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Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]
ATG4C (Autophagy Related 4C Cysteine Peptidase) is a Protein Coding gene. Among its related pathways are Macroautophagy and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include peptidase activity and cysteine-type peptidase activity. An important paralog of this gene is ATG4D.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004197 | cysteine-type endopeptidase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 32814053 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008234 | cysteine-type peptidase activity | IEA,IDA | 21177865 |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005575 | cellular_component | ND | -- |
GO:0005737 | cytoplasm | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Macroautophagy |
.34
|
|
2 | Autophagy - animal | ||
3 | Autophagy Pathway | ||
4 | Cellular Senescence (REACTOME) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA,IDA | 21177865 |
GO:0006914 | autophagy | IEA | -- |
GO:0015031 | protein transport | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Nimodipine | Approved, Investigational | Pharma | Ca2+ channel blocker (L-type) | 43 | ||
Omeprazole | Approved, Investigational, Vet_approved | Pharma | H+,K+-ATPase inhibitor | 452 | ||
Chloroquine diphosphate | Pharma | Antimalarial drug | 222 | |||
Dexamethasone (DHAP) | Pharma | Glucocorticoidan;ti-inflammatory | 0 | |||
Sulfacetamide Sodium | Pharma | Sulfonamide antibiotic | 0 |
Compound | Action | Cas Number |
---|---|---|
Chloroquine diphosphate | Antimalarial drug | 50-63-5 |
Dexamethasone (DHAP) | Glucocorticoidan;ti-inflammatory | 1950-02-2 |
Divalproex Sodium | Epilepsy/migraines/bipolar disorder medicine | 76584-70-8 |
Nimodipine | 66085-59-4 | |
Omeprazole | H+,K+-ATPase inhibitor | 73590-58-6 |
Sulfacetamide Sodium | Sulfonamide antibiotic | 127-56-0 |
Trifluoperazine 2HCl | 440-17-5 |
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ATG4C 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ATG4C 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ATG4C 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Atg4c 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Atg4c 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | ATG4C 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ATG4C 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ATG4C 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ATG4C 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | atg4c 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.1688 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | atg4c 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG6194 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | atg-4.2 31 |
|
ManyToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ATG4 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.753 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3577901 | CNV | loss | 25503493 |
nsv1145348 | CNV | deletion | 24896259 |
nsv830015 | CNV | gain | 17160897 |
No disorders were found for ATG4C Gene.