Aliases for ATF7IP2 Gene

Aliases for ATF7IP2 Gene

  • Activating Transcription Factor 7 Interacting Protein 2 2 3 5
  • Activating Transcription Factor 7-Interacting Protein 2 3 4
  • ATF7-Interacting Protein 2 3 4
  • MCAF2 3 4
  • MBD1-Containing Chromatin Associated Factor 2 3
  • MBD1-Containing Chromatin-Associated Factor 2 4
  • FLJ12668 2
  • ATF7IP2 5

External Ids for ATF7IP2 Gene

Previous GeneCards Identifiers for ATF7IP2 Gene

  • GC16P010582
  • GC16P010479
  • GC16P010491
  • GC16P010489
  • GC16P010430

Summaries for ATF7IP2 Gene

GeneCards Summary for ATF7IP2 Gene

ATF7IP2 (Activating Transcription Factor 7 Interacting Protein 2) is a Protein Coding gene. An important paralog of this gene is ATF7IP.

UniProtKB/Swiss-Prot Summary for ATF7IP2 Gene

  • Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ATF7IP2 Gene

Genomics for ATF7IP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ATF7IP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J010385 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 274.4 +60.1 60067 3 TBP ZBTB10 MXD4 SP1 CEBPA MNT SMAD5 MBD2 ZNF217 POLR2A ATF7IP2 HNRNPCP4 SOCS1 NUBP1 piR-49097-040 lnc-NUBP1-4 lnc-ATF7IP2-3 EMP2
GH16J010361 Enhancer 1.2 Ensembl ENCODE 34.4 +36.2 36185 2 MXD4 CEBPA MNT IKZF1 HES1 MBD2 BHLHE40 NONO HOMEZ KDM6A HSALNG0109512 ATF7IP2 HNRNPCP4 GRIN2A ENSG00000260756 lnc-ATF7IP2-3 EMP2
GH16J010405 Enhancer 1 Ensembl ENCODE 37.6 +78.9 78867 1.8 IKZF1 MBD2 HOMEZ ZNF395 SAP130 ZEB2 TAL1 ETV4 RARA TEAD3 lnc-NUBP1-4 ATF7IP2 piR-49097-040 lnc-ATF7IP2-3 EMP2
GH16J010356 Enhancer 1 Ensembl ENCODE 29 +31.0 31024 2 ZNF395 VEZF1 SMAD4 TAL1 ETV4 ZFP91 BCL6 TBP ZNF316 CREM ENSG00000260756 ATF7IP2 EMP2 HSALNG0109512 lnc-ATF7IP2-3 lnc-NUBP1-5
GH16J010383 Enhancer 0.6 Ensembl 22.4 +57.4 57367 0.4 TAL1 ZBTB33 TCF12 EGR1 TEAD4 RFX1 ARID1B CBFA2T2 TRIM24 HMBOX1 ATF7IP2 piR-49097-040 lnc-NUBP1-4 lnc-ATF7IP2-3 EMP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATF7IP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ATF7IP2

Top Transcription factor binding sites by QIAGEN in the ATF7IP2 gene promoter:
  • aMEF-2
  • Chx10
  • Evi-1
  • Lhx3a
  • LHX3b
  • MEF-2A
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • RSRFC4

Genomic Locations for ATF7IP2 Gene

Latest Assembly
chr16:10,326,434-10,483,643
(GRCh38/hg38)
Size:
157,210 bases
Orientation:
Plus strand

Previous Assembly
chr16:10,479,918-10,577,495
(GRCh37/hg19 by Entrez Gene)
Size:
97,578 bases
Orientation:
Plus strand

chr16:10,420,291-10,577,495
(GRCh37/hg19 by Ensembl)
Size:
157,205 bases
Orientation:
Plus strand

Genomic View for ATF7IP2 Gene

Genes around ATF7IP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATF7IP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATF7IP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF7IP2 Gene

Proteins for ATF7IP2 Gene

  • Protein details for ATF7IP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5U623-MCAF2_HUMAN
    Recommended name:
    Activating transcription factor 7-interacting protein 2
    Protein Accession:
    Q5U623
    Secondary Accessions:
    • B2RNR2
    • Q53EZ7
    • Q658U2
    • Q6IS97
    • Q8N9X8
    • Q9H9L6

    Protein attributes for ATF7IP2 Gene

    Size:
    682 amino acids
    Molecular mass:
    75764 Da
    Quaternary structure:
    • Interacts with MBD1, SETDB1 and SP1. Probably forms a complex with SETDB1 and MBD1.
    SequenceCaution:
    • Sequence=BAB14209.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ATF7IP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATF7IP2 Gene

Post-translational modifications for ATF7IP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATF7IP2 Gene

Domains & Families for ATF7IP2 Gene

Gene Families for ATF7IP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ATF7IP2 Gene

Suggested Antigen Peptide Sequences for ATF7IP2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57516, highly similar to Homo sapiens activating transcription factor 7 interacting protein 2 (ATF7IP2), mRNA (B4DKH3_HUMAN)
  • MBD1-containing chromatin-associated factor 2 (MCAF2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5U623

UniProtKB/Swiss-Prot:

MCAF2_HUMAN :
  • Belongs to the MCAF family.
Family:
  • Belongs to the MCAF family.
genes like me logo Genes that share domains with ATF7IP2: view

Function for ATF7IP2 Gene

Molecular function for ATF7IP2 Gene

UniProtKB/Swiss-Prot Function:
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable).

Phenotypes From GWAS Catalog for ATF7IP2 Gene

Gene Ontology (GO) - Molecular Function for ATF7IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ATF7IP2: view
genes like me logo Genes that share phenotypes with ATF7IP2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF7IP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATF7IP2 Gene

Localization for ATF7IP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF7IP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATF7IP2 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ATF7IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ATF7IP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ATF7IP2 Gene

Pathways & Interactions for ATF7IP2 Gene

PathCards logo

SuperPathways for ATF7IP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATF7IP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ATF7IP2 Gene

Drugs & Compounds for ATF7IP2 Gene

No Compound Related Data Available

Transcripts for ATF7IP2 Gene

mRNA/cDNA for ATF7IP2 Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ATF7IP2

Alternative Splicing Database (ASD) splice patterns (SP) for ATF7IP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1:
SP2: -

Relevant External Links for ATF7IP2 Gene

GeneLoc Exon Structure for
ATF7IP2

Expression for ATF7IP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ATF7IP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATF7IP2 Gene

This gene is overexpressed in Testis (x5.6) and Liver (x4.5).

Protein differential expression in normal tissues from HIPED for ATF7IP2 Gene

This gene is overexpressed in Testis (42.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ATF7IP2 Gene



Protein tissue co-expression partners for ATF7IP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ATF7IP2

SOURCE GeneReport for Unigene cluster for ATF7IP2 Gene:

Hs.513343

Evidence on tissue expression from TISSUES for ATF7IP2 Gene

  • Lung(4.2)
  • Stomach(4.2)
genes like me logo Genes that share expression patterns with ATF7IP2: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATF7IP2 Gene

Orthologs for ATF7IP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATF7IP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ATF7IP2 30 31
  • 99.26 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ATF7IP2 30 31
  • 82.47 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ATF7IP2 30 31
  • 81.72 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Atf7ip2 30 17 31
  • 78.83 (n)
OneToOne
Gm50496 17
Rat
(Rattus norvegicus)
Mammalia Atf7ip2 30
  • 78.69 (n)
Oppossum
(Monodelphis domestica)
Mammalia ATF7IP2 31
  • 40 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ATF7IP2 31
  • 38 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ATF7IP2 31
  • 20 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii atf7ip2 31
  • 22 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta wde 31
  • 8 (a)
OneToMany
Species where no ortholog for ATF7IP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ATF7IP2 Gene

ENSEMBL:
Gene Tree for ATF7IP2 (if available)
TreeFam:
Gene Tree for ATF7IP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATF7IP2: view image

Paralogs for ATF7IP2 Gene

Paralogs for ATF7IP2 Gene

(1) SIMAP similar genes for ATF7IP2 Gene using alignment to 8 proteins:

  • MCAF2_HUMAN
  • B4DKH3_HUMAN
  • F5GY73_HUMAN
  • H3BNE6_HUMAN
  • H3BPC9_HUMAN
  • H3BR07_HUMAN
  • H3BUP1_HUMAN
  • I3L4M8_HUMAN

Pseudogenes.org Pseudogenes for ATF7IP2 Gene

genes like me logo Genes that share paralogs with ATF7IP2: view

Variants for ATF7IP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ATF7IP2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
993813 Uncertain Significance: none provided 10,482,012(+) G/C
NM_001256160.3(ATF7IP2):c.*113G>C
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR
rs34834862 - p.Ser527Leu
rs9931441 - p.Ala543Thr
rs9932051 - p.Thr537Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ATF7IP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ATF7IP2 Gene

Variant ID Type Subtype PubMed ID
dgv2727n100 CNV gain 25217958
dgv4907n54 CNV loss 21841781
esv2662100 CNV deletion 23128226
esv2713960 CNV deletion 23290073
esv3637899 CNV loss 21293372
esv3637900 CNV loss 21293372
esv3637901 CNV loss 21293372
esv3892790 CNV loss 25118596
nsv1036128 CNV loss 25217958
nsv1040428 CNV gain 25217958
nsv1051406 CNV loss 25217958
nsv457405 CNV loss 19166990
nsv471892 CNV novel sequence insertion 20440878
nsv519263 CNV gain+loss 19592680
nsv571448 CNV loss 21841781
nsv571451 CNV loss 21841781
nsv833139 CNV loss 17160897

Variation tolerance for ATF7IP2 Gene

Residual Variation Intolerance Score: 86.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.88; 74.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATF7IP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATF7IP2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF7IP2 Gene

Disorders for ATF7IP2 Gene

Additional Disease Information for ATF7IP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for ATF7IP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATF7IP2 Gene

Publications for ATF7IP2 Gene

  1. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. (PMID: 20195266) Adkins DE … van den Oord EJ (Molecular psychiatry 2011) 3 41
  2. Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins. (PMID: 15691849) Ichimura T … Nakao M (The Journal of biological chemistry 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ATF7IP2 Gene

  • Biorbyt antibodies for ATF7IP2

Sources for ATF7IP2 Gene