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Aliases for ATP5ME Gene

Aliases for ATP5ME Gene

  • ATP Synthase Membrane Subunit E 2 3 5
  • ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit E 2 2 3
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit E 2 3
  • ATPase Subunit E 3 4
  • ATP5K 3 4
  • ATP Synthase, H+ Transporting, Mitochondrial Fo Complex, Subunit E 2
  • ATP Synthase Subunit E, Mitochondrial 3
  • ATP Synthase E Chain, Mitochondrial 3
  • F1F0-ATP Synthase, Murine E Subunit 3
  • ATP5I 3

External Ids for ATP5ME Gene

Previous HGNC Symbols for ATP5ME Gene

  • ATP5I

Summaries for ATP5ME Gene

Entrez Gene Summary for ATP5ME Gene

  • Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

GeneCards Summary for ATP5ME Gene

ATP5ME (ATP Synthase Membrane Subunit E) is a Protein Coding gene. Among its related pathways are Metabolism and purine nucleotides de novo biosynthesis.

UniProtKB/Swiss-Prot for ATP5ME Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Wiki entry for ATP5ME Gene

Additional gene information for ATP5ME Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP5ME Gene

Genomics for ATP5ME Gene

GeneHancer (GH) Regulatory Elements for ATP5ME Gene

Promoters and enhancers for ATP5ME Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J000686 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.4 -14.2 -14162 3.5 HDGF PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZNF48 ETS1 POLR2B ZNF766 SLC49A3 ATP5ME LOC101928521 PCGF3 GAK MYL5 GC04M000683 GC04M000682 GC04P000669
GH04J000673 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -3.1 -3107 8.7 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZBTB7B IRF4 YY1 POLR2B ATP5ME MYL5 SLC49A3 LOC101928521 ENSG00000251188 GC04P000674 GC04M000683 GC04M000682 GC04P000669
GH04J000617 Enhancer 0.6 ENCODE 10.9 +56.5 56511 0.1 MAZ ESRRA SIN3A DPF2 ZNF217 CTBP1 TARDBP MLLT1 FOS FOSL2 ATP5ME MYL5 GC04M000604 GC04P000592 PDE6B
GH04J000741 Enhancer 0.2 ENCODE 11.5 -66.8 -66770 0.2 PCGF3 SLC49A3 MYL5 ATP5ME GC04P000749 ENSG00000248416
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATP5ME on UCSC Golden Path with GeneCards custom track

Genomic Locations for ATP5ME Gene

Genomic Locations for ATP5ME Gene
chr4:672,436-674,338
(GRCh38/hg38)
Size:
1,903 bases
Orientation:
Minus strand
chr4:666,225-668,127
(GRCh37/hg19)
Size:
1,903 bases
Orientation:
Minus strand

Genomic View for ATP5ME Gene

Genes around ATP5ME on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5ME Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5ME Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5ME Gene

Proteins for ATP5ME Gene

  • Protein details for ATP5ME Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56385-ATP5I_HUMAN
    Recommended name:
    ATP synthase subunit e, mitochondrial
    Protein Accession:
    P56385
    Secondary Accessions:
    • Q0D2L9

    Protein attributes for ATP5ME Gene

    Size:
    69 amino acids
    Molecular mass:
    7933 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).

neXtProt entry for ATP5ME Gene

Post-translational modifications for ATP5ME Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP5ME Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP5ME Gene

Domains & Families for ATP5ME Gene

Gene Families for ATP5ME Gene

Protein Domains for ATP5ME Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATP5ME Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56385

UniProtKB/Swiss-Prot:

ATP5I_HUMAN :
  • Belongs to the ATPase e subunit family.
Family:
  • Belongs to the ATPase e subunit family.
genes like me logo Genes that share domains with ATP5ME: view

Function for ATP5ME Gene

Molecular function for ATP5ME Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Ontology (GO) - Molecular Function for ATP5ME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015078 proton transmembrane transporter activity IEA --
GO:0016887 contributes_to ATPase activity IDA 12110673
GO:0022857 transmembrane transporter activity IC 12110673
genes like me logo Genes that share ontologies with ATP5ME: view
genes like me logo Genes that share phenotypes with ATP5ME: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ATP5ME Gene

Localization for ATP5ME Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5ME Gene

Mitochondrion. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5ME gene
Compartment Confidence
mitochondrion 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATP5ME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA --
GO:0005739 mitochondrion IDA,IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005753 mitochondrial proton-transporting ATP synthase complex IDA,IEA 12110673
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ATP5ME: view

Pathways & Interactions for ATP5ME Gene

genes like me logo Genes that share pathways with ATP5ME: view

Gene Ontology (GO) - Biological Process for ATP5ME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process TAS --
GO:0006811 ion transport IEA --
GO:0015986 ATP synthesis coupled proton transport IEA --
GO:0042407 cristae formation TAS --
GO:0042776 mitochondrial ATP synthesis coupled proton transport TAS --
genes like me logo Genes that share ontologies with ATP5ME: view

No data available for SIGNOR curated interactions for ATP5ME Gene

Drugs & Compounds for ATP5ME Gene

(3) Drugs for ATP5ME Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phenethyl isothiocyanate Investigational Pharma Target 12
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(2) Additional Compounds for ATP5ME Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14265-44-2
genes like me logo Genes that share compounds with ATP5ME: view

Transcripts for ATP5ME Gene

mRNA/cDNA for ATP5ME Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5ME Gene

No ASD Table

Relevant External Links for ATP5ME Gene

GeneLoc Exon Structure for
ATP5ME
ECgene alternative splicing isoforms for
ATP5ME

Expression for ATP5ME Gene

NURSA nuclear receptor signaling pathways regulating expression of ATP5ME Gene:

ATP5ME

Evidence on tissue expression from TISSUES for ATP5ME Gene

  • Liver(4.7)
  • Kidney(4.5)
  • Nervous system(4.4)
  • Heart(2.6)
  • Muscle(2.6)
  • Adrenal gland(2.3)
  • Stomach(2.2)
  • Bone marrow(2)
  • Intestine(2)
  • Lymph node(2)
  • Spleen(2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP5ME Gene

Orthologs for ATP5ME Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATP5ME Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5I 34 33
  • 99.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ATP5I 34
  • 86 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ATP5I 34
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp5k 34
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 73 (a)
OneToMany
-- 34
  • 68 (a)
OneToMany
-- 34
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ATP5I 34
  • 21 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBF 34
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP5I 34
  • 73 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii atp5ib 34
  • 65 (a)
OneToMany
atp5ia 34
  • 62 (a)
OneToMany
Species where no ortholog for ATP5ME was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5ME Gene

ENSEMBL:
Gene Tree for ATP5ME (if available)
TreeFam:
Gene Tree for ATP5ME (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATP5ME: view image

Paralogs for ATP5ME Gene

No data available for Paralogs for ATP5ME Gene

Variants for ATP5ME Gene

Sequence variations from dbSNP and Humsavar for ATP5ME Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1001512894 -- 673,541(-) A/G intron_variant
rs1001610147 -- 672,978(-) G/C intron_variant
rs1002173072 -- 673,763(-) C/A intron_variant
rs1002450535 -- 675,821(-) G/T upstream_transcript_variant
rs1003211430 -- 673,744(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ATP5ME Gene

Variant ID Type Subtype PubMed ID
esv2759217 CNV loss 17122850
nsv10413 CNV gain 18304495
nsv508986 CNV insertion 20534489
nsv593206 CNV loss 21841781
nsv593208 CNV loss 21841781
nsv822425 CNV loss 20364138
nsv829834 CNV loss 17160897
nsv950325 CNV deletion 24416366

Variation tolerance for ATP5ME Gene

Residual Variation Intolerance Score: 59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATP5ME Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5ME

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP5ME Gene

Disorders for ATP5ME Gene

Additional Disease Information for ATP5ME

No disorders were found for ATP5ME Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP5ME Gene

Publications for ATP5ME Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The e subunit gene of murine F1F0-ATP synthase. Genomic sequence, chromosomal mapping, and diet regulation. (PMID: 8702853) Swartz DA … Kaput J (The Journal of biological chemistry 1996) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58

Products for ATP5ME Gene

Sources for ATP5ME Gene

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