Aliases for ATG14 Gene
External Ids for ATG14 Gene
Previous HGNC Symbols for ATG14 Gene
Previous GeneCards Identifiers for ATG14 Gene
GeneCards Summary for ATG14 Gene
ATG14 (Autophagy Related 14) is a Protein Coding gene. Diseases associated with ATG14 include Vici Syndrome and Myopathy, X-Linked, With Excessive Autophagy. Among its related pathways are Autophagy - animal and Autophagy Pathway.
UniProtKB/Swiss-Prot Summary for ATG14 Gene
Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).