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Aliases for ATP4B Gene

Aliases for ATP4B Gene

  • ATPase H+/K+ Transporting Beta Subunit 2 3 5
  • ATPase, H+/K+ Exchanging, Beta Polypeptide 2 3
  • Gastric H(+)/K(+) ATPase Subunit Beta 3 4
  • Proton Pump Beta Chain 3 4
  • ATPase, H+/K+ Transporting, Beta Polypeptide 3
  • Potassium-Transporting ATPase Subunit Beta 3
  • Potassium-Transporting ATPase Beta Chain 3
  • Gastric Hydrogen-Potassium ATPase, Beta 3
  • Gastric H+/K+ ATPase Beta Subunit 3
  • ATP6B 3

External Ids for ATP4B Gene

Previous GeneCards Identifiers for ATP4B Gene

  • GC13U990004
  • GC13M112251
  • GC13M113351
  • GC13M114303
  • GC13M094742

Summaries for ATP4B Gene

Entrez Gene Summary for ATP4B Gene

  • The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP4B Gene

ATP4B (ATPase H+/K+ Transporting Beta Subunit) is a Protein Coding gene. Among its related pathways are Salivary secretion and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include hydrogen:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1B2.

UniProtKB/Swiss-Prot for ATP4B Gene

  • Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.

Additional gene information for ATP4B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP4B Gene

Genomics for ATP4B Gene

GeneHancer (GH) Regulatory Elements for ATP4B Gene

Promoters and enhancers for ATP4B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I113656 Promoter/Enhancer 0.9 EPDnew ENCODE 550.8 +0.2 230 2 STAT1 POLR2A BCL6 ATP4B GRK1 TMEM255B TMCO3 LINC00552 GC13P113655 PIR44469
GH13I113653 Enhancer 0.5 ENCODE 0.8 +4.5 4484 0.6 POLR2A GLIS1 ZIC2 ZNF18 GC13P113655 PIR44469 TMCO3 ATP4B PIR60549
GH13I113650 Enhancer 0.4 dbSUPER 0.4 +7.5 7542 0.7 GATA3 MAFK GRK1 DCUN1D2 DCUN1D2-AS GC13P113655 PIR44469 ATP4B PIR60549
GH13I113664 Enhancer 0.3 ENCODE 0.4 -6.7 -6723 0.2 ESRRA GRK1 ATP4B
GH13I113651 Enhancer 0.2 dbSUPER 0.4 +5.9 5931 0.7 TMEM255B GC13P113655 PIR44469 ATP4B PIR60549
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ATP4B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ATP4B gene promoter:

Genomic Locations for ATP4B Gene

Genomic Locations for ATP4B Gene
9,395 bases
Minus strand

Genomic View for ATP4B Gene

Genes around ATP4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP4B Gene

Proteins for ATP4B Gene

  • Protein details for ATP4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium-transporting ATPase subunit beta
    Protein Accession:
    Secondary Accessions:
    • B1B0N8

    Protein attributes for ATP4B Gene

    291 amino acids
    Molecular mass:
    33367 Da
    Quaternary structure:
    • Composed of two subunits: alpha (catalytic) and beta.

neXtProt entry for ATP4B Gene

Post-translational modifications for ATP4B Gene

  • Glycosylation at posLast=9999, posLast=103103, Asn130, posLast=146146, Asn161, posLast=193193, and posLast=222222
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP4B Gene

Domains & Families for ATP4B Gene

Gene Families for ATP4B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for ATP4B Gene

Suggested Antigen Peptide Sequences for ATP4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
  • Belongs to the X(+)/potassium ATPases subunit beta family.
  • The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
  • Belongs to the X(+)/potassium ATPases subunit beta family.
genes like me logo Genes that share domains with ATP4B: view

Function for ATP4B Gene

Molecular function for ATP4B Gene

GENATLAS Biochemistry:
ATPase,H+,K+ transporting,beta polypeptide
UniProtKB/Swiss-Prot Function:
Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.

Gene Ontology (GO) - Molecular Function for ATP4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008900 hydrogen:potassium-exchanging ATPase activity TAS 1656976
genes like me logo Genes that share ontologies with ATP4B: view
genes like me logo Genes that share phenotypes with ATP4B: view

Animal Models for ATP4B Gene

MGI Knock Outs for ATP4B:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ATP4B Gene

Localization for ATP4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP4B Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP4B gene
Compartment Confidence
plasma membrane 5
mitochondrion 1
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ATP4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005890 sodium:potassium-exchanging ATPase complex IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ATP4B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ATP4B Gene

Pathways & Interactions for ATP4B Gene

genes like me logo Genes that share pathways with ATP4B: view

Gene Ontology (GO) - Biological Process for ATP4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with ATP4B: view

No data available for SIGNOR curated interactions for ATP4B Gene

Drugs & Compounds for ATP4B Gene

(16) Drugs for ATP4B Gene - From: DrugBank, ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rabeprazole Approved, Investigational Pharma inhibitor 162
Dexlansoprazole Approved, Investigational Pharma Target, inhibitor 225
Esomeprazole Approved, Investigational Pharma Proton pump inhibitor 350
Lansoprazole Approved, Investigational Pharma H+,K+-ATPase inhibitor 225
Pantoprazole Approved Pharma H+/K+-ATPase inhibitor 181

(2) Additional Compounds for ATP4B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)

(13) ApexBio Compounds for ATP4B Gene

Compound Action Cas Number
BCH 20448-79-7
Dexlansoprazole 138530-94-6
Esomeprazole Magnesium Proton pump inhibitor 161973-10-0
Esomeprazole magnesium salt 1198768-91-0
Esomeprazole Magnesium trihydrate Proton pump inhibitor 217087-09-7
Esomeprazole Sodium Proton pump inhibitor 161796-78-7
Lansoprazole H+,K+-ATPase inhibitor 103577-45-3
N2-Methyl-L-arginine 2480-28-6
Pantoprazole H+/K+-ATPase inhibitor 102625-70-7
Rabeprazole 117976-89-3
Rabeprazole sodium 117976-90-6
Tenatoprazole 113712-98-4
Zinc Pyrithione 13463-41-7
genes like me logo Genes that share compounds with ATP4B: view

Drug Products

Transcripts for ATP4B Gene

mRNA/cDNA for ATP4B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP4B Gene

ATPase, H+/K+ exchanging, beta polypeptide:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP4B Gene

No ASD Table

Relevant External Links for ATP4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP4B Gene

This gene is overexpressed in Stomach (x52.5).

Protein differential expression in normal tissues from HIPED for ATP4B Gene

This gene is overexpressed in Stomach (64.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATP4B Gene

Protein tissue co-expression partners for ATP4B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATP4B Gene:


SOURCE GeneReport for Unigene cluster for ATP4B Gene:


Evidence on tissue expression from TISSUES for ATP4B Gene

  • Stomach(4.3)
  • Intestine(4)
  • Liver(4)
genes like me logo Genes that share expression patterns with ATP4B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP4B Gene

Orthologs for ATP4B Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP4B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATP4B 34 33
  • 99.54 (n)
(Bos Taurus)
Mammalia ATP4B 34 33
  • 84.02 (n)
(Rattus norvegicus)
Mammalia Atp4b 33
  • 83.28 (n)
(Canis familiaris)
Mammalia ATP4B 34 33
  • 83.1 (n)
(Mus musculus)
Mammalia Atp4b 34 16 33
  • 82.82 (n)
(Monodelphis domestica)
Mammalia ATP4B 34
  • 74 (a)
(Gallus gallus)
Aves ATP4B 34 33
  • 69.7 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp4b 33
  • 58.39 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC64342 33
fruit fly
(Drosophila melanogaster)
Insecta nrv3 34
  • 23 (a)
nrv1 34
  • 20 (a)
nrv2 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea nkb-1 34
  • 23 (a)
nkb-3 34
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10387 34
  • 24 (a)
Species where no ortholog for ATP4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ATP4B Gene

Gene Tree for ATP4B (if available)
Gene Tree for ATP4B (if available)

Paralogs for ATP4B Gene

Paralogs for ATP4B Gene

(4) SIMAP similar genes for ATP4B Gene using alignment to 1 proteins: Pseudogenes for ATP4B Gene

genes like me logo Genes that share paralogs with ATP4B: view

Variants for ATP4B Gene

Sequence variations from dbSNP and Humsavar for ATP4B Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000017906 -- 113,651,392(-) C/A intron_variant
rs1000160201 -- 113,650,066(-) G/C intron_variant
rs1000400109 -- 113,657,380(-) C/T intron_variant
rs1000439952 -- 113,649,203(-) G/A 3_prime_UTR_variant
rs1000660976 -- 113,650,295(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ATP4B Gene

Variant ID Type Subtype PubMed ID
nsv832726 CNV loss 17160897

Variation tolerance for ATP4B Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATP4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP4B Gene

Disorders for ATP4B Gene

Additional Disease Information for ATP4B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ATP4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP4B Gene

Publications for ATP4B Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 2 3 4 58
  2. A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules. (PMID: 19694409) Bab-Dinitz E … Karlish SJ (Biochemistry 2009) 3 4 58
  3. Pharmacological effects of lipid-lowering drugs recapitulate with a larger amplitude the phenotypic effects of common variants within their target genes. (PMID: 18787507) Knouff CW … Mooser V (Pharmacogenetics and genomics 2008) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells. (PMID: 9315713) Yoshida T … Maeda M (FEBS letters 1997) 3 4 58

Products for ATP4B Gene

Sources for ATP4B Gene

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