Aliases for ATP11A Gene
External Ids for ATP11A Gene
Previous GeneCards Identifiers for ATP11A Gene
The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ATP11A Gene
ATP11A (ATPase Phospholipid Transporting 11A) is a Protein Coding gene. Diseases associated with ATP11A include Pulmonary Fibrosis, Idiopathic and Cholestasis, Benign Recurrent Intrahepatic, 1. Among its related pathways are Lung fibrosis and Innate Immune System. Gene Ontology (GO) annotations related to this gene include nucleotide binding and cation-transporting ATPase activity. An important paralog of this gene is ATP11C.
UniProtKB/Swiss-Prot Summary for ATP11A Gene
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.