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Aliases for ATG14 Gene

Aliases for ATG14 Gene

  • Autophagy Related 14 2 3 5
  • KIAA0831 2 3 4
  • Beclin 1-Associated Autophagy-Related Key Regulator 2 3
  • Autophagy-Related Protein 14-Like Protein 3 4
  • Barkor 2 4
  • ATG14L 3 4
  • ATG14 Autophagy Related 14 Homolog (S. Cerevisiae) 2
  • ATG14 Autophagy Related 14 Homolog 3
  • Beclin 1-Interacting Protein 3
  • BARKOR 3
  • Atg14L 4

External Ids for ATG14 Gene

Previous HGNC Symbols for ATG14 Gene

  • KIAA0831

Previous GeneCards Identifiers for ATG14 Gene

  • GC14M055834
  • GC14M035996

Summaries for ATG14 Gene

GeneCards Summary for ATG14 Gene

ATG14 (Autophagy Related 14) is a Protein Coding gene. Among its related pathways are Autophagy Pathway and Senescence and Autophagy in Cancer.

UniProtKB/Swiss-Prot for ATG14 Gene

  • Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).

Additional gene information for ATG14 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG14 Gene

Genomics for ATG14 Gene

GeneHancer (GH) Regulatory Elements for ATG14 Gene

Promoters and enhancers for ATG14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J055410 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 663.7 -0.2 -216 2.6 PKNOX1 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF766 ZNF213 ATG14 GC14M055415 LOC105370509 SOCS4 MAPK1IP1L GC14M054989
GH14J054487 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 58.9 +922.4 922441 3.8 HDGF PKNOX1 CLOCK ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 ZNF207 GMFB ATG14 BMP4 MAPK1IP1L SOCS4 ENSG00000259318 ENSG00000258753 ATP5F1CP1 ENSG00000258050 RPL34P28
GH14J055578 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 41.6 -169.7 -169692 6.7 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 KLF13 KTN1-AS1 KTN1 ATG14 MAPK1IP1L SOCS4 TBPL2 GC14P055652
GH14J055598 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 19.3 -188.5 -188549 3.7 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS DEK SP5 KTN1 KTN1-AS1 ATG14 WDHD1 ENSG00000259318 TBPL2 SOCS4 GC14P055652
GH14J055802 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 22.2 -393.5 -393512 6.3 PKNOX1 ATF1 FOXA2 BRCA1 YY1 GTF3C2 TCF12 GLIS2 GATA2 ATF7 LOC105370515 ATG14 MAPK1IP1L SOCS4 LINC00520 PIR35523
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATG14 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ATG14 Gene

Genomic Locations for ATG14 Gene
chr14:55,366,391-55,411,880
(GRCh38/hg38)
Size:
45,490 bases
Orientation:
Minus strand
chr14:55,833,109-55,878,576
(GRCh37/hg19)
Size:
45,468 bases
Orientation:
Minus strand

Genomic View for ATG14 Gene

Genes around ATG14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG14 Gene

Proteins for ATG14 Gene

  • Protein details for ATG14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNE5-BAKOR_HUMAN
    Recommended name:
    Beclin 1-associated autophagy-related key regulator
    Protein Accession:
    Q6ZNE5
    Secondary Accessions:
    • A6NJE4
    • A8K9U5
    • B7ZWP5
    • O94920
    • Q32MK7
    • Q32MK8

    Protein attributes for ATG14 Gene

    Size:
    492 amino acids
    Molecular mass:
    55309 Da
    Quaternary structure:
    • Forms homooligomers; homo-oligomerization is essential for the roles in membrane tethering and enhancement of SNARE-mediated fusion (PubMed:25686604). Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex I (PI3KC3-C1) in which the core composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 is associated with ATG14 (PubMed:18843052, PubMed:19050071, PubMed:19270696, PubMed:22314358, PubMed:23878393). PI3KC3-C1 displays a V-shaped architecture with PIK3R4 serving as a bridge between PIK3C3 and the ATG14:BECN1 subcomplex (PubMed:25490155). PI3KC3-C1 can associate with further regulatory subunits. Interacts with PIK3CB (By similarity). Interacts (via coiled-coil domain) with BECN2 (via coiled-coil domain); this interaction is tighter than BECN2 self-association (PubMed:23954414, PubMed:28218432). Interacts with the STX17-SNAP29 binary t-SNARE complex (PubMed:25686604). Interacts with NRBF2 (By similarity).
    SequenceCaution:
    • Sequence=BAA74854.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ATG14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG14 Gene

Post-translational modifications for ATG14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATG14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATG14 Gene

Domains & Families for ATG14 Gene

Gene Families for ATG14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ATG14 Gene

Suggested Antigen Peptide Sequences for ATG14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNE5

UniProtKB/Swiss-Prot:

BAKOR_HUMAN :
  • The coiled-coil domain is required for BECN1- and PIK3C3-binding and for autophagy.
  • Belongs to the ATG14 family.
Domain:
  • The coiled-coil domain is required for BECN1- and PIK3C3-binding and for autophagy.
  • The final 80 residues in the C-terminus define a minimum required region for autophagosome binding called BATS.
  • The N-terminal cysteine repeats are required for proper localization to the endoplasmic reticulum.
Family:
  • Belongs to the ATG14 family.
genes like me logo Genes that share domains with ATG14: view

Function for ATG14 Gene

Molecular function for ATG14 Gene

UniProtKB/Swiss-Prot Function:
Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).

Phenotypes From GWAS Catalog for ATG14 Gene

Gene Ontology (GO) - Molecular Function for ATG14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19050071
GO:0051020 GTPase binding IPI 25891078
genes like me logo Genes that share ontologies with ATG14: view
genes like me logo Genes that share phenotypes with ATG14: view

Animal Model Products

Clone Products

  • Addgene plasmids for ATG14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATG14 Gene

Localization for ATG14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG14 Gene

Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein. Note=Cytosolic under nutrient-rich conditions (PubMed:19050071). Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes (PubMed:19050071). Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). {ECO:0000250 UniProtKB:Q8CDJ3}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATG14 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 5
cytoskeleton 4
nucleus 3
lysosome 2
endosome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ATG14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005776 autophagosome IDA 19270696
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with ATG14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ATG14 Gene

Pathways & Interactions for ATG14 Gene

genes like me logo Genes that share pathways with ATG14: view

Pathways by source for ATG14 Gene

1 GeneTex pathway for ATG14 Gene
2 Reactome pathways for ATG14 Gene
1 R&D Systems pathway for ATG14 Gene

SIGNOR curated interactions for ATG14 Gene

Activates:

Gene Ontology (GO) - Biological Process for ATG14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IMP 19270696
GO:0000423 mitophagy IMP 23878393
GO:0001932 regulation of protein phosphorylation IMP 23878393
GO:0001933 negative regulation of protein phosphorylation ISS --
GO:0001934 positive regulation of protein phosphorylation ISS --
genes like me logo Genes that share ontologies with ATG14: view

Drugs & Compounds for ATG14 Gene

No Compound Related Data Available

Transcripts for ATG14 Gene

mRNA/cDNA for ATG14 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATG14 Gene

Autophagy related 14:
Representative Sequences:

Clone Products

  • Addgene plasmids for ATG14

Alternative Splicing Database (ASD) splice patterns (SP) for ATG14 Gene

No ASD Table

Relevant External Links for ATG14 Gene

GeneLoc Exon Structure for
ATG14
ECgene alternative splicing isoforms for
ATG14

Expression for ATG14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATG14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATG14 Gene

This gene is overexpressed in Pancreatic juice (29.0), Testis (16.2), Heart (12.1), and Placenta (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATG14 Gene



Protein tissue co-expression partners for ATG14 Gene

NURSA nuclear receptor signaling pathways regulating expression of ATG14 Gene:

ATG14

SOURCE GeneReport for Unigene cluster for ATG14 Gene:

Hs.414809

Evidence on tissue expression from TISSUES for ATG14 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ATG14: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATG14 Gene

Orthologs for ATG14 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATG14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATG14 34 33
  • 99.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ATG14 34 33
  • 91.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ATG14 34 33
  • 90.65 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Atg14 16 34 33
  • 86.86 (n)
rat
(Rattus norvegicus)
Mammalia Atg14 33
  • 85.03 (n)
oppossum
(Monodelphis domestica)
Mammalia ATG14 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATG14 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATG14 34 33
  • 78.62 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATG14 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atg14 33
  • 72.03 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:113944 33
  • 65.73 (n)
ATG14 34
  • 43 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012246 33
  • 42.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11877 34 33
  • 42.72 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2684 34
  • 32 (a)
OneToMany
-- 34
  • 23 (a)
OneToMany
Species where no ortholog for ATG14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATG14 Gene

ENSEMBL:
Gene Tree for ATG14 (if available)
TreeFam:
Gene Tree for ATG14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATG14: view image

Paralogs for ATG14 Gene

No data available for Paralogs for ATG14 Gene

Variants for ATG14 Gene

Sequence variations from dbSNP and Humsavar for ATG14 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000043192 -- 55,383,618(-) AACAA/AA intron_variant
rs1000054702 -- 55,405,807(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000099990 -- 55,383,421(-) G/A intron_variant
rs1000156089 -- 55,370,067(-) G/A intron_variant
rs1000235421 -- 55,398,498(-) T/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ATG14 Gene

Variant ID Type Subtype PubMed ID
esv3581209 CNV loss 25503493
nsv977470 CNV duplication 23825009

Variation tolerance for ATG14 Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.71; 66.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATG14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATG14

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG14 Gene

Disorders for ATG14 Gene

Additional Disease Information for ATG14

No disorders were found for ATG14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG14 Gene

Publications for ATG14 Gene

  1. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. (PMID: 18843052) Itakura E … Mizushima N (Molecular biology of the cell 2008) 2 3 4 58
  2. BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy. (PMID: 28218432) Su M … Sinha SC (Protein science : a publication of the Protein Society 2017) 3 4 58
  3. ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes. (PMID: 25686604) Diao J … Zhong Q (Nature 2015) 3 4 58
  4. Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex. (PMID: 25490155) Baskaran S … Hurley JH (eLife 2014) 3 4 58
  5. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. (PMID: 23954414) He C … Levine B (Cell 2013) 3 4 58

Products for ATG14 Gene

Sources for ATG14 Gene

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