Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling t... See more...

Aliases for ATG4D Gene

Aliases for ATG4D Gene

  • Autophagy Related 4D Cysteine Peptidase 2 3 5
  • Autophagy-Related Cysteine Endopeptidase 4 3 4
  • Autophagy-Related Protein 4 Homolog D 3 4
  • AUT-Like 4 Cysteine Endopeptidase 3 4
  • Cysteine Protease ATG4D 3 4
  • Autophagin-4 3 4
  • APG4-D 2 3
  • APG4D 3 4
  • AUTL4 3 4
  • AUT-Like 4, Cysteine Endopeptidase (S. Cerevisiae) 2
  • ATG4 Autophagy Related 4 Homolog D (S. Cerevisiae) 2
  • APG4 Autophagy 4 Homolog D (S. Cerevisiae) 2
  • Autophagy Related 4D, Cysteine Peptidase 2
  • Cysteine Protease Involved In Autophagy 3
  • ATG4 Autophagy Related 4 Homolog D 3
  • APG4 Autophagy 4 Homolog D 3
  • EC 3.4.22.- 4
  • EC 3.4.22 51
  • ATG4D 5

External Ids for ATG4D Gene

Previous HGNC Symbols for ATG4D Gene

  • AUTL4
  • APG4D

Previous GeneCards Identifiers for ATG4D Gene

  • GC19P010518
  • GC19P010654
  • GC19P010232

Summaries for ATG4D Gene

Entrez Gene Summary for ATG4D Gene

  • Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for ATG4D Gene

ATG4D (Autophagy Related 4D Cysteine Peptidase) is a Protein Coding gene. Among its related pathways are Macroautophagy and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type peptidase activity. An important paralog of this gene is ATG4C.

UniProtKB/Swiss-Prot Summary for ATG4D Gene

  • [Cysteine protease ATG4D]: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
  • [Cysteine protease ATG4D, mitochondrial]: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.

Additional gene information for ATG4D Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATG4D Gene

Genomics for ATG4D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ATG4D Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J010543 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.6 556 2.6 ZBTB33 IKZF1 KDM1A POLR2A RCOR2 BACH1 LARP7 MTA2 ZIC2 RBFOX2 ATG4D KRI1 ILF3 ZNF562 LOC100419831 ZNF121 FBXL12 RAVER1 ZNF561 PRKCSH
GH19J010541 Enhancer 0.9 Ensembl ENCODE 600.7 -2.0 -1995 1.4 CTCF JUND PRDM1 ZNF143 REST RAD21 TRIM22 DPF2 SMARCA5 NFE2 ATG4D lnc-ATG4D-2 KRI1 AP1M2 MG828563 S1PR5 lnc-TIMM29-1
GH19J010514 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.8 -26.7 -26679 5.2 HNRNPL PRDM10 ZNF629 IKZF1 KDM1A ZIC2 ZSCAN4 PATZ1 ZNF501 EZH2 S1PR5 LOC100419831 ILF3 KRI1 QTRT1 ATG4D ZNF846 CDKN2D SLC44A2 ZNF562
GH19J010564 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 +23.4 23449 5.9 BRCA1 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 TFE3 RFX1 LEF1 KRI1 CDKN2D ILF3 PPAN DNMT1 ZNF627 FBXL12 LOC100419831 TIMM29 ZNF561
GH19J010415 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 9.9 -123.0 -122979 10.6 ZNF221 BRCA1 RNF2 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 PDE4A CDC37 ILF3 ZNF266 KRI1 LOC100419831 DNMT1 RAVER1 FBXL12 PPAN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATG4D on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ATG4D

Top Transcription factor binding sites by QIAGEN in the ATG4D gene promoter:
  • HOXA5
  • YY1

Genomic Locations for ATG4D Gene

Genomic Locations for ATG4D Gene
chr19:10,543,895-10,553,418
(GRCh38/hg38)
Size:
9,524 bases
Orientation:
Plus strand
chr19:10,654,571-10,664,094
(GRCh37/hg19)
Size:
9,524 bases
Orientation:
Plus strand

Genomic View for ATG4D Gene

Genes around ATG4D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG4D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG4D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG4D Gene

Proteins for ATG4D Gene

  • Protein details for ATG4D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TL0-ATG4D_HUMAN
    Recommended name:
    Cysteine protease ATG4D
    Protein Accession:
    Q86TL0
    Secondary Accessions:
    • Q969K0

    Protein attributes for ATG4D Gene

    Size:
    474 amino acids
    Molecular mass:
    52922 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ATG4D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG4D Gene

Selected DME Specific Peptides for ATG4D Gene

Q86TL0:
  • ILVPVRLGGE
  • AGDWYGP
  • WGCMLRSGQM
  • FPLESFHC
  • VYVSQDCTVYKAD
  • HSLYFIGYQD
  • AWNNVKYGW
  • KMDPSCT
  • WLTYRRDFP

Post-translational modifications for ATG4D Gene

  • Cleaved by CASP3 during apoptosis which leads to increased activity. The cleavage by CASP3 reveals a cryptic mitochondrial targeting sequence immediately downstream of their canonical caspase cleavage sites which leads to mitochondrial import of the protein.
  • Ubiquitination at Lys281, Lys298, and Lys322
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for ATG4D
  • Boster Bio Antibodies for ATG4D

Domains & Families for ATG4D Gene

Gene Families for ATG4D Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Transporters

Protein Domains for ATG4D Gene

Suggested Antigen Peptide Sequences for ATG4D Gene

GenScript: Design optimal peptide antigens:
  • Autophagy-related protein 4 homolog D (ATG4D_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86TL0

UniProtKB/Swiss-Prot:

ATG4D_HUMAN :
  • Residues 64 to 103 constitute a cryptic mitochondrial transit peptide which is revealed after cleavage by caspase of residues 1 to 63 upon oxidative stress and cell death. It acts then as a functional transit peptide, and allows the import of the cleaved protein into the mitochondria (PubMed:22441018).
  • Belongs to the peptidase C54 family.
Domain:
  • Residues 64 to 103 constitute a cryptic mitochondrial transit peptide which is revealed after cleavage by caspase of residues 1 to 63 upon oxidative stress and cell death. It acts then as a functional transit peptide, and allows the import of the cleaved protein into the mitochondria (PubMed:22441018).
Family:
  • Belongs to the peptidase C54 family.
genes like me logo Genes that share domains with ATG4D: view

Function for ATG4D Gene

Molecular function for ATG4D Gene

UniProtKB/Swiss-Prot Function:
[Cysteine protease ATG4D]: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
UniProtKB/Swiss-Prot Function:
[Cysteine protease ATG4D, mitochondrial]: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=13.1 uM for MAP1LC3B {ECO:0000269|PubMed:21177865}; KM=7.2 uM for GABARAPL2 {ECO:0000269|PubMed:21177865};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide.

Enzyme Numbers (IUBMB) for ATG4D Gene

Phenotypes From GWAS Catalog for ATG4D Gene

Gene Ontology (GO) - Molecular Function for ATG4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA,IDA 21177865
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ATG4D: view
genes like me logo Genes that share phenotypes with ATG4D: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ATG4D

CRISPR Products

miRNA for ATG4D Gene

miRTarBase miRNAs that target ATG4D

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATG4D

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATG4D Gene

Localization for ATG4D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG4D Gene

[Cysteine protease ATG4D]: Cytoplasm.
[Cysteine protease ATG4D, mitochondrial]: Cytoplasm. Mitochondrion matrix. Note=Imported into mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death. {ECO:0000269 PubMed:22441018}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATG4D gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 3
lysosome 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ATG4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with ATG4D: view

Pathways & Interactions for ATG4D Gene

genes like me logo Genes that share pathways with ATG4D: view

Pathways by source for ATG4D Gene

1 Sino Biological pathway for ATG4D Gene
2 Reactome pathways for ATG4D Gene
2 KEGG pathways for ATG4D Gene
1 GeneTex pathway for ATG4D Gene

Gene Ontology (GO) - Biological Process for ATG4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IDA 21177865
GO:0006914 autophagy IEA --
GO:0006915 apoptotic process IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with ATG4D: view

No data available for SIGNOR curated interactions for ATG4D Gene

Drugs & Compounds for ATG4D Gene

(8) Drugs for ATG4D Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nimodipine Approved, Investigational Pharma Activator, Potentiation Ca2+ channel blocker (L-type) 42
Omeprazole Approved, Investigational, Vet_approved Pharma Activator H+,K+-ATPase inhibitor 436
Nocodazole Experimental Pharma Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor 0
Chloroquine diphosphate Pharma Antimalarial drug 216
Dexamethasone (DHAP) Pharma Glucocorticoidan;ti-inflammatory 0

(8) ApexBio Compounds for ATG4D Gene

Compound Action Cas Number
Chloroquine diphosphate Antimalarial drug 50-63-5
Dexamethasone (DHAP) Glucocorticoidan;ti-inflammatory 1950-02-2
Divalproex Sodium Epilepsy/migraines/bipolar disorder medicine 76584-70-8
Nimodipine 66085-59-4
Nocodazole Tubulin production inhibitor,anti-neoplastic agent 31430-18-9
Omeprazole H+,K+-ATPase inhibitor 73590-58-6
Sulfacetamide Sodium Sulfonamide antibiotic 127-56-0
Trifluoperazine 2HCl 440-17-5
genes like me logo Genes that share compounds with ATG4D: view

Drug Products

Transcripts for ATG4D Gene

mRNA/cDNA for ATG4D Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATG4D

Alternative Splicing Database (ASD) splice patterns (SP) for ATG4D Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1:
SP2: - - -
SP3:
SP4: - - - -
SP5: - - -
SP6: -
SP7:
SP8:
SP9:

Relevant External Links for ATG4D Gene

GeneLoc Exon Structure for
ATG4D

Expression for ATG4D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ATG4D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATG4D Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ATG4D Gene



Protein tissue co-expression partners for ATG4D Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ATG4D

SOURCE GeneReport for Unigene cluster for ATG4D Gene:

Hs.512799

mRNA Expression by UniProt/SwissProt for ATG4D Gene:

Q86TL0-ATG4D_HUMAN
Tissue specificity: Mainly expressed in skeletal muscle and, to a lower extent, in testis.

Evidence on tissue expression from TISSUES for ATG4D Gene

  • Lung(4.3)
  • Pancreas(3.5)
  • Muscle(2.4)
  • Nervous system(2.4)
  • Heart(2.2)
  • Skin(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with ATG4D: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATG4D Gene

Orthologs for ATG4D Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATG4D Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ATG4D 30 31
  • 99.08 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ATG4D 30 31
  • 89.92 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ATG4D 30 31
  • 88.91 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Atg4d 30
  • 83.51 (n)
Mouse
(Mus musculus)
Mammalia Atg4d 30 17 31
  • 83.33 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ATG4D 31
  • 72 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ATG4D 31
  • 72 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ATG4D 31
  • 57 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia atg4d 30
  • 59.93 (n)
Zebrafish
(Danio rerio)
Actinopterygii atg4da 31
  • 51 (a)
OneToMany
atg4db 31
  • 41 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004023 30
  • 56.96 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG6194 30 31
  • 53.43 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea atg-4.2 30 31
  • 46.18 (n)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG4 31
  • 21 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.753 31
  • 30 (a)
OneToMany
Species where no ortholog for ATG4D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ATG4D Gene

ENSEMBL:
Gene Tree for ATG4D (if available)
TreeFam:
Gene Tree for ATG4D (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATG4D: view image

Paralogs for ATG4D Gene

Paralogs for ATG4D Gene

(4) SIMAP similar genes for ATG4D Gene using alignment to 12 proteins:

  • ATG4D_HUMAN
  • K7EJA5_HUMAN
  • K7EKP6_HUMAN
  • K7EMB9_HUMAN
  • K7EN30_HUMAN
  • K7EP43_HUMAN
  • K7EPJ0_HUMAN
  • K7EQ67_HUMAN
  • K7EQN3_HUMAN
  • K7ERK1_HUMAN
  • K7ESM7_HUMAN
  • Q969K0_HUMAN
genes like me logo Genes that share paralogs with ATG4D: view

Variants for ATG4D Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ATG4D Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
784385 Benign: not provided 10,547,195(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ATG4D Gene

Structural Variations from Database of Genomic Variants (DGV) for ATG4D Gene

Variant ID Type Subtype PubMed ID
nsv833744 CNV loss 17160897
nsv833745 CNV loss 17160897

Variation tolerance for ATG4D Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATG4D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATG4D

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG4D Gene

Disorders for ATG4D Gene

No disorders were found for ATG4D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG4D Gene

Publications for ATG4D Gene

  1. Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. (PMID: 19549685) Betin VM … Lane JD (Journal of cell science 2009) 3 4 23
  2. A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress. (PMID: 22441018) Betin VM … Lane JD (Autophagy 2012) 3 4
  3. Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates. (PMID: 21177865) Li M … Yin XM (The Journal of biological chemistry 2011) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. (PMID: 12446702) Mariño G … López-Otín C (The Journal of biological chemistry 2003) 2 4

Products for ATG4D Gene

  • Signalway Proteins for ATG4D

Sources for ATG4D Gene