Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, ... See more...

Aliases for ATP5MG Gene

Aliases for ATP5MG Gene

  • ATP Synthase Membrane Subunit G 2 3 4 5
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit G 2 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit G 2 3
  • ATP Synthase Subunit G, Mitochondrial 3 4
  • ATPase Subunit G 3 4
  • ATP5L 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit G 2
  • ATP Synthase, H+ Transporting, Mitochondrial F1F0, Subunit G 3
  • F1Fo-ATP Synthase Complex Fo Membrane Domain G Subunit 3
  • ATP Synthase G Chain, Mitochondrial 3
  • F1F0-Type ATP Synthase Subunit G 3
  • ATP5JG 3

External Ids for ATP5MG Gene

Previous HGNC Symbols for ATP5MG Gene

  • ATP5L

Summaries for ATP5MG Gene

Entrez Gene Summary for ATP5MG Gene

  • Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

GeneCards Summary for ATP5MG Gene

ATP5MG (ATP Synthase Membrane Subunit G) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and purine nucleotides de novo biosynthesis. An important paralog of this gene is ATP5MGL.

UniProtKB/Swiss-Prot Summary for ATP5MG Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Wiki entry for ATP5MG Gene

Additional gene information for ATP5MG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATP5MG Gene

Genomics for ATP5MG Gene

GeneHancer (GH) Regulatory Elements for ATP5MG Gene

Promoters and enhancers for ATP5MG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATP5MG on UCSC Golden Path with GeneCards custom track

Genomic Locations for ATP5MG Gene

Genomic Locations for ATP5MG Gene
chr11:118,401,389-118,431,496
(GRCh38/hg38)
Size:
30,108 bases
Orientation:
Plus strand
chr11:118,271,869-118,302,211
(GRCh37/hg19)
Size:
30,343 bases
Orientation:
Plus strand

Genomic View for ATP5MG Gene

Genes around ATP5MG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5MG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5MG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5MG Gene

Proteins for ATP5MG Gene

  • Protein details for ATP5MG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75964-ATP5L_HUMAN
    Recommended name:
    ATP synthase subunit g, mitochondrial
    Protein Accession:
    O75964
    Secondary Accessions:
    • A8K0K3
    • Q96BV6
    • Q9UBZ7

    Protein attributes for ATP5MG Gene

    Size:
    103 amino acids
    Molecular mass:
    11428 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MD and ATP5MPL (By similarity).

neXtProt entry for ATP5MG Gene

Post-translational modifications for ATP5MG Gene

  • Ubiquitination at Lys24 and Lys66
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP5MG Gene

No data available for DME Specific Peptides for ATP5MG Gene

Domains & Families for ATP5MG Gene

Gene Families for ATP5MG Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ATP5MG Gene

Suggested Antigen Peptide Sequences for ATP5MG Gene

GenScript: Design optimal peptide antigens:
  • ATP synthase subunit g, mitochondrial (ATP5L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75964

UniProtKB/Swiss-Prot:

ATP5L_HUMAN :
  • Belongs to the ATPase g subunit family.
Family:
  • Belongs to the ATPase g subunit family.
genes like me logo Genes that share domains with ATP5MG: view

Function for ATP5MG Gene

Molecular function for ATP5MG Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Phenotypes From GWAS Catalog for ATP5MG Gene

Gene Ontology (GO) - Molecular Function for ATP5MG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015078 proton transmembrane transporter activity IEA --
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0022857 transmembrane transporter activity IC 12110673
GO:0046933 contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA 21873635
genes like me logo Genes that share ontologies with ATP5MG: view
genes like me logo Genes that share phenotypes with ATP5MG: view

Animal Models for ATP5MG Gene

MGI Knock Outs for ATP5MG:
  • Atp5l Atp5l<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for ATP5MG Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATP5MG

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP5MG Gene

Localization for ATP5MG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5MG Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5MG gene
Compartment Confidence
mitochondrion 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATP5MG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA 21873635
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex IDA 12110673
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ATP5MG: view

Pathways & Interactions for ATP5MG Gene

genes like me logo Genes that share pathways with ATP5MG: view

Gene Ontology (GO) - Biological Process for ATP5MG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process TAS --
GO:0006811 ion transport IEA --
GO:0015986 ATP synthesis coupled proton transport IBA,IEA 21873635
GO:0042407 cristae formation TAS --
GO:0042776 mitochondrial ATP synthesis coupled proton transport TAS --
genes like me logo Genes that share ontologies with ATP5MG: view

No data available for SIGNOR curated interactions for ATP5MG Gene

Drugs & Compounds for ATP5MG Gene

(2) Drugs for ATP5MG Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Experimental, Investigational Pharma Target, ligand 108
Phenethyl isothiocyanate Investigational Pharma Target 14
genes like me logo Genes that share compounds with ATP5MG: view

Transcripts for ATP5MG Gene

mRNA/cDNA for ATP5MG Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATP5MG

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5MG Gene

No ASD Table

Relevant External Links for ATP5MG Gene

GeneLoc Exon Structure for
ATP5MG
ECgene alternative splicing isoforms for
ATP5MG

Expression for ATP5MG Gene

NURSA nuclear receptor signaling pathways regulating expression of ATP5MG Gene:

ATP5MG

Evidence on tissue expression from TISSUES for ATP5MG Gene

  • Nervous system(4.8)
  • Blood(4.5)
  • Kidney(4.5)
  • Liver(4.5)
  • Lung(4.5)
  • Heart(2.8)
  • Spleen(2.4)
  • Intestine(2.3)
  • Muscle(2.3)
  • Adrenal gland(2)
  • Lymph node(2)
  • Pancreas(2)
  • Stomach(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP5MG Gene

Orthologs for ATP5MG Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP5MG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5L 33 32
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ATP5L 32
  • 92.56 (n)
-- 33
  • 88 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ATP5L 33 32
  • 91.26 (n)
ManyToMany
-- 33
  • 91 (a)
ManyToMany
-- 33
  • 91 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Atp5l 17 33 32
  • 87.7 (n)
Gm10221 33
  • 83 (a)
ManyToMany
Atp5l-ps1 33
  • 80 (a)
ManyToMany
Gm5426 33
  • 76 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Atp5l 32
  • 86.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves ATP5L 32
  • 74.81 (n)
-- 33
  • 65 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5l 32
  • 66.02 (n)
Str.2477 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.23932 32
zebrafish
(Danio rerio)
Actinopterygii atp5l 33 32
  • 67.31 (n)
OneToMany
mgbb02g11 32
fruit fly
(Drosophila melanogaster)
Insecta l(2)06225 33 32
  • 57.39 (n)
ManyToMany
CG7211 33
  • 42 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009491 32
  • 51.2 (n)
Species where no ortholog for ATP5MG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5MG Gene

ENSEMBL:
Gene Tree for ATP5MG (if available)
TreeFam:
Gene Tree for ATP5MG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATP5MG: view image

Paralogs for ATP5MG Gene

Paralogs for ATP5MG Gene

genes like me logo Genes that share paralogs with ATP5MG: view

Variants for ATP5MG Gene

Sequence variations from dbSNP and Humsavar for ATP5MG Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000696808 -- 118,401,075(+) G/A upstream_transcript_variant
rs1001185452 -- 118,408,510(+) A/G intron_variant
rs1001672645 -- 118,408,192(+) G/C intron_variant
rs1003402595 -- 118,403,240(+) A/C/G intron_variant
rs1003455491 -- 118,402,890(+) G/A intron_variant

Variation tolerance for ATP5MG Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATP5MG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5MG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ATP5MG Gene

Disorders for ATP5MG Gene

Additional Disease Information for ATP5MG

No disorders were found for ATP5MG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5MG Gene

Publications for ATP5MG Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 56
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56
  5. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3 56

Products for ATP5MG Gene

Sources for ATP5MG Gene