Aliases for ATOX1 Gene
External Ids for ATOX1 Gene
Previous GeneCards Identifiers for ATOX1 Gene
This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for ATOX1 Gene
ATOX1 (Antioxidant 1 Copper Chaperone) is a Protein Coding gene. Diseases associated with ATOX1 include Menkes Disease and Wilson Disease. Among its related pathways are Detoxification of Reactive Oxygen Species and Copper homeostasis. Gene Ontology (GO) annotations related to this gene include copper ion binding and copper-dependent protein binding.
UniProtKB/Swiss-Prot Summary for ATOX1 Gene
Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.