The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasm... See more...

Aliases for ATP4B Gene

Aliases for ATP4B Gene

  • ATPase H+/K+ Transporting Subunit Beta 2 3 5
  • ATPase, H+/K+ Exchanging, Beta Polypeptide 2 3
  • Potassium-Transporting ATPase Subunit Beta 3 4
  • ATPase H+/K+ Transporting Beta Subunit 2 3
  • Gastric H(+)/K(+) ATPase Subunit Beta 3 4
  • Proton Pump Beta Chain 3 4
  • ATP6B 2 3
  • ATPase, H+/K+ Transporting, Beta Polypeptide 3
  • Potassium-Transporting ATPase Beta Chain 3
  • Gastric Hydrogen-Potassium ATPase, Beta 3
  • Gastric H+/K+ ATPase Beta Subunit 3
  • ATP4B 5

External Ids for ATP4B Gene

Previous GeneCards Identifiers for ATP4B Gene

  • GC13U990004
  • GC13M112251
  • GC13M113351
  • GC13M114303
  • GC13M094742

Summaries for ATP4B Gene

Entrez Gene Summary for ATP4B Gene

  • The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP4B Gene

ATP4B (ATPase H+/K+ Transporting Subunit Beta) is a Protein Coding gene. Diseases associated with ATP4B include Gastric Diffuse Adenocarcinoma and Linitis Plastica. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology (GO) annotations related to this gene include potassium:proton exchanging ATPase activity. An important paralog of this gene is ATP1B2.

UniProtKB/Swiss-Prot Summary for ATP4B Gene

  • Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.

Additional gene information for ATP4B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATP4B Gene

Genomics for ATP4B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ATP4B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J113656 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 600.7 +0.2 230 2 POLR2A STAT1 BCL6 ATP4B GRK1 TMEM255B TMCO3 LINC00552 piR-50470
GH13J113646 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +10.8 10798 2.4 NR2C1 SP1 ZNF140 SMARCC1 ZBTB10 SMARCA4 CHD2 BCL11A ESRRA E2F4 GRK1 CDC16 PCID2 CHAMP1 DCUN1D2 DCUN1D2-AS GAS6 TMEM255B piR-50470 ATP4B
GH13J113653 Enhancer 0.6 Ensembl ENCODE 0.7 +4.3 4297 1 ZIC2 POLR2A ZNF18 GLIS1 piR-50470 TMCO3 ATP4B GRK1
GH13J113724 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 0.2 -67.5 -67503 3 SP1 CTCF PRDM10 MTA2 ZNF143 ZIC2 PATZ1 REST TRIM22 HDAC1 TMEM255B GRK1 DCUN1D2 lnc-GAS6-4 LOC105377805 ATP4B
GH13J113654 Enhancer 0.6 Ensembl dbSUPER 0.4 +7.5 7497 0.2 MAFF MAFK CREB1 DCUN1D2 DCUN1D2-AS GRK1 piR-50470 ATP4B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATP4B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ATP4B

Top Transcription factor binding sites by QIAGEN in the ATP4B gene promoter:
  • aMEF-2
  • AML1a
  • AP-2gamma
  • ATF-2
  • CREB
  • deltaCREB
  • GATA-1
  • MEF-2A
  • Olf-1
  • RORalpha1

Genomic Locations for ATP4B Gene

Genomic Locations for ATP4B Gene
chr13:113,648,804-113,658,198
(GRCh38/hg38)
Size:
9,395 bases
Orientation:
Minus strand
chr13:114,303,119-114,312,513
(GRCh37/hg19)
Size:
9,395 bases
Orientation:
Minus strand

Genomic View for ATP4B Gene

Genes around ATP4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP4B Gene

Proteins for ATP4B Gene

  • Protein details for ATP4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51164-ATP4B_HUMAN
    Recommended name:
    Potassium-transporting ATPase subunit beta
    Protein Accession:
    P51164
    Secondary Accessions:
    • B1B0N8

    Protein attributes for ATP4B Gene

    Size:
    291 amino acids
    Molecular mass:
    33367 Da
    Quaternary structure:
    • Composed of two subunits: alpha (catalytic) and beta.

neXtProt entry for ATP4B Gene

Post-translational modifications for ATP4B Gene

  • Glycosylation at Asn99, Asn103, Asn130, Asn146, Asn161, Asn193, and Asn222
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP4B Gene

Domains & Families for ATP4B Gene

Gene Families for ATP4B Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for ATP4B Gene

InterPro:
Blocks:
  • Na+/K+ ATPase, beta subunit
ProtoNet:

Suggested Antigen Peptide Sequences for ATP4B Gene

GenScript: Design optimal peptide antigens:
  • Proton pump beta chain (ATP4B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51164

UniProtKB/Swiss-Prot:

ATP4B_HUMAN :
  • The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
  • Belongs to the X(+)/potassium ATPases subunit beta family.
Domain:
  • The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
Family:
  • Belongs to the X(+)/potassium ATPases subunit beta family.
genes like me logo Genes that share domains with ATP4B: view

Function for ATP4B Gene

Molecular function for ATP4B Gene

UniProtKB/Swiss-Prot Function:
Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.
GENATLAS Biochemistry:
ATPase,H+,K+ transporting,beta polypeptide

Phenotypes From GWAS Catalog for ATP4B Gene

Gene Ontology (GO) - Molecular Function for ATP4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IBA 21873635
GO:0005391 contributes_to sodium:potassium-exchanging ATPase activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0008144 drug binding IEA --
GO:0008900 potassium:proton exchanging ATPase activity TAS 1656976
genes like me logo Genes that share ontologies with ATP4B: view
genes like me logo Genes that share phenotypes with ATP4B: view

Animal Models for ATP4B Gene

MGI Knock Outs for ATP4B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATP4B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ATP4B Gene

Localization for ATP4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP4B Gene

Cell membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP4B gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ATP4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0005890 sodium:potassium-exchanging ATPase complex IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ATP4B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ATP4B Gene

Pathways & Interactions for ATP4B Gene

genes like me logo Genes that share pathways with ATP4B: view

Gene Ontology (GO) - Biological Process for ATP4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0006883 cellular sodium ion homeostasis IBA 21873635
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with ATP4B: view

No data available for SIGNOR curated interactions for ATP4B Gene

Drugs & Compounds for ATP4B Gene

(15) Drugs for ATP4B Gene - From: DrugBank, ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rabeprazole Approved, Investigational Pharma inhibitor 189
Dexlansoprazole Approved, Investigational Pharma Target, inhibitor 255
Esomeprazole Approved, Investigational Pharma Proton pump inhibitor 413
Potassium gluconate Approved Pharma Transporter, substrate 0
Lansoprazole Approved, Investigational Pharma H+,K+-ATPase inhibitor 255

(2) Additional Compounds for ATP4B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2

(12) ApexBio Compounds for ATP4B Gene

Compound Action Cas Number
BCH 20448-79-7
Dexlansoprazole 138530-94-6
Esomeprazole Magnesium Proton pump inhibitor 161973-10-0
Esomeprazole Magnesium trihydrate Proton pump inhibitor 217087-09-7
Esomeprazole Sodium Proton pump inhibitor 161796-78-7
Lansoprazole H+,K+-ATPase inhibitor 103577-45-3
N2-Methyl-L-arginine 2480-28-6
Pantoprazole H+/K+-ATPase inhibitor 102625-70-7
Rabeprazole 117976-89-3
Rabeprazole sodium 117976-90-6
Tenatoprazole 113712-98-4
Zinc Pyrithione 13463-41-7
genes like me logo Genes that share compounds with ATP4B: view

Drug Products

Transcripts for ATP4B Gene

mRNA/cDNA for ATP4B Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATP4B

Alternative Splicing Database (ASD) splice patterns (SP) for ATP4B Gene

No ASD Table

Relevant External Links for ATP4B Gene

GeneLoc Exon Structure for
ATP4B

Expression for ATP4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ATP4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP4B Gene

This gene is overexpressed in Stomach (x52.5).

Protein differential expression in normal tissues from HIPED for ATP4B Gene

This gene is overexpressed in Stomach (64.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ATP4B Gene



Protein tissue co-expression partners for ATP4B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ATP4B

SOURCE GeneReport for Unigene cluster for ATP4B Gene:

Hs.434202

Evidence on tissue expression from TISSUES for ATP4B Gene

  • Stomach(4.5)
  • Intestine(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ATP4B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP4B Gene

Orthologs for ATP4B Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP4B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ATP4B 30 31
  • 99.54 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ATP4B 30 31
  • 84.02 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Atp4b 30
  • 83.28 (n)
Dog
(Canis familiaris)
Mammalia ATP4B 30 31
  • 83.1 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Atp4b 30 17 31
  • 82.82 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ATP4B 31
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ATP4B 30 31
  • 69.7 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia atp4b 30
  • 58.39 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC64342 30
Fruit Fly
(Drosophila melanogaster)
Insecta nrv3 31
  • 23 (a)
ManyToMany
nrv1 31
  • 20 (a)
ManyToMany
nrv2 31
  • 19 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea nkb-1 31
  • 23 (a)
ManyToMany
nkb-3 31
  • 23 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10387 31
  • 24 (a)
OneToMany
Species where no ortholog for ATP4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for ATP4B Gene

ENSEMBL:
Gene Tree for ATP4B (if available)
TreeFam:
Gene Tree for ATP4B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATP4B: view image

Paralogs for ATP4B Gene

Paralogs for ATP4B Gene

(4) SIMAP similar genes for ATP4B Gene using alignment to 1 proteins:

  • ATP4B_HUMAN

Pseudogenes.org Pseudogenes for ATP4B Gene

genes like me logo Genes that share paralogs with ATP4B: view

Variants for ATP4B Gene

Additional dbSNP identifiers (rs#s) for ATP4B Gene

Structural Variations from Database of Genomic Variants (DGV) for ATP4B Gene

Variant ID Type Subtype PubMed ID
nsv832726 CNV loss 17160897

Variation tolerance for ATP4B Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATP4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP4B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ATP4B Gene

Disorders for ATP4B Gene

MalaCards: The human disease database

(4) MalaCards diseases for ATP4B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gastric diffuse adenocarcinoma
  • adenocarcinoma of linitis plastica type
linitis plastica
  • leather-bottle stomach
autoimmune gastritis
gastric adenocarcinoma
  • adenocarcinoma of stomach
- elite association - COSMIC cancer census association via MalaCards
Search ATP4B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ATP4B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ATP4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATP4B Gene

Publications for ATP4B Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 2 3 4
  2. A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules. (PMID: 19694409) Bab-Dinitz E … Karlish SJ (Biochemistry 2009) 3 4
  3. Pharmacological effects of lipid-lowering drugs recapitulate with a larger amplitude the phenotypic effects of common variants within their target genes. (PMID: 18787507) Knouff CW … Mooser V (Pharmacogenetics and genomics 2008) 3 41
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells. (PMID: 9315713) Yoshida T … Maeda M (FEBS letters 1997) 3 4

Products for ATP4B Gene

Sources for ATP4B Gene