The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled... See more...

Aliases for ATP1B3 Gene

Aliases for ATP1B3 Gene

  • ATPase Na+/K+ Transporting Subunit Beta 3 2 3 5
  • Sodium/Potassium-Transporting ATPase Subunit Beta-3 2 3 4
  • Sodium-Potassium ATPase Subunit Beta 3 (Non-Catalytic) 2 3
  • Sodium/Potassium-Dependent ATPase Subunit Beta-3 3 4
  • ATPase, Na+/K+ Transporting, Beta 3 Polypeptide 2 3
  • Sodium Pump Subunit Beta-3 2 3
  • ATPB-3 3 4
  • Sodium/Potassium-Transporting ATPase Beta-3 Chain 3
  • Na, K-ATPase Beta-3 Polypeptide 3
  • CD298 Antigen 4
  • CD298 3

External Ids for ATP1B3 Gene

Previous GeneCards Identifiers for ATP1B3 Gene

  • GC03P138528
  • GC03P142424
  • GC03P142876
  • GC03P142916
  • GC03P143078
  • GC03P141594
  • GC03P138968

Summaries for ATP1B3 Gene

Entrez Gene Summary for ATP1B3 Gene

  • The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP1B3 Gene

ATP1B3 (ATPase Na+/K+ Transporting Subunit Beta 3) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include ATPase binding and sodium:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1B2.

UniProtKB/Swiss-Prot Summary for ATP1B3 Gene

  • This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

Tocris Summary for ATP1B3 Gene

  • The Na+/K+ ATPase is a membrane protein that is composed of two subunits - alpha and beta. The pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions.

Gene Wiki entry for ATP1B3 Gene

Additional gene information for ATP1B3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATP1B3 Gene

Genomics for ATP1B3 Gene

GeneHancer (GH) Regulatory Elements for ATP1B3 Gene

Promoters and enhancers for ATP1B3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATP1B3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ATP1B3 gene promoter:
  • AML1a
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-2
  • Pbx1a
  • PPAR-gamma1
  • PPAR-gamma2
  • Sox5

Genomic Locations for ATP1B3 Gene

Genomic Locations for ATP1B3 Gene
chr3:141,876,124-141,926,549
(GRCh38/hg38)
Size:
50,426 bases
Orientation:
Plus strand
chr3:141,594,966-141,645,382
(GRCh37/hg19)
Size:
50,417 bases
Orientation:
Plus strand

Genomic View for ATP1B3 Gene

Genes around ATP1B3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP1B3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP1B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP1B3 Gene

Proteins for ATP1B3 Gene

  • Protein details for ATP1B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54709-AT1B3_HUMAN
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-3
    Protein Accession:
    P54709
    Secondary Accessions:
    • B7Z1N7

    Protein attributes for ATP1B3 Gene

    Size:
    279 amino acids
    Molecular mass:
    31513 Da
    Quaternary structure:
    • The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

    Alternative splice isoforms for ATP1B3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP1B3 Gene

Post-translational modifications for ATP1B3 Gene

  • Glycosylation at Asn124 and Asn240
  • Ubiquitination at Lys7, Lys115, and Lys194
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • AT1B3_HUMAN (1759)

Other Protein References for ATP1B3 Gene

Antibody Products

  • Abcam antibodies for ATP1B3
  • Boster Bio Antibodies for ATP1B3

No data available for DME Specific Peptides for ATP1B3 Gene

Domains & Families for ATP1B3 Gene

Gene Families for ATP1B3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for ATP1B3 Gene

Suggested Antigen Peptide Sequences for ATP1B3 Gene

GenScript: Design optimal peptide antigens:
  • Sodium/potassium-dependent ATPase subunit beta-3 (AT1B3_HUMAN)
  • cDNA FLJ50753, highly similar to Sodium/potassium-transporting ATPase subunit beta-3 (B7Z1N7_HUMAN)
  • ATPase, Na+/K+ transporting, beta 3 polypeptide, isoform CRA_a (D3DNF9_HUMAN)
  • Na+/K+ transporting ATPase beta 3 polypeptide (Q58I18_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P54709

UniProtKB/Swiss-Prot:

AT1B3_HUMAN :
  • The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.
  • Belongs to the X(+)/potassium ATPases subunit beta family.
Domain:
  • The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.
Family:
  • Belongs to the X(+)/potassium ATPases subunit beta family.
genes like me logo Genes that share domains with ATP1B3: view

Function for ATP1B3 Gene

Molecular function for ATP1B3 Gene

UniProtKB/Swiss-Prot Function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.
GENATLAS Biochemistry:
ATPase,Na+K+,beta 3 polypeptide,widely expressed throughout the CNS,dimerizing with ATP alpha 1,2 or 3,with structural homology to ATP1B2 and ATP4B

Phenotypes From GWAS Catalog for ATP1B3 Gene

Gene Ontology (GO) - Molecular Function for ATP1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 10636900
GO:0005391 contributes_to sodium:potassium-exchanging ATPase activity IEA,IDA 10636900
GO:0051117 ATPase binding IPI 10636900
genes like me logo Genes that share ontologies with ATP1B3: view
genes like me logo Genes that share phenotypes with ATP1B3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ATP1B3

CRISPR Products

miRNA for ATP1B3 Gene

miRTarBase miRNAs that target ATP1B3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATP1B3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP1B3 Gene

Localization for ATP1B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP1B3 Gene

Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP1B3 gene
Compartment Confidence
plasma membrane 5
mitochondrion 1
cytosol 1
extracellular 0
cytoskeleton 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ATP1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005890 sodium:potassium-exchanging ATPase complex IEA,IDA 10636900
GO:0005901 caveola IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ATP1B3: view

Pathways & Interactions for ATP1B3 Gene

genes like me logo Genes that share pathways with ATP1B3: view

Pathways by source for ATP1B3 Gene

2 Qiagen pathways for ATP1B3 Gene
  • Aldosterone Signaling in Epithelial Cells
  • Hepatic ABC Transporters

Gene Ontology (GO) - Biological Process for ATP1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0006883 cellular sodium ion homeostasis IDA,IBA 10636900
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA --
genes like me logo Genes that share ontologies with ATP1B3: view

No data available for SIGNOR curated interactions for ATP1B3 Gene

Drugs & Compounds for ATP1B3 Gene

(9) Drugs for ATP1B3 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rubidium Rb-82 Approved, Investigational Pharma Carrier, substrate 0
Magnesium Approved, Experimental, Investigational Pharma 0
Potassium Approved, Experimental Pharma 0
Water Approved Pharma 0
Digoxin Approved Pharma Na+/K+ ATPase inhibitor 167

(3) Additional Compounds for ATP1B3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
sodium
  • Na(+)
  • Na+
  • SODIUM ion
7440-23-5

(4) Tocris Compounds for ATP1B3 Gene

Compound Action Cas Number
Digoxin Na+/K+ ATPase inhibitor 20830-75-5
Lithium carbonate Mood stabilizer; inhibits Na+/K+ ATPase pump activity 554-13-2
Ouabain Na+/K+ ATPase inhibitor 630-60-4
Rostafuroxin Na+/K+ ATPase modulator; antihypertensive agent 156722-18-8
genes like me logo Genes that share compounds with ATP1B3: view

Transcripts for ATP1B3 Gene

mRNA/cDNA for ATP1B3 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATP1B3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP1B3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -
SP3: - - -
SP4: - - - - -
SP5:

Relevant External Links for ATP1B3 Gene

GeneLoc Exon Structure for
ATP1B3
ECgene alternative splicing isoforms for
ATP1B3

Expression for ATP1B3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP1B3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATP1B3 Gene



Protein tissue co-expression partners for ATP1B3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATP1B3 Gene:

ATP1B3

SOURCE GeneReport for Unigene cluster for ATP1B3 Gene:

Hs.477789

Evidence on tissue expression from TISSUES for ATP1B3 Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Skin(3.1)
  • Stomach(2.7)
  • Intestine(2.6)
  • Adrenal gland(2.5)
genes like me logo Genes that share expression patterns with ATP1B3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP1B3 Gene

Orthologs for ATP1B3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP1B3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP1B3 33 32
  • 99.88 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ATP1B3 33 32
  • 86.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ATP1B3 33 32
  • 83.03 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp1b3 32
  • 80.41 (n)
mouse
(Mus musculus)
Mammalia Atp1b3 17 33 32
  • 79.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ATP1B3 33
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP1B3 33 32
  • 67.27 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP1B3 33
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp1b3 32
  • 61.42 (n)
MGC76183 32
zebrafish
(Danio rerio)
Actinopterygii atp1b3a 33 32
  • 56.73 (n)
OneToMany
atp1b3b 33
  • 52 (a)
OneToMany
-- 32
fruit fly
(Drosophila melanogaster)
Insecta nrv1 33
  • 29 (a)
ManyToMany
nrv3 33
  • 26 (a)
ManyToMany
nrv2 33
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nkb-1 33
  • 26 (a)
ManyToMany
nkb-3 33
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10387 33
  • 27 (a)
OneToMany
Species where no ortholog for ATP1B3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP1B3 Gene

ENSEMBL:
Gene Tree for ATP1B3 (if available)
TreeFam:
Gene Tree for ATP1B3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATP1B3: view image

Paralogs for ATP1B3 Gene

Paralogs for ATP1B3 Gene

(4) SIMAP similar genes for ATP1B3 Gene using alignment to 10 proteins:

  • AT1B3_HUMAN
  • B7Z1N7_HUMAN
  • C9J6S2_HUMAN
  • C9JA36_HUMAN
  • C9JXZ1_HUMAN
  • D3DNF9_HUMAN
  • F8WBY4_HUMAN
  • H7C4L9_HUMAN
  • H7C547_HUMAN
  • Q58I18_HUMAN

Pseudogenes.org Pseudogenes for ATP1B3 Gene

genes like me logo Genes that share paralogs with ATP1B3: view

Variants for ATP1B3 Gene

Sequence variations from dbSNP and Humsavar for ATP1B3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000099204 -- 141,884,262(+) G/C intron_variant
rs1000129013 -- 141,910,566(+) A/G intron_variant
rs1000130822 -- 141,902,369(+) A/C/T intron_variant
rs1000193111 -- 141,905,501(+) A/G intron_variant
rs1000224389 -- 141,905,894(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ATP1B3 Gene

Variant ID Type Subtype PubMed ID
dgv8623n54 CNV gain 21841781
dgv8624n54 CNV gain 21841781
esv25294 CNV loss 19812545
esv2656624 CNV deletion 23128226
esv33484 CNV gain 17666407
nsv1013352 CNV gain 25217958
nsv1126657 CNV deletion 24896259
nsv591902 CNV gain 21841781
nsv591905 CNV gain 21841781
nsv591906 CNV loss 21841781
nsv591907 CNV gain+loss 21841781
nsv591910 CNV gain 21841781
nsv963364 CNV duplication 23825009

Variation tolerance for ATP1B3 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATP1B3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP1B3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP1B3 Gene

Disorders for ATP1B3 Gene

Additional Disease Information for ATP1B3

No disorders were found for ATP1B3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP1B3 Gene

Publications for ATP1B3 Gene

  1. Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene. (PMID: 9457675) Malik N … Levenson R (Mammalian genome : official journal of the International Mammalian Genome Society 1998) 2 3 4 56
  2. Identification of the mammalian Na,K-ATPase 3 subunit. (PMID: 8798450) Malik N … Levenson R (The Journal of biological chemistry 1996) 2 3 4 56
  3. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A … Hunt DF (Journal of proteome research 2006) 3 4 56
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for ATP1B3 Gene

Sources for ATP1B3 Gene