Aliases for ATG16L1 Gene
External Ids for ATG16L1 Gene
Previous HGNC Symbols for ATG16L1 Gene
Previous GeneCards Identifiers for ATG16L1 Gene
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
GeneCards Summary for ATG16L1 Gene
ATG16L1 (Autophagy Related 16 Like 1) is a Protein Coding gene. Diseases associated with ATG16L1 include Inflammatory Bowel Disease 10 and Crohn's Disease. Among its related pathways are Autophagy - animal and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is ATG16L2.
UniProtKB/Swiss-Prot Summary for ATG16L1 Gene
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).