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Aliases for ATG101 Gene
Aliases for ATG101 Gene
External Ids for ATG101 Gene
- HGNC: 25679
- Entrez Gene: 60673
- Ensembl: ENSG00000123395
- OMIM: 615089
- UniProtKB: Q9BSB4
Previous HGNC Symbols for ATG101 Gene
- C12orf44
Previous GeneCards Identifiers for ATG101 Gene
- GC12P052464
Summaries for ATG101 Gene
GeneCards Summary for ATG101 Gene
ATG101 (Autophagy Related 101) is a Protein Coding gene. Among its related pathways are Macroautophagy and Spinocerebellar ataxia. Gene Ontology (GO) annotations related to this gene include identical protein binding.
UniProtKB/Swiss-Prot Summary for ATG101 Gene
-
Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.
Additional gene information for ATG101 Gene
- HGNC(25679)
- Entrez Gene(60673)
- Ensembl(ENSG00000123395)
- OMIM(615089)
- UniProtKB(Q9BSB4)
- Open Targets Platform(ENSG00000123395)
- Search for ATG101 at DataMed
- Search for ATG101 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATG101 Gene
Genomics for ATG101 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ATG101 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ATG101 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ATG101
Genomic Locations for ATG101 Gene
Genomic Locations for ATG101 Gene
- chr12:52,069,246-52,077,495
- (GRCh38/hg38)
- Size:
- 8,250 bases
- Orientation:
- Plus strand
- chr12:52,463,030-52,471,279
- (GRCh37/hg19)
- Size:
- 8,250 bases
- Orientation:
- Plus strand
Genomic View for ATG101 Gene
Genes around ATG101 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by HGNC
- 12q13.13 by Entrez Gene
- 12q13.13 by Ensembl
ATG101 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ATG101 Gene
Proteins for ATG101 Gene
-
Protein details for ATG101 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BSB4-ATGA1_HUMAN
- Recommended name:
- Autophagy-related protein 101
- Protein Accession:
- Q9BSB4
- Q9HAE2
- Q9HBN1
Protein attributes for ATG101 Gene
- Size:
- 218 amino acids
- Molecular mass:
- 25003 Da
- Quaternary structure:
-
- Interacts with ATG13 (PubMed:19287211, PubMed:19597335, PubMed:26299944). Associates with a complex composed of ATG13, ULK1 and RB1CC1; the association with this complex requires the presence of ATG13 (PubMed:19287211, PubMed:19597335).
- SequenceCaution:
-
- Sequence=AAG17273.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for ATG101 Gene
Post-translational modifications for ATG101 Gene
Other Protein References for ATG101 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-ATG101 polyclonal antibody
- Novus Biologicals Antibodies for ATG101
-
Abcam antibodies for ATG101
- Invitrogen Antibodies for ATG101 (AFLGC-ATG101)
-
Biorbyt antibodies for ATG101
-
Boster Bio Antibodies for ATG101
-
Custom Antibody ServicesProSci Antibodies for ATG101
Protein Products
-
OriGene Purified Proteins for ATG101
- Search Origene for MassSpec and Protein Over-expression Lysates for ATG101
- Origene Custom Protein Services for ATG101
- antibodies-online: Show 7 available C12orf44 Proteins ranked by validation data
- Compare Top C12orf44 Proteins
-
Quality Products:
No data available for DME Specific Peptides for ATG101 Gene
Domains & Families for ATG101 Gene
Gene Families for ATG101 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transporters
Protein Domains for ATG101 Gene
Suggested Antigen Peptide Sequences for ATG101 Gene
- GenScript: Design optimal peptide antigens:
-
- Autophagy-related protein 101 (ATGA1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9BSB4- Family:
-
- Belongs to the ATG101 family.
Function for ATG101 Gene
Molecular function for ATG101 Gene
- UniProtKB/Swiss-Prot Function:
- Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.
Phenotypes From GWAS Catalog for ATG101 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 19597335 |
| GO:0042802 | identical protein binding | IPI | 20562859 |
| GO:0044877 | protein-containing complex binding | IPI | 19597335 |
Phenotypes for ATG101 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ATG101 - Select products 50% OFF >
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-
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-
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miRNA Products
Inhibitory RNA Products
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Clone Products
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-
- MG202440
- MR202440
- MR202440L3
- MR202440L4
- RC201011
- RC201011L1
- RC201011L2
- RC201011L3
- RC201011L4
- RC221963
- RC221963L3
- RC221963L4
- RG201011
- RG221963
- RR211204
- RR211204L3
- RR211204L4
- RR216072
- MR202440L3V
- MR202440L4V
- RC201011L1V
- RC201011L2V
- RC201011L3V
- RC201011L4V
- RC221963L3V
- RC221963L4V
- RR211204L3V
- RR211204L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ATG101
- Addgene plasmids for ATG101
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATG101
Cell Line Products
-
Horizon Cell Lines for ATG101
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ATG101 Gene
Localization for ATG101 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ATG101 Gene
- Cytoplasm. Preautophagosomal structure. Note=Under starvation conditions, it is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. {ECO:0000269 PubMed:19597335}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| endoplasmic reticulum | 4 |
| mitochondrion | 3 |
| lysosome | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| nucleus | 2 |
| endosome | 2 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000407 | phagophore assembly site | IEA,IDA | 19597335 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ATG101 Gene
Pathways & Interactions for ATG101 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Parkinson disease | ||
| 2 | Macroautophagy |
.34
|
|
| 3 | Autophagy - animal | ||
| 4 | Longevity regulating pathway | ||
| 5 | Spinocerebellar ataxia | ||
Pathways by source for ATG101 Gene
2 Reactome pathways for ATG101 Gene
6 KEGG pathways for ATG101 Gene
1 GeneTex pathway for ATG101 Gene
Interacting Proteins for ATG101 Gene
Selected Interacting proteins:
Q9BSB4-ATGA1_HUMAN
ENSP00000338990
for ATG101 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ATG101
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000045 | autophagosome assembly | IBA,IMP | 19597335 |
| GO:0006914 | autophagy | IEA | -- |
| GO:0016236 | macroautophagy | TAS | -- |
| GO:0016241 | regulation of macroautophagy | TAS | -- |
Transcripts for ATG101 Gene
mRNA/cDNA for ATG101 Gene
- 2 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000547409 759 nts (view in UCSC)
- ENST00000336854 1439 nts (view in UCSC)
- ENST00000552544 837 nts (view in UCSC)
- ENST00000550604 671 nts (view in UCSC)
- ENST00000553049 846 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ATG101 - Select products 50% OFF >
- * ATG101 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ATG101
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATG101
-
Santa Cruz Biotechnology (SCBT) CRISPR for ATG101
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ATG101
- Browse OriGene Inhibitory RNA Products For ATG101
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATG101
Clone Products
- Applied Biological Materials (abm): Clones for ATG101 - Select products 50% OFF >
- * ATG101 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG202440
- MR202440
- MR202440L3
- MR202440L4
- RC201011
- RC201011L1
- RC201011L2
- RC201011L3
- RC201011L4
- RC221963
- RC221963L3
- RC221963L4
- RG201011
- RG221963
- RR211204
- RR211204L3
- RR211204L4
- RR216072
- MR202440L3V
- MR202440L4V
- RC201011L1V
- RC201011L2V
- RC201011L3V
- RC201011L4V
- RC221963L3V
- RC221963L4V
- RR211204L3V
- RR211204L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ATG101
- Addgene plasmids for ATG101
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATG101
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: | - | - | |||||||||||||||||
| SP3: | - | ||||||||||||||||||
| SP4: |
Relevant External Links for ATG101 Gene
- GeneLoc Exon Structure for
- ATG101
Expression for ATG101 Gene
This gene is overexpressed in Brain (17.8), Peripheral blood mononuclear cells (13.5), and Frontal cortex (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATG101 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ATG101
Evidence on tissue expression from TISSUES for ATG101 Gene
- Nervous system(4.6)
- Muscle(2.8)
- Lung(2.8)
- Heart(2.7)
- Liver(2.7)
- Stomach(2.7)
- Kidney(2.5)
- Intestine(2.5)
- Skin(2.4)
- Lymph node(2.1)
- Spleen(2.1)
- Pancreas(2.1)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs for ATG101
-
OriGene qPCR primer pairs and template standards for ATG101
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATG101 Gene
Orthologs for ATG101 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | C12orf44 31 |
|
OneToOne | |
| C12H12orf44 30 |
|
||||
| Cow (Bos Taurus) |
Mammalia | ATG101 31 |
|
OneToOne | |
| C5H12orf44 30 |
|
||||
| Dog (Canis familiaris) |
Mammalia | C12ORF44 31 |
|
OneToOne | |
| C27H12orf44 30 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | RGD1359310 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | 9430023L20Rik 30 31 |
|
OneToOne | |
| Atg101 17 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | C12orf44 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | c12orf44 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.11635 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | C10H12orf44 31 |
|
OneToOne | |
| atg101 30 |
|
||||
| Dr.12242 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8586 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG7053 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | CELE_Y69A2AR.7 30 |
|
||
| epg-9 31 |
|
OneToOne | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9278 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.11146 30 |
|
- Species where no ortholog for ATG101 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ATG101 Gene
- ENSEMBL:
- Gene Tree for ATG101 (if available)
- TreeFam:
- Gene Tree for ATG101 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ATG101: view image
Paralogs for ATG101 Gene
(1) SIMAP similar genes for ATG101 Gene using alignment to 1 proteins:
- ATGA1_HUMAN
No data available for Paralogs for ATG101 Gene
Variants for ATG101 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ATG101 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 722003 | Likely Benign: not provided | 52,073,674(+) | G/A | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.31;
6.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ATG101 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ATG101
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG101 Gene
Disorders for ATG101 Gene
Additional Disease Information for ATG101
No disorders were found for ATG101 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG101 Gene
Publications for ATG101 Gene
- Atg101, a novel mammalian autophagy protein interacting with Atg13. (PMID: 19597335) Hosokawa N … Mizushima N (Autophagy 2009) 2 3 4
- A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. (PMID: 19287211) Mercer CA … Dennis PB (Autophagy 2009) 2 3 4
- Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex. (PMID: 26299944) Qi S … Hurley JH (Structure (London, England : 1993) 2015) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
ExternalLinks
Products for ATG101 Gene
- Custom Antibody Services
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for ATG101
- Browse OriGene Inhibitory RNA Products For ATG101
- OriGene qPCR primer pairs for ATG101
- OriGene qPCR primer pairs and template standards for ATG101
- OriGene CRISPR knockouts for ATG101
- MG202440
- MR202440
- MR202440L3
- MR202440L4
- RC201011
- RC201011L1
- RC201011L2
- RC201011L3
- RC201011L4
- RC221963
- RC221963L3
- RC221963L4
- RG201011
- RG221963
- RR211204
- RR211204L3
- RR211204L4
- RR216072
- MR202440L3V
- MR202440L4V
- RC201011L1V
- RC201011L2V
- RC201011L3V
- RC201011L4V
- RC221963L3V
- RC221963L4V
- RR211204L3V
- RR211204L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ATG101
- Sino Biological Human cDNA Clone for ATG101
- Browse Sino Biological Recombinant Proteins
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- High-throughput Antibody Production Service
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- Invitrogen Antibodies for ATG101 (AFLGC-ATG101)
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- Addgene plasmids for ATG101
- antibodies-online: Show 4 available C12orf44 Antibodies ranked by validation data
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- antibodies-online: Search results for available C12orf44 related products ranked by validation data
- antibodies-online: Show 7 available C12orf44 Proteins ranked by validation data
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- Quality Products:
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- Search for ATG101 Proteins at ProSci
- Horizon Cell Lines for ATG101
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ATG101
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ATG101
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- Boster Bio Antibodies for ATG101
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for ATG101
Sources for ATG101 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
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