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This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]
ATOX1 (Antioxidant 1 Copper Chaperone) is a Protein Coding gene. Diseases associated with ATOX1 include Menkes Disease and Wilson Disease. Among its related pathways are Detoxification of Reactive Oxygen Species and Copper homeostasis. Gene Ontology (GO) annotations related to this gene include copper ion binding and copper-dependent protein binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005507 | copper ion binding | IDA | 12029094 |
GO:0005515 | protein binding | IPI | 12968035 |
GO:0016530 | metallochaperone activity | TAS | 15670166 |
GO:0016531 | copper chaperone activity | IBA,IDA | 12029094 |
GO:0032767 | copper-dependent protein binding | IPI | 10497213 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005829 | cytosol | IBA,TAS | 12029094 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Defensins | ||
2 | Innate Immune System |
.61
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|
3 | Mineral absorption | ||
4 | Cellular Senescence (REACTOME) | ||
5 | Detoxification of Reactive Oxygen Species |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | IEA | -- |
GO:0006825 | copper ion transport | TAS | 15670166 |
GO:0006878 | cellular copper ion homeostasis | TAS,IBA | 21873635 |
GO:0006979 | response to oxidative stress | IBA | 21873635 |
GO:0030001 | metal ion transport | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Copper | Approved, Investigational | Pharma | Carrier, binder | 249 | ||
Cisplatin | Approved | Pharma | Target | Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum | 3412 | |
Furan | Approved, Experimental, Investigational | Pharma | Target | 0 | ||
benzamidine | Experimental | Pharma | Target | 0 | ||
DC_AC50 | Pharma | Selective Atox1 and CCS inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
DC_AC50 | Selective Atox1 and CCS inhibitor | 497061-48-0 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||
SP4: | - | ||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||
SP6: | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ATOX1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Atox1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Atox1 30 |
|
||
Dog (Canis familiaris) |
Mammalia | ATOX1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ATOX1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ATOX1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ATOX1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ATOX1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | atox1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | atox1 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10767 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Atox1 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
menkes disease |
|
|
wilson disease |
|
|
occipital horn syndrome |
|
|
metal metabolism disorder |
|
|
spinal muscular atrophy, distal, x-linked 3 |
|
|