Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, ... See more...

Aliases for ATP5ME Gene

Aliases for ATP5ME Gene

  • ATP Synthase Membrane Subunit E 2 3 4 5
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit E 2 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit E 2 3
  • ATP Synthase Subunit E, Mitochondrial 3 4
  • ATPase Subunit E 3 4
  • ATP5I 3 4
  • ATP5K 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit E 2
  • ATP Synthase E Chain, Mitochondrial 3
  • F1F0-ATP Synthase, Murine E Subunit 3
  • ATP5ME 5

External Ids for ATP5ME Gene

Previous HGNC Symbols for ATP5ME Gene

  • ATP5I

Previous GeneCards Identifiers for ATP5ME Gene

  • GC04M000673
  • GC04M000677

Summaries for ATP5ME Gene

Entrez Gene Summary for ATP5ME Gene

  • Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

GeneCards Summary for ATP5ME Gene

ATP5ME (ATP Synthase Membrane Subunit E) is a Protein Coding gene. Diseases associated with ATP5ME include Complex Partial Epilepsy. Among its related pathways are purine nucleotides de novo biosynthesis and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

UniProtKB/Swiss-Prot Summary for ATP5ME Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Wiki entry for ATP5ME Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATP5ME Gene

Genomics for ATP5ME Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ATP5ME Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J000673 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 -3.2 -3171 9.4 BCLAF1 SP1 ZNF207 MYC ZNF600 JUND ZNF580 ZNF592 ATF2 KLF9 ATP5ME MYL5 PCGF3 PIGG UVSSA ENSG00000272588 ZNF718 GAK IDUA SLC49A3
GH04J000686 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 250.4 -14.3 -14346 3.9 MYC IKZF1 JUND ZNF592 CEBPA POLR2A CEBPB SMAD5 ETS1 BHLHE40 SLC49A3 HSALNG0032174 lnc-ATP5ME-4 ATP5ME PDE6B-AS1 PCGF3 GAK MYL5
GH04J000617 Enhancer 0.8 Ensembl ENCODE 11.8 +56.5 56529 0.8 ZNF217 CTBP1 MLLT1 SIN3A JUND ZBTB40 MAZ DPF2 FOS ESRRA MYL5 ATP5ME PDE6B-AS1 HSALNG0032159 PDE6B LOC105374338
GH04J000741 Enhancer 0.3 ENCODE 11.5 -66.8 -66778 0.2 MAFK CHD1 LOC107986246 PCGF3 SLC49A3 MYL5 ATP5ME lnc-MYL5-3 CPLX1
GH04J000683 Enhancer 1.1 ENCODE dbSUPER 0.4 -10.0 -9980 0.8 ZNF654 IKZF1 ZNF600 SSRP1 ZIC2 CHD4 ZBTB10 MXD4 CTCF REST HSALNG0032170 HSALNG0032171 lnc-ATP5ME-3 SLC49A3 PDE6B-AS1 ATP5ME
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATP5ME on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ATP5ME

Genomic Locations for ATP5ME Gene

Latest Assembly
chr4:672,436-674,330
(GRCh38/hg38)
Size:
1,895 bases
Orientation:
Minus strand

Previous Assembly
chr4:666,225-668,065
(GRCh37/hg19 by Entrez Gene)
Size:
1,841 bases
Orientation:
Minus strand

chr4:666,225-668,127
(GRCh37/hg19 by Ensembl)
Size:
1,903 bases
Orientation:
Minus strand

Genomic View for ATP5ME Gene

Genes around ATP5ME on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5ME Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5ME Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5ME Gene

Proteins for ATP5ME Gene

  • Protein details for ATP5ME Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56385-ATP5I_HUMAN
    Recommended name:
    ATP synthase subunit e, mitochondrial
    Protein Accession:
    P56385
    Secondary Accessions:
    • Q0D2L9

    Protein attributes for ATP5ME Gene

    Size:
    69 amino acids
    Molecular mass:
    7933 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MD and ATP5MPL (By similarity).

neXtProt entry for ATP5ME Gene

Post-translational modifications for ATP5ME Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5ME Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP5ME Gene

Domains & Families for ATP5ME Gene

Gene Families for ATP5ME Gene

Protein Domains for ATP5ME Gene

InterPro:
Blocks:
  • ATP synthase E

Suggested Antigen Peptide Sequences for ATP5ME Gene

GenScript: Design optimal peptide antigens:
  • ATP synthase subunit e, mitochondrial (ATP5I_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P56385

UniProtKB/Swiss-Prot:

ATP5I_HUMAN :
  • Belongs to the ATPase e subunit family.
Family:
  • Belongs to the ATPase e subunit family.
genes like me logo Genes that share domains with ATP5ME: view

Function for ATP5ME Gene

Molecular function for ATP5ME Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Ontology (GO) - Molecular Function for ATP5ME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0015078 proton transmembrane transporter activity IEA --
GO:0044877 protein-containing complex binding IEA --
GO:0046933 contributes_to proton-transporting ATP synthase activity, rotational mechanism IDA 12110673
genes like me logo Genes that share ontologies with ATP5ME: view
genes like me logo Genes that share phenotypes with ATP5ME: view

miRNA for ATP5ME Gene

miRTarBase miRNAs that target ATP5ME

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP5ME Gene

Localization for ATP5ME Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5ME Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5ME gene
Compartment Confidence
mitochondrion 5
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATP5ME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA --
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex IEA,IDA 12110673
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ATP5ME: view

Pathways & Interactions for ATP5ME Gene

genes like me logo Genes that share pathways with ATP5ME: view

Gene Ontology (GO) - Biological Process for ATP5ME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process TAS --
GO:0006811 ion transport IEA --
GO:0015986 ATP synthesis coupled proton transport IEA --
GO:0042407 cristae formation TAS --
GO:0042776 mitochondrial ATP synthesis coupled proton transport TAS --
genes like me logo Genes that share ontologies with ATP5ME: view

No data available for SIGNOR curated interactions for ATP5ME Gene

Drugs & Compounds for ATP5ME Gene

(4) Drugs for ATP5ME Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0
Phenethyl isothiocyanate Investigational Pharma Target 12
ATP Investigational Nutra 0

(1) Additional Compounds for ATP5ME Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with ATP5ME: view

Transcripts for ATP5ME Gene

mRNA/cDNA for ATP5ME Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5ME Gene

No ASD Table

Relevant External Links for ATP5ME Gene

GeneLoc Exon Structure for
ATP5ME

Expression for ATP5ME Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ATP5ME

Evidence on tissue expression from TISSUES for ATP5ME Gene

  • Liver(4.8)
  • Nervous system(4.5)
  • Kidney(4.5)
  • Muscle(3.1)
  • Heart(3.1)
  • Skin(2.5)
  • Bone marrow(2.4)
  • Intestine(2.4)
  • Adrenal gland(2.3)
  • Stomach(2.2)
  • Lymph node(2)
  • Spleen(2)
No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP5ME Gene

Orthologs for ATP5ME Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATP5ME Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ATP5I 29 30
  • 99.52 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ATP5I 30
  • 86 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ATP5I 30
  • 86 (a)
OneToMany
-- 30
  • 82 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Atp5k 30
  • 85 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 73 (a)
OneToMany
-- 30
  • 68 (a)
OneToMany
-- 30
  • 65 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia ATP5I 30
  • 21 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RBF 30
  • 73 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ATP5I 30
  • 73 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii atp5ib 30
  • 65 (a)
OneToMany
atp5ia 30
  • 62 (a)
OneToMany
Species where no ortholog for ATP5ME was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ATP5ME Gene

ENSEMBL:
Gene Tree for ATP5ME (if available)
TreeFam:
Gene Tree for ATP5ME (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATP5ME: view image
Alliance of Genome Resources:
Additional Orthologs for ATP5ME

Paralogs for ATP5ME Gene

No data available for Paralogs for ATP5ME Gene

Variants for ATP5ME Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ATP5ME Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ATP5ME Gene

Variant ID Type Subtype PubMed ID
esv2759217 CNV loss 17122850
nsv10413 CNV gain 18304495
nsv508986 CNV insertion 20534489
nsv593206 CNV loss 21841781
nsv593208 CNV loss 21841781
nsv822425 CNV loss 20364138
nsv829834 CNV loss 17160897
nsv950325 CNV deletion 24416366

Variation tolerance for ATP5ME Gene

Residual Variation Intolerance Score: 59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATP5ME Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5ME
Leiden Open Variation Database (LOVD)
ATP5ME

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ATP5ME Gene

Disorders for ATP5ME Gene

MalaCards: The human disease database

(1) MalaCards diseases for ATP5ME Gene - From: COP

Disorder Aliases PubMed IDs
complex partial epilepsy
  • complex partial epileptic seizure
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ATP5ME

genes like me logo Genes that share disorders with ATP5ME: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATP5ME Gene

Publications for ATP5ME Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. The e subunit gene of murine F1F0-ATP synthase. Genomic sequence, chromosomal mapping, and diet regulation. (PMID: 8702853) Swartz DA … Kaput J (The Journal of biological chemistry 1996) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. (PMID: 32203420) Müller PM … Rocks O (Nature cell biology 2020) 3
  5. A High-Density Human Mitochondrial Proximity Interaction Network. (PMID: 32877691) Antonicka H … Shoubridge EA (Cell metabolism 2020) 3

Products for ATP5ME Gene

Sources for ATP5ME Gene