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Aliases for ATG10 Gene

Aliases for ATG10 Gene

  • Autophagy Related 10 2 3 5
  • Autophagy-Related Protein 10 3 4
  • APG10L 3 4
  • ATG10 Autophagy Related 10 Homolog (S. Cerevisiae) 2
  • APG10 Autophagy 10-Like (S. Cerevisiae) 2
  • Ubiquitin-Like-Conjugating Enzyme ATG10 3
  • ATG10 Autophagy Related 10 Homolog 3
  • APG10 Autophagy 10-Like 3
  • APG10-Like 4
  • EC 6.3.2.- 4
  • Pp12616 3
  • APG10 3

External Ids for ATG10 Gene

Previous HGNC Symbols for ATG10 Gene

  • APG10L

Previous GeneCards Identifiers for ATG10 Gene

  • GC05P081304
  • GC05P081267
  • GC05P076475

Summaries for ATG10 Gene

Entrez Gene Summary for ATG10 Gene

  • Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ATG10 Gene

ATG10 (Autophagy Related 10) is a Protein Coding gene. Diseases associated with ATG10 include Anthracosis. Among its related pathways are Autophagy Pathway and Senescence and Autophagy in Cancer. Gene Ontology (GO) annotations related to this gene include ligase activity and Atg12 transferase activity.

UniProtKB/Swiss-Prot for ATG10 Gene

  • E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.

Gene Wiki entry for ATG10 Gene

Additional gene information for ATG10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG10 Gene

Genomics for ATG10 Gene

GeneHancer (GH) Regulatory Elements for ATG10 Gene

Promoters and enhancers for ATG10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I081970 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 602.3 -0.2 -249 2.8 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF766 ATG10 ATP6AP1L RPS23 SEM1P1
GH05I082276 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22.8 +306.0 305952 3.6 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 ZNF207 ZNF143 ATP6AP1L RPS23 GC05P082278 GC05M082258 ZCCHC9 ATG10 CKMT2-AS1 ENSG00000251374
GH05I082356 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 25.7 +385.6 385574 2.2 HDGF PKNOX1 ARNT POLR2B ZNF766 CBX5 FOS REST ZNF592 SMARCA4 ATG10 RPS23 GC05M082354 GC05M082258 ATP6AP1L
GH05I082018 Enhancer 1 Ensembl ENCODE 28.9 +46.8 46775 0.4 FOXA2 ARID4B RAD21 CHAMP1 HSF1 MIXL1 CEBPB REST PPARG KAT8 ATG10 ATG10-AS1 PPIAP11 GC05P082067
GH05I081748 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 -221.5 -221486 4.5 CLOCK FEZF1 IRF4 YY1 ZNF213 SP3 ZNF610 GLIS1 NR2C1 NBN SSBP2 ZCCHC9 CKMT2-AS1 RPS23 ATG10 GC05M081517
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ATG10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ATG10 gene promoter:

Genomic Locations for ATG10 Gene

Genomic Locations for ATG10 Gene
304,833 bases
Plus strand

Genomic View for ATG10 Gene

Genes around ATG10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG10 Gene

Proteins for ATG10 Gene

  • Protein details for ATG10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-like-conjugating enzyme ATG10
    Protein Accession:
    Secondary Accessions:
    • B2RE09
    • Q6PIX1
    • Q9H842

    Protein attributes for ATG10 Gene

    220 amino acids
    Molecular mass:
    25279 Da
    Quaternary structure:
    • Interacts with MAP1LC3A. By interacting with MAP1LC3A, it plays a role in the conjugation of ATG12 to ATG5. Also able to directly interact either with ATG5 or ATG7 (By similarity). Interacts with IRGM.
    • Sequence=BC004551; Type=Frameshift; Positions=26; Evidence={ECO:0000305}; Sequence=BC027718; Type=Frameshift; Positions=26; Evidence={ECO:0000305};

    Alternative splice isoforms for ATG10 Gene


neXtProt entry for ATG10 Gene

Post-translational modifications for ATG10 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ATG10 Gene

Domains & Families for ATG10 Gene

Gene Families for ATG10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ATG10 Gene


Suggested Antigen Peptide Sequences for ATG10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ATG10 family.
  • Belongs to the ATG10 family.
genes like me logo Genes that share domains with ATG10: view

Function for ATG10 Gene

Molecular function for ATG10 Gene

UniProtKB/Swiss-Prot Function:
E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.

Enzyme Numbers (IUBMB) for ATG10 Gene

Phenotypes From GWAS Catalog for ATG10 Gene

Gene Ontology (GO) - Molecular Function for ATG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
GO:0019777 Atg12 transferase activity ISS 20723759
genes like me logo Genes that share ontologies with ATG10: view
genes like me logo Genes that share phenotypes with ATG10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATG10 Gene

Localization for ATG10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG10 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATG10 gene
Compartment Confidence
cytosol 5
nucleus 3
lysosome 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ATG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ATG10: view

Pathways & Interactions for ATG10 Gene

genes like me logo Genes that share pathways with ATG10: view

Pathways by source for ATG10 Gene

1 GeneTex pathway for ATG10 Gene
2 Reactome pathways for ATG10 Gene
2 KEGG pathways for ATG10 Gene
1 R&D Systems pathway for ATG10 Gene

SIGNOR curated interactions for ATG10 Gene


Gene Ontology (GO) - Biological Process for ATG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006497 protein lipidation ISS --
GO:0006810 transport IEA --
GO:0006914 autophagy IMP 15657430
GO:0006983 ER overload response IMP 17256008
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with ATG10: view

Drugs & Compounds for ATG10 Gene

No Compound Related Data Available

Transcripts for ATG10 Gene

Unigene Clusters for ATG10 Gene

Autophagy related 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG10 Gene

No ASD Table

Relevant External Links for ATG10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATG10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATG10 Gene

Protein differential expression in normal tissues from HIPED for ATG10 Gene

This gene is overexpressed in Bone marrow stromal cell (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATG10 Gene

Protein tissue co-expression partners for ATG10 Gene

NURSA nuclear receptor signaling pathways regulating expression of ATG10 Gene:


SOURCE GeneReport for Unigene cluster for ATG10 Gene:

genes like me logo Genes that share expression patterns with ATG10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATG10 Gene

Orthologs for ATG10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATG10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATG10 33 34
  • 99.54 (n)
(Bos Taurus)
Mammalia ATG10 33
  • 88.74 (n)
MGC138057 34
  • 79 (a)
(Canis familiaris)
Mammalia ATG10 33 34
  • 88.28 (n)
(Mus musculus)
Mammalia Atg10 33 16 34
  • 83.81 (n)
(Rattus norvegicus)
Mammalia Atg10 33
  • 82.79 (n)
(Ornithorhynchus anatinus)
Mammalia ATG10 34
  • 56 (a)
(Monodelphis domestica)
Mammalia ATG10 34
  • 53 (a)
(Gallus gallus)
Aves ATG10 33 34
  • 65.44 (n)
(Anolis carolinensis)
Reptilia ATG10 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atg10 33
  • 61.35 (n)
(Danio rerio)
Actinopterygii atg10 33 34
  • 53.9 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5721 33
fruit fly
(Drosophila melanogaster)
Insecta CG12821 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea atg-10 34
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATG10 33
  • 46.52 (n)
Species where no ortholog for ATG10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG10 Gene

Gene Tree for ATG10 (if available)
Gene Tree for ATG10 (if available)

Paralogs for ATG10 Gene

No data available for Paralogs for ATG10 Gene

Variants for ATG10 Gene

Sequence variations from dbSNP and Humsavar for ATG10 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000005023 -- 82,244,967(+) G/A intron_variant
rs1000023263 -- 82,166,074(+) A/G intron_variant
rs1000056171 -- 82,138,674(+) T/C intron_variant
rs1000059863 -- 82,076,098(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000060573 -- 82,029,692(+) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ATG10 Gene

Variant ID Type Subtype PubMed ID
nsv980692 CNV duplication 23825009
nsv830364 CNV loss 17160897
nsv821002 CNV duplication 20802225
nsv598766 CNV gain 21841781
nsv598761 CNV loss 21841781
nsv598758 CNV gain 21841781
nsv598754 CNV gain 21841781
nsv598753 CNV gain 21841781
nsv520938 CNV gain 19592680
nsv477460 CNV novel sequence insertion 20440878
nsv471018 CNV gain 18288195
nsv328970 CNV insertion 16902084
nsv10712 CNV loss 18304495
nsv1028322 CNV gain 25217958
nsv1027178 CNV gain 25217958
esv3605607 CNV loss 21293372
esv3605606 CNV loss 21293372
esv3570235 CNV loss 25503493
esv2759353 CNV loss 17122850
esv2752082 CNV gain 17911159
esv2730390 CNV deletion 23290073
esv2730389 CNV deletion 23290073
esv2730388 CNV deletion 23290073
esv2669720 CNV deletion 23128226
esv25341 CNV loss 19812545
esv1267942 CNV deletion 17803354
dgv9903n54 CNV gain 21841781
dgv9902n54 CNV gain 21841781
dgv9901n54 CNV loss 21841781
dgv9900n54 CNV gain 21841781
dgv1110e214 CNV gain 21293372

Variation tolerance for ATG10 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATG10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG10 Gene

Disorders for ATG10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ATG10 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
  • pneumoconiosis
- elite association - COSMIC cancer census association via MalaCards
Search ATG10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ATG10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ATG10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATG10 Gene

Publications for ATG10 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Regulation of autophagy by the inositol trisphosphate receptor. (PMID: 17256008) Criollo A … Kroemer G (Cell death and differentiation 2007) 3 22 58
  3. Stimulation of ATG12-ATG5 conjugation by ribonucleic acid. (PMID: 16963840) Shao Y … Jiang X (Autophagy 2007) 3 22 58
  4. Inhibition of macroautophagy triggers apoptosis. (PMID: 15657430) Boya P … Kroemer G (Molecular and cellular biology 2005) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ATG10 Gene

Sources for ATG10 Gene

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