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Aliases for ATG2B Gene

Aliases for ATG2B Gene

  • Autophagy Related 2B 2 3 5
  • C14orf103 3 4
  • ATG2 Autophagy Related 2 Homolog B (S. Cerevisiae) 2
  • Autophagy-Related Protein 2 Homolog B 3
  • Chromosome 14 Open Reading Frame 103 2
  • ATG2 Autophagy Related 2 Homolog B 3

External Ids for ATG2B Gene

Previous HGNC Symbols for ATG2B Gene

  • C14orf103

Previous GeneCards Identifiers for ATG2B Gene

  • GC14M095817
  • GC14M096747
  • GC14M076932

Summaries for ATG2B Gene

Entrez Gene Summary for ATG2B Gene

  • This gene encodes a protein required for autophagy. The encoded protein is involved in autophagosome formation. A germline duplication of a region that includes this gene is associated with predisposition to myeloid malignancies. [provided by RefSeq, Jul 2016]

GeneCards Summary for ATG2B Gene

ATG2B (Autophagy Related 2B) is a Protein Coding gene. Diseases associated with ATG2B include Hypertrophy Of Breast. Among its related pathways are Autophagy - animal and Autophagy Pathway. An important paralog of this gene is ATG2A.

UniProtKB/Swiss-Prot for ATG2B Gene

  • Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.

Additional gene information for ATG2B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG2B Gene

Genomics for ATG2B Gene

GeneHancer (GH) Regulatory Elements for ATG2B Gene

Promoters and enhancers for ATG2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I096361 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.2 182 4.7 PKNOX1 CLOCK ATF1 FOXA2 ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF121 GSKIP ATG2B
GH14I095494 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14.6 +867.7 867734 4 HDGF PKNOX1 NFIB BMI1 BATF KLF5 IRF4 ZBTB40 ZNF143 ATF7 ATG2B SNHG10 BDKRB1 SYNE3 CLMN LOC101929107 LOC105370641
GH14I096796 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.1 -433.9 -433896 2.1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 E2F8 ZNF143 VRK1 PAPOLA ATG2B GC14P096860
GH14I096224 Enhancer 1 Ensembl ENCODE dbSUPER 14.6 +138.6 138581 2.5 CTCF STAT1 KLF1 ZNF140 MNT RAD21 FOXA1 ZFP36 SMC3 EGR2 SNHG10 SCARNA13 PAPOLA ATG2B GC14P096224 ENSG00000259036 ENSG00000258691 BDKRB2
GH14I096888 Enhancer 1.1 UCNEbase 9.8 -524.9 -524858 0.3 PKNOX1 ARNT FEZF1 ZNF2 ZNF302 KLF7 REST TSHZ1 ZNF488 GLIS1 PAPOLA ATG2B GC14P096860 LINC00618 VRK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ATG2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ATG2B gene promoter:

Genomic Locations for ATG2B Gene

Genomic Locations for ATG2B Gene
84,669 bases
Minus strand

Genomic View for ATG2B Gene

Genes around ATG2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG2B Gene

Proteins for ATG2B Gene

  • Protein details for ATG2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Autophagy-related protein 2 homolog B
    Protein Accession:
    Secondary Accessions:
    • Q6ZRE7
    • Q96DQ3
    • Q9NW80

    Protein attributes for ATG2B Gene

    2078 amino acids
    Molecular mass:
    232763 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91504.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB70872.1; Type=Erroneous termination; Positions=800; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAC87363.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ATG2B Gene

Post-translational modifications for ATG2B Gene

No Post-translational modifications

Other Protein References for ATG2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATG2B Gene

Domains & Families for ATG2B Gene

Gene Families for ATG2B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ATG2B Gene

Suggested Antigen Peptide Sequences for ATG2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ATG2 family.
  • Belongs to the ATG2 family.
genes like me logo Genes that share domains with ATG2B: view

Function for ATG2B Gene

Molecular function for ATG2B Gene

UniProtKB/Swiss-Prot Function:
Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.

Phenotypes From GWAS Catalog for ATG2B Gene

genes like me logo Genes that share phenotypes with ATG2B: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATG2B Gene

Localization for ATG2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG2B Gene

Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATG2B gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATG2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 phagophore assembly site IBA --
GO:0005654 nucleoplasm IDA --
GO:0005811 lipid droplet IEA --
GO:0016020 membrane IEA --
GO:0019898 extrinsic component of membrane IBA --
genes like me logo Genes that share ontologies with ATG2B: view

Pathways & Interactions for ATG2B Gene

genes like me logo Genes that share pathways with ATG2B: view

Pathways by source for ATG2B Gene

2 KEGG pathways for ATG2B Gene

Gene Ontology (GO) - Biological Process for ATG2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0000422 autophagy of mitochondrion IBA --
GO:0006914 autophagy IEA --
GO:0044804 autophagy of nucleus IBA --
genes like me logo Genes that share ontologies with ATG2B: view

No data available for SIGNOR curated interactions for ATG2B Gene

Drugs & Compounds for ATG2B Gene

No Compound Related Data Available

Transcripts for ATG2B Gene

Unigene Clusters for ATG2B Gene

Autophagy related 2B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG2B Gene

No ASD Table

Relevant External Links for ATG2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATG2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATG2B Gene

Protein differential expression in normal tissues from HIPED for ATG2B Gene

This gene is overexpressed in Fetal Brain (12.0), Bone marrow mesenchymal stem cell (10.0), Frontal cortex (9.4), Retina (8.6), and Pancreas (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATG2B Gene

Protein tissue co-expression partners for ATG2B Gene

NURSA nuclear receptor signaling pathways regulating expression of ATG2B Gene:


SOURCE GeneReport for Unigene cluster for ATG2B Gene:


Evidence on tissue expression from TISSUES for ATG2B Gene

  • Liver(4.2)
  • Skin(4.2)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with ATG2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATG2B Gene

Orthologs for ATG2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATG2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATG2B 33 34
  • 99.6 (n)
(Canis familiaris)
Mammalia ATG2B 33 34
  • 91.13 (n)
(Bos Taurus)
Mammalia ATG2B 33 34
  • 90.38 (n)
(Monodelphis domestica)
Mammalia ATG2B 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia ATG2B 34
  • 86 (a)
(Mus musculus)
Mammalia Atg2b 33 16 34
  • 85.69 (n)
(Gallus gallus)
Aves ATG2B 33 34
  • 78.8 (n)
(Anolis carolinensis)
Reptilia ATG2B 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atg2b 33
  • 71.22 (n)
Str.8303 33
(Danio rerio)
Actinopterygii ATG2B 34
  • 75 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004092 33
  • 46.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta Atg2 33 34
  • 45.03 (n)
(Caenorhabditis elegans)
Secernentea atg-2 34
  • 18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG2 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1201 34
  • 35 (a)
Species where no ortholog for ATG2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG2B Gene

Gene Tree for ATG2B (if available)
Gene Tree for ATG2B (if available)

Paralogs for ATG2B Gene

Paralogs for ATG2B Gene

(1) SIMAP similar genes for ATG2B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATG2B: view

Variants for ATG2B Gene

Sequence variations from dbSNP and Humsavar for ATG2B Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000047617 -- 96,353,595(-) C/T intron_variant
rs1000169867 -- 96,281,917(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000218978 -- 96,291,820(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000234409 -- 96,287,058(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000339339 -- 96,323,432(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ATG2B Gene

Variant ID Type Subtype PubMed ID
esv3635420 CNV gain 21293372

Variation tolerance for ATG2B Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.67; 78.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATG2B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG2B Gene

Disorders for ATG2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ATG2B Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
hypertrophy of breast
  • breasts enlarged
- elite association - COSMIC cancer census association via MalaCards
Search ATG2B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ATG2B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ATG2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATG2B Gene

Publications for ATG2B Gene

  1. miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells. (PMID: 22350415) Kovaleva V … Seiffert M (Cancer research 2012) 2 3 58
  2. Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. (PMID: 22219374) Velikkakath AK … Mizushima N (Molecular biology of the cell 2012) 3 4 58
  3. Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability. (PMID: 19197948) Kang MR … Lee SH (The Journal of pathology 2009) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ATG2B Gene

Sources for ATG2B Gene

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