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Aliases for ATG16L2 Gene

Aliases for ATG16L2 Gene

  • Autophagy Related 16 Like 2 2 3 5
  • WD Repeat-Containing Protein 80 3 4
  • APG16-Like 2 3 4
  • WDR80 3 4
  • ATG16 Autophagy Related 16-Like 2 (S. Cerevisiae) 2
  • Autophagy Related 16-Like 2 (S. Cerevisiae) 2
  • ATG16 Autophagy Related 16-Like 2 3
  • Autophagy-Related Protein 16-2 3
  • ATG16B 3

External Ids for ATG16L2 Gene

Previous GeneCards Identifiers for ATG16L2 Gene

  • GC11P072203
  • GC11P072525
  • GC11P068820

Summaries for ATG16L2 Gene

GeneCards Summary for ATG16L2 Gene

ATG16L2 (Autophagy Related 16 Like 2) is a Protein Coding gene. Among its related pathways are Autophagy - animal. An important paralog of this gene is ATG16L1.

UniProtKB/Swiss-Prot for ATG16L2 Gene

  • May play a role in autophagy.

Additional gene information for ATG16L2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG16L2 Gene

Genomics for ATG16L2 Gene

GeneHancer (GH) Regulatory Elements for ATG16L2 Gene

Promoters and enhancers for ATG16L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J072811 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 655.2 -0.1 -98 5.5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A ATG16L2 STARD10 ALG1L9P NUMA1 LOC100128494 LOC105369379 ENSG00000255672 ENSG00000256739 LOC220077 LOC401703
GH11J072792 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.3 -20.2 -20246 3.3 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 STARD10 ARAP1 LOC105369380 ATG16L2
GH11J072735 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.4 -74.1 -74101 10 HDGF FOXA2 PKNOX1 SIN3A YY1 ZNF143 FOS ZNF263 SP5 REST ARAP1 NUMA1 LOC100128494 STARD10 ATG16L2 ZNF705E IL18BP PDE2A P2RY2 FCHSD2
GH11J072831 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14.2 +19.7 19733 5.9 RB1 SIN3A ZNF2 ZNF48 RAD21 RFX5 GLIS2 ARID2 ZNF143 ZFP91 ATG16L2 ARAP1 STARD10 PDE2A FCHSD2 RNU6-672P GC11M072870
GH11J072762 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 11.7 -49.0 -48996 5.6 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 RUNX3 RXRA SP5 MXD4 ENSG00000202522 GC11P072768 ARAP1 STARD10 ATG16L2 RPS12P20 ARAP1-AS2 PDE2A ARAP1-AS1 RNU6-672P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATG16L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ATG16L2 gene promoter:
  • Nkx2-5
  • Sp1
  • AML1a
  • RORalpha2
  • Meis-1
  • Meis-1a
  • Meis-1b
  • LCR-F1

Genomic Locations for ATG16L2 Gene

Genomic Locations for ATG16L2 Gene
29,367 bases
Plus strand
29,367 bases
Plus strand

Genomic View for ATG16L2 Gene

Genes around ATG16L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG16L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG16L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG16L2 Gene

Proteins for ATG16L2 Gene

  • Protein details for ATG16L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Autophagy-related protein 16-2
    Protein Accession:
    Secondary Accessions:
    • A5PL30
    • B2RPK5
    • Q658V4
    • Q6PID3
    • Q8NBG0

    Protein attributes for ATG16L2 Gene

    619 amino acids
    Molecular mass:
    68998 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ATG16L2 Gene


neXtProt entry for ATG16L2 Gene

Post-translational modifications for ATG16L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATG16L2 Gene

Domains & Families for ATG16L2 Gene

Gene Families for ATG16L2 Gene

Suggested Antigen Peptide Sequences for ATG16L2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat ATG16 family.
  • Belongs to the WD repeat ATG16 family.
genes like me logo Genes that share domains with ATG16L2: view

Function for ATG16L2 Gene

Molecular function for ATG16L2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in autophagy.

Phenotypes From GWAS Catalog for ATG16L2 Gene

Gene Ontology (GO) - Molecular Function for ATG16L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ATG16L2: view
genes like me logo Genes that share phenotypes with ATG16L2: view

Animal Model Products

miRNA for ATG16L2 Gene

miRTarBase miRNAs that target ATG16L2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATG16L2 Gene

Localization for ATG16L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG16L2 Gene

Cytoplasm. Note=Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATG16L2 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATG16L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ATG16L2: view

Pathways & Interactions for ATG16L2 Gene

SuperPathways for ATG16L2 Gene

SuperPathway Contained pathways
1 Autophagy - animal
genes like me logo Genes that share pathways with ATG16L2: view

Pathways by source for ATG16L2 Gene

1 GeneTex pathway for ATG16L2 Gene
1 KEGG pathway for ATG16L2 Gene

Gene Ontology (GO) - Biological Process for ATG16L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0006914 autophagy IEA --
GO:0015031 protein transport IEA --
GO:0039689 negative stranded viral RNA replication IEA,IBA --
genes like me logo Genes that share ontologies with ATG16L2: view

No data available for SIGNOR curated interactions for ATG16L2 Gene

Drugs & Compounds for ATG16L2 Gene

No Compound Related Data Available

Transcripts for ATG16L2 Gene

Unigene Clusters for ATG16L2 Gene

Autophagy related 16-like 2 (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG16L2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - -
SP7: - - - - - - - - - - - - - - - - - - - -
SP8: - -
SP9: - -

ExUns: 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19
SP7: - - - -

Relevant External Links for ATG16L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATG16L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATG16L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATG16L2 Gene

This gene is overexpressed in Whole Blood (x15.7) and Spleen (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of ATG16L2 Gene:


SOURCE GeneReport for Unigene cluster for ATG16L2 Gene:


Evidence on tissue expression from TISSUES for ATG16L2 Gene

  • Nervous system(4.5)
  • Spleen(4.4)
  • Stomach(4.3)
  • Liver(4.1)
  • Eye(4)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with ATG16L2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATG16L2 Gene

Orthologs for ATG16L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATG16L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATG16L2 34 33
  • 98.24 (n)
(Bos Taurus)
Mammalia ATG16L2 34 33
  • 88.04 (n)
(Canis familiaris)
Mammalia ATG16L2 34 33
  • 87.11 (n)
(Mus musculus)
Mammalia Atg16l2 16 34 33
  • 85.5 (n)
(Rattus norvegicus)
Mammalia Atg16l2 33
  • 84.9 (n)
(Ornithorhynchus anatinus)
Mammalia ATG16L2 34
  • 70 (a)
(Monodelphis domestica)
Mammalia ATG16L2 34
  • 65 (a)
(Anolis carolinensis)
Reptilia ATG16L2 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485143 33
  • 55.18 (n)
(Danio rerio)
Actinopterygii LOC100007282 33
  • 61.58 (n)
ATG16L2 (2 of 2) 34
  • 59 (a)
atg16l2 34
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31033 34
  • 30 (a)
(Caenorhabditis elegans)
Secernentea atg-16.2 34
  • 26 (a)
atg-16.1 34
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
Species where no ortholog for ATG16L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG16L2 Gene

Gene Tree for ATG16L2 (if available)
Gene Tree for ATG16L2 (if available)
Evolutionary constrained regions (ECRs) for ATG16L2: view image

Paralogs for ATG16L2 Gene

Paralogs for ATG16L2 Gene

(5) SIMAP similar genes for ATG16L2 Gene using alignment to 13 proteins:

  • A16L2_HUMAN
  • F5H7B6_HUMAN
  • H0YF72_HUMAN
  • H0YG45_HUMAN
  • H0YG67_HUMAN
genes like me logo Genes that share paralogs with ATG16L2: view

Variants for ATG16L2 Gene

Sequence variations from dbSNP and Humsavar for ATG16L2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000091446 -- 72,839,645(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000148970 -- 72,843,657(+) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000215235 -- 72,844,021(+) AAAAAAA/AAA downstream_transcript_variant
rs1000486286 -- 72,818,897(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000698528 -- 72,838,160(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ATG16L2 Gene

Variant ID Type Subtype PubMed ID
nsv473572 CNV novel sequence insertion 20440878
nsv951039 CNV deletion 24416366

Variation tolerance for ATG16L2 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATG16L2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG16L2 Gene

Disorders for ATG16L2 Gene

Additional Disease Information for ATG16L2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ATG16L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG16L2 Gene

Publications for ATG16L2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 58
  3. A functional variant of ATG16L2 is associated with Crohn's disease in the Chinese population. (PMID: 27611316) Ma T … Zhou C (Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 2016) 3 58
  4. Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans. (PMID: 26663301) Lessard CJ … Tsao BP (Arthritis & rheumatology (Hoboken, N.J.) 2016) 3 58
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58

Products for ATG16L2 Gene

Sources for ATG16L2 Gene

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