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Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling t... See more...
Aliases for ATG4D Gene
Aliases for ATG4D Gene
- AUT-Like 4, Cysteine Endopeptidase (S. Cerevisiae) 2
- ATG4 Autophagy Related 4 Homolog D (S. Cerevisiae) 2
- APG4 Autophagy 4 Homolog D (S. Cerevisiae) 2
- Autophagy Related 4D, Cysteine Peptidase 2
- Cysteine Protease Involved In Autophagy 3
- ATG4 Autophagy Related 4 Homolog D 3
- APG4 Autophagy 4 Homolog D 3
- EC 3.4.22.- 4
- EC 3.4.22 51
- ATG4D 5
External Ids for ATG4D Gene
- HGNC: 20789
- Entrez Gene: 84971
- Ensembl: ENSG00000130734
- OMIM: 611340
- UniProtKB: Q86TL0
Previous HGNC Symbols for ATG4D Gene
- AUTL4
- APG4D
Previous GeneCards Identifiers for ATG4D Gene
- GC19P010518
- GC19P010654
- GC19P010232
Summaries for ATG4D Gene
-
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for ATG4D Gene
ATG4D (Autophagy Related 4D Cysteine Peptidase) is a Protein Coding gene. Among its related pathways are Macroautophagy and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type peptidase activity. An important paralog of this gene is ATG4C.
UniProtKB/Swiss-Prot Summary for ATG4D Gene
-
[Cysteine protease ATG4D]: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
-
[Cysteine protease ATG4D, mitochondrial]: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.
Additional gene information for ATG4D Gene
- HGNC(20789)
- Entrez Gene(84971)
- Ensembl(ENSG00000130734)
- OMIM(611340)
- UniProtKB(Q86TL0)
- Open Targets Platform(ENSG00000130734)
- Search for ATG4D at DataMed
- Search for ATG4D at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATG4D Gene
Genomics for ATG4D Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ATG4D Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ATG4D on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ATG4D
- Top Transcription factor binding sites by QIAGEN in the ATG4D gene promoter:
-
- HOXA5
- YY1
Genomic Locations for ATG4D Gene
Genomic Locations for ATG4D Gene
- chr19:10,543,895-10,553,418
- (GRCh38/hg38)
- Size:
- 9,524 bases
- Orientation:
- Plus strand
- chr19:10,654,571-10,664,094
- (GRCh37/hg19)
- Size:
- 9,524 bases
- Orientation:
- Plus strand
Genomic View for ATG4D Gene
Genes around ATG4D on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
ATG4D Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ATG4D Gene
Proteins for ATG4D Gene
-
Protein details for ATG4D Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86TL0-ATG4D_HUMAN
- Recommended name:
- Cysteine protease ATG4D
- Protein Accession:
- Q86TL0
- Q969K0
Protein attributes for ATG4D Gene
- Size:
- 474 amino acids
- Molecular mass:
- 52922 Da
- Quaternary structure:
- No Data Available
Protein Expression for ATG4D Gene
Selected DME Specific Peptides for ATG4D Gene
- Q86TL0:
-
- ILVPVRLGGE
- AGDWYGP
- WGCMLRSGQM
- FPLESFHC
- VYVSQDCTVYKAD
- HSLYFIGYQD
- AWNNVKYGW
- KMDPSCT
- WLTYRRDFP
Post-translational modifications for ATG4D Gene
- Cleaved by CASP3 during apoptosis which leads to increased activity. The cleavage by CASP3 reveals a cryptic mitochondrial targeting sequence immediately downstream of their canonical caspase cleavage sites which leads to mitochondrial import of the protein.
-
Ubiquitination at Lys281, Lys298, and Lys322
- NX_Q86TL0 (NX_Q86TL0-1)
- Modification sites at PhosphoSitePlus
Other Protein References for ATG4D Gene
Antibody Products
- LifeSpan BioSciences ATG4D Antibody
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-
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-
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- Invitrogen Antibodies for ATG4D (AFLGC-Atg4d)
-
Boster Bio Antibodies for ATG4D
-
Custom Antibody ServicesProSci Antibodies for ATG4D
-
Santa Cruz Biotechnology (SCBT) Antibodies for ATG4D
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ATG4D
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-
Signalway Proteins for ATG4D
-
Abcam proteins for ATG4D
Domains & Families for ATG4D Gene
Gene Families for ATG4D Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Transporters
Protein Domains for ATG4D Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ATG4D Gene
- GenScript: Design optimal peptide antigens:
-
- Autophagy-related protein 4 homolog D (ATG4D_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q86TL0UniProtKB/Swiss-Prot:
ATG4D_HUMAN :- Residues 64 to 103 constitute a cryptic mitochondrial transit peptide which is revealed after cleavage by caspase of residues 1 to 63 upon oxidative stress and cell death. It acts then as a functional transit peptide, and allows the import of the cleaved protein into the mitochondria (PubMed:22441018).
- Belongs to the peptidase C54 family.
- Domain:
-
- Residues 64 to 103 constitute a cryptic mitochondrial transit peptide which is revealed after cleavage by caspase of residues 1 to 63 upon oxidative stress and cell death. It acts then as a functional transit peptide, and allows the import of the cleaved protein into the mitochondria (PubMed:22441018).
- Family:
-
- Belongs to the peptidase C54 family.
Function for ATG4D Gene
Molecular function for ATG4D Gene
- UniProtKB/Swiss-Prot Function:
- [Cysteine protease ATG4D]: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
- UniProtKB/Swiss-Prot Function:
- [Cysteine protease ATG4D, mitochondrial]: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=13.1 uM for MAP1LC3B {ECO:0000269|PubMed:21177865}; KM=7.2 uM for GABARAPL2 {ECO:0000269|PubMed:21177865};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by N-ethylmaleimide.
Enzyme Numbers (IUBMB) for ATG4D Gene
Phenotypes From GWAS Catalog for ATG4D Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008234 | cysteine-type peptidase activity | IEA,IDA | 21177865 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for ATG4D Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for ATG4D
CRISPR Products
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-
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miRNA for ATG4D Gene
- miRTarBase miRNAs that target ATG4D
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for ATG4D - Select products 50% OFF >
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Cell Line Products
-
Horizon Cell Lines for ATG4D
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATG4D Gene
Localization for ATG4D Gene
Subcellular locations from UniProtKB/Swiss-Prot for ATG4D Gene
- [Cysteine protease ATG4D]: Cytoplasm.
- [Cysteine protease ATG4D, mitochondrial]: Cytoplasm. Mitochondrion matrix. Note=Imported into mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death. {ECO:0000269 PubMed:22441018}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 4 |
| cytosol | 3 |
| lysosome | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Mitochondria (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0005759 | mitochondrial matrix | IEA | -- |
Pathways & Interactions for ATG4D Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Macroautophagy |
.34
|
|
| 2 | Autophagy - animal | ||
| 3 | Autophagy Pathway | ||
| 4 | Cellular Senescence (REACTOME) | ||
Pathways by source for ATG4D Gene
1 Sino Biological pathway for ATG4D Gene
2 Reactome pathways for ATG4D Gene
2 KEGG pathways for ATG4D Gene
1 GeneTex pathway for ATG4D Gene
Interacting Proteins for ATG4D Gene
GPS-Prot Interaction Network for ATG4D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA,IDA | 21177865 |
| GO:0006914 | autophagy | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
No data available for SIGNOR curated interactions for ATG4D Gene
Drugs & Compounds for ATG4D Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Nimodipine | Approved, Investigational | Pharma | Activator, Potentiation | Ca2+ channel blocker (L-type) | 42 | |
| Omeprazole | Approved, Investigational, Vet_approved | Pharma | Activator | H+,K+-ATPase inhibitor | 436 | |
| Nocodazole | Experimental | Pharma | Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor | 0 | ||
| Chloroquine diphosphate | Pharma | Antimalarial drug | 216 | |||
| Dexamethasone (DHAP) | Pharma | Glucocorticoidan;ti-inflammatory | 0 |
(8) ApexBio Compounds for ATG4D Gene
| Compound | Action | Cas Number |
|---|---|---|
| Chloroquine diphosphate | Antimalarial drug | 50-63-5 |
| Dexamethasone (DHAP) | Glucocorticoidan;ti-inflammatory | 1950-02-2 |
| Divalproex Sodium | Epilepsy/migraines/bipolar disorder medicine | 76584-70-8 |
| Nimodipine | 66085-59-4 | |
| Nocodazole | Tubulin production inhibitor,anti-neoplastic agent | 31430-18-9 |
| Omeprazole | H+,K+-ATPase inhibitor | 73590-58-6 |
| Sulfacetamide Sodium | Sulfonamide antibiotic | 127-56-0 |
| Trifluoperazine 2HCl | 440-17-5 |
Transcripts for ATG4D Gene
mRNA/cDNA for ATG4D Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000586417 1752 nts (view in UCSC)
- ENST00000590096 1282 nts (view in UCSC)
- ENST00000588857 1555 nts (view in UCSC)
- ENST00000585752 729 nts (view in UCSC)
- ENST00000309469 1963 nts (view in UCSC)
CRISPR Products
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-
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATG4D
-
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miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ATG4D
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Clone Products
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- Sino Biological Human cDNA Clone for ATG4D
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| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
Relevant External Links for ATG4D Gene
- GeneLoc Exon Structure for
- ATG4D
Expression for ATG4D Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
This gene is overexpressed in Placenta (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ATG4D Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ATG4D
SOURCE GeneReport for Unigene cluster for ATG4D Gene:
Hs.512799mRNA Expression by UniProt/SwissProt for ATG4D Gene:
Q86TL0-ATG4D_HUMAN
Tissue specificity:
Mainly expressed in skeletal muscle and, to a lower extent, in testis.
Evidence on tissue expression from TISSUES for ATG4D Gene
- Lung(4.3)
- Pancreas(3.5)
- Muscle(2.4)
- Nervous system(2.4)
- Heart(2.2)
- Skin(2.1)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs for ATG4D
-
OriGene qPCR primer pairs and template standards for ATG4D
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATG4D Gene
Orthologs for ATG4D Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ATG4D 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ATG4D 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ATG4D 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Atg4d 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Atg4d 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ATG4D 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ATG4D 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ATG4D 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | atg4d 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | atg4da 31 |
|
OneToMany | |
| atg4db 31 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004023 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG6194 30 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | atg-4.2 30 31 |
|
ManyToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ATG4 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.753 31 |
|
OneToMany |
- Species where no ortholog for ATG4D was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ATG4D Gene
- ENSEMBL:
- Gene Tree for ATG4D (if available)
- TreeFam:
- Gene Tree for ATG4D (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ATG4D: view image
Paralogs for ATG4D Gene
(4) SIMAP similar genes for ATG4D Gene using alignment to 12 proteins:
- ATG4D_HUMAN
- K7EJA5_HUMAN
- K7EKP6_HUMAN
- K7EMB9_HUMAN
- K7EN30_HUMAN
- K7EP43_HUMAN
- K7EPJ0_HUMAN
- K7EQ67_HUMAN
- K7EQN3_HUMAN
- K7ERK1_HUMAN
- K7ESM7_HUMAN
- Q969K0_HUMAN
Variants for ATG4D Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ATG4D Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 784385 | Benign: not provided | 10,547,195(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.97;
36.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ATG4D Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ATG4D
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG4D Gene
Disorders for ATG4D Gene
Additional Disease Information for ATG4D
No disorders were found for ATG4D Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG4D Gene
Publications for ATG4D Gene
- Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. (PMID: 19549685) Betin VM … Lane JD (Journal of cell science 2009) 3 4 23
- A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress. (PMID: 22441018) Betin VM … Lane JD (Autophagy 2012) 3 4
- Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates. (PMID: 21177865) Li M … Yin XM (The Journal of biological chemistry 2011) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. (PMID: 12446702) Mariño G … López-Otín C (The Journal of biological chemistry 2003) 2 4
ExternalLinks
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- Abcam antibodies for ATG4D
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- Taconic Biosciences Mouse Models for ATG4D
- Find your next knockout model in the Taconic Knockout Repository
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- Invitrogen Antibodies for ATG4D (AFLGC-Atg4d)
- ApexBio compounds for ATG4D
- VectorBuilder Custom and pre-made DNA vectors for ATG4D (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ATG4D (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ATG4D (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ATG4D CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ATG4D
- antibodies-online: Show 73 available ATG4D Antibodies ranked by validation data
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- antibodies-online: Search results for available ATG4D related products ranked by validation data
- antibodies-online: Search results for available ATG4D related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for ATG4D
- Search Santa Cruz Biotechnology (SCBT) for ATG4D siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ATG4D
- Custom Antibody ServicesProSci Antibodies for ATG4D
- Search for ATG4D Proteins at ProSci
- Horizon Cell Lines for ATG4D
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATG4D
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATG4D
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ATG4D
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATG4D
- Boster Bio Antibodies for ATG4D
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- Signalway Proteins for ATG4D
Sources for ATG4D Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB