Aliases for ATG2B Gene
External Ids for ATG2B Gene
Previous HGNC Symbols for ATG2B Gene
Previous GeneCards Identifiers for ATG2B Gene
This gene encodes a protein required for autophagy. The encoded protein is involved in autophagosome formation. A germline duplication of a region that includes this gene is associated with predisposition to myeloid malignancies. [provided by RefSeq, Jul 2016]
GeneCards Summary for ATG2B Gene
ATG2B (Autophagy Related 2B) is a Protein Coding gene. Among its related pathways are Pathways of neurodegeneration - multiple diseases and Autophagy Pathway. An important paralog of this gene is ATG2A.
UniProtKB/Swiss-Prot Summary for ATG2B Gene
Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:31721365).