Aliases for ATG10 Gene
External Ids for ATG10 Gene
Previous HGNC Symbols for ATG10 Gene
Previous GeneCards Identifiers for ATG10 Gene
Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ATG10 Gene
ATG10 (Autophagy Related 10) is a Protein Coding gene. Among its related pathways are Macroautophagy and Nanoparticle triggered autophagic cell death. Gene Ontology (GO) annotations related to this gene include ligase activity and Atg12 transferase activity.
UniProtKB/Swiss-Prot Summary for ATG10 Gene
E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.