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Aliases for ATG101 Gene

Aliases for ATG101 Gene

  • Autophagy Related 101 2 3 5
  • C12orf44 3 4
  • Chromosome 12 Open Reading Frame 44 2
  • Autophagy-Related Protein 101 3
  • Atg13-Interacting Protein 3

External Ids for ATG101 Gene

Previous HGNC Symbols for ATG101 Gene

  • C12orf44

Previous GeneCards Identifiers for ATG101 Gene

  • GC12P052464

Summaries for ATG101 Gene

GeneCards Summary for ATG101 Gene

ATG101 (Autophagy Related 101) is a Protein Coding gene. Among its related pathways are Autophagy Pathway and Longevity regulating pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for ATG101 Gene

  • Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.

Gene Wiki entry for ATG101 Gene

Additional gene information for ATG101 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG101 Gene

Genomics for ATG101 Gene

GeneHancer (GH) Regulatory Elements for ATG101 Gene

Promoters and enhancers for ATG101 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J052068 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 664.5 +1.2 1178 2.9 CLOCK MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ATG101 HNRNPA3P10 EIF4B TFCP2 OR7E47P KRT6C ENSG00000284791
GH12J052894 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 22.9 +833.7 833682 16.1 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 GC12M052900 AAAS ZNF740 PCBP2 SP1 MAP3K12 LOC100652999 ATF7 EIF4B ENSG00000257808
GH12J052941 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.8 +878.4 878365 11.7 CLOCK MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 E2F8 SP3 NFYC KRT18 AAAS PCBP2 SP1 ZNF740 LOC100652999 ENSG00000257808 EIF4B ATG101 ATF7
GH12J053003 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14 +937.4 937407 5.3 CLOCK MLX YBX1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 EIF4B SP1 ZNF740 ATF7 AAAS CSAD LOC100652999 ENSG00000257808 LOC105378250 ENSG00000257500
GH12J051969 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.2 -96.7 -96653 5.2 PKNOX1 FOXA2 ARNT ZNF2 IRF4 YY1 ZNF766 E2F8 ZNF143 FOS NR4A1 HNRNPA3P10 GRASP ATG101 ACVR1B ACVRL1 ANKRD33 SMAGP GC12P051989
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATG101 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ATG101 Gene

Genomic Locations for ATG101 Gene
chr12:52,069,246-52,077,495
(GRCh38/hg38)
Size:
8,250 bases
Orientation:
Plus strand
chr12:52,463,030-52,471,279
(GRCh37/hg19)
Size:
8,250 bases
Orientation:
Plus strand

Genomic View for ATG101 Gene

Genes around ATG101 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG101 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG101 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG101 Gene

Proteins for ATG101 Gene

  • Protein details for ATG101 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSB4-ATGA1_HUMAN
    Recommended name:
    Autophagy-related protein 101
    Protein Accession:
    Q9BSB4
    Secondary Accessions:
    • Q9HAE2
    • Q9HBN1

    Protein attributes for ATG101 Gene

    Size:
    218 amino acids
    Molecular mass:
    25003 Da
    Quaternary structure:
    • Interacts with ATG13 (PubMed:19287211, PubMed:19597335, PubMed:26299944). Associates with a complex composed of ATG13, ULK1 and RB1CC1; the association with this complex requires the presence of ATG13 (PubMed:19287211, PubMed:19597335).
    SequenceCaution:
    • Sequence=AAG17273.1; Type=Frameshift; Positions=110; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ATG101 Gene

neXtProt entry for ATG101 Gene

Post-translational modifications for ATG101 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATG101 Gene

No data available for DME Specific Peptides for ATG101 Gene

Domains & Families for ATG101 Gene

Gene Families for ATG101 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ATG101 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATG101 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BSB4

UniProtKB/Swiss-Prot:

ATGA1_HUMAN :
  • Belongs to the ATG101 family.
Family:
  • Belongs to the ATG101 family.
genes like me logo Genes that share domains with ATG101: view

Function for ATG101 Gene

Molecular function for ATG101 Gene

UniProtKB/Swiss-Prot Function:
Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.

Phenotypes From GWAS Catalog for ATG101 Gene

Gene Ontology (GO) - Molecular Function for ATG101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19597335
GO:0042802 identical protein binding IPI 20562859
GO:0044877 protein-containing complex binding IPI 19597335
genes like me logo Genes that share ontologies with ATG101: view
genes like me logo Genes that share phenotypes with ATG101: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATG101

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ATG101 Gene

Localization for ATG101 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG101 Gene

Cytoplasm. Preautophagosomal structure. Note=Under starvation conditions, it is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. {ECO:0000269 PubMed:19597335}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATG101 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
lysosome 2
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATG101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 phagophore assembly site IDA,IEA 19597335
GO:0005737 cytoplasm IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ATG101: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ATG101 Gene

Pathways & Interactions for ATG101 Gene

genes like me logo Genes that share pathways with ATG101: view

Pathways by source for ATG101 Gene

1 GeneTex pathway for ATG101 Gene
2 Reactome pathways for ATG101 Gene

SIGNOR curated interactions for ATG101 Gene

Activates:

Gene Ontology (GO) - Biological Process for ATG101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IMP 19597335
GO:0006914 autophagy IEA --
GO:0016236 macroautophagy TAS --
GO:0016241 regulation of macroautophagy TAS --
genes like me logo Genes that share ontologies with ATG101: view

Drugs & Compounds for ATG101 Gene

No Compound Related Data Available

Transcripts for ATG101 Gene

mRNA/cDNA for ATG101 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATG101

Alternative Splicing Database (ASD) splice patterns (SP) for ATG101 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for ATG101 Gene

GeneLoc Exon Structure for
ATG101
ECgene alternative splicing isoforms for
ATG101

Expression for ATG101 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATG101 Gene

Protein differential expression in normal tissues from HIPED for ATG101 Gene

This gene is overexpressed in Brain (17.8), Peripheral blood mononuclear cells (13.5), and Frontal cortex (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATG101 Gene



NURSA nuclear receptor signaling pathways regulating expression of ATG101 Gene:

ATG101

Evidence on tissue expression from TISSUES for ATG101 Gene

  • Nervous system(4.4)
  • Lung(2.2)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with ATG101: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATG101 Gene

Orthologs for ATG101 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATG101 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12orf44 34
  • 100 (a)
OneToOne
C12H12orf44 33
  • 99.69 (n)
cow
(Bos Taurus)
Mammalia ATG101 34
  • 99 (a)
OneToOne
C5H12orf44 33
  • 93.12 (n)
dog
(Canis familiaris)
Mammalia C12ORF44 34
  • 99 (a)
OneToOne
C27H12orf44 33
  • 92.05 (n)
rat
(Rattus norvegicus)
Mammalia RGD1359310 33
  • 91.44 (n)
mouse
(Mus musculus)
Mammalia 9430023L20Rik 34 33
  • 91.13 (n)
OneToOne
Atg101 16
lizard
(Anolis carolinensis)
Reptilia C12orf44 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c12orf44 33
  • 78.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11635 33
zebrafish
(Danio rerio)
Actinopterygii C10H12orf44 34
  • 87 (a)
OneToOne
atg101 33
  • 80.12 (n)
Dr.12242 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8586 33
fruit fly
(Drosophila melanogaster)
Insecta CG7053 34 33
  • 61.77 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y69A2AR.7 33
  • 51.28 (n)
epg-9 34
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9278 34
  • 50 (a)
OneToOne
Cin.11146 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11146 33
Species where no ortholog for ATG101 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG101 Gene

ENSEMBL:
Gene Tree for ATG101 (if available)
TreeFam:
Gene Tree for ATG101 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATG101: view image

Paralogs for ATG101 Gene

(1) SIMAP similar genes for ATG101 Gene using alignment to 1 proteins:

  • ATGA1_HUMAN
genes like me logo Genes that share paralogs with ATG101: view

No data available for Paralogs for ATG101 Gene

Variants for ATG101 Gene

Sequence variations from dbSNP and Humsavar for ATG101 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001053778 -- 52,071,738(+) C/T intron_variant
rs1001149777 -- 52,072,006(+) C/T intron_variant
rs1001155595 -- 52,070,202(+) C/T 5_prime_UTR_variant, intron_variant
rs1001268854 -- 52,076,061(+) T/C intron_variant
rs1001704666 -- 52,068,948(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ATG101 Gene

Variant ID Type Subtype PubMed ID
nsv470292 CNV loss 18288195
nsv558898 CNV loss 21841781
nsv832409 CNV loss 17160897

Variation tolerance for ATG101 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATG101 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATG101

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG101 Gene

Disorders for ATG101 Gene

Additional Disease Information for ATG101

No disorders were found for ATG101 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG101 Gene

Publications for ATG101 Gene

  1. Atg101, a novel mammalian autophagy protein interacting with Atg13. (PMID: 19597335) Hosokawa N … Mizushima N (Autophagy 2009) 2 3 4 58
  2. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. (PMID: 19287211) Mercer CA … Dennis PB (Autophagy 2009) 2 3 4 58
  3. Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex. (PMID: 26299944) Qi S … Hurley JH (Structure (London, England : 1993) 2015) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ATG101 Gene

Sources for ATG101 Gene

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