Aliases for ATP1B2 Gene
External Ids for ATP1B2 Gene
Previous GeneCards Identifiers for ATP1B2 Gene
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
GeneCards Summary for ATP1B2 Gene
ATP1B2 (ATPase Na+/K+ Transporting Subunit Beta 2) is a Protein Coding gene. Diseases associated with ATP1B2 include Familial Hemiplegic Migraine and Retinoschisis 1, X-Linked, Juvenile. Among its related pathways are Collagen chain trimerization and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include ATPase binding and sodium:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1B3.
UniProtKB/Swiss-Prot Summary for ATP1B2 Gene
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known.
Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.
The Na+/K+ ATPase is a membrane protein that is composed of two subunits - alpha and beta. The pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions.