-2 |
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This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ATP5F1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ATP5F1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LOC479901 30 |
|
||
ATP5F1 31 |
|
OneToOne | |||
Mouse (Mus musculus) |
Mammalia | Atp5f1 30 31 |
|
OneToOne | |
Atp5pb 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Atp5f1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ATP5F1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ATP5F1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ATP5F1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ATP5F1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | atp5f1 30 |
|
||
MGC75766 30 |
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African clawed frog (Xenopus laevis) |
Amphibia | Xl.9224 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | atp5f1 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9026 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | ATPsyn-b 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001138 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | asb-2 31 |
|
OneToMany | |
asb-1 31 |
|
OneToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ATP4 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7988 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1264895 | -. - | p.Thr152Asnp.Thr152Met |
Disorder | Aliases | PubMed IDs |
---|---|---|
huntington disease |
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alzheimer disease |
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