Aliases for ATP4B Gene
External Ids for ATP4B Gene
Previous GeneCards Identifiers for ATP4B Gene
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]
GeneCards Summary for ATP4B Gene
ATP4B (ATPase H+/K+ Transporting Subunit Beta) is a Protein Coding gene. Diseases associated with ATP4B include Gastric Diffuse Adenocarcinoma and Linitis Plastica. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology (GO) annotations related to this gene include potassium:proton exchanging ATPase activity. An important paralog of this gene is ATP1B2.
UniProtKB/Swiss-Prot Summary for ATP4B Gene
Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.