Aliases for ATP5IF1 Gene
External Ids for ATP5IF1 Gene
Previous HGNC Symbols for ATP5IF1 Gene
This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for ATP5IF1 Gene
ATP5IF1 (ATP Synthase Inhibitory Factor Subunit 1) is a Protein Coding gene. Diseases associated with ATP5IF1 include Fallopian Tube Adenocarcinoma and Lymphocytic Choriomeningitis. Among its related pathways are Glucose / Energy Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. An important paralog of this gene is MTHFS.
UniProtKB/Swiss-Prot Summary for ATP5IF1 Gene
Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.