Aliases for ATP1B4 Gene
External Ids for ATP1B4 Gene
Previous GeneCards Identifiers for ATP1B4 Gene
This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
GeneCards Summary for ATP1B4 Gene
ATP1B4 (ATPase Na+/K+ Transporting Family Member Beta 4) is a Protein Coding gene. Diseases associated with ATP1B4 include Acantholytic Acanthoma and Thyrotoxic Periodic Paralysis. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include monovalent inorganic cation transmembrane transporter activity. An important paralog of this gene is ATP1B2.
UniProtKB/Swiss-Prot Summary for ATP1B4 Gene
May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit.
The Na+/K+ ATPase is a membrane protein that is composed of two subunits - alpha and beta. The pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions.