Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATG16L1 Gene

Aliases for ATG16L1 Gene

  • Autophagy Related 16 Like 1 2 3 5
  • APG16L 3 4
  • ATG16 Autophagy Related 16-Like 1 (S. Cerevisiae) 2
  • ATG16 Autophagy Related 16-Like (S. Cerevisiae) 2
  • APG16 Autophagy 16-Like (S. Cerevisiae) 2
  • ATG16 Autophagy Related 16-Like 1 3
  • Autophagy-Related Protein 16-1 3
  • WD Repeat Domain 30 3
  • APG16-Like 1 4
  • APG16L Beta 3
  • ATG16A 3
  • ATG16L 3
  • IBD10 3
  • WDR30 3

External Ids for ATG16L1 Gene

Previous HGNC Symbols for ATG16L1 Gene

  • APG16L
  • ATG16L

Previous GeneCards Identifiers for ATG16L1 Gene

  • GC02P233943
  • GC02P233825
  • GC02P234118
  • GC02P225960

Summaries for ATG16L1 Gene

Entrez Gene Summary for ATG16L1 Gene

  • The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]

GeneCards Summary for ATG16L1 Gene

ATG16L1 (Autophagy Related 16 Like 1) is a Protein Coding gene. Diseases associated with ATG16L1 include Inflammatory Bowel Disease 10 and Crohn's Disease. Among its related pathways are Autophagy Pathway and Senescence and Autophagy in Cancer. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is ATG16L2.

UniProtKB/Swiss-Prot for ATG16L1 Gene

  • Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).

Gene Wiki entry for ATG16L1 Gene

Additional gene information for ATG16L1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG16L1 Gene

Genomics for ATG16L1 Gene

GeneHancer (GH) Regulatory Elements for ATG16L1 Gene

Promoters and enhancers for ATG16L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J233249 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 664.3 +41.6 41592 3.6 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ATG16L1 GC02P233277
GH02J233208 Enhancer 0.7 Ensembl ENCODE 650.7 -0.1 -121 1.9 ZFHX2 PKNOX1 POLR2A GLIS1 JUN VEZF1 ATG16L1 RN7SL32P
GH02J233210 Enhancer 0.6 Ensembl ENCODE 650.7 +1.2 1237 0.8 POLR2A PRDM1 ATG16L1 GC02P233277
GH02J233348 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.3 +144.3 144323 11.5 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 DGKD ENSG00000259793 ATG16L1 USP40 SAG SCARNA5 GIGYF2 SCARNA6 INPP5D
GH02J233384 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 16.9 +176.7 176746 5.3 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 RUNX3 NFKBIZ RXRA DGKD ATG16L1 USP40 SAG SCARNA5 SCARNA6 GC02M233380 ENSG00000201013 PIR59405
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ATG16L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ATG16L1 gene promoter:

Genomic Locations for ATG16L1 Gene

Genomic Locations for ATG16L1 Gene
chr2:233,210,051-233,295,674
(GRCh38/hg38)
Size:
85,624 bases
Orientation:
Plus strand
chr2:234,118,697-234,204,320
(GRCh37/hg19)

Genomic View for ATG16L1 Gene

Genes around ATG16L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG16L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG16L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG16L1 Gene

Proteins for ATG16L1 Gene

  • Protein details for ATG16L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q676U5-A16L1_HUMAN
    Recommended name:
    Autophagy-related protein 16-1
    Protein Accession:
    Q676U5
    Secondary Accessions:
    • A3EXK9
    • A3EXL0
    • B6ZDH0
    • Q6IPN1
    • Q6UXW4
    • Q6ZVZ5
    • Q8NCY2
    • Q96JV5
    • Q9H619

    Protein attributes for ATG16L1 Gene

    Size:
    607 amino acids
    Molecular mass:
    68265 Da
    Quaternary structure:
    • Homodimer (PubMed:25484072). Homooligomer (By similarity). Interacts with WIPI2 (PubMed:24954904). Interacts with RB1CC1; the interaction is required for ULK1 complex-dependent autophagy (PubMed:23262492, PubMed:24954904, PubMed:23392225). Interacts with ATG5 (PubMed:23202584, PubMed:24191030, PubMed:25484072, PubMed:26812546). Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa) (PubMed:26083323, PubMed:23202584, PubMed:24191030). Interacts with RAB33B (PubMed:21808068). Interacts (via WD repeats) with TMEM59; the interaction mediates unconventional autophagic activity of TMEM59 (PubMed:23376921, PubMed:27273576). Interacts with TLR2 and NOD2 (PubMed:23376921). Interacts (via WD repeats) with MEFV (PubMed:26347139). Interacts with PPP1CA; the interaction dephosphorylates ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex (PubMed:26083323). Interacts (via N-terminal) with CLTC (PubMed:20639872). Interacts with NOD2 (PubMed:20637199). Interacts with TUFM (PubMed:22749352).
    SequenceCaution:
    • Sequence=BAB15448.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB55412.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ATG16L1 Gene

    Alternative splice isoforms for ATG16L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG16L1 Gene

Post-translational modifications for ATG16L1 Gene

  • Proteolytic cleavage by activated CASP3 leads to degradation and may regulate autophagy upon cellular stress and apoptotic stimuli.
  • Phosphorylation at Ser-139 promotes association with the ATG12-ATG5 conjugate to form the ATG12-ATG5-ATG16L1 complex.
  • Ubiquitination at Lys513
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ATG16L1 Gene

Domains & Families for ATG16L1 Gene

Gene Families for ATG16L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q676U5

UniProtKB/Swiss-Prot:

A16L1_HUMAN :
  • Belongs to the WD repeat ATG16 family.
Family:
  • Belongs to the WD repeat ATG16 family.
genes like me logo Genes that share domains with ATG16L1: view

Function for ATG16L1 Gene

Molecular function for ATG16L1 Gene

UniProtKB/Swiss-Prot Function:
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).

Phenotypes From GWAS Catalog for ATG16L1 Gene

Gene Ontology (GO) - Molecular Function for ATG16L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17353931
GO:0019787 ubiquitin-like protein transferase activity TAS --
GO:0042802 identical protein binding IPI 20562859
GO:0051020 GTPase binding IPI 25891078
genes like me logo Genes that share ontologies with ATG16L1: view
genes like me logo Genes that share phenotypes with ATG16L1: view

Animal Models for ATG16L1 Gene

MGI Knock Outs for ATG16L1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATG16L1 Gene

Localization for ATG16L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG16L1 Gene

Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Recruited to omegasomes membranes by WIPI2. Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000250 UniProtKB:Q8C0J2}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATG16L1 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 3
endoplasmic reticulum 2
lysosome 2
endosome 2
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATG16L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IBA --
GO:0005737 cytoplasm IEA --
GO:0005776 autophagosome ISS 15620219
GO:0005829 cytosol TAS --
GO:0005930 axoneme ISS --
genes like me logo Genes that share ontologies with ATG16L1: view

Pathways & Interactions for ATG16L1 Gene

genes like me logo Genes that share pathways with ATG16L1: view

Pathways by source for ATG16L1 Gene

1 GeneTex pathway for ATG16L1 Gene
2 Reactome pathways for ATG16L1 Gene
1 R&D Systems pathway for ATG16L1 Gene

SIGNOR curated interactions for ATG16L1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ATG16L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly NAS 15620219
GO:0006914 autophagy IEA --
GO:0015031 protein transport IEA --
GO:0016236 macroautophagy TAS --
GO:0034497 protein localization to phagophore assembly site IEA --
genes like me logo Genes that share ontologies with ATG16L1: view

Drugs & Compounds for ATG16L1 Gene

(1) Drugs for ATG16L1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adalimumab Approved Pharma 521
genes like me logo Genes that share compounds with ATG16L1: view

Transcripts for ATG16L1 Gene

Unigene Clusters for ATG16L1 Gene

Autophagy related 16-like 1 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG16L1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a ·
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - -
SP8: -
SP9:
SP10: - -
SP11:
SP12: - - - - - - -
SP13:
SP14:
SP15: -

ExUns: 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:

Relevant External Links for ATG16L1 Gene

GeneLoc Exon Structure for
ATG16L1
ECgene alternative splicing isoforms for
ATG16L1

Expression for ATG16L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATG16L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATG16L1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.3), Brain (7.6), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATG16L1 Gene



Protein tissue co-expression partners for ATG16L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATG16L1 Gene:

ATG16L1

SOURCE GeneReport for Unigene cluster for ATG16L1 Gene:

Hs.529322

Evidence on tissue expression from TISSUES for ATG16L1 Gene

  • Nervous system(4.8)
  • Intestine(4.6)
  • Lymph node(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with ATG16L1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATG16L1 Gene

Orthologs for ATG16L1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATG16L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATG16L1 34 33
  • 99.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ATG16L1 34 33
  • 89.9 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atg16l1 33
  • 89.82 (n)
mouse
(Mus musculus)
Mammalia Atg16l1 16 34 33
  • 89.49 (n)
cow
(Bos Taurus)
Mammalia ATG16L1 34 33
  • 88.58 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATG16L1 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATG16L1 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATG16L1 34 33
  • 80.07 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATG16L1 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atg16l1 33
  • 72.4 (n)
zebrafish
(Danio rerio)
Actinopterygii atg16l1 34 33
  • 65.71 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31033 34 33
  • 49.44 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atg-16.1 34
  • 29 (a)
ManyToMany
atg-16.2 34
  • 29 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G50230 33
  • 43.9 (n)
rice
(Oryza sativa)
Liliopsida Os03g0746600 33
  • 43.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToMany
Species where no ortholog for ATG16L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG16L1 Gene

ENSEMBL:
Gene Tree for ATG16L1 (if available)
TreeFam:
Gene Tree for ATG16L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATG16L1: view image

Paralogs for ATG16L1 Gene

Paralogs for ATG16L1 Gene

(7) SIMAP similar genes for ATG16L1 Gene using alignment to 13 proteins:

  • A16L1_HUMAN
  • A5YM60_HUMAN
  • B7ZLM5_HUMAN
  • C9J1B2_HUMAN
  • C9J8C6_HUMAN
  • C9JAY7_HUMAN
  • C9JK97_HUMAN
  • D9N2U2_HUMAN
  • D9N2U3_HUMAN
  • E7EVC7_HUMAN
  • F8WAF9_HUMAN
  • L7UQD0_HUMAN
  • Q17RG0_HUMAN
genes like me logo Genes that share paralogs with ATG16L1: view

Variants for ATG16L1 Gene

Sequence variations from dbSNP and Humsavar for ATG16L1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs2241880 risk-factor, benign, Inflammatory bowel disease 10, susceptibility to, not specified, Inflammatory bowel disease 10 (IBD10) [MIM:611081] 233,274,722(+) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs794727513 uncertain-significance, not specified 233,263,140(+) G/A/C 5_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000079513 -- 233,289,812(+) C/G intron_variant
rs1000146200 -- 233,296,161(+) G/A downstream_transcript_variant
rs1000155515 -- 233,284,177(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ATG16L1 Gene

Variant ID Type Subtype PubMed ID
nsv584699 CNV gain 21841781
nsv584700 CNV gain 21841781

Variation tolerance for ATG16L1 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.19; 87.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATG16L1 Gene

Human Gene Mutation Database (HGMD)
ATG16L1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATG16L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG16L1 Gene

Disorders for ATG16L1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for ATG16L1 Gene - From: HGMD, OMIM, GTR, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 10
  • ibd10
crohn's disease
  • ileitis
inflammatory bowel disease
  • inflammatory bowel diseases
colitis
ulcerative colitis
  • left-sided ulcerative colitis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

A16L1_HUMAN
  • Inflammatory bowel disease 10 (IBD10) [MIM:611081]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:17200669, ECO:0000269 PubMed:17435756, ECO:0000269 PubMed:17484864, ECO:0000269 PubMed:18047540, ECO:0000269 PubMed:18499543, ECO:0000269 PubMed:18985712, ECO:0000269 PubMed:19659808, ECO:0000269 PubMed:24553140, ECO:0000269 PubMed:24656308, ECO:0000269 PubMed:25645662, ECO:0000269 PubMed:27273576}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for ATG16L1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ATG16L1: view

No data available for Genatlas for ATG16L1 Gene

Publications for ATG16L1 Gene

  1. Autophagy 16-like 1 rs2241880 G allele is associated with Crohn's disease in German children. (PMID: 19659808) Lacher M … Koletzko S (Acta paediatrica (Oslo, Norway : 1992) 2009) 3 4 22 44 58
  2. ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands. (PMID: 18047540) Weersma RK … Dijkstra G (The American journal of gastroenterology 2008) 3 4 22 44 58
  3. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. (PMID: 17200669) Hampe J … Schreiber S (Nature genetics 2007) 3 4 22 44 58
  4. Replication and meta-analysis of 13,000 cases defines the risk for interleukin-23 receptor and autophagy-related 16-like 1 variants in Crohn's disease. (PMID: 20485703) Cotterill L … Newman WG (Canadian journal of gastroenterology = Journal canadien de gastroenterologie 2010) 3 22 44 58
  5. NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn's disease. (PMID: 20380008) Gazouli M … Roma-Giannikou E (World journal of gastroenterology 2010) 3 22 44 58

Products for ATG16L1 Gene

Sources for ATG16L1 Gene

Content
Loading form....