Aliases for ATF7IP Gene
External Ids for ATF7IP Gene
Previous GeneCards Identifiers for ATF7IP Gene
ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]
GeneCards Summary for ATF7IP Gene
ATF7IP (Activating Transcription Factor 7 Interacting Protein) is a Protein Coding gene. Diseases associated with ATF7IP include Testicular Germ Cell Cancer and Germ Cell Cancer. Among its related pathways are PKMTs methylate histone lysines and Chromatin organization. Gene Ontology (GO) annotations related to this gene include ATPase activity and transcription corepressor activity. An important paralog of this gene is ATF7IP2.
UniProtKB/Swiss-Prot Summary for ATF7IP Gene
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100).