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ATG4D Gene(Protein Coding)

Autophagy Related 4D Cysteine Peptidase

GCID:
GC19P010518
GIFtS:
43
Genes Participants
UDN Logo

Aliases for ATG4D Gene

Aliases for ATG4D Gene

  • Autophagy Related 4D Cysteine Peptidase 2 3 5
  • Autophagy-Related Cysteine Endopeptidase 4 3 4
  • Autophagy-Related Protein 4 Homolog D 3 4
  • AUT-Like 4 Cysteine Endopeptidase 3 4
  • Cysteine Protease ATG4D 3 4
  • Autophagin-4 3 4
  • APG4D 3 4
  • AUTL4 3 4
  • AUT-Like 4, Cysteine Endopeptidase (S. Cerevisiae) 2
  • ATG4 Autophagy Related 4 Homolog D (S. Cerevisiae) 2
  • APG4 Autophagy 4 Homolog D (S. Cerevisiae) 2
  • Autophagy Related 4D, Cysteine Peptidase 2
  • Cysteine Protease Involved In Autophagy 3
  • ATG4 Autophagy Related 4 Homolog D 3
  • APG4 Autophagy 4 Homolog D 3
  • EC 3.4.22.- 4
  • EC 3.4.22 56
  • APG4-D 3

External Ids for ATG4D Gene

Previous HGNC Symbols for ATG4D Gene

  • AUTL4
  • APG4D

Previous GeneCards Identifiers for ATG4D Gene

  • GC19P010654
  • GC19P010232

Summaries for ATG4D Gene

Entrez Gene Summary for ATG4D Gene

  • Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for ATG4D Gene

ATG4D (Autophagy Related 4D Cysteine Peptidase) is a Protein Coding gene. Among its related pathways are Autophagy Pathway and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type peptidase activity. An important paralog of this gene is ATG4C.

UniProtKB/Swiss-Prot for ATG4D Gene

  • Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
  • Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.

Additional gene information for ATG4D Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG4D Gene

Genomics for ATG4D Gene

GeneHancer (GH) Regulatory Elements for ATG4D Gene

Promoters and enhancers for ATG4D Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J010543 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 600.7 +0.3 278 3.1 CC2D1A ZFX CBFA2T2 NKRF ZNF121 POLR2A ZNF687 NFIB ZNF24 MAFK ATG4D KRI1 ILF3 ZNF562 LOC100419831 ZNF121 FBXL12 RAVER1 ZNF561 PRKCSH
GH19J010514 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.8 -26.7 -26678 5.2 ZNF148 ZNF121 ZSCAN21 ZBTB7A YY1 KLF14 EGR1 GLIS2 IKZF1 ZBTB8A S1PR5 LOC100419831 ILF3 KRI1 QTRT1 ATG4D ZNF846 CDKN2D SLC44A2 ZNF562
GH19J010595 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.9 +52.3 52337 1.9 IKZF1 ZBTB33 IKZF2 ZSCAN4 TRIM22 KLF9 DPF2 RUNX3 NBN NR2F2 KRI1 CDKN2D SLC44A2 ICAM3 ATG4D ILF3 TYK2 DNM2 C19orf38 S1PR5
GH19J010418 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.9 -124.1 -124114 3.6 ZNF652 CC2D1A SP1 MNT ZNF148 NKRF GTF2F1 ZSCAN21 NCOA3 CDC5L CDC37 PDE4A ILF3 ZNF266 KRI1 DNMT1 LOC100419831 RAVER1 FBXL12 ZNF562
GH19J011354 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.8 +811.8 811817 1.9 CC2D1A ZFX ZNF148 MLLT1 ZSCAN21 CDC5L MCM2 ZBTB7A SP7 POLR2A PLPPR2 ZNF627 ZNF625 ZNF20 ILF3 ZNF844 ENSG00000242615 ZNF136 ZNF439 ZNF44
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATG4D on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ATG4D gene promoter:
  • HOXA5
  • YY1

Genomic Locations for ATG4D Gene

Genomic Locations for ATG4D Gene
chr19:10,543,894-10,553,423
(GRCh38/hg38)
Size:
9,530 bases
Orientation:
Plus strand
chr19:10,654,571-10,664,094
(GRCh37/hg19)
Size:
9,524 bases
Orientation:
Plus strand

Genomic View for ATG4D Gene

Genes around ATG4D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG4D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG4D Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ATG4D Gene

Proteins for ATG4D Gene

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  • Protein details for ATG4D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TL0-ATG4D_HUMAN
    Recommended name:
    Cysteine protease ATG4D
    Protein Accession:
    Q86TL0
    Secondary Accessions:
    • Q969K0

    Protein attributes for ATG4D Gene

    Size:
    474 amino acids
    Molecular mass:
    52922 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ATG4D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG4D Gene

Protein Expression for ATG4D Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ATG4D Gene

Q86TL0:
  • ILVPVRLGGE
  • AGDWYGP
  • WGCMLRSGQM
  • FPLESFHC
  • VYVSQDCTVYKAD
  • HSLYFIGYQD
  • AWNNVKYGW
  • KMDPSCT
  • WLTYRRDFP

Post-translational modifications for ATG4D Gene

  • Cleaved by CASP3 during apoptosis which leads to increased activity. The cleavage by CASP3 reveals a cryptic mitochondrial targeting sequence immediately downstream of their canonical caspase cleavage sites which leads to mitochondrial import of the protein.
  • Ubiquitination at posLast=298298, isoforms=322, and posLast=281281
  • Modification sites at PhosphoSitePlus

Other Protein References for ATG4D Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ATG4D Gene

Gene Families for ATG4D Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ATG4D Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATG4D Gene

GenScript: Design optimal peptide antigens:
  • Autophagy-related protein 4 homolog D (ATG4D_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86TL0

UniProtKB/Swiss-Prot:

ATG4D_HUMAN :
  • Residues 64 to 103 constitute a cryptic mitochondrial transit peptide which is revealed after cleavage by caspase of residues 1 to 63 upon oxidative stress and cell death. It acts then as a functional transit peptide, and allows the import of the cleaved protein into the mitochondria (PubMed:22441018).
  • Belongs to the peptidase C54 family.
Domain:
  • Residues 64 to 103 constitute a cryptic mitochondrial transit peptide which is revealed after cleavage by caspase of residues 1 to 63 upon oxidative stress and cell death. It acts then as a functional transit peptide, and allows the import of the cleaved protein into the mitochondria (PubMed:22441018).
Family:
  • Belongs to the peptidase C54 family.
genes like me logo Genes that share domains with ATG4D: view

Function for ATG4D Gene

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Molecular function for ATG4D Gene

UniProtKB/Swiss-Prot Function:
Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
UniProtKB/Swiss-Prot Function:
Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=13.1 uM for MAP1LC3B {ECO:0000269 PubMed:21177865}; KM=7.2 uM for GABARAPL2 {ECO:0000269 PubMed:21177865};

Enzyme Numbers (IUBMB) for ATG4D Gene

Phenotypes From GWAS Catalog for ATG4D Gene

Gene Ontology (GO) - Molecular Function for ATG4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ATG4D: view
genes like me logo Genes that share phenotypes with ATG4D: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ATG4D

CRISPR Products

miRNA for ATG4D Gene

miRTarBase miRNAs that target ATG4D

Inhibitory RNA Products

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No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATG4D Gene

Localization for ATG4D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG4D Gene

Cysteine protease ATG4D: Cytoplasm.
Cysteine protease ATG4D, mitochondrial: Cytoplasm. Mitochondrion matrix. Note=Imported into mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death. {ECO:0000269 PubMed:22441018}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATG4D gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytosol 1
lysosome 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for ATG4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with ATG4D: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ATG4D Gene

Pathways & Interactions for ATG4D Gene

GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards
genes like me logo Genes that share pathways with ATG4D: view

Pathways by source for ATG4D Gene

2 Reactome pathways for ATG4D Gene
2 KEGG pathways for ATG4D Gene
1 GeneTex pathway for ATG4D Gene

Gene Ontology (GO) - Biological Process for ATG4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006914 autophagy IEA --
GO:0006915 apoptotic process IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with ATG4D: view

No data available for SIGNOR curated interactions for ATG4D Gene

Drugs & Compounds for ATG4D Gene

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(8) Drugs for ATG4D Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nimodipine Approved, Investigational Pharma Potentiation, Activator Ca2+ channel blocker (L-type) 32
Omeprazole Approved, Investigational, Vet_approved Pharma Activator H+,K+-ATPase inhibitor 406
Nocodazole Experimental Pharma Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor 0
Chloroquine diphosphate Pharma Antimalarial drug 163
Dexamethasone (DHAP) Pharma Glucocorticoidan;ti-inflammatory 0

(8) ApexBio Compounds for ATG4D Gene

Compound Action Cas Number
Chloroquine diphosphate Antimalarial drug 50-63-5
Dexamethasone (DHAP) Glucocorticoidan;ti-inflammatory 1950-02-2
Divalproex Sodium Epilepsy/migraines/bipolar disorder medicine 76584-70-8
Nimodipine 66085-59-4
Nocodazole Tubulin production inhibitor,anti-neoplastic agent 31430-18-9
Omeprazole H+,K+-ATPase inhibitor 73590-58-6
Sulfacetamide Sodium Sulfonamide antibiotic 127-56-0
Trifluoperazine 2HCl 440-17-5
genes like me logo Genes that share compounds with ATG4D: view

Drug Products

Transcripts for ATG4D Gene

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mRNA/cDNA for ATG4D Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(127) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ATG4D Gene

Autophagy related 4D, cysteine peptidase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

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Clone Products

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Alternative Splicing Database (ASD) splice patterns (SP) for ATG4D Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1:
SP2: - - -
SP3:
SP4: - - - -
SP5: - - -
SP6: -
SP7:
SP8:
SP9:

Relevant External Links for ATG4D Gene

GeneLoc Exon Structure for
ATG4D
ECgene alternative splicing isoforms for
ATG4D

Expression for ATG4D Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATG4D Gene

mRNA expression in normal human tissues for ATG4D Gene
mRNA expression by GTEx for ATG4D GenemRNA expression by BioGPS for ATG4D Gene

Protein differential expression in normal tissues from HIPED for ATG4D Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ATG4D Gene



Protein tissue co-expression partners for ATG4D Gene

NURSA nuclear receptor signaling pathways regulating expression of ATG4D Gene:

ATG4D

SOURCE GeneReport for Unigene cluster for ATG4D Gene:

Hs.512799

mRNA Expression by UniProt/SwissProt for ATG4D Gene:

Q86TL0-ATG4D_HUMAN
Tissue specificity: Mainly expressed in skeletal muscle and, to a lower extent, in testis.

Evidence on tissue expression from TISSUES for ATG4D Gene

  • Lung(4.2)
  • Pancreas(3.2)
genes like me logo Genes that share expression patterns with ATG4D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATG4D Gene

Orthologs for ATG4D Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATG4D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ATG4D 35 34
  • 99.08 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia ATG4D 35 34
  • 89.92 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia ATG4D 35 34
  • 88.91 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Atg4d 34
  • 83.51 (n)
mouse
(Mus musculus)
 Mammalia Atg4d 17 35 34
  • 83.33 (n)
oppossum
(Monodelphis domestica)
 Mammalia ATG4D 35
  • 72 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ATG4D 35
  • 72 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ATG4D 35
  • 57 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia atg4d 34
  • 59.93 (n)
zebrafish
(Danio rerio)
 Actinopterygii atg4da 35
  • 51 (a)
 OneToMany
atg4db 35
  • 41 (a)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP004023 34
  • 56.96 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG6194 35 34
  • 53.43 (n)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea atg-4.2 35 34
  • 46.18 (n)
 ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes ATG4 35
  • 21 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.753 35
  • 30 (a)
 OneToMany
Species where no ortholog for ATG4D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG4D Gene

ENSEMBL:
Gene Tree for ATG4D (if available)
TreeFam:
Gene Tree for ATG4D (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATG4D: view image

Paralogs for ATG4D Gene

Paralogs for ATG4D Gene

(4) SIMAP similar genes for ATG4D Gene using alignment to 12 proteins:

  • ATG4D_HUMAN
  • K7EJA5_HUMAN
  • K7EKP6_HUMAN
  • K7EMB9_HUMAN
  • K7EN30_HUMAN
  • K7EP43_HUMAN
  • K7EPJ0_HUMAN
  • K7EQ67_HUMAN
  • K7EQN3_HUMAN
  • K7ERK1_HUMAN
  • K7ESM7_HUMAN
  • Q969K0_HUMAN
genes like me logo Genes that share paralogs with ATG4D: view

Variants for ATG4D Gene

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Sequence variations from dbSNP and Humsavar for ATG4D Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000024901 -- 10,548,634(+) G/A intron_variant
rs1000179148 -- 10,542,729(+) C/T upstream_transcript_variant
rs1000543180 -- 10,544,124(+) C/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000613152 -- 10,543,077(+) G/A upstream_transcript_variant
rs1000916464 -- 10,544,006(+) C/A/T 5_prime_UTR_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ATG4D Gene

Variant ID Type Subtype PubMed ID
nsv833744 CNV loss 17160897
nsv833745 CNV loss 17160897

Variation tolerance for ATG4D Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATG4D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATG4D

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG4D Gene

Disorders for ATG4D Gene

Additional Disease Information for ATG4D

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ATG4D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG4D Gene

Publications for ATG4D Gene

  1. Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. (PMID: 19549685) Betin VM … Lane JD (Journal of cell science 2009) 3 4 23 58
  2. A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress. (PMID: 22441018) Betin VM … Lane JD (Autophagy 2012) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. (PMID: 12446702) Mariño G … López-Otín C (The Journal of biological chemistry 2003) 2 4 58
  5. The Influence of Tumor Microenvironment on ATG4D Gene Expression in Colorectal Cancer Patients. (PMID: 30374741) Gil J … Sasiadek MM (Medical oncology (Northwood, London, England) 2018) 3 58

ExternalLinks

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