Aliases for ATP12A Gene
External Ids for ATP12A Gene
Previous HGNC Symbols for ATP12A Gene
Previous GeneCards Identifiers for ATP12A Gene
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
GeneCards Summary for ATP12A Gene
ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit) is a Protein Coding gene. Diseases associated with ATP12A include Esophageal Disease and Peptic Esophagitis. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Ion channel transport. Gene Ontology (GO) annotations related to this gene include nucleotide binding and hydrogen:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1A1.
UniProtKB/Swiss-Prot for ATP12A Gene
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.