Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATP1B3 Gene

Aliases for ATP1B3 Gene

  • ATPase Na+/K+ Transporting Subunit Beta 3 2 3 5
  • Sodium-Potassium ATPase Subunit Beta 3 (Non-Catalytic) 2 3
  • Sodium/Potassium-Transporting ATPase Subunit Beta-3 2 3
  • Sodium/Potassium-Dependent ATPase Subunit Beta-3 3 4
  • ATPase, Na+/K+ Transporting, Beta 3 Polypeptide 2 3
  • Sodium Pump Subunit Beta-3 2 3
  • ATPB-3 3 4
  • Sodium/Potassium-Transporting ATPase Beta-3 Chain 3
  • Na, K-ATPase Beta-3 Polypeptide 3
  • CD298 Antigen 4
  • CD298 3

External Ids for ATP1B3 Gene

Previous GeneCards Identifiers for ATP1B3 Gene

  • GC03P138528
  • GC03P142424
  • GC03P142876
  • GC03P142916
  • GC03P143078
  • GC03P141594
  • GC03P138968

Summaries for ATP1B3 Gene

Entrez Gene Summary for ATP1B3 Gene

  • The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP1B3 Gene

ATP1B3 (ATPase Na+/K+ Transporting Subunit Beta 3) is a Protein Coding gene. Among its related pathways are Salivary secretion and Cardiac conduction. Gene Ontology (GO) annotations related to this gene include ATPase binding and sodium:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1B2.

UniProtKB/Swiss-Prot for ATP1B3 Gene

  • This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

Tocris Summary for ATP1B3 Gene

  • The Na+/K+ ATPase is a membrane protein that is composed of two subunits - alpha and beta. The pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions.

Gene Wiki entry for ATP1B3 Gene

Additional gene information for ATP1B3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP1B3 Gene

Genomics for ATP1B3 Gene

GeneHancer (GH) Regulatory Elements for ATP1B3 Gene

Promoters and enhancers for ATP1B3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I141874 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 558.8 +1.0 1022 4.7 SMAD1 ARID4B SIN3A YY1 POLR2B E2F8 ZNF143 KLF13 SP5 MXD4 ATP1B3 XRN1 RASA2 ATR GK5 GC03P141887
GH03I141736 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 11.6 -136.2 -136182 6 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B ZNF766 RNF7 RASA2 ATP1B3 ATP1B3-AS1 GRK7 RNU6-509P ATR
GH03I141913 Enhancer 0.8 ENCODE 20.6 +37.3 37270 0.2 HDGF RAD21 CHAMP1 ZNF280A CBX5 ZSCAN5C ZNF143 BCLAF1 RUNX3 ZNF654 ATP1B3 TRPC1 RNF7 GRK7 RNU6-425P ATP1B3-AS1 GC03M141903 RNU6-509P
GH03I141848 Enhancer 0.9 Ensembl 18.1 -26.7 -26674 0.9 HDGF ARNT NCOA2 TCF12 ZNF766 GATA2 E2F8 ATF7 NCOA1 ZNF592 ATP1B3 RNF7 GRK7 GK5 LOC105374134 PIR31846
GH03I142026 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 7 +152.1 152116 3.9 PKNOX1 SIN3A FEZF1 YY1 TCF12 POLR2B ZNF766 RUNX3 NCOA1 REST TFDP2 RNU6-425P GK5 ATP1B3 RPL19P6 PIR46950
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ATP1B3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ATP1B3 gene promoter:

Genomic Locations for ATP1B3 Gene

Genomic Locations for ATP1B3 Gene
50,417 bases
Plus strand

Genomic View for ATP1B3 Gene

Genes around ATP1B3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP1B3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP1B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP1B3 Gene

Proteins for ATP1B3 Gene

  • Protein details for ATP1B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-3
    Protein Accession:
    Secondary Accessions:
    • B7Z1N7

    Protein attributes for ATP1B3 Gene

    279 amino acids
    Molecular mass:
    31513 Da
    Quaternary structure:
    • The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

    Alternative splice isoforms for ATP1B3 Gene


neXtProt entry for ATP1B3 Gene

Post-translational modifications for ATP1B3 Gene

  • Ubiquitination at posLast=77, posLast=115115, and posLast=194194
  • Glycosylation at Asn124 and Asn240
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP1B3 Gene

No data available for DME Specific Peptides for ATP1B3 Gene

Domains & Families for ATP1B3 Gene

Gene Families for ATP1B3 Gene

Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for ATP1B3 Gene

Graphical View of Domain Structure for InterPro Entry



  • The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.
  • Belongs to the X(+)/potassium ATPases subunit beta family.
  • The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.
  • Belongs to the X(+)/potassium ATPases subunit beta family.
genes like me logo Genes that share domains with ATP1B3: view

Function for ATP1B3 Gene

Molecular function for ATP1B3 Gene

GENATLAS Biochemistry:
ATPase,Na+K+,beta 3 polypeptide,widely expressed throughout the CNS,dimerizing with ATP alpha 1,2 or 3,with structural homology to ATP1B2 and ATP4B
UniProtKB/Swiss-Prot Function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

Phenotypes From GWAS Catalog for ATP1B3 Gene

Gene Ontology (GO) - Molecular Function for ATP1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 10636900
GO:0005391 contributes_to sodium:potassium-exchanging ATPase activity IDA,IEA 10636900
GO:0051117 ATPase binding IPI 10636900
genes like me logo Genes that share ontologies with ATP1B3: view
genes like me logo Genes that share phenotypes with ATP1B3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ATP1B3

miRNA for ATP1B3 Gene

miRTarBase miRNAs that target ATP1B3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP1B3 Gene

Localization for ATP1B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP1B3 Gene

Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP1B3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ATP1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005890 sodium:potassium-exchanging ATPase complex IEA,IDA 10636900
GO:0005901 caveola IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ATP1B3: view

Pathways & Interactions for ATP1B3 Gene

genes like me logo Genes that share pathways with ATP1B3: view

Gene Ontology (GO) - Biological Process for ATP1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8798450
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0006883 cellular sodium ion homeostasis IDA 10636900
genes like me logo Genes that share ontologies with ATP1B3: view

No data available for SIGNOR curated interactions for ATP1B3 Gene

Drugs & Compounds for ATP1B3 Gene

(8) Drugs for ATP1B3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rubidium chloride Rb-82 Approved, Investigational Pharma Carrier, substrate 0
Potassium Approved, Investigational Pharma 0
Water Approved Pharma 0
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist 0

(4) Additional Compounds for ATP1B3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
  • Sodium
  • Sodium ion

(4) Tocris Compounds for ATP1B3 Gene

Compound Action Cas Number
Digoxin Na+/K+ ATPase inhibitor 20830-75-5
Lithium carbonate Mood stabilizer; inhibits Na+/K+ ATPase pump activity 554-13-2
Ouabain Na+/K+ ATPase inhibitor 630-60-4
Rostafuroxin Na+/K+ ATPase modulator; antihypertensive agent 156722-18-8
genes like me logo Genes that share compounds with ATP1B3: view

Transcripts for ATP1B3 Gene

Unigene Clusters for ATP1B3 Gene

ATPase, Na+/K+ transporting, beta 3 polypeptide:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP1B3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP2: -
SP3: - - -
SP4: - - - - -

Relevant External Links for ATP1B3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP1B3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP1B3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATP1B3 Gene

Protein tissue co-expression partners for ATP1B3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATP1B3 Gene:


SOURCE GeneReport for Unigene cluster for ATP1B3 Gene:


Evidence on tissue expression from TISSUES for ATP1B3 Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Skin(3.1)
  • Stomach(2.7)
  • Intestine(2.6)
  • Adrenal gland(2.5)
genes like me logo Genes that share expression patterns with ATP1B3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP1B3 Gene

Orthologs for ATP1B3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP1B3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATP1B3 33 34
  • 99.88 (n)
(Canis familiaris)
Mammalia ATP1B3 33 34
  • 86.57 (n)
(Bos Taurus)
Mammalia ATP1B3 33 34
  • 83.03 (n)
(Rattus norvegicus)
Mammalia Atp1b3 33
  • 80.41 (n)
(Mus musculus)
Mammalia Atp1b3 33 16 34
  • 79.38 (n)
(Ornithorhynchus anatinus)
Mammalia ATP1B3 34
  • 60 (a)
(Gallus gallus)
Aves ATP1B3 33 34
  • 67.27 (n)
(Anolis carolinensis)
Reptilia ATP1B3 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp1b3 33
  • 61.42 (n)
MGC76183 33
(Danio rerio)
Actinopterygii atp1b3a 33 34
  • 56.73 (n)
atp1b3b 34
  • 52 (a)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta nrv1 34
  • 29 (a)
nrv3 34
  • 26 (a)
nrv2 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea nkb-1 34
  • 26 (a)
nkb-3 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10387 34
  • 27 (a)
Species where no ortholog for ATP1B3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP1B3 Gene

Gene Tree for ATP1B3 (if available)
Gene Tree for ATP1B3 (if available)

Paralogs for ATP1B3 Gene

Paralogs for ATP1B3 Gene Pseudogenes for ATP1B3 Gene

genes like me logo Genes that share paralogs with ATP1B3: view

Variants for ATP1B3 Gene

Sequence variations from dbSNP and Humsavar for ATP1B3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000099204 -- 141,884,262(+) G/C intron_variant
rs1000129013 -- 141,910,566(+) A/G intron_variant
rs1000130822 -- 141,902,369(+) A/C intron_variant
rs1000193111 -- 141,905,501(+) A/G intron_variant
rs1000224389 -- 141,905,894(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ATP1B3 Gene

Variant ID Type Subtype PubMed ID
dgv8623n54 CNV gain 21841781
dgv8624n54 CNV gain 21841781
esv25294 CNV loss 19812545
esv2656624 CNV deletion 23128226
esv33484 CNV gain 17666407
nsv1013352 CNV gain 25217958
nsv1126657 CNV deletion 24896259
nsv591902 CNV gain 21841781
nsv591905 CNV gain 21841781
nsv591906 CNV loss 21841781
nsv591907 CNV gain+loss 21841781
nsv591910 CNV gain 21841781
nsv963364 CNV duplication 23825009

Variation tolerance for ATP1B3 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATP1B3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP1B3 Gene

Disorders for ATP1B3 Gene

Additional Disease Information for ATP1B3

No disorders were found for ATP1B3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP1B3 Gene

Publications for ATP1B3 Gene

  1. Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene. (PMID: 9457675) Malik N … Levenson R (Mammalian genome : official journal of the International Mammalian Genome Society 1998) 2 3 4 58
  2. Identification of the mammalian Na,K-ATPase 3 subunit. (PMID: 8798450) Malik N … Levenson R (The Journal of biological chemistry 1996) 2 3 4 58
  3. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A … Hunt DF (Journal of proteome research 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ATP1B3 Gene

Sources for ATP1B3 Gene

Loading form....