Aliases for ATP5F1EP2 Gene

Aliases for ATP5F1EP2 Gene

  • ATP Synthase F1 Subunit Epsilon Pseudogene 2 2 3 4 5
  • ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Epsilon Subunit Pseudogene 2 2 3
  • ATP5EP2 3 4
  • ATP Synthase Subunit Epsilon-Like Protein, Mitochondrial 4

External Ids for ATP5F1EP2 Gene

Previous HGNC Symbols for ATP5F1EP2 Gene

  • ATP5EP2

Summaries for ATP5F1EP2 Gene

GeneCards Summary for ATP5F1EP2 Gene

ATP5F1EP2 (ATP Synthase F1 Subunit Epsilon Pseudogene 2) is a Pseudogene. Among its related pathways are purine nucleotides de novo biosynthesis.

UniProtKB/Swiss-Prot Summary for ATP5F1EP2 Gene

  • Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity).

Additional gene information for ATP5F1EP2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATP5F1EP2 Gene

Genomics for ATP5F1EP2 Gene

Genomic Locations for ATP5F1EP2 Gene

Genomic Locations for ATP5F1EP2 Gene
chr13:27,945,206-27,945,573
(GRCh38/hg38)
Size:
368 bases
Orientation:
Plus strand
chr13:28,519,343-28,519,727
(GRCh37/hg19)
Size:
385 bases
Orientation:
Plus strand

Genomic View for ATP5F1EP2 Gene

Genes around ATP5F1EP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP5F1EP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP5F1EP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP5F1EP2 Gene

No data available for GeneHancer (GH) Regulatory Elements for ATP5F1EP2 Gene

Proteins for ATP5F1EP2 Gene

  • Protein details for ATP5F1EP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VTU8-AT5EL_HUMAN
    Recommended name:
    ATP synthase subunit epsilon-like protein, mitochondrial
    Protein Accession:
    Q5VTU8

    Protein attributes for ATP5F1EP2 Gene

    Size:
    51 amino acids
    Molecular mass:
    5807 Da
    Quaternary structure:
    • F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L) (By similarity).

neXtProt entry for ATP5F1EP2 Gene

Post-translational modifications for ATP5F1EP2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ATP5F1EP2 Gene

Domains & Families for ATP5F1EP2 Gene

Protein Domains for ATP5F1EP2 Gene

Blocks:
  • Mitochondrial ATP synthase epsilon chain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATP5F1EP2 Gene

GenScript: Design optimal peptide antigens:
  • ATP synthase subunit epsilon-like protein, mitochondrial (AT5EL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5VTU8

UniProtKB/Swiss-Prot:

AT5EL_HUMAN :
  • Belongs to the eukaryotic ATPase epsilon family.
Family:
  • Belongs to the eukaryotic ATPase epsilon family.
genes like me logo Genes that share domains with ATP5F1EP2: view

No data available for Gene Families for ATP5F1EP2 Gene

Function for ATP5F1EP2 Gene

Molecular function for ATP5F1EP2 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity).

Phenotypes From GWAS Catalog for ATP5F1EP2 Gene

Gene Ontology (GO) - Molecular Function for ATP5F1EP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016887 contributes_to ATPase activity IBA 21873635
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism IEA --
genes like me logo Genes that share ontologies with ATP5F1EP2: view
genes like me logo Genes that share phenotypes with ATP5F1EP2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ATP5F1EP2 Gene

Localization for ATP5F1EP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP5F1EP2 Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP5F1EP2 gene
Compartment Confidence
mitochondrion 4
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ATP5F1EP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) IEA --
GO:0005739 mitochondrion HDA 20833797
GO:0005743 mitochondrial inner membrane IBA 21873635
genes like me logo Genes that share ontologies with ATP5F1EP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ATP5F1EP2 Gene

Pathways & Interactions for ATP5F1EP2 Gene

genes like me logo Genes that share pathways with ATP5F1EP2: view

Interacting Proteins for ATP5F1EP2 Gene

Selected Interacting proteins: Q5VTU8-AT5EL_HUMAN for ATP5F1EP2 Gene via IID

;

Gene Ontology (GO) - Biological Process for ATP5F1EP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015986 ATP synthesis coupled proton transport IEA --
genes like me logo Genes that share ontologies with ATP5F1EP2: view

No data available for SIGNOR curated interactions for ATP5F1EP2 Gene

Drugs & Compounds for ATP5F1EP2 Gene

(1) Drugs for ATP5F1EP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clotrimazole Approved, Vet_approved Pharma Inhibition, Pore Blocker, Antagonist, Agonist, Gating inhibitor, Channel blocker 39
genes like me logo Genes that share compounds with ATP5F1EP2: view

Transcripts for ATP5F1EP2 Gene

mRNA/cDNA for ATP5F1EP2 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP5F1EP2 Gene

No ASD Table

Relevant External Links for ATP5F1EP2 Gene

GeneLoc Exon Structure for
ATP5F1EP2

Expression for ATP5F1EP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ATP5F1EP2

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP5F1EP2 Gene

Orthologs for ATP5F1EP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATP5F1EP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP5EP2 31
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 92 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ATP5E 31 31
  • 90 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Atp5e 31
  • 88 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 82 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii atp5e 31
  • 63 (a)
OneToMany
Species where no ortholog for ATP5F1EP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP5F1EP2 Gene

ENSEMBL:
Gene Tree for ATP5F1EP2 (if available)
TreeFam:
Gene Tree for ATP5F1EP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATP5F1EP2: view image

Paralogs for ATP5F1EP2 Gene

No data available for Paralogs for ATP5F1EP2 Gene

Variants for ATP5F1EP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ATP5F1EP2 Gene

Variant ID Type Subtype PubMed ID
dgv538e212 CNV gain 25503493
esv2761780 CNV gain 21179565
esv3582294 CNV gain 25503493
esv3631625 CNV gain 21293372

Variation tolerance for ATP5F1EP2 Gene

Gene Damage Index Score: 1.20; 24.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATP5F1EP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP5F1EP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Additional dbSNP identifiers (rs#s) for ATP5F1EP2 Gene

Disorders for ATP5F1EP2 Gene

No disorders were found for ATP5F1EP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for ATP5F1EP2 Gene

Publications for ATP5F1EP2 Gene

  1. Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers. (PMID: 27684187) Rosenbluh J … Hahn WC (Cell systems 2016) 3 54
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 54
  3. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J … Shi Y (Genes & development 2015) 3 54
  4. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin BM … Amundadottir LT (Nature genetics 2014) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for ATP5F1EP2 Gene

Sources for ATP5F1EP2 Gene