Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATP5PB Gene

Aliases for ATP5PB Gene

  • ATP Synthase Peripheral Stalk-Membrane Subunit B 2 3 5
  • ATP Synthase Proton-Transporting Mitochondrial F(0) Complex Subunit B1 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit B1 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit B1 2 3
  • ATPase Subunit B 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit B, Isoform 1 2
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit B1 2
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit B 3
  • ATP Synthase F(0) Complex Subunit B1, Mitochondrial 3
  • Cell Proliferation-Inducing Protein 47 3
  • ATP Synthase Subunit B, Mitochondrial 3
  • ATP Synthase B Chain, Mitochondrial 3
  • H+-ATP Synthase Subunit B 3
  • ATP Synthase Subunit B 4
  • ATP5F1 3
  • PIG47 3

External Ids for ATP5PB Gene

Previous HGNC Symbols for ATP5PB Gene

  • ATP5F1

Summaries for ATP5PB Gene

Entrez Gene Summary for ATP5PB Gene

  • This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP5PB Gene

ATP5PB (ATP Synthase Peripheral Stalk-Membrane Subunit B) is a Protein Coding gene. Among its related pathways are Metabolism and Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics.

UniProtKB/Swiss-Prot for ATP5PB Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Gene Wiki entry for ATP5PB Gene

Additional gene information for ATP5PB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5PB Gene

Genomics for ATP5PB Gene

GeneHancer (GH) Regulatory Elements for ATP5PB Gene

Promoters and enhancers for ATP5PB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J111445 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -0.6 -578 4.9 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ATP5PB ENSG00000199890 GC01P111447 GC01P111450 GC01P111451 PIR44385 WDR77 OVGP1 ENSG00000260948 DENND2D
GH01J111618 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 +171.7 171747 4.6 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 SLC30A9 POLR2B ZNF766 ZNF213 RAP1A ENSG00000243960 CEPT1 KRT18P57 RNU6-151P ATP5PB WDR77 INKA2 UBE2FP3 LINC01160
GH01J111212 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 -227.1 -227117 19.3 HDGF PKNOX1 FOXA2 SMAD1 FEZF1 YBX1 ZNF2 IRF4 YY1 ZNF213 CHI3L2 DDX20 LOC105378903 ENSG00000232240 PIFO WDR77 ATP5PB OVGP1 DENND2D CEPT1
GH01J111615 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.5 +167.5 167475 2.2 HDGF PKNOX1 SMAD1 RB1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 RAP1A RNU6-151P KRT18P57 WDR77 ATP5PB UBE2FP3 PIFO LINC01160 GC01P111550
GH01J111469 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 11.4 +22.5 22545 3 HDGF PKNOX1 EBF1 SP1 NFIC TARDBP IKZF1 ZFP91 HMBOX1 ZNF24 ENSG00000260948 RAP1A WDR77 ATP5PB OVGP1 INKA2 C1orf162 RNU6-792P GC01M111493
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ATP5PB on UCSC Golden Path with GeneCards custom track

Genomic Locations for ATP5PB Gene

Genomic Locations for ATP5PB Gene
chr1:111,448,864-111,462,773
(GRCh38/hg38)
Size:
13,910 bases
Orientation:
Plus strand
chr1:111,991,486-112,005,395
(GRCh37/hg19)

Genomic View for ATP5PB Gene

Genes around ATP5PB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5PB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5PB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5PB Gene

Proteins for ATP5PB Gene

  • Protein details for ATP5PB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24539-AT5F1_HUMAN
    Recommended name:
    ATP synthase F(0) complex subunit B1, mitochondrial
    Protein Accession:
    P24539
    Secondary Accessions:
    • Q9BQ68
    • Q9BRU8

    Protein attributes for ATP5PB Gene

    Size:
    256 amino acids
    Molecular mass:
    28909 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

neXtProt entry for ATP5PB Gene

Post-translational modifications for ATP5PB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5PB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP5PB Gene

Domains & Families for ATP5PB Gene

Gene Families for ATP5PB Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for ATP5PB Gene

Suggested Antigen Peptide Sequences for ATP5PB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24539

UniProtKB/Swiss-Prot:

AT5F1_HUMAN :
  • Belongs to the eukaryotic ATPase B chain family.
Family:
  • Belongs to the eukaryotic ATPase B chain family.
genes like me logo Genes that share domains with ATP5PB: view

Function for ATP5PB Gene

Molecular function for ATP5PB Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Phenotypes From GWAS Catalog for ATP5PB Gene

Gene Ontology (GO) - Molecular Function for ATP5PB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19016746
GO:0015078 proton transmembrane transporter activity IEA --
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0022857 transmembrane transporter activity IC 12110673
GO:0046933 contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA --
genes like me logo Genes that share ontologies with ATP5PB: view
genes like me logo Genes that share phenotypes with ATP5PB: view

Animal Models for ATP5PB Gene

MGI Knock Outs for ATP5PB:
  • Atp5f1 Atp5f1<tm1b(EUCOMM)Wtsi>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP5PB Gene

Localization for ATP5PB Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5PB Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5PB gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATP5PB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA --
GO:0005634 nucleus HDA 21630459
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with ATP5PB: view

Pathways & Interactions for ATP5PB Gene

genes like me logo Genes that share pathways with ATP5PB: view

Gene Ontology (GO) - Biological Process for ATP5PB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process TAS --
GO:0006811 ion transport IEA --
GO:0015986 ATP synthesis coupled proton transport IEA,IBA --
GO:0021762 substantia nigra development HEP 22926577
GO:0042407 cristae formation TAS --
genes like me logo Genes that share ontologies with ATP5PB: view

No data available for SIGNOR curated interactions for ATP5PB Gene

Drugs & Compounds for ATP5PB Gene

(3) Drugs for ATP5PB Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clotrimazole Approved, Vet_approved Pharma Inhibition, Pore Blocker, Antagonist, Agonist, Channel blocker, Gating inhibitor 38
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(2) Additional Compounds for ATP5PB Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14265-44-2
genes like me logo Genes that share compounds with ATP5PB: view

Transcripts for ATP5PB Gene

mRNA/cDNA for ATP5PB Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5PB Gene

No ASD Table

Relevant External Links for ATP5PB Gene

GeneLoc Exon Structure for
ATP5PB
ECgene alternative splicing isoforms for
ATP5PB

Expression for ATP5PB Gene

NURSA nuclear receptor signaling pathways regulating expression of ATP5PB Gene:

ATP5PB

Evidence on tissue expression from TISSUES for ATP5PB Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Skin(3.7)
  • Lung(3.6)
  • Kidney(3.4)
  • Muscle(3.1)
  • Heart(2.8)
  • Stomach(2.5)
  • Eye(2.2)
  • Intestine(2.1)
  • Spleen(2.1)
  • Adrenal gland(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP5PB Gene

Orthologs for ATP5PB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP5PB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5F1 34 33
  • 99.74 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ATP5F1 34 33
  • 88.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC479901 33
  • 85.94 (n)
ATP5F1 34
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp5f1 16 34 33
  • 84.77 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911417 33
  • 84.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5F1 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP5F1 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP5F1 34 33
  • 66.4 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP5F1 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5f1 33
  • 63.71 (n)
MGC75766 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.9224 33
zebrafish
(Danio rerio)
Actinopterygii atp5f1 34 33
  • 60.24 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9026 33
fruit fly
(Drosophila melanogaster)
Insecta ATPsyn-b 34 33
  • 53.37 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001138 33
  • 49.72 (n)
worm
(Caenorhabditis elegans)
Secernentea asb-2 34
  • 18 (a)
OneToMany
asb-1 34
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP4 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7988 34
  • 27 (a)
OneToOne
Species where no ortholog for ATP5PB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP5PB Gene

ENSEMBL:
Gene Tree for ATP5PB (if available)
TreeFam:
Gene Tree for ATP5PB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATP5PB: view image

Paralogs for ATP5PB Gene

No data available for Paralogs for ATP5PB Gene

Variants for ATP5PB Gene

Sequence variations from dbSNP and Humsavar for ATP5PB Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000008481 -- 111,454,456(+) G/A intron_variant
rs1000076570 -- 111,452,640(+) C/T intron_variant
rs1000095505 -- 111,461,111(+) A/T 3_prime_UTR_variant
rs1000142370 -- 111,448,548(+) C/G upstream_transcript_variant
rs1000195140 -- 111,448,116(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ATP5PB Gene

Variant ID Type Subtype PubMed ID
esv3451263 CNV insertion 20981092
nsv463250 CNV loss 19166990
nsv547535 CNV loss 21841781
nsv946140 CNV duplication 23825009

Variation tolerance for ATP5PB Gene

Residual Variation Intolerance Score: 28.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATP5PB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5PB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5PB Gene

Disorders for ATP5PB Gene

Additional Disease Information for ATP5PB

No disorders were found for ATP5PB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5PB Gene

Publications for ATP5PB Gene

  1. Molecular cloning of cDNA for the import precursor of human subunit B of H(+)-ATP synthase in mitochondria. (PMID: 1831354) Higuti T … Ichihara A (Biochemical and biophysical research communications 1991) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58

Products for ATP5PB Gene

Sources for ATP5PB Gene

Content
Loading form....