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Aliases for ATP5MG Gene

Aliases for ATP5MG Gene

  • ATP Synthase Membrane Subunit G 2 3 5
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit G 2 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit G 2 3
  • ATPase Subunit G 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit G 2
  • ATP Synthase, H+ Transporting, Mitochondrial F1F0, Subunit G 3
  • F1Fo-ATP Synthase Complex Fo Membrane Domain G Subunit 3
  • ATP Synthase Subunit G, Mitochondrial 3
  • ATP Synthase G Chain, Mitochondrial 3
  • F1F0-Type ATP Synthase Subunit G 3
  • ATP5JG 3
  • ATP5L 3

External Ids for ATP5MG Gene

Previous HGNC Symbols for ATP5MG Gene

  • ATP5L

Summaries for ATP5MG Gene

Entrez Gene Summary for ATP5MG Gene

  • Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

GeneCards Summary for ATP5MG Gene

ATP5MG (ATP Synthase Membrane Subunit G) is a Protein Coding gene. Among its related pathways are Metabolism and purine nucleotides de novo biosynthesis. An important paralog of this gene is ATP5MGL.

UniProtKB/Swiss-Prot for ATP5MG Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Wiki entry for ATP5MG Gene

Additional gene information for ATP5MG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5MG Gene

Genomics for ATP5MG Gene

GeneHancer (GH) Regulatory Elements for ATP5MG Gene

Promoters and enhancers for ATP5MG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J118398 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.4 -355 5.1 CLOCK FOXA2 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B YY1 POLR2B ATP5MG ENSG00000254873 ARCN1 RNF26 ENSG00000254909 ENSG00000254428 RPL23AP64 UBE4A IFT46 TMEM25
GH11J118433 Promoter/Enhancer 2.7 VISTA EPDnew Ensembl ENCODE dbSUPER 10.6 +36.9 36934 8.2 CLOCK ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 KMT2A VPS11 HINFP ARCN1 TMEM25 CCDC84 IFT46 UBE4A THY1 BCL9L
GH11J118603 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.4 +207.5 207474 9.9 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF207 ZNF143 FOS PHLDB1 IFT46 TREHP1 KMT2A VPS11 LOC105369519 HINFP CCDC84 TREH SETP16
GH11J118614 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 9.4 +218.2 218216 9.2 HDGF PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B NEUROD1 SIN3A YBX1 TREHP1 LOC105369519 TREH KMT2A IFT46 MPZL2 RNU6-1157P ARCN1 RPL5P30 ENSG00000255384
GH11J118442 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.9 +42.1 42085 1.1 BACH1 EBF1 BMI1 BATF IRF4 RELA ZFHX2 GATA3 EED ATF7 ENSG00000254873 ATP5MG TMEM25 LOC101929089 TTC36 KMT2A GC11M118474
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ATP5MG on UCSC Golden Path with GeneCards custom track

Genomic Locations for ATP5MG Gene

Genomic Locations for ATP5MG Gene
chr11:118,401,154-118,431,496
(GRCh38/hg38)
Size:
30,343 bases
Orientation:
Plus strand
chr11:118,271,869-118,302,211
(GRCh37/hg19)

Genomic View for ATP5MG Gene

Genes around ATP5MG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5MG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5MG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5MG Gene

Proteins for ATP5MG Gene

  • Protein details for ATP5MG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75964-ATP5L_HUMAN
    Recommended name:
    ATP synthase subunit g, mitochondrial
    Protein Accession:
    O75964
    Secondary Accessions:
    • A8K0K3
    • Q96BV6
    • Q9UBZ7

    Protein attributes for ATP5MG Gene

    Size:
    103 amino acids
    Molecular mass:
    11428 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

neXtProt entry for ATP5MG Gene

Post-translational modifications for ATP5MG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5MG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP5MG Gene

Domains & Families for ATP5MG Gene

Gene Families for ATP5MG Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ATP5MG Gene

Suggested Antigen Peptide Sequences for ATP5MG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75964

UniProtKB/Swiss-Prot:

ATP5L_HUMAN :
  • Belongs to the ATPase g subunit family.
Family:
  • Belongs to the ATPase g subunit family.
genes like me logo Genes that share domains with ATP5MG: view

Function for ATP5MG Gene

Molecular function for ATP5MG Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Phenotypes From GWAS Catalog for ATP5MG Gene

Gene Ontology (GO) - Molecular Function for ATP5MG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015078 proton transmembrane transporter activity IEA --
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0022857 transmembrane transporter activity IC 12110673
GO:0046933 contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA --
genes like me logo Genes that share ontologies with ATP5MG: view
genes like me logo Genes that share phenotypes with ATP5MG: view

Animal Models for ATP5MG Gene

MGI Knock Outs for ATP5MG:
  • Atp5l Atp5l<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for ATP5MG Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATP5MG

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP5MG Gene

Localization for ATP5MG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5MG Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5MG gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATP5MG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex IDA 12110673
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ATP5MG: view

Pathways & Interactions for ATP5MG Gene

genes like me logo Genes that share pathways with ATP5MG: view

Gene Ontology (GO) - Biological Process for ATP5MG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process TAS --
GO:0006811 ion transport IEA --
GO:0015986 ATP synthesis coupled proton transport IBA,IEA --
GO:0042407 cristae formation TAS --
GO:0042776 mitochondrial ATP synthesis coupled proton transport TAS --
genes like me logo Genes that share ontologies with ATP5MG: view

No data available for SIGNOR curated interactions for ATP5MG Gene

Drugs & Compounds for ATP5MG Gene

(2) Drugs for ATP5MG Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Approved, Investigational Pharma Target, ligand 100
Phenethyl isothiocyanate Investigational Pharma Target 12
genes like me logo Genes that share compounds with ATP5MG: view

Transcripts for ATP5MG Gene

mRNA/cDNA for ATP5MG Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATP5MG

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5MG Gene

No ASD Table

Relevant External Links for ATP5MG Gene

GeneLoc Exon Structure for
ATP5MG
ECgene alternative splicing isoforms for
ATP5MG

Expression for ATP5MG Gene

NURSA nuclear receptor signaling pathways regulating expression of ATP5MG Gene:

ATP5MG

Evidence on tissue expression from TISSUES for ATP5MG Gene

  • Nervous system(4.8)
  • Blood(4.5)
  • Kidney(4.5)
  • Liver(4.5)
  • Lung(4.5)
  • Heart(2.8)
  • Spleen(2.4)
  • Intestine(2.3)
  • Muscle(2.3)
  • Adrenal gland(2)
  • Lymph node(2)
  • Pancreas(2)
  • Stomach(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP5MG Gene

Orthologs for ATP5MG Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP5MG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5L 34 33
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ATP5L 33
  • 92.56 (n)
-- 34
  • 88 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ATP5L 34 33
  • 91.26 (n)
ManyToMany
-- 34
  • 91 (a)
ManyToMany
-- 34
  • 91 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Atp5l 16 34 33
  • 87.7 (n)
Gm10221 34
  • 83 (a)
ManyToMany
Atp5l-ps1 34
  • 80 (a)
ManyToMany
Gm5426 34
  • 76 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Atp5l 33
  • 86.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves ATP5L 33
  • 74.81 (n)
-- 34
  • 65 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia atp5l 33
  • 66.02 (n)
Str.2477 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23932 33
zebrafish
(Danio rerio)
Actinopterygii atp5l 34 33
  • 67.31 (n)
OneToMany
mgbb02g11 33
fruit fly
(Drosophila melanogaster)
Insecta l(2)06225 34 33
  • 57.39 (n)
ManyToMany
CG7211 34
  • 42 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009491 33
  • 51.2 (n)
Species where no ortholog for ATP5MG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5MG Gene

ENSEMBL:
Gene Tree for ATP5MG (if available)
TreeFam:
Gene Tree for ATP5MG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATP5MG: view image

Paralogs for ATP5MG Gene

Paralogs for ATP5MG Gene

genes like me logo Genes that share paralogs with ATP5MG: view

Variants for ATP5MG Gene

Sequence variations from dbSNP and Humsavar for ATP5MG Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000696808 -- 118,401,075(+) G/A upstream_transcript_variant
rs1001185452 -- 118,408,510(+) A/G intron_variant
rs1001672645 -- 118,408,192(+) G/C intron_variant
rs1003402595 -- 118,403,240(+) A/C/G intron_variant
rs1003455491 -- 118,402,890(+) G/A intron_variant

Variation tolerance for ATP5MG Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATP5MG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5MG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ATP5MG Gene

Disorders for ATP5MG Gene

No disorders were found for ATP5MG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for ATP5MG Gene

Publications for ATP5MG Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. miR-570 interacts with mitochondrial ATPase subunit g (ATP5L) encoding mRNA in stored platelets. (PMID: 27561077) Dahiya N … Atreya CD (Platelets 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ATP5MG Gene

Sources for ATP5MG Gene

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