Aliases for ATP5MF Gene
- ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit F, Isoform 2 2
- ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit F2 2
- ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit F2 2
- ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit F 3
- ATP Synthase Subunit F, Mitochondrial 3
- F1F0-Type ATPase Subunit F 3
Previous HGNC Symbols for ATP5MF Gene
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The catalytic portion of mitochondrial ATP synthase consists of five different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has multiple pseudogenes. Naturally occurring read-through transcription also exists between this gene and the downstream pentatricopeptide repeat domain 1 (PTCD1) gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for ATP5MF Gene
ATP5MF (ATP Synthase Membrane Subunit F) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism.
UniProtKB/Swiss-Prot for ATP5MF Gene
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.